A Comparative Trial of Occupational Therapy Using Ayres Sensory Integration and Applied Behavior Analysis Interventions for Autistic Children / Roseann C. SCHAAF in Autism Research, 18-10 (October 2025)  

Public ISBD [article]  inAutism Research > 18-10 (October 2025) . - p.2120-2134 Titre : A Comparative Trial of Occupational Therapy Using Ayres Sensory Integration and Applied Behavior Analysis Interventions for Autistic Children Type de document : texte imprimé Auteurs : Roseann C. SCHAAF, Auteur ; Elizabeth RIDGWAY, Auteur ; Emily A. JONES, Auteur ; Rachel L. DUMONT, Auteur ; John J. FOXE, Auteur ; Tim CONLY, Auteur ; Catherine SANCIMINO, Auteur ; Misung YI, Auteur ; Zoe MAILLOUX, Auteur ; Joanne HUNT, Auteur ; Leon KIRSCHNER, Auteur ; Benjamin E. LEIBY, Auteur ; Sophie MOLHOLM, Auteur Article en page(s) : p.2120-2134 Langues : Anglais (eng) Mots-clés : applied behavior analysis  autism  autistic  autistic children  Ayres Sensory Integration  occupational therapy Index. décimale : PER Périodiques Résumé : ABSTRACT Many autistic children demonstrate sensory integration differences that impact their participation in daily living activities and tasks. Occupational Therapy using Ayres Sensory Integration (OT-ASI) is an evidence-based intervention for autistic children that addresses the sensory integrative factors impacting daily living skills and participation in a variety of tasks and activities. Applied Behavior Analysis (ABA) is the recommended evidence-based practice for autism to improve a range of developmental domains. This study compared Occupational Therapy using Ayres Sensory Integration, Applied Behavior Analysis, and no treatment on daily living skills and individualized goals for autistic children who also show sensory differences. A parallel arm comparative effectiveness trial design with participants randomized equally to OT-ASI, ABA, or no treatment. Intervention consisted of 30 one-hour sessions. Significant gains in individualized goals, measured by Goal Attainment Scaling, were found in both treatment arms over the no treatment group. Both the OT-ASI and the ABA groups improved in daily living skills measured on the Pediatric Evaluation of Disabilities Inventory; although the improvements over the no treatment group were not significant. Both OT-ASI and ABA improved individualized goals and daily living skills at comparable levels. These findings are discussed in light of their implications for intervention. Trial Registration: NCT02536365 En ligne : https://doi.org/10.1002/aur.70099 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] A Comparative Trial of Occupational Therapy Using Ayres Sensory Integration and Applied Behavior Analysis Interventions for Autistic Children [texte imprimé] / Roseann C. SCHAAF, Auteur ; Elizabeth RIDGWAY, Auteur ; Emily A. JONES, Auteur ; Rachel L. DUMONT, Auteur ; John J. FOXE, Auteur ; Tim CONLY, Auteur ; Catherine SANCIMINO, Auteur ; Misung YI, Auteur ; Zoe MAILLOUX, Auteur ; Joanne HUNT, Auteur ; Leon KIRSCHNER, Auteur ; Benjamin E. LEIBY, Auteur ; Sophie MOLHOLM, Auteur . - p.2120-2134. Langues : Anglais (eng) in Autism Research > 18-10 (October 2025) . - p.2120-2134 Mots-clés : applied behavior analysis  autism  autistic  autistic children  Ayres Sensory Integration  occupational therapy Index. décimale : PER Périodiques Résumé : ABSTRACT Many autistic children demonstrate sensory integration differences that impact their participation in daily living activities and tasks. Occupational Therapy using Ayres Sensory Integration (OT-ASI) is an evidence-based intervention for autistic children that addresses the sensory integrative factors impacting daily living skills and participation in a variety of tasks and activities. Applied Behavior Analysis (ABA) is the recommended evidence-based practice for autism to improve a range of developmental domains. This study compared Occupational Therapy using Ayres Sensory Integration, Applied Behavior Analysis, and no treatment on daily living skills and individualized goals for autistic children who also show sensory differences. A parallel arm comparative effectiveness trial design with participants randomized equally to OT-ASI, ABA, or no treatment. Intervention consisted of 30 one-hour sessions. Significant gains in individualized goals, measured by Goal Attainment Scaling, were found in both treatment arms over the no treatment group. Both the OT-ASI and the ABA groups improved in daily living skills measured on the Pediatric Evaluation of Disabilities Inventory; although the improvements over the no treatment group were not significant. Both OT-ASI and ABA improved individualized goals and daily living skills at comparable levels. These findings are discussed in light of their implications for intervention. Trial Registration: NCT02536365 En ligne : https://doi.org/10.1002/aur.70099 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Sensory Phenotypes in Autism: Making a Case for the Inclusion of Sensory Integration Functions / Zoe MAILLOUX ; Elizabeth RIDGWAY ; Alaina S. BERRUTI ; Rachel L. DUMONT ; Emily A. JONES ; Benjamin E. LEIBY ; Catherine SANCIMINO ; Misung YI ; Sophie MOLHOLM in Journal of Autism and Developmental Disorders, 53-12 (December 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-12 (December 2023) . - p.4759-4771 Titre : Sensory Phenotypes in Autism: Making a Case for the Inclusion of Sensory Integration Functions Type de document : texte imprimé Auteurs : Zoe MAILLOUX, Auteur ; Elizabeth RIDGWAY, Auteur ; Alaina S. BERRUTI, Auteur ; Rachel L. DUMONT, Auteur ; Emily A. JONES, Auteur ; Benjamin E. LEIBY, Auteur ; Catherine SANCIMINO, Auteur ; Misung YI, Auteur ; Sophie MOLHOLM, Auteur Article en page(s) : p.4759-4771 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Sensory features are part of the diagnostic criteria for autism and include sensory hypo/hyper reactivity and unusual sensory interest; however, additional sensory differences, namely differences in sensory integration, have not been routinely explored. This study characterized sensory integration differences in a cohort of children (n=93) with a confirmed diagnosis of autism (5-9 years) using a standardized, norm-referenced battery. Mean z scores, autism diagnostic scores, and IQ are reported. Participants showed substantial deficits in tactile perception, praxis, balance, visual perception, and visual-motor skills. Relationship with autism diagnostic test scores were weak or absent. Findings suggest additional sensory difficulties that are not typically assessed or considered when characterizing sensory features in autism. These data have implications for a greater understanding of the sensory features in the autism phenotype and the development of personalized treatments. En ligne : https://doi.org/10.1007/s10803-022-05763-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=516 [article] Sensory Phenotypes in Autism: Making a Case for the Inclusion of Sensory Integration Functions [texte imprimé] / Zoe MAILLOUX, Auteur ; Elizabeth RIDGWAY, Auteur ; Alaina S. BERRUTI, Auteur ; Rachel L. DUMONT, Auteur ; Emily A. JONES, Auteur ; Benjamin E. LEIBY, Auteur ; Catherine SANCIMINO, Auteur ; Misung YI, Auteur ; Sophie MOLHOLM, Auteur . - p.4759-4771. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-12 (December 2023) . - p.4759-4771 Index. décimale : PER Périodiques Résumé : Sensory features are part of the diagnostic criteria for autism and include sensory hypo/hyper reactivity and unusual sensory interest; however, additional sensory differences, namely differences in sensory integration, have not been routinely explored. This study characterized sensory integration differences in a cohort of children (n=93) with a confirmed diagnosis of autism (5-9 years) using a standardized, norm-referenced battery. Mean z scores, autism diagnostic scores, and IQ are reported. Participants showed substantial deficits in tactile perception, praxis, balance, visual perception, and visual-motor skills. Relationship with autism diagnostic test scores were weak or absent. Findings suggest additional sensory difficulties that are not typically assessed or considered when characterizing sensory features in autism. These data have implications for a greater understanding of the sensory features in the autism phenotype and the development of personalized treatments. En ligne : https://doi.org/10.1007/s10803-022-05763-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=516

The Brain Gene Registry: a data snapshot / Dustin BALDRIDGE in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : The Brain Gene Registry: a data snapshot Type de document : texte imprimé Auteurs : Dustin BALDRIDGE, Auteur ; Levi KASTER, Auteur ; Catherine SANCIMINO, Auteur ; Siddharth SRIVASTAVA, Auteur ; Sophie MOLHOLM, Auteur ; Aditi GUPTA, Auteur ; Inez OH, Auteur ; Virginia LANZOTTI, Auteur ; Daleep GREWAL, Auteur ; Erin Rooney RIGGS, Auteur ; Juliann M. SAVATT, Auteur ; Rachel HAUCK, Auteur ; Abigail SVEDEN, Auteur ; BRAIN GENE REGISTRY CONSORTIUM, Auteur ; John N. CONSTANTINO, Auteur ; Joseph PIVEN, Auteur ; Christina A. GURNETT, Auteur ; Maya CHOPRA, Auteur ; Heather HAZLETT, Auteur ; Philip R.O. PAYNE, Auteur Langues : Anglais (eng) Mots-clés : Humans  Male  Female  Autism Spectrum Disorder/genetics  Autistic Disorder  Neurodevelopmental Disorders  Intellectual Disability  Brain  Registries  Methyltransferases  Brain gene registry  Electronic health records  Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : Monogenic disorders account for a large proportion of population-attributable risk for neurodevelopmental disabilities. However, the data necessary to infer a causal relationship between a given genetic variant and a particular neurodevelopmental disorder is often lacking. Recognizing this scientific roadblock, 13 Intellectual and Developmental Disabilities Research Centers (IDDRCs) formed a consortium to create the Brain Gene Registry (BGR), a repository pairing clinical genetic data with phenotypic data from participants with variants in putative brain genes. Phenotypic profiles are assembled from the electronic health record (EHR) and a battery of remotely administered standardized assessments collectively referred to as the Rapid Neurobehavioral Assessment Protocol (RNAP), which include cognitive, neurologic, and neuropsychiatric assessments, as well as assessments for attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Co-enrollment of BGR participants in the Clinical Genome Resource's (ClinGen's) GenomeConnect enables display of variant information in ClinVar. The BGR currently contains data on 479 participants who are 55% male, 6% Asian, 6% Black or African American, 76% white, and 12% Hispanic/Latine. Over 200 genes are represented in the BGR, with 12 or more participants harboring variants in each of these genes: CACNA1A, DNMT3A, SLC6A1, SETD5, and MYT1L. More than 30% of variants are de novo and 43% are classified as variants of uncertain significance (VUSs). Mean standard scores on cognitive or developmental screens are below average for the BGR cohort. EHR data reveal developmental delay as the earliest and most common diagnosis in this sample, followed by speech and language disorders, ASD, and ADHD. BGR data has already been used to accelerate gene-disease validity curation of 36 genes evaluated by ClinGen's BGR Intellectual Disability (ID)-Autism (ASD) Gene Curation Expert Panel. In summary, the BGR is a resource for use by stakeholders interested in advancing translational research for brain genes and continues to recruit participants with clinically reported variants to establish a rich and well-characterized national resource to promote research on neurodevelopmental disorders. En ligne : https://dx.doi.org/10.1186/s11689-024-09530-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] The Brain Gene Registry: a data snapshot [texte imprimé] / Dustin BALDRIDGE, Auteur ; Levi KASTER, Auteur ; Catherine SANCIMINO, Auteur ; Siddharth SRIVASTAVA, Auteur ; Sophie MOLHOLM, Auteur ; Aditi GUPTA, Auteur ; Inez OH, Auteur ; Virginia LANZOTTI, Auteur ; Daleep GREWAL, Auteur ; Erin Rooney RIGGS, Auteur ; Juliann M. SAVATT, Auteur ; Rachel HAUCK, Auteur ; Abigail SVEDEN, Auteur ; BRAIN GENE REGISTRY CONSORTIUM, Auteur ; John N. CONSTANTINO, Auteur ; Joseph PIVEN, Auteur ; Christina A. GURNETT, Auteur ; Maya CHOPRA, Auteur ; Heather HAZLETT, Auteur ; Philip R.O. PAYNE, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Humans  Male  Female  Autism Spectrum Disorder/genetics  Autistic Disorder  Neurodevelopmental Disorders  Intellectual Disability  Brain  Registries  Methyltransferases  Brain gene registry  Electronic health records  Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : Monogenic disorders account for a large proportion of population-attributable risk for neurodevelopmental disabilities. However, the data necessary to infer a causal relationship between a given genetic variant and a particular neurodevelopmental disorder is often lacking. Recognizing this scientific roadblock, 13 Intellectual and Developmental Disabilities Research Centers (IDDRCs) formed a consortium to create the Brain Gene Registry (BGR), a repository pairing clinical genetic data with phenotypic data from participants with variants in putative brain genes. Phenotypic profiles are assembled from the electronic health record (EHR) and a battery of remotely administered standardized assessments collectively referred to as the Rapid Neurobehavioral Assessment Protocol (RNAP), which include cognitive, neurologic, and neuropsychiatric assessments, as well as assessments for attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Co-enrollment of BGR participants in the Clinical Genome Resource's (ClinGen's) GenomeConnect enables display of variant information in ClinVar. The BGR currently contains data on 479 participants who are 55% male, 6% Asian, 6% Black or African American, 76% white, and 12% Hispanic/Latine. Over 200 genes are represented in the BGR, with 12 or more participants harboring variants in each of these genes: CACNA1A, DNMT3A, SLC6A1, SETD5, and MYT1L. More than 30% of variants are de novo and 43% are classified as variants of uncertain significance (VUSs). Mean standard scores on cognitive or developmental screens are below average for the BGR cohort. EHR data reveal developmental delay as the earliest and most common diagnosis in this sample, followed by speech and language disorders, ASD, and ADHD. BGR data has already been used to accelerate gene-disease validity curation of 36 genes evaluated by ClinGen's BGR Intellectual Disability (ID)-Autism (ASD) Gene Curation Expert Panel. In summary, the BGR is a resource for use by stakeholders interested in advancing translational research for brain genes and continues to recruit participants with clinically reported variants to establish a rich and well-characterized national resource to promote research on neurodevelopmental disorders. En ligne : https://dx.doi.org/10.1186/s11689-024-09530-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

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