Anatomy and aging of the amygdala and hippocampus in autism spectrum disorder: an in vivo magnetic resonance imaging study of Asperger syndrome / Clodagh M. MURPHY in Autism Research, 5-1 (February 2012)  

Public ISBD [article]  inAutism Research > 5-1 (February 2012) . - p.3-12 Titre : Anatomy and aging of the amygdala and hippocampus in autism spectrum disorder: an in vivo magnetic resonance imaging study of Asperger syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Clodagh M. MURPHY, Auteur ; Quinton DEELEY, Auteur ; Eileen DALY, Auteur ; Christine ECKER, Auteur ; F. M. O'BRIEN, Auteur ; B. HALLAHAN, Auteur ; Eva LOTH, Auteur ; F. TOAL, Auteur ; S. REED, Auteur ; S. HALES, Auteur ; D. M. ROBERTSON, Auteur ; Michael C. CRAIG, Auteur ; D. MULLINS, Auteur ; Gareth J. BARKER, Auteur ; T. LAVENDER, Auteur ; P. JOHNSTON, Auteur ; Kieran C. MURPHY, Auteur ; Declan G. MURPHY, Auteur Année de publication : 2012 Article en page(s) : p.3-12 Langues : Anglais (eng) Mots-clés : Asperger syndrome  autism  amygdala  hippocampus  age Index. décimale : PER Périodiques Résumé : It has been proposed that people with autism spectrum disorder (ASD) have abnormal morphometry and development of the amygdala and hippocampus (AH). However, previous reports are inconsistent, perhaps because they included people of different ASD diagnoses, ages, and health. We compared, using magnetic resonance imaging, the in vivo anatomy of the AH in 32 healthy individuals with Asperger syndrome (12–47 years) and 32 healthy controls who did not differ significantly in age or IQ. We measured bulk (gray + white matter) volume of the AH using manual tracing (MEASURE). We first compared the volume of AH between individuals with Asperger syndrome and controls and then investigated age-related differences. We compared differences in anatomy before, and after, correcting for whole brain size. There was no significant between group differences in whole brain volume. However, individuals with Asperger syndrome had a significantly larger raw bulk volume of total (P<0.01), right (P<0.01), and left amygdala (P<0.05); and when corrected for overall brain size, total (P<0.05), and right amygdala (P<0.01). There was a significant group difference in aging of left amygdala; controls, but not individuals with Asperger syndrome, had a significant age-related increase in volume (r = 0.486, P<0.01, and r = 0.007, P = 0.97, z = 1.995). There were no significant group differences in volume or age-related effects in hippocampus. Individuals with Asperger syndrome have significant differences from controls in bulk volume and aging of the amygdala. En ligne : http://dx.doi.org/10.1002/aur.227 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153 [article] Anatomy and aging of the amygdala and hippocampus in autism spectrum disorder: an in vivo magnetic resonance imaging study of Asperger syndrome [Texte imprimé et/ou numérique] / Clodagh M. MURPHY, Auteur ; Quinton DEELEY, Auteur ; Eileen DALY, Auteur ; Christine ECKER, Auteur ; F. M. O'BRIEN, Auteur ; B. HALLAHAN, Auteur ; Eva LOTH, Auteur ; F. TOAL, Auteur ; S. REED, Auteur ; S. HALES, Auteur ; D. M. ROBERTSON, Auteur ; Michael C. CRAIG, Auteur ; D. MULLINS, Auteur ; Gareth J. BARKER, Auteur ; T. LAVENDER, Auteur ; P. JOHNSTON, Auteur ; Kieran C. MURPHY, Auteur ; Declan G. MURPHY, Auteur . - 2012 . - p.3-12. Langues : Anglais (eng) in Autism Research > 5-1 (February 2012) . - p.3-12 Mots-clés : Asperger syndrome  autism  amygdala  hippocampus  age Index. décimale : PER Périodiques Résumé : It has been proposed that people with autism spectrum disorder (ASD) have abnormal morphometry and development of the amygdala and hippocampus (AH). However, previous reports are inconsistent, perhaps because they included people of different ASD diagnoses, ages, and health. We compared, using magnetic resonance imaging, the in vivo anatomy of the AH in 32 healthy individuals with Asperger syndrome (12–47 years) and 32 healthy controls who did not differ significantly in age or IQ. We measured bulk (gray + white matter) volume of the AH using manual tracing (MEASURE). We first compared the volume of AH between individuals with Asperger syndrome and controls and then investigated age-related differences. We compared differences in anatomy before, and after, correcting for whole brain size. There was no significant between group differences in whole brain volume. However, individuals with Asperger syndrome had a significantly larger raw bulk volume of total (P<0.01), right (P<0.01), and left amygdala (P<0.05); and when corrected for overall brain size, total (P<0.05), and right amygdala (P<0.01). There was a significant group difference in aging of left amygdala; controls, but not individuals with Asperger syndrome, had a significant age-related increase in volume (r = 0.486, P<0.01, and r = 0.007, P = 0.97, z = 1.995). There were no significant group differences in volume or age-related effects in hippocampus. Individuals with Asperger syndrome have significant differences from controls in bulk volume and aging of the amygdala. En ligne : http://dx.doi.org/10.1002/aur.227 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153

The impact of COVID-19 on the mental health and wellbeing of caregivers of autistic children and youth: A scoping review / V. LEE in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2477-2494 Titre : The impact of COVID-19 on the mental health and wellbeing of caregivers of autistic children and youth: A scoping review Type de document : Texte imprimé et/ou numérique Auteurs : V. LEE, Auteur ; Carly ALBAUM, Auteur ; Paula TABLON-MODICA, Auteur ; F. AHMAD, Auteur ; J. W. GORTER, Auteur ; N. KHANLOU, Auteur ; C. MCMORRIS, Auteur ; J. LAI, Auteur ; C. HARRISON, Auteur ; T. HEDLEY, Auteur ; P. JOHNSTON, Auteur ; C. PUTTERMAN, Auteur ; M. SPOELSTRA, Auteur ; J. A. WEISS, Auteur Article en page(s) : p.2477-2494 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder  Autistic Disorder  Covid-19  Caregivers  Child  Communicable Disease Control  Humans  Mental Health  Pandemics  SARS-CoV-2  Covid  autism  caregivers  literature review  mental health Index. décimale : PER Périodiques Résumé : Caregivers and families of autistic people have experienced stress and increase in demands due to the COVID-19 pandemic that may have long-term negative consequences for both their own and their children's mental health. A scoping review was conducted to identify pandemic related demands experienced by caregivers and families of autistic children and youth. The review also consolidated information on coping strategies and parenting-related guidelines that have emerged to help parents meet these demands. Search strategies were approved by a research librarian and were conducted in peer-reviewed and gray literature databases between May 2020 and February 2021. Additional resources were solicited through author networks and social media. All articles were published between December 2019 and February 2021. Article summaries were charted, and a thematic analysis was conducted with confirmation of findings with our knowledge users. Twenty-three published articles and 14 pieces of gray literature were included in the review. The majority of articles characterized and highlighted the increase in demands on caregivers of autistic children and youth during the pandemic globally. Both quantitative and qualitative studies suggest that parents have experienced an increase in stress and mental health-related symptoms during lockdown measures. Findings suggest that families are employing coping strategies, but there no evidence-based supports were identified. The review highlighted the potential long-term impact of prolonged exposure to increasing demands on the mental health and wellbeing of caregivers and families of autistic people, and pointed to a need for the rapid development and evaluation of flexible and timely support programs. LAY SUMMARY: Caregivers and families of autistic children and youth have faced increased demands due to pandemic-related lockdown measures. We reviewed the literature to outline sources of stress, links to their influence on caregiver mental health, and if support programs have emerged to help them. Our findings suggest a number of demands have increased caregivers' risk to mental health challenges, and their potential impact on family wellbeing. Ongoing development of evidence-based supports of all families of autistic children and youth are needed. En ligne : http://dx.doi.org/10.1002/aur.2616 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] The impact of COVID-19 on the mental health and wellbeing of caregivers of autistic children and youth: A scoping review [Texte imprimé et/ou numérique] / V. LEE, Auteur ; Carly ALBAUM, Auteur ; Paula TABLON-MODICA, Auteur ; F. AHMAD, Auteur ; J. W. GORTER, Auteur ; N. KHANLOU, Auteur ; C. MCMORRIS, Auteur ; J. LAI, Auteur ; C. HARRISON, Auteur ; T. HEDLEY, Auteur ; P. JOHNSTON, Auteur ; C. PUTTERMAN, Auteur ; M. SPOELSTRA, Auteur ; J. A. WEISS, Auteur . - p.2477-2494. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2477-2494 Mots-clés : Adolescent  Autism Spectrum Disorder  Autistic Disorder  Covid-19  Caregivers  Child  Communicable Disease Control  Humans  Mental Health  Pandemics  SARS-CoV-2  Covid  autism  caregivers  literature review  mental health Index. décimale : PER Périodiques Résumé : Caregivers and families of autistic people have experienced stress and increase in demands due to the COVID-19 pandemic that may have long-term negative consequences for both their own and their children's mental health. A scoping review was conducted to identify pandemic related demands experienced by caregivers and families of autistic children and youth. The review also consolidated information on coping strategies and parenting-related guidelines that have emerged to help parents meet these demands. Search strategies were approved by a research librarian and were conducted in peer-reviewed and gray literature databases between May 2020 and February 2021. Additional resources were solicited through author networks and social media. All articles were published between December 2019 and February 2021. Article summaries were charted, and a thematic analysis was conducted with confirmation of findings with our knowledge users. Twenty-three published articles and 14 pieces of gray literature were included in the review. The majority of articles characterized and highlighted the increase in demands on caregivers of autistic children and youth during the pandemic globally. Both quantitative and qualitative studies suggest that parents have experienced an increase in stress and mental health-related symptoms during lockdown measures. Findings suggest that families are employing coping strategies, but there no evidence-based supports were identified. The review highlighted the potential long-term impact of prolonged exposure to increasing demands on the mental health and wellbeing of caregivers and families of autistic people, and pointed to a need for the rapid development and evaluation of flexible and timely support programs. LAY SUMMARY: Caregivers and families of autistic children and youth have faced increased demands due to pandemic-related lockdown measures. We reviewed the literature to outline sources of stress, links to their influence on caregiver mental health, and if support programs have emerged to help them. Our findings suggest a number of demands have increased caregivers' risk to mental health challenges, and their potential impact on family wellbeing. Ongoing development of evidence-based supports of all families of autistic children and youth are needed. En ligne : http://dx.doi.org/10.1002/aur.2616 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

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