Plasma Amino Acid Profile in Children with Autism Spectrum Disorder in Southern China: Analysis of 110 Cases / Wen-Xiong CHEN in Journal of Autism and Developmental Disorders, 54-4 (April 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-4 (April 2024) . - p.1567-1581 Titre : Plasma Amino Acid Profile in Children with Autism Spectrum Disorder in Southern China: Analysis of 110 Cases Type de document : texte imprimé Auteurs : Wen-Xiong CHEN, Auteur ; Yi-Ru CHEN, Auteur ; Min-Zhi PENG, Auteur ; Xian LIU, Auteur ; Yan-Na CAI, Auteur ; Zhi-Fang HUANG, Auteur ; Si-Yuan YANG, Auteur ; Jing-Yu HUANG, Auteur ; Ruo-Han WANG, Auteur ; Peng YI, Auteur ; Li LIU, Auteur Article en page(s) : p.1567-1581 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : To retrospectively explore the characteristics of plasma amino acids (PAAs) in children with autism spectrum disorder and their clinical association via case-control study. A total of 110 autistic and 55 healthy children were recruited from 2014 to 2018. The clinical phenotypes included severity of autism, cognition, adaptability, and regression. Compared with the control group, autistic children had significantly elevated glutamate, ?-Amino-n-butyric acid, glutamine, sarcosine, ?-aminolevulinic acid, glycine and citrulline. In contrast, their plasma level of ethanolamine, phenylalanine, tryptophan, homocysteine, pyroglutamic acid, hydroxyproline, ornithine, histidine, lysine, and glutathione were significantly lower. Elevated neuroactive amino acids (glutamate) and decreased essential amino acids were mostly distinct characteristics of PAAs of autistic children. Increased level of tryptophan might be associated with severity of autism. En ligne : https://doi.org/10.1007/s10803-022-05829-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526 [article] Plasma Amino Acid Profile in Children with Autism Spectrum Disorder in Southern China: Analysis of 110 Cases [texte imprimé] / Wen-Xiong CHEN, Auteur ; Yi-Ru CHEN, Auteur ; Min-Zhi PENG, Auteur ; Xian LIU, Auteur ; Yan-Na CAI, Auteur ; Zhi-Fang HUANG, Auteur ; Si-Yuan YANG, Auteur ; Jing-Yu HUANG, Auteur ; Ruo-Han WANG, Auteur ; Peng YI, Auteur ; Li LIU, Auteur . - p.1567-1581. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-4 (April 2024) . - p.1567-1581 Index. décimale : PER Périodiques Résumé : To retrospectively explore the characteristics of plasma amino acids (PAAs) in children with autism spectrum disorder and their clinical association via case-control study. A total of 110 autistic and 55 healthy children were recruited from 2014 to 2018. The clinical phenotypes included severity of autism, cognition, adaptability, and regression. Compared with the control group, autistic children had significantly elevated glutamate, ?-Amino-n-butyric acid, glutamine, sarcosine, ?-aminolevulinic acid, glycine and citrulline. In contrast, their plasma level of ethanolamine, phenylalanine, tryptophan, homocysteine, pyroglutamic acid, hydroxyproline, ornithine, histidine, lysine, and glutathione were significantly lower. Elevated neuroactive amino acids (glutamate) and decreased essential amino acids were mostly distinct characteristics of PAAs of autistic children. Increased level of tryptophan might be associated with severity of autism. En ligne : https://doi.org/10.1007/s10803-022-05829-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526

Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-analysis and Meta-regression / Xian LIU in Journal of Autism and Developmental Disorders, 52-2 (February 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.522-539 Titre : Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-analysis and Meta-regression Type de document : texte imprimé Auteurs : Xian LIU, Auteur ; Mingyang ZOU, Auteur ; Caihong SUN, Auteur ; Lijie WU, Auteur ; Wen-Xiong CHEN, Auteur Article en page(s) : p.522-539 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/chemically induced/epidemiology  Diet  Dietary Supplements  Female  Folic Acid  Humans  Pregnancy  Vitamins  Autism spectrum disorder  Folic acid  Meta-analysis  Meta-regression  Prenatal Index. décimale : PER Périodiques Résumé : We systematically reviewed the evidence on the association between maternal folic acid supplementation and the risk of offspring's autism spectrum disorders (ASD). A total of 10 studies with 23 sub-studies (9795 ASD cases) were included. Folic acid supplementation during early pregnancy was associated with a lower risk of offspring's ASD [OR 0.57, 95% CI 0.41-0.78]. The consumption of a daily amount of at least 400 μg folic acid from dietary sources and supplements, was associated with a reduced risk of offspring ASD [OR 0.55, 95% CI 0.36-0.83]. Critical effective maternal folic acid supplementation strategies, such as intake timing and intake dosage, may aid the reduction in the risk of offspring ASD. This meta-analysis provided new insights for the prevention of offspring's ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-04951-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 [article] Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-analysis and Meta-regression [texte imprimé] / Xian LIU, Auteur ; Mingyang ZOU, Auteur ; Caihong SUN, Auteur ; Lijie WU, Auteur ; Wen-Xiong CHEN, Auteur . - p.522-539. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.522-539 Mots-clés : Autism Spectrum Disorder/chemically induced/epidemiology  Diet  Dietary Supplements  Female  Folic Acid  Humans  Pregnancy  Vitamins  Autism spectrum disorder  Folic acid  Meta-analysis  Meta-regression  Prenatal Index. décimale : PER Périodiques Résumé : We systematically reviewed the evidence on the association between maternal folic acid supplementation and the risk of offspring's autism spectrum disorders (ASD). A total of 10 studies with 23 sub-studies (9795 ASD cases) were included. Folic acid supplementation during early pregnancy was associated with a lower risk of offspring's ASD [OR 0.57, 95% CI 0.41-0.78]. The consumption of a daily amount of at least 400 μg folic acid from dietary sources and supplements, was associated with a reduced risk of offspring ASD [OR 0.55, 95% CI 0.36-0.83]. Critical effective maternal folic acid supplementation strategies, such as intake timing and intake dosage, may aid the reduction in the risk of offspring ASD. This meta-analysis provided new insights for the prevention of offspring's ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-04951-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455

Prevalence of epilepsy in autism spectrum disorders: A systematic review and meta-analysis / Xian LIU in Autism, 26-1 (January 2022)  

Public ISBD [article]  inAutism > 26-1 (January 2022) . - p.33-50 Titre : Prevalence of epilepsy in autism spectrum disorders: A systematic review and meta-analysis Type de document : texte imprimé Auteurs : Xian LIU, Auteur ; Xin SUN, Auteur ; Caihong SUN, Auteur ; Mingyang ZOU, Auteur ; Yiru CHEN, Auteur ; Junping HUANG, Auteur ; Lijie WU, Auteur ; Wen-Xiong CHEN, Auteur Année de publication : 2022 Article en page(s) : p.33-50 Langues : Anglais (eng) Mots-clés : adulthood  autism spectrum disorder (ASD)  childhood  co-occurrence  epilepsy  meta-analyses Index. décimale : PER Périodiques Résumé : Autistic individuals experience higher co-occurring medical conditions than the general population, and yet the estimates of autistic individuals with epilepsy are not updated. Co-occurrence of epilepsy in autistic individuals often aggravated cognitive impairment and increased the risk of poor long-term prognosis. Thus, an updated systematic review and meta-analysis was conducted to study the relevant articles published from inception to 2020, evaluate the prevalence of epilepsy in autistic individuals, and further explore the putative factors influencing the prevalence. A total of 66 studies from 53 articles were included in this study. The results showed that epilepsy is more common in autistic individuals than in the general population. The prevalence of epilepsy in autistic individuals in the clinical sample-based studies was higher than that in the population-based based cross-sectional or cohort studies. The prevalence of epilepsy in autistic adults was higher than that in autistic children. A significantly increased prevalence of epilepsy was detected in the autistic adolescent group (11-17 years old), and a higher trend of prevalence of epilepsy was observed in the autistic pre-school group (⩽ 6 -years-old) than that of the autistic school-aged group (7-10 years-old). The prevalence of epilepsy increased with age, female rate, and low intellectual function rate of autistic individuals. However, the human development index of countries was negatively associated with the pooled prevalence, which could be attributed to the different levels of awareness, diagnostic technologies, and autism-service support worldwide. About 1/10 autistic individuals also had epilepsy, which was common in the clinical setting, adolescents, adults, females, or patients with intellectual disability and less common in the country with high human development index. Thus, these findings provided critical and innovative views on the prevalence of epilepsy in autistic individuals and contributed to the targeted clinical management and preventive measures. En ligne : http://dx.doi.org/10.1177/13623613211045029 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 [article] Prevalence of epilepsy in autism spectrum disorders: A systematic review and meta-analysis [texte imprimé] / Xian LIU, Auteur ; Xin SUN, Auteur ; Caihong SUN, Auteur ; Mingyang ZOU, Auteur ; Yiru CHEN, Auteur ; Junping HUANG, Auteur ; Lijie WU, Auteur ; Wen-Xiong CHEN, Auteur . - 2022 . - p.33-50. Langues : Anglais (eng) in Autism > 26-1 (January 2022) . - p.33-50 Mots-clés : adulthood  autism spectrum disorder (ASD)  childhood  co-occurrence  epilepsy  meta-analyses Index. décimale : PER Périodiques Résumé : Autistic individuals experience higher co-occurring medical conditions than the general population, and yet the estimates of autistic individuals with epilepsy are not updated. Co-occurrence of epilepsy in autistic individuals often aggravated cognitive impairment and increased the risk of poor long-term prognosis. Thus, an updated systematic review and meta-analysis was conducted to study the relevant articles published from inception to 2020, evaluate the prevalence of epilepsy in autistic individuals, and further explore the putative factors influencing the prevalence. A total of 66 studies from 53 articles were included in this study. The results showed that epilepsy is more common in autistic individuals than in the general population. The prevalence of epilepsy in autistic individuals in the clinical sample-based studies was higher than that in the population-based based cross-sectional or cohort studies. The prevalence of epilepsy in autistic adults was higher than that in autistic children. A significantly increased prevalence of epilepsy was detected in the autistic adolescent group (11-17 years old), and a higher trend of prevalence of epilepsy was observed in the autistic pre-school group (⩽ 6 -years-old) than that of the autistic school-aged group (7-10 years-old). The prevalence of epilepsy increased with age, female rate, and low intellectual function rate of autistic individuals. However, the human development index of countries was negatively associated with the pooled prevalence, which could be attributed to the different levels of awareness, diagnostic technologies, and autism-service support worldwide. About 1/10 autistic individuals also had epilepsy, which was common in the clinical setting, adolescents, adults, females, or patients with intellectual disability and less common in the country with high human development index. Thus, these findings provided critical and innovative views on the prevalence of epilepsy in autistic individuals and contributed to the targeted clinical management and preventive measures. En ligne : http://dx.doi.org/10.1177/13623613211045029 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451

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