[article]
| Titre : |
Visual feedback and motor memory contributions to sustained motor control deficits in autism spectrum disorder across childhood and into adulthood |
| Type de document : |
texte imprimé |
| Auteurs : |
Robin L. SHAFER, Auteur ; James BARTOLOTTI, Auteur ; Abigail DRIGGERS, Auteur ; Erin BOJANEK, Auteur ; Zheng WANG, Auteur ; Matthew W. MOSCONI, Auteur |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Humans Adolescent Child Autism Spectrum Disorder/physiopathology/complications Male Young Adult Feedback, Sensory/physiology Adult Female Psychomotor Performance/physiology Memory/physiology Motor Skills/physiology Hand Strength/physiology Autism spectrum disorders Entropy Fine motor control Grip force Motor memory Sensorimotor Sensory integration Visual feedback Visuomotor provided written informed consent after a complete description of the study, in accordance with the Declaration of Helsinki. For participants under the age of 18 and adults who were under legal guardianship, a parent or legal guardian provided written informed consent on behalf of the participant, and the participant provided written assent. All study procedures were approved by the University of Kansas Medical Center Institutional Review Board (IRB#: STUDY00140269). Consent for publication: Not applicable. Competing interests: MWM is PI on an investigator initiated clinical trial of behavioral inflexibility in autism funded by Acadia Pharmaceuticals. MWM and ZW received funding from Novartis Pharmaceuticals Corporation for an investigator-initiated study of Phelan McDermid Syndrome. The other authors declare that they have no competing interests. |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: Autistic individuals show deficits in sustained fine motor control which are associated with an over-reliance on visual feedback. Motor memory deficits also have been reported during sustained fine motor control in autism spectrum disorders (ASD). The development of motor memory and visuomotor feedback processes contributing to sustained motor control issues in ASD are not known. The present study aimed to characterize age-related changes in visual feedback and motor memory processes contributing to sustained fine motor control issues in ASD. METHODS: Fifty-four autistic participants and 31 neurotypical (NT) controls ages 10-25 years completed visually guided and memory guided sustained precision gripping tests by pressing on force sensors with their dominant hand index finger and thumb. For visually guided trials, participants viewed a stationary target bar and a force bar that moved upwards with increased force for 15s. During memory guided trials, the force bar was visible for 3s, after which participants attempted to maintain their force output without visual feedback for another 12s. To assess visual feedback processing, force accuracy, variability (standard deviation), and regularity (sample entropy) were examined. To assess motor memory, force decay latency, slope, and magnitude were examined during epochs without visual feedback. RESULTS: Relative to NT controls, autistic individuals showed a greater magnitude and a trend for a steeper slope of force decay during memory guided trials. Across conditions, the ASD group showed reduced force accuracy (β = 0.41, R(2) = 0.043, t(79.3)=2.36, p = .021) and greater force variability (β=-2.16, R(2) = 0.143, t(77.1)=-4.04, p = .0001) and regularity (β=-0.52, R(2) = 0.021, t(77.4)=-2.21, p = .030) relative to NT controls at younger ages, but these differences normalized by adolescence (age x group interactions). Lower force accuracy and greater force variability during visually guided trials and steeper decay slope during memory guided trials were associated with overall autism severity. CONCLUSIONS: Our findings that autistic individuals show a greater magnitude and tendency for a greater rate of force decay than NT individuals following the removal of visual feedback indicate that motor memory deficits contribute to fine motor control issues in ASD. Findings that sensorimotor differences in ASD were specific to younger ages suggest delayed development across multiple motor control processes. |
| En ligne : |
https://dx.doi.org/10.1186/s11689-025-09607-7 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 |
in Journal of Neurodevelopmental Disorders > 17 (2025)
[article] Visual feedback and motor memory contributions to sustained motor control deficits in autism spectrum disorder across childhood and into adulthood [texte imprimé] / Robin L. SHAFER, Auteur ; James BARTOLOTTI, Auteur ; Abigail DRIGGERS, Auteur ; Erin BOJANEK, Auteur ; Zheng WANG, Auteur ; Matthew W. MOSCONI, Auteur. Langues : Anglais ( eng) in Journal of Neurodevelopmental Disorders > 17 (2025)
| Mots-clés : |
Humans Adolescent Child Autism Spectrum Disorder/physiopathology/complications Male Young Adult Feedback, Sensory/physiology Adult Female Psychomotor Performance/physiology Memory/physiology Motor Skills/physiology Hand Strength/physiology Autism spectrum disorders Entropy Fine motor control Grip force Motor memory Sensorimotor Sensory integration Visual feedback Visuomotor provided written informed consent after a complete description of the study, in accordance with the Declaration of Helsinki. For participants under the age of 18 and adults who were under legal guardianship, a parent or legal guardian provided written informed consent on behalf of the participant, and the participant provided written assent. All study procedures were approved by the University of Kansas Medical Center Institutional Review Board (IRB#: STUDY00140269). Consent for publication: Not applicable. Competing interests: MWM is PI on an investigator initiated clinical trial of behavioral inflexibility in autism funded by Acadia Pharmaceuticals. MWM and ZW received funding from Novartis Pharmaceuticals Corporation for an investigator-initiated study of Phelan McDermid Syndrome. The other authors declare that they have no competing interests. |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: Autistic individuals show deficits in sustained fine motor control which are associated with an over-reliance on visual feedback. Motor memory deficits also have been reported during sustained fine motor control in autism spectrum disorders (ASD). The development of motor memory and visuomotor feedback processes contributing to sustained motor control issues in ASD are not known. The present study aimed to characterize age-related changes in visual feedback and motor memory processes contributing to sustained fine motor control issues in ASD. METHODS: Fifty-four autistic participants and 31 neurotypical (NT) controls ages 10-25 years completed visually guided and memory guided sustained precision gripping tests by pressing on force sensors with their dominant hand index finger and thumb. For visually guided trials, participants viewed a stationary target bar and a force bar that moved upwards with increased force for 15s. During memory guided trials, the force bar was visible for 3s, after which participants attempted to maintain their force output without visual feedback for another 12s. To assess visual feedback processing, force accuracy, variability (standard deviation), and regularity (sample entropy) were examined. To assess motor memory, force decay latency, slope, and magnitude were examined during epochs without visual feedback. RESULTS: Relative to NT controls, autistic individuals showed a greater magnitude and a trend for a steeper slope of force decay during memory guided trials. Across conditions, the ASD group showed reduced force accuracy (β = 0.41, R(2) = 0.043, t(79.3)=2.36, p = .021) and greater force variability (β=-2.16, R(2) = 0.143, t(77.1)=-4.04, p = .0001) and regularity (β=-0.52, R(2) = 0.021, t(77.4)=-2.21, p = .030) relative to NT controls at younger ages, but these differences normalized by adolescence (age x group interactions). Lower force accuracy and greater force variability during visually guided trials and steeper decay slope during memory guided trials were associated with overall autism severity. CONCLUSIONS: Our findings that autistic individuals show a greater magnitude and tendency for a greater rate of force decay than NT individuals following the removal of visual feedback indicate that motor memory deficits contribute to fine motor control issues in ASD. Findings that sensorimotor differences in ASD were specific to younger ages suggest delayed development across multiple motor control processes. |
| En ligne : |
https://dx.doi.org/10.1186/s11689-025-09607-7 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 |
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Faire une suggestion Affiner la rechercheVisual feedback and motor memory contributions to sustained motor control deficits in autism spectrum disorder across childhood and into adulthood / Robin L. SHAFER in Journal of Neurodevelopmental Disorders, 17 (2025)
