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Auteur Simon BARON-COHEN |
Documents disponibles écrits par cet auteur (211)
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Preference for biological motion is reduced in ASD: implications for clinical trials and the search for biomarkers / L. MASON in Molecular Autism, 12 (2021)
[article]
Titre : Preference for biological motion is reduced in ASD: implications for clinical trials and the search for biomarkers Type de document : Texte imprimé et/ou numérique Auteurs : L. MASON, Auteur ; F. SHIC, Auteur ; T. FALCK-YTTER, Auteur ; Bhismadev CHAKRABARTI, Auteur ; Tony CHARMAN, Auteur ; E. LOTH, Auteur ; J. TILLMANN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Sven BÖLTE, Auteur ; Jan K. BUITELAAR, Auteur ; S. DURSTON, Auteur ; B. ORANJE, Auteur ; A. M. PERSICO, Auteur ; C. BECKMANN, Auteur ; T. BOUGERON, Auteur ; F. DELL'ACQUA, Auteur ; C. ECKER, Auteur ; C. MOESSNANG, Auteur ; D. MURPHY, Auteur ; M. H. JOHNSON, Auteur ; E. J. H. JONES, Auteur Article en page(s) : 74 p. Langues : Anglais (eng) Mots-clés : Autism Biological motion Biomarker Development Eye tracking in the last 3 years acted as an author, consultant or lecturer for Medice and Roche. He receives royalties for text books and diagnostic tools from Hogrefe, Kohlhammer and UTB. JB has been in the past 3 years a consultant to/member of advisory board of/and/or speaker for Takeda/Shire, Roche, Medice, Angelini, Janssen and Servier. He is not an employee of any of these companies and not a stock shareholder of any of these companies. He has no other financial or material support, including expert testimony, patents, royalties. Index. décimale : PER Périodiques Résumé : BACKGROUND: The neurocognitive mechanisms underlying autism spectrum disorder (ASD) remain unclear. Progress has been largely hampered by small sample sizes, variable age ranges and resulting inconsistent findings. There is a pressing need for large definitive studies to delineate the nature and extent of key case/control differences to direct research towards fruitful areas for future investigation. Here we focus on perception of biological motion, a promising index of social brain function which may be altered in ASD. In a large sample ranging from childhood to adulthood, we assess whether biological motion preference differs in ASD compared to neurotypical participants (NT), how differences are modulated by age and sex and whether they are associated with dimensional variation in concurrent or later symptomatology. METHODS: Eye-tracking data were collected from 486 6-to-30-year-old autistic (N?=?282) and non-autistic control (N?=?204) participants whilst they viewed 28 trials pairing biological (BM) and control (non-biological, CTRL) motion. Preference for the biological motion stimulus was calculated as (1) proportion looking time difference (BM-CTRL) and (2) peak look duration difference (BM-CTRL). RESULTS: The ASD group showed a present but weaker preference for biological motion than the NT group. The nature of the control stimulus modulated preference for biological motion in both groups. Biological motion preference did not vary with age, gender, or concurrent or prospective social communicative skill within the ASD group, although a lack of clear preference for either stimulus was associated with higher social-communicative symptoms at baseline. LIMITATIONS: The paired visual preference we used may underestimate preference for a stimulus in younger and lower IQ individuals. Our ASD group had a lower average IQ by approximately seven points. 18% of our sample was not analysed for various technical and behavioural reasons. CONCLUSIONS: Biological motion preference elicits small-to-medium-sized case-control effects, but individual differences do not strongly relate to core social autism associated symptomatology. We interpret this as an autistic difference (as opposed to a deficit) likely manifest in social brain regions. The extent to which this is an innate difference present from birth and central to the autistic phenotype, or the consequence of a life lived with ASD, is unclear. En ligne : http://dx.doi.org/10.1186/s13229-021-00476-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459
in Molecular Autism > 12 (2021) . - 74 p.[article] Preference for biological motion is reduced in ASD: implications for clinical trials and the search for biomarkers [Texte imprimé et/ou numérique] / L. MASON, Auteur ; F. SHIC, Auteur ; T. FALCK-YTTER, Auteur ; Bhismadev CHAKRABARTI, Auteur ; Tony CHARMAN, Auteur ; E. LOTH, Auteur ; J. TILLMANN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Sven BÖLTE, Auteur ; Jan K. BUITELAAR, Auteur ; S. DURSTON, Auteur ; B. ORANJE, Auteur ; A. M. PERSICO, Auteur ; C. BECKMANN, Auteur ; T. BOUGERON, Auteur ; F. DELL'ACQUA, Auteur ; C. ECKER, Auteur ; C. MOESSNANG, Auteur ; D. MURPHY, Auteur ; M. H. JOHNSON, Auteur ; E. J. H. JONES, Auteur . - 74 p.
Langues : Anglais (eng)
in Molecular Autism > 12 (2021) . - 74 p.
Mots-clés : Autism Biological motion Biomarker Development Eye tracking in the last 3 years acted as an author, consultant or lecturer for Medice and Roche. He receives royalties for text books and diagnostic tools from Hogrefe, Kohlhammer and UTB. JB has been in the past 3 years a consultant to/member of advisory board of/and/or speaker for Takeda/Shire, Roche, Medice, Angelini, Janssen and Servier. He is not an employee of any of these companies and not a stock shareholder of any of these companies. He has no other financial or material support, including expert testimony, patents, royalties. Index. décimale : PER Périodiques Résumé : BACKGROUND: The neurocognitive mechanisms underlying autism spectrum disorder (ASD) remain unclear. Progress has been largely hampered by small sample sizes, variable age ranges and resulting inconsistent findings. There is a pressing need for large definitive studies to delineate the nature and extent of key case/control differences to direct research towards fruitful areas for future investigation. Here we focus on perception of biological motion, a promising index of social brain function which may be altered in ASD. In a large sample ranging from childhood to adulthood, we assess whether biological motion preference differs in ASD compared to neurotypical participants (NT), how differences are modulated by age and sex and whether they are associated with dimensional variation in concurrent or later symptomatology. METHODS: Eye-tracking data were collected from 486 6-to-30-year-old autistic (N?=?282) and non-autistic control (N?=?204) participants whilst they viewed 28 trials pairing biological (BM) and control (non-biological, CTRL) motion. Preference for the biological motion stimulus was calculated as (1) proportion looking time difference (BM-CTRL) and (2) peak look duration difference (BM-CTRL). RESULTS: The ASD group showed a present but weaker preference for biological motion than the NT group. The nature of the control stimulus modulated preference for biological motion in both groups. Biological motion preference did not vary with age, gender, or concurrent or prospective social communicative skill within the ASD group, although a lack of clear preference for either stimulus was associated with higher social-communicative symptoms at baseline. LIMITATIONS: The paired visual preference we used may underestimate preference for a stimulus in younger and lower IQ individuals. Our ASD group had a lower average IQ by approximately seven points. 18% of our sample was not analysed for various technical and behavioural reasons. CONCLUSIONS: Biological motion preference elicits small-to-medium-sized case-control effects, but individual differences do not strongly relate to core social autism associated symptomatology. We interpret this as an autistic difference (as opposed to a deficit) likely manifest in social brain regions. The extent to which this is an innate difference present from birth and central to the autistic phenotype, or the consequence of a life lived with ASD, is unclear. En ligne : http://dx.doi.org/10.1186/s13229-021-00476-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 Prenatal versus postnatal sex steroid hormone effects on autistic traits in children at 18 to 24 months of age / Bonnie AUYEUNG in Molecular Autism, (December 2012)
[article]
Titre : Prenatal versus postnatal sex steroid hormone effects on autistic traits in children at 18 to 24 months of age Type de document : Texte imprimé et/ou numérique Auteurs : Bonnie AUYEUNG, Auteur ; Jag AHLUWALIA, Auteur ; Lynn THOMSON, Auteur ; Kevin TAYLOR, Auteur ; Gerald HACKETT, Auteur ; Kieran J. O'DONNELL, Auteur ; Simon BARON-COHEN, Auteur Année de publication : 2012 Article en page(s) : 5 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND:Studies of prenatal exposure to sex steroid hormones predict autistic traits in children at 18 to 24 and at 96 months of age. However, it is not known whether postnatal exposure to these hormones has a similar effect. This study compares prenatal and postnatal sex steroid hormone levels in relation to autistic traits in 18 to 24-month-old children.Fetal testosterone (fT) and fetal estradiol (fE) levels were measured in amniotic fluid from pregnant women (n = 35) following routine second-trimester amniocentesis. Saliva samples were collected from these children when they reached three to four months of age and were analyzed for postnatal testosterone (pT) levels. Mothers were asked to complete the Quantitative Checklist for Autism in Toddlers (Q-CHAT), a measure of autistic traits in children 18 to 24 months old.FINDING:fT (but not pT) levels were positively associated with scores on the Q-CHAT. fE and pT levels showed no sex differences and no relationships with fT levels. fT levels were the only variable that predicted Q-CHAT scores.CONCLUSIONS:These preliminary findings are consistent with the hypothesis that prenatal (but not postnatal) androgen exposure, coinciding with the critical period for sexual differentiation of the brain, is associated with the development of autistic traits in 18 to 24 month old toddlers. However, it is recognized that further work with a larger sample population is needed before the effects of postnatal androgen exposure on autistic traits can be ruled out. These results are also in line with the fetal androgen theory of autism, which suggests that prenatal, organizational effects of androgen hormones influence the development of autistic traits in later life. En ligne : http://dx.doi.org/10.1186/2040-2392-3-17 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202
in Molecular Autism > (December 2012) . - 5 p.[article] Prenatal versus postnatal sex steroid hormone effects on autistic traits in children at 18 to 24 months of age [Texte imprimé et/ou numérique] / Bonnie AUYEUNG, Auteur ; Jag AHLUWALIA, Auteur ; Lynn THOMSON, Auteur ; Kevin TAYLOR, Auteur ; Gerald HACKETT, Auteur ; Kieran J. O'DONNELL, Auteur ; Simon BARON-COHEN, Auteur . - 2012 . - 5 p.
Langues : Anglais (eng)
in Molecular Autism > (December 2012) . - 5 p.
Index. décimale : PER Périodiques Résumé : BACKGROUND:Studies of prenatal exposure to sex steroid hormones predict autistic traits in children at 18 to 24 and at 96 months of age. However, it is not known whether postnatal exposure to these hormones has a similar effect. This study compares prenatal and postnatal sex steroid hormone levels in relation to autistic traits in 18 to 24-month-old children.Fetal testosterone (fT) and fetal estradiol (fE) levels were measured in amniotic fluid from pregnant women (n = 35) following routine second-trimester amniocentesis. Saliva samples were collected from these children when they reached three to four months of age and were analyzed for postnatal testosterone (pT) levels. Mothers were asked to complete the Quantitative Checklist for Autism in Toddlers (Q-CHAT), a measure of autistic traits in children 18 to 24 months old.FINDING:fT (but not pT) levels were positively associated with scores on the Q-CHAT. fE and pT levels showed no sex differences and no relationships with fT levels. fT levels were the only variable that predicted Q-CHAT scores.CONCLUSIONS:These preliminary findings are consistent with the hypothesis that prenatal (but not postnatal) androgen exposure, coinciding with the critical period for sexual differentiation of the brain, is associated with the development of autistic traits in 18 to 24 month old toddlers. However, it is recognized that further work with a larger sample population is needed before the effects of postnatal androgen exposure on autistic traits can be ruled out. These results are also in line with the fetal androgen theory of autism, which suggests that prenatal, organizational effects of androgen hormones influence the development of autistic traits in later life. En ligne : http://dx.doi.org/10.1186/2040-2392-3-17 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 Prevalence of autism in mainland China, Hong Kong and Taiwan: a systematic review and meta-analysis / Xiang SUN in Molecular Autism, (April 2013)
[article]
Titre : Prevalence of autism in mainland China, Hong Kong and Taiwan: a systematic review and meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Xiang SUN, Auteur ; Carrie ALLISON, Auteur ; Fiona E. MATTHEWS, Auteur ; Stephen SHARP, Auteur ; Bonnie AUYEUNG, Auteur ; Simon BARON-COHEN, Auteur ; Carol BRAYNE, Auteur Année de publication : 2013 Article en page(s) : 13 p. Langues : Anglais (eng) Mots-clés : Autism spectrum conditions Prevalence Screening Diagnosis Chinese population Index. décimale : PER Périodiques Résumé : BACKGROUND:The prevalence of autism spectrum conditions (ASC) is 1% in developed countries, but little data are available from mainland China, Hong Kong and Taiwan. This study synthesizes evidence relating to the prevalence of ASC in these areas and assesses the effects of research methodology on prevalence estimates.METHODS:Systematic literature searches were conducted in PubMed, Web of Knowledge, China Web of Knowledge and Weipu databases, as well as relevant papers published from 1987 to 2011, reporting prevalence estimates of ASC or childhood autism in mainland China, Hong Kong and Taiwan. Summary estimates of prevalence were calculated with a random effects model. The effects of research methodology on the prevalence estimates were assessed using a meta-regression model.RESULTS:There were 25 studies eligible for review, 18 of which were suitable for inclusion in a meta-analysis. Pooled prevalence of childhood autism was 11.8 per 10,000 individuals (95% confidence interval (CI): 8.2, 15.3) in mainland China. Pooled prevalence of ASC was 26.6 per 10,000 (95% CI: 18.5, 34.6) in three areas. Substantial heterogeneity was identified between studies (I275%). The prevalence estimate of childhood autism was most strongly associated with the choice of screening instrument. After adjustment for age group, the odds ratio for prevalence estimates when using the Autism Behavior Checklist (ABC) as the screening instrument compared with those using the Clancy Autism Behavior Scale (CABS) was 0.29 (95% CI: 0.12, 0.69), and 1.79 (95% CI: 0.70, 4.55; P= 0.20) when using the Checklist for Autism in Toddlers (CHAT) compared to the CABS.CONCLUSIONS:The available studies investigating the prevalence of ASC in China, Hong Kong and Taiwan have focused mainly on childhood autism rather than the whole spectrum. The prevalence estimates are lower than estimates from developed countries. Studies using more recently developed screening instruments reported higher prevalence than older ones. However, available studies have methodological weaknesses and therefore these results lack comparability with those from developed countries. Our findings indicate a potential under-diagnosis and under-detection of ASC in mainland China, Hong Kong and Taiwan, and a need to adopt more advanced methods for research of ASC in these areas. En ligne : http://dx.doi.org/10.1186/2040-2392-4-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202
in Molecular Autism > (April 2013) . - 13 p.[article] Prevalence of autism in mainland China, Hong Kong and Taiwan: a systematic review and meta-analysis [Texte imprimé et/ou numérique] / Xiang SUN, Auteur ; Carrie ALLISON, Auteur ; Fiona E. MATTHEWS, Auteur ; Stephen SHARP, Auteur ; Bonnie AUYEUNG, Auteur ; Simon BARON-COHEN, Auteur ; Carol BRAYNE, Auteur . - 2013 . - 13 p.
Langues : Anglais (eng)
in Molecular Autism > (April 2013) . - 13 p.
Mots-clés : Autism spectrum conditions Prevalence Screening Diagnosis Chinese population Index. décimale : PER Périodiques Résumé : BACKGROUND:The prevalence of autism spectrum conditions (ASC) is 1% in developed countries, but little data are available from mainland China, Hong Kong and Taiwan. This study synthesizes evidence relating to the prevalence of ASC in these areas and assesses the effects of research methodology on prevalence estimates.METHODS:Systematic literature searches were conducted in PubMed, Web of Knowledge, China Web of Knowledge and Weipu databases, as well as relevant papers published from 1987 to 2011, reporting prevalence estimates of ASC or childhood autism in mainland China, Hong Kong and Taiwan. Summary estimates of prevalence were calculated with a random effects model. The effects of research methodology on the prevalence estimates were assessed using a meta-regression model.RESULTS:There were 25 studies eligible for review, 18 of which were suitable for inclusion in a meta-analysis. Pooled prevalence of childhood autism was 11.8 per 10,000 individuals (95% confidence interval (CI): 8.2, 15.3) in mainland China. Pooled prevalence of ASC was 26.6 per 10,000 (95% CI: 18.5, 34.6) in three areas. Substantial heterogeneity was identified between studies (I275%). The prevalence estimate of childhood autism was most strongly associated with the choice of screening instrument. After adjustment for age group, the odds ratio for prevalence estimates when using the Autism Behavior Checklist (ABC) as the screening instrument compared with those using the Clancy Autism Behavior Scale (CABS) was 0.29 (95% CI: 0.12, 0.69), and 1.79 (95% CI: 0.70, 4.55; P= 0.20) when using the Checklist for Autism in Toddlers (CHAT) compared to the CABS.CONCLUSIONS:The available studies investigating the prevalence of ASC in China, Hong Kong and Taiwan have focused mainly on childhood autism rather than the whole spectrum. The prevalence estimates are lower than estimates from developed countries. Studies using more recently developed screening instruments reported higher prevalence than older ones. However, available studies have methodological weaknesses and therefore these results lack comparability with those from developed countries. Our findings indicate a potential under-diagnosis and under-detection of ASC in mainland China, Hong Kong and Taiwan, and a need to adopt more advanced methods for research of ASC in these areas. En ligne : http://dx.doi.org/10.1186/2040-2392-4-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 Psychological Correlates of Handedness and Corpus Callosum Asymmetry in Autism: The left Hemisphere Dysfunction Theory Revisited / Dorothea L. FLORIS in Journal of Autism and Developmental Disorders, 43-8 (August 2013)
[article]
Titre : Psychological Correlates of Handedness and Corpus Callosum Asymmetry in Autism: The left Hemisphere Dysfunction Theory Revisited Type de document : Texte imprimé et/ou numérique Auteurs : Dorothea L. FLORIS, Auteur ; Lindsay R. CHURA, Auteur ; Rosemary J. HOLT, Auteur ; John SUCKLING, Auteur ; Edward T. BULLMORE, Auteur ; Simon BARON-COHEN, Auteur ; Michael D. SPENCER, Auteur Article en page(s) : p.1758-1772 Langues : Anglais (eng) Mots-clés : Autism Corpus callosum Handedness Asymmetry Lateralization Broader autism phenotype Index. décimale : PER Périodiques Résumé : Rightward cerebral lateralization has been suggested to be involved in the neuropathology of autism spectrum conditions. We investigated functional and neuroanatomical asymmetry, in terms of handedness and corpus callosum measurements in male adolescents with autism, their unaffected siblings and controls, and their associations with executive dysfunction and symptom severity. Adolescents with autism did not differ from controls in functional asymmetry, but neuroanatomically showed the expected pattern of stronger rightward lateralization in the posterior and anterior midbody based on their hand-preference. Measures of symptom severity were related to rightward asymmetry in three subregions (splenium, posterior midbody and rostral body). We found the opposite pattern for the isthmus and rostrum with better cognitive and less severe clinical scores associated with rightward lateralization. En ligne : http://dx.doi.org/10.1007/s10803-012-1720-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=205
in Journal of Autism and Developmental Disorders > 43-8 (August 2013) . - p.1758-1772[article] Psychological Correlates of Handedness and Corpus Callosum Asymmetry in Autism: The left Hemisphere Dysfunction Theory Revisited [Texte imprimé et/ou numérique] / Dorothea L. FLORIS, Auteur ; Lindsay R. CHURA, Auteur ; Rosemary J. HOLT, Auteur ; John SUCKLING, Auteur ; Edward T. BULLMORE, Auteur ; Simon BARON-COHEN, Auteur ; Michael D. SPENCER, Auteur . - p.1758-1772.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-8 (August 2013) . - p.1758-1772
Mots-clés : Autism Corpus callosum Handedness Asymmetry Lateralization Broader autism phenotype Index. décimale : PER Périodiques Résumé : Rightward cerebral lateralization has been suggested to be involved in the neuropathology of autism spectrum conditions. We investigated functional and neuroanatomical asymmetry, in terms of handedness and corpus callosum measurements in male adolescents with autism, their unaffected siblings and controls, and their associations with executive dysfunction and symptom severity. Adolescents with autism did not differ from controls in functional asymmetry, but neuroanatomically showed the expected pattern of stronger rightward lateralization in the posterior and anterior midbody based on their hand-preference. Measures of symptom severity were related to rightward asymmetry in three subregions (splenium, posterior midbody and rostral body). We found the opposite pattern for the isthmus and rostrum with better cognitive and less severe clinical scores associated with rightward lateralization. En ligne : http://dx.doi.org/10.1007/s10803-012-1720-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=205 Psychometric properties, factor structure and cross-cultural validity of the quantitative CHecklist for autism in toddlers (Q-CHAT) in an Italian community setting / Liliana RUTAA in Research in Autism Spectrum Disorders, 64 (August 2019)
[article]
Titre : Psychometric properties, factor structure and cross-cultural validity of the quantitative CHecklist for autism in toddlers (Q-CHAT) in an Italian community setting Type de document : Texte imprimé et/ou numérique Auteurs : Liliana RUTAA, Auteur ; Giuseppe Maurizio ARDUINO, Auteur ; Antonella GAGLIANO, Auteur ; Fabio APICELLA, Auteur ; Elisa LEONARDI, Auteur ; Francesca I. FAMÀ, Auteur ; Natasha CHERICONI, Auteur ; Valeria COSTANZO, Auteur ; Nazarena TURCO, Auteur ; Gennaro TARTARISCO, Auteur ; Carrie ALLISON, Auteur ; Simon BARON-COHEN, Auteur ; Giovanni PIOGGIA, Auteur ; Flavia CHIAROTTI, Auteur ; Filippo MURATORI, Auteur Article en page(s) : p.39-48 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Screening Cross-cultural validity Q?CHAT Index. décimale : PER Périodiques Résumé : Background In the past decade, several screening instruments have been developed to detect toddlers at risk for autism, both in clinical and unselected samples.We aimed to assess the validity and cross-cultural stability of the Quantitative CHecklist for Autism in Toddlers (Q?CHAT), a quantitative and normally distributed measure of autistic traits, during routine paediatric developmental surveillance in a large Italian community of toddlers. Methods A group of n?=?2400 unselected Italian toddlers were screened by paediatricians during routine well?CHild visits between 18 and 24 months,in three Italian regions, representative of the North, Centre and South of Italy. The psychometric properties and factor structure of the Q?CHAT were explored and compared with published literature from Asia and the UK. Results The total Q?CHAT scores in our sample confirmed a normal distribution. Mean Q?CHAT scores across regions were consistent with those reported in UK studies and likewise, a gender effect was found, with boys scoring higher than girls.We also found a remarkable consistency with the three-factor structure of the Asian Q?CHAT. Internal consistency was acceptable for both the Q?CHAT total score and the three factors. Conclusions Our results confirm the dimensional distribution of autistic traits and related symptoms in unselected populations across different cultures. The Q?CHAT is a valid and reliable dimensional screening instrument to be used within a routine paediatric setting during well-child assessments.The main normative data and factor structure replicated in our sample En ligne : https://doi.org/10.1016/j.rasd.2019.04.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=399
in Research in Autism Spectrum Disorders > 64 (August 2019) . - p.39-48[article] Psychometric properties, factor structure and cross-cultural validity of the quantitative CHecklist for autism in toddlers (Q-CHAT) in an Italian community setting [Texte imprimé et/ou numérique] / Liliana RUTAA, Auteur ; Giuseppe Maurizio ARDUINO, Auteur ; Antonella GAGLIANO, Auteur ; Fabio APICELLA, Auteur ; Elisa LEONARDI, Auteur ; Francesca I. FAMÀ, Auteur ; Natasha CHERICONI, Auteur ; Valeria COSTANZO, Auteur ; Nazarena TURCO, Auteur ; Gennaro TARTARISCO, Auteur ; Carrie ALLISON, Auteur ; Simon BARON-COHEN, Auteur ; Giovanni PIOGGIA, Auteur ; Flavia CHIAROTTI, Auteur ; Filippo MURATORI, Auteur . - p.39-48.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 64 (August 2019) . - p.39-48
Mots-clés : Autism spectrum disorders Screening Cross-cultural validity Q?CHAT Index. décimale : PER Périodiques Résumé : Background In the past decade, several screening instruments have been developed to detect toddlers at risk for autism, both in clinical and unselected samples.We aimed to assess the validity and cross-cultural stability of the Quantitative CHecklist for Autism in Toddlers (Q?CHAT), a quantitative and normally distributed measure of autistic traits, during routine paediatric developmental surveillance in a large Italian community of toddlers. Methods A group of n?=?2400 unselected Italian toddlers were screened by paediatricians during routine well?CHild visits between 18 and 24 months,in three Italian regions, representative of the North, Centre and South of Italy. The psychometric properties and factor structure of the Q?CHAT were explored and compared with published literature from Asia and the UK. Results The total Q?CHAT scores in our sample confirmed a normal distribution. Mean Q?CHAT scores across regions were consistent with those reported in UK studies and likewise, a gender effect was found, with boys scoring higher than girls.We also found a remarkable consistency with the three-factor structure of the Asian Q?CHAT. Internal consistency was acceptable for both the Q?CHAT total score and the three factors. Conclusions Our results confirm the dimensional distribution of autistic traits and related symptoms in unselected populations across different cultures. The Q?CHAT is a valid and reliable dimensional screening instrument to be used within a routine paediatric setting during well-child assessments.The main normative data and factor structure replicated in our sample En ligne : https://doi.org/10.1016/j.rasd.2019.04.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=399 Psychometric Properties of the Mandarin Version of the Childhood Autism Spectrum Test (CAST): An Exploratory Study / Xiang SUN in Journal of Autism and Developmental Disorders, 44-7 (July 2014)
Permalink“Putting on My Best Normal”: Social Camouflaging in Adults with Autism Spectrum Conditions / Laura HULL in Journal of Autism and Developmental Disorders, 47-8 (August 2017)
PermalinkA qualitative exploration of autistic mothers' experiences I: Pregnancy experiences / Sarah HAMPTON in Autism, 27-5 (July 2023)
PermalinkQuantifying and exploring camouflaging in men and women with autism / Meng-Chuan LAI in Autism, 21-6 (August 2017)
PermalinkQuotas, and Anti-discrimination Policies Relating to Autism in the EU: Scoping Review and Policy Mapping in Germany, France, Netherlands, United Kingdom, Slovakia, Poland, and Romania / Danielle BUNT in Autism Research, 13-8 (August 2020)
PermalinkReality Monitoring and Metamemory in Adults with Autism Spectrum Conditions / Rose A. COOPER in Journal of Autism and Developmental Disorders, 46-6 (June 2016)
PermalinkRecommandations additionnelles sur l'administration et la notation du CHAT / Peter DOEHRING
PermalinkReexamining empathy in autism: Empathic disequilibrium as a novel predictor of autism diagnosis and autistic traits / Ido SHALEV in Autism Research, 15-10 (October 2022)
PermalinkReflections on a university based social group for students with Asperger syndrome / Joanna HASTWELL in Good Autism Practice - GAP, 18-1 (May 2017)
PermalinkReliability of self, parental, and researcher measurements of head circumference / Jillian SULLIVAN in Molecular Autism, (January 2014)
PermalinkResponse to Smith’s Letter to the Editor ‘Emotional Empathy in Autism Spectrum Conditions: Weak, Intact, or Heightened?’ / Ilaria MINIO-PALUELLO in Journal of Autism and Developmental Disorders, 39-12 (December 2009)
PermalinkResting state EEG power spectrum and functional connectivity in autism: a cross-sectional analysis / Pilar GARCES in Molecular Autism, 13 (2022)
Permalink"Revêtir ma meilleure panoplie de normalité" : camouflage social chez les adultes présentant une condition du spectre autistique / L. HULL in Approche Neuropsychologique des Apprentissages chez l'Enfant - A.N.A.E., 150 (Novembre/Décembre 2017)
PermalinkRevised scored Sensory Perception Quotient reveals sensory hypersensitivity in women with autism / Emily TAYLOR in Molecular Autism, 11 (2020)
PermalinkRigor in science and science reporting: updated guidelines for submissions to Molecular Autism / Joseph D. BUXBAUM in Molecular Autism, 10 (2019)
PermalinkPermalinkA Role for Fetal Testosterone in Human Sex Differences : Implications for Understanding Autism / Bonnie AUYEUNG
PermalinkSavant syndrome has a distinct psychological profile in autism / J. E. A. HUGHES in Molecular Autism, 9 (2018)
PermalinkScreening for Autism Spectrum Disorders in Populations: Progress, Challenges, and Questions for Future Research and Practice / Tony CHARMAN
PermalinkSelf-referential and social cognition in a case of autism and agenesis of the corpus callosum / Michael V. LOMBARDO in Molecular Autism, (November 2012)
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