[article]
| Titre : |
Phenotypic variation in neural sensory processing by deletion size, age, and sex in Phelan-McDermid syndrome |
| Type de document : |
texte imprimé |
| Auteurs : |
Melody Reese SMITH, Auteur ; Elizabeth BERRY-KRAVIS, Auteur ; Andrew THALIATH, Auteur ; Emily L. ISENSTEIN, Auteur ; Allison R. DURKIN, Auteur ; Jennifer FOSS-FEIG, Auteur ; Paige M. SIPER, Auteur ; Charles A. NELSON, Auteur ; Lauren BACZEWSKI, Auteur ; April R. LEVIN, Auteur ; Craig M. POWELL, Auteur ; Stormi L. PULVER, Auteur ; Matthew W. MOSCONI, Auteur ; Alexander KOLEVZON, Auteur ; Lauren E. ETHRIDGE, Auteur |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Humans Female Male Adolescent Child Electroencephalography Chromosomes, Human, Pair 22/genetics Chromosome Disorders/physiopathology/genetics Chromosome Deletion Phenotype Evoked Potentials/physiology Age Factors Sensory Gating/physiology Acoustic Stimulation Brain/physiopathology Evoked Potentials, Auditory/physiology Auditory Perception/physiology Sex Factors |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: Phelan-McDermid Syndrome (PMS) is a rare genetic condition characterized by deletion or mutation of region 22q13.3, which includes the SHANK3 gene. Clinical descriptions of this population include severely impaired or absent expressive language, mildly dysmorphic features, neonatal hypotonia, developmental delays, intellectual impairments, and autistic-like traits including abnormal reactivity to sensory stimuli. Electroencephalography (EEG) has shown promise as a tool for identifying neurophysiological abnormalities in neurodevelopmental disorders. However, few EEG studies focused on sensory processing have been performed on this population. Thus, this study focuses on comparisons of event-related potential (ERP), event-related spectral perturbation (ERSP), and inter-trial coherence (ITC) between PMS and typically developing (TD) individuals in a standard auditory gating task measuring attenuation of neural activity to repetitive auditory stimuli. METHODS: A total of 37 participants, 21 PMS (12 females, age range 8-18.6 years) and 16 TD individuals (8 females, age range 8.2-15.3 years) were included. Analysis consisted of a series of general linear models using a regional (frontal) and global (whole-head) approach to characterize neural activity between PMS and TD participants by age, sex, and group. RESULTS: Most notably, individuals with PMS had delayed or low amplitude P50, N1, and P2 responses in frontal and whole-head analyses as well as poor frontal phase-locking to auditory stimuli for alpha, beta and gamma ITC, indicating impaired processing of stimulus properties. Additionally, individuals with PMS differed from TD by age in delta, theta, and alpha power, as well as frontal beta-gamma ITC, suggesting different developmental trajectories for individuals with PMS. Within PMS, larger deletion sizes were associated with increased auditory processing abnormalities for frontal P50 as well as whole-head P50 and N1. LIMITATIONS: This is one of the largest EEG studies of PMS. However, PMS is a rare genetic condition, and our small sample has limited statistical power for subgroup comparisons. Findings should be considered exploratory. CONCLUSIONS: Results suggest that participants with PMS exhibit auditory processing abnormalities with complex variation by deletion-size, age, and sex with congruency to impaired early recognition (P50), feature processing (N1), information integration (delta, theta), sensory processing and auditory inhibition (alpha), and inhibitory modulation of repeated auditory stimuli (beta, gamma). Findings may provide valuable insight into clinical characterization of sensory and speech behaviors in future studies. |
| En ligne : |
https://dx.doi.org/10.1186/s11689-025-09642-4 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 |
in Journal of Neurodevelopmental Disorders > 17 (2025)
[article] Phenotypic variation in neural sensory processing by deletion size, age, and sex in Phelan-McDermid syndrome [texte imprimé] / Melody Reese SMITH, Auteur ; Elizabeth BERRY-KRAVIS, Auteur ; Andrew THALIATH, Auteur ; Emily L. ISENSTEIN, Auteur ; Allison R. DURKIN, Auteur ; Jennifer FOSS-FEIG, Auteur ; Paige M. SIPER, Auteur ; Charles A. NELSON, Auteur ; Lauren BACZEWSKI, Auteur ; April R. LEVIN, Auteur ; Craig M. POWELL, Auteur ; Stormi L. PULVER, Auteur ; Matthew W. MOSCONI, Auteur ; Alexander KOLEVZON, Auteur ; Lauren E. ETHRIDGE, Auteur. Langues : Anglais ( eng) in Journal of Neurodevelopmental Disorders > 17 (2025)
| Mots-clés : |
Humans Female Male Adolescent Child Electroencephalography Chromosomes, Human, Pair 22/genetics Chromosome Disorders/physiopathology/genetics Chromosome Deletion Phenotype Evoked Potentials/physiology Age Factors Sensory Gating/physiology Acoustic Stimulation Brain/physiopathology Evoked Potentials, Auditory/physiology Auditory Perception/physiology Sex Factors |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: Phelan-McDermid Syndrome (PMS) is a rare genetic condition characterized by deletion or mutation of region 22q13.3, which includes the SHANK3 gene. Clinical descriptions of this population include severely impaired or absent expressive language, mildly dysmorphic features, neonatal hypotonia, developmental delays, intellectual impairments, and autistic-like traits including abnormal reactivity to sensory stimuli. Electroencephalography (EEG) has shown promise as a tool for identifying neurophysiological abnormalities in neurodevelopmental disorders. However, few EEG studies focused on sensory processing have been performed on this population. Thus, this study focuses on comparisons of event-related potential (ERP), event-related spectral perturbation (ERSP), and inter-trial coherence (ITC) between PMS and typically developing (TD) individuals in a standard auditory gating task measuring attenuation of neural activity to repetitive auditory stimuli. METHODS: A total of 37 participants, 21 PMS (12 females, age range 8-18.6 years) and 16 TD individuals (8 females, age range 8.2-15.3 years) were included. Analysis consisted of a series of general linear models using a regional (frontal) and global (whole-head) approach to characterize neural activity between PMS and TD participants by age, sex, and group. RESULTS: Most notably, individuals with PMS had delayed or low amplitude P50, N1, and P2 responses in frontal and whole-head analyses as well as poor frontal phase-locking to auditory stimuli for alpha, beta and gamma ITC, indicating impaired processing of stimulus properties. Additionally, individuals with PMS differed from TD by age in delta, theta, and alpha power, as well as frontal beta-gamma ITC, suggesting different developmental trajectories for individuals with PMS. Within PMS, larger deletion sizes were associated with increased auditory processing abnormalities for frontal P50 as well as whole-head P50 and N1. LIMITATIONS: This is one of the largest EEG studies of PMS. However, PMS is a rare genetic condition, and our small sample has limited statistical power for subgroup comparisons. Findings should be considered exploratory. CONCLUSIONS: Results suggest that participants with PMS exhibit auditory processing abnormalities with complex variation by deletion-size, age, and sex with congruency to impaired early recognition (P50), feature processing (N1), information integration (delta, theta), sensory processing and auditory inhibition (alpha), and inhibitory modulation of repeated auditory stimuli (beta, gamma). Findings may provide valuable insight into clinical characterization of sensory and speech behaviors in future studies. |
| En ligne : |
https://dx.doi.org/10.1186/s11689-025-09642-4 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 |
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