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Auteur Andrew J. O. WHITEHOUSE |
Documents disponibles écrits par cet auteur (81)
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Developmental vitamin D deficiency increases foetal exposure to testosterone / Asad Amanat ALI in Molecular Autism, 11 (2020)
[article]
Titre : Developmental vitamin D deficiency increases foetal exposure to testosterone Type de document : Texte imprimé et/ou numérique Auteurs : Asad Amanat ALI, Auteur ; Xiaoying CUI, Auteur ; Renata Aparecida Nedel PERTILE, Auteur ; Xiang LI, Auteur ; Gregory MEDLEY, Auteur ; Suzanne Adele ALEXANDER, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; John Joseph MCGRATH, Auteur ; Darryl Walter EYLES, Auteur Langues : Anglais (eng) Mots-clés : Animal model Aromatase Autism Developmental vitamin D deficiency Methylation Testosterone Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders which are more common in males. The 'prenatal sex steroid' hypothesis links excessive sex-steroid exposure during foetal life with the behavioural differences observed in ASD. However, the reason why sex steroid exposure may be excessive remains unclear. Epidemiological studies have identified several environmental risk factors associated with ASD, including developmental vitamin D (DVD) deficiency. We have demonstrated in an animal model that DVD-deficiency is associated with a hyper-inflammatory response in placentas from male but not female foetuses. Vitamin D also regulates the expression of several steroidogenic enzymes in vitro. Therefore using this animal model, we have examined whether DVD-deficiency leads to increased sex-steroid levels in both the maternal and foetal compartments. METHODS: Female rats are fed a vitamin D deficient diet from 6 weeks before mating until tissue collection at embryonic day 18. We examined the levels of testosterone, androstenedione and corticosterone in maternal plasma, foetal brains and amniotic fluid. We further examined gene expressions of steroidogenic enzymes and DNA methylation of aromatase promoters in foetal brains as a potential molecular mechanism regulating testosterone expression. RESULTS: We show that DVD-deficiency increases testosterone levels in maternal blood. We also show elevated levels of testosterone and androstenedione in the amniotic fluid of female but not male DVD-deficient foetuses. Testosterone levels were also elevated in DVD-deficient male brains. Vitamin D, like other steroid-related hormones, regulates gene expression via methylation. Therefore we examined whether the significant elevation in testosterone in male brains was due to such a potential gene-silencing mechanism. We show that the promoter of aromatase was hyper-methylated compared to male controls. LIMITATIONS: A reduction in aromatase, in addition to causing excessive testosterone, could also lead to a reduction in estradiol which was not examined here. CONCLUSIONS: This study is the first to show how an epidemiologically established environmental risk factor for ASD may selectively elevate testosterone in male embryonic brains. These findings provide further mechanistic support for the prenatal sex steroid theory of ASD. En ligne : http://dx.doi.org/10.1186/s13229-020-00399-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438
in Molecular Autism > 11 (2020)[article] Developmental vitamin D deficiency increases foetal exposure to testosterone [Texte imprimé et/ou numérique] / Asad Amanat ALI, Auteur ; Xiaoying CUI, Auteur ; Renata Aparecida Nedel PERTILE, Auteur ; Xiang LI, Auteur ; Gregory MEDLEY, Auteur ; Suzanne Adele ALEXANDER, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; John Joseph MCGRATH, Auteur ; Darryl Walter EYLES, Auteur.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020)
Mots-clés : Animal model Aromatase Autism Developmental vitamin D deficiency Methylation Testosterone Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders which are more common in males. The 'prenatal sex steroid' hypothesis links excessive sex-steroid exposure during foetal life with the behavioural differences observed in ASD. However, the reason why sex steroid exposure may be excessive remains unclear. Epidemiological studies have identified several environmental risk factors associated with ASD, including developmental vitamin D (DVD) deficiency. We have demonstrated in an animal model that DVD-deficiency is associated with a hyper-inflammatory response in placentas from male but not female foetuses. Vitamin D also regulates the expression of several steroidogenic enzymes in vitro. Therefore using this animal model, we have examined whether DVD-deficiency leads to increased sex-steroid levels in both the maternal and foetal compartments. METHODS: Female rats are fed a vitamin D deficient diet from 6 weeks before mating until tissue collection at embryonic day 18. We examined the levels of testosterone, androstenedione and corticosterone in maternal plasma, foetal brains and amniotic fluid. We further examined gene expressions of steroidogenic enzymes and DNA methylation of aromatase promoters in foetal brains as a potential molecular mechanism regulating testosterone expression. RESULTS: We show that DVD-deficiency increases testosterone levels in maternal blood. We also show elevated levels of testosterone and androstenedione in the amniotic fluid of female but not male DVD-deficient foetuses. Testosterone levels were also elevated in DVD-deficient male brains. Vitamin D, like other steroid-related hormones, regulates gene expression via methylation. Therefore we examined whether the significant elevation in testosterone in male brains was due to such a potential gene-silencing mechanism. We show that the promoter of aromatase was hyper-methylated compared to male controls. LIMITATIONS: A reduction in aromatase, in addition to causing excessive testosterone, could also lead to a reduction in estradiol which was not examined here. CONCLUSIONS: This study is the first to show how an epidemiologically established environmental risk factor for ASD may selectively elevate testosterone in male embryonic brains. These findings provide further mechanistic support for the prenatal sex steroid theory of ASD. En ligne : http://dx.doi.org/10.1186/s13229-020-00399-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438 Do Children with Specific Language Impairment have a Cognitive Profile Reminiscent of Autism? A Review of the Literature / Lauren J. TAYLOR in Journal of Autism and Developmental Disorders, 42-10 (October 2012)
[article]
Titre : Do Children with Specific Language Impairment have a Cognitive Profile Reminiscent of Autism? A Review of the Literature Type de document : Texte imprimé et/ou numérique Auteurs : Lauren J. TAYLOR, Auteur ; Murray T. MAYBERY, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Année de publication : 2012 Article en page(s) : p.2067-2083 Langues : Anglais (eng) Mots-clés : Autism Specific language impairment Cognition Etiological overlap Index. décimale : PER Périodiques Résumé : There is debate regarding the relationship between autism and specific language impairment (SLI), with some researchers proposing aetiological overlap between the conditions and others maintaining their aetiological distinction. Although considerable research has investigated the language phenotypes of these disorders, the relationship between the cognitive phenotypes has been left relatively unexplored. This paper reviews relevant literature on whether individuals with SLI exhibit cognitive characteristics reminiscent of autism. Overall, findings are inconsistent and there is a lack of substantive evidence supporting overlapping cognitive phenotypes in autism and SLI. Better powered and more rigorous experimental designs, as well as studies directly comparing the cognitive phenotype of children with SLI and those with autism will further elucidate the aetiological relationship between these two conditions. En ligne : http://dx.doi.org/10.1007/s10803-012-1456-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180
in Journal of Autism and Developmental Disorders > 42-10 (October 2012) . - p.2067-2083[article] Do Children with Specific Language Impairment have a Cognitive Profile Reminiscent of Autism? A Review of the Literature [Texte imprimé et/ou numérique] / Lauren J. TAYLOR, Auteur ; Murray T. MAYBERY, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - 2012 . - p.2067-2083.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-10 (October 2012) . - p.2067-2083
Mots-clés : Autism Specific language impairment Cognition Etiological overlap Index. décimale : PER Périodiques Résumé : There is debate regarding the relationship between autism and specific language impairment (SLI), with some researchers proposing aetiological overlap between the conditions and others maintaining their aetiological distinction. Although considerable research has investigated the language phenotypes of these disorders, the relationship between the cognitive phenotypes has been left relatively unexplored. This paper reviews relevant literature on whether individuals with SLI exhibit cognitive characteristics reminiscent of autism. Overall, findings are inconsistent and there is a lack of substantive evidence supporting overlapping cognitive phenotypes in autism and SLI. Better powered and more rigorous experimental designs, as well as studies directly comparing the cognitive phenotype of children with SLI and those with autism will further elucidate the aetiological relationship between these two conditions. En ligne : http://dx.doi.org/10.1007/s10803-012-1456-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180 Does perinatal exposure to exogenous oxytocin influence child behavioural problems and autistic-like behaviours to 20 years of age? / A. J. GUASTELLA in Journal of Child Psychology and Psychiatry, 59-12 (December 2018)
[article]
Titre : Does perinatal exposure to exogenous oxytocin influence child behavioural problems and autistic-like behaviours to 20 years of age? Type de document : Texte imprimé et/ou numérique Auteurs : A. J. GUASTELLA, Auteur ; Matthew N. COOPER, Auteur ; C. R. H. WHITE, Auteur ; M. K. WHITE, Auteur ; C. E. PENNELL, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.1323-1332 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders behaviour problems developmental psychopathology empathy public health Index. décimale : PER Périodiques Résumé : BACKGROUND: The neuropeptide and hormone oxytocin is known to have a significant impact on social cognition and behaviour in humans. There is growing concern regarding the influence of exogenous oxytocin (OT) administration in early life on later social and emotional development, including autism spectrum disorder (ASD). No study has examined offspring development in relation to the dose of exogenous oxytocin administered during labour. METHODS: Between 1989 and 1992, 2,900 mothers were recruited prior to the 18th week of pregnancy, delivering 2,868 live offspring. The Child Behaviour Checklist was used to measure offspring behavioural difficulties at ages 5, 8, 10, 14 and 17 years. Autism spectrum disorder was formally diagnosed by consensus of a team of specialists. At 20 years, offspring completed a measure of autistic-like traits, the Autism Spectrum Quotient (AQ). Oxytocin exposure prior to birth was analysed using categorical and continuous approaches (maternal oxytocin dose) with univariate and multivariate statistical techniques. RESULTS: Categorical analyses of oxytocin exposure prior to birth demonstrated no group differences in any measures of child behaviour. A small in magnitude dose-response association was observed for clinically significant total behaviour symptoms (adjusted odds ratio 1.03; 95% CI: 1.01-1.06, p < .01). Exogenous oxytocin administration prior to birth was not associated with ASD (OR: 0.64; 95% CI: 0.15-2.12, p = .46) or high levels of autistic-like traits (p = .93), as assessed by the AQ. CONCLUSIONS: This study is the first to investigate longitudinal mental health outcomes associated with the use of oxytocin-based medications during labour. The results do not provide evidence to support the theory that exogenous OT has a clinically significant negative impact on the long-term mental health of children. En ligne : http://dx.doi.org/10.1111/jcpp.12924 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1323-1332[article] Does perinatal exposure to exogenous oxytocin influence child behavioural problems and autistic-like behaviours to 20 years of age? [Texte imprimé et/ou numérique] / A. J. GUASTELLA, Auteur ; Matthew N. COOPER, Auteur ; C. R. H. WHITE, Auteur ; M. K. WHITE, Auteur ; C. E. PENNELL, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.1323-1332.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1323-1332
Mots-clés : Autism spectrum disorders behaviour problems developmental psychopathology empathy public health Index. décimale : PER Périodiques Résumé : BACKGROUND: The neuropeptide and hormone oxytocin is known to have a significant impact on social cognition and behaviour in humans. There is growing concern regarding the influence of exogenous oxytocin (OT) administration in early life on later social and emotional development, including autism spectrum disorder (ASD). No study has examined offspring development in relation to the dose of exogenous oxytocin administered during labour. METHODS: Between 1989 and 1992, 2,900 mothers were recruited prior to the 18th week of pregnancy, delivering 2,868 live offspring. The Child Behaviour Checklist was used to measure offspring behavioural difficulties at ages 5, 8, 10, 14 and 17 years. Autism spectrum disorder was formally diagnosed by consensus of a team of specialists. At 20 years, offspring completed a measure of autistic-like traits, the Autism Spectrum Quotient (AQ). Oxytocin exposure prior to birth was analysed using categorical and continuous approaches (maternal oxytocin dose) with univariate and multivariate statistical techniques. RESULTS: Categorical analyses of oxytocin exposure prior to birth demonstrated no group differences in any measures of child behaviour. A small in magnitude dose-response association was observed for clinically significant total behaviour symptoms (adjusted odds ratio 1.03; 95% CI: 1.01-1.06, p < .01). Exogenous oxytocin administration prior to birth was not associated with ASD (OR: 0.64; 95% CI: 0.15-2.12, p = .46) or high levels of autistic-like traits (p = .93), as assessed by the AQ. CONCLUSIONS: This study is the first to investigate longitudinal mental health outcomes associated with the use of oxytocin-based medications during labour. The results do not provide evidence to support the theory that exogenous OT has a clinically significant negative impact on the long-term mental health of children. En ligne : http://dx.doi.org/10.1111/jcpp.12924 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 Early Intervention Delivery Methods for New Zealand Children with Autism: Current Practices Versus Parental Preferences / C. WALLACE-WATKIN in Journal of Autism and Developmental Disorders, 51-9 (September 2021)
[article]
Titre : Early Intervention Delivery Methods for New Zealand Children with Autism: Current Practices Versus Parental Preferences Type de document : Texte imprimé et/ou numérique Auteurs : C. WALLACE-WATKIN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; H. WADDINGTON, Auteur Article en page(s) : p.3199-3211 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/therapy Autistic Disorder Child Early Intervention, Educational Humans New Zealand Parents Autism spectrum disorder (ASD) Delivery methods Early intervention Parent perspectives Index. décimale : PER Périodiques Résumé : Little is known about parent preferences regarding delivery methods of early interventions. This research examined, through parent report, the current and preferred delivery methods of seven common educational early interventions accessed by New Zealand children with autism spectrum disorder. Responses from 63 eligible participants were collected via an online questionnaire. Results suggested that four of the seven early intervention services were predominantly delivered through some form of professional advice to parents. Participants who were receiving at least one privately funded service were more likely to have at least one service delivered directly to their child. Parents' most preferred delivery method for all early intervention services, except parent education programs, involved a professional working directly with their child. En ligne : http://dx.doi.org/10.1007/s10803-020-04777-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453
in Journal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3199-3211[article] Early Intervention Delivery Methods for New Zealand Children with Autism: Current Practices Versus Parental Preferences [Texte imprimé et/ou numérique] / C. WALLACE-WATKIN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; H. WADDINGTON, Auteur . - p.3199-3211.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3199-3211
Mots-clés : Autism Spectrum Disorder/therapy Autistic Disorder Child Early Intervention, Educational Humans New Zealand Parents Autism spectrum disorder (ASD) Delivery methods Early intervention Parent perspectives Index. décimale : PER Périodiques Résumé : Little is known about parent preferences regarding delivery methods of early interventions. This research examined, through parent report, the current and preferred delivery methods of seven common educational early interventions accessed by New Zealand children with autism spectrum disorder. Responses from 63 eligible participants were collected via an online questionnaire. Results suggested that four of the seven early intervention services were predominantly delivered through some form of professional advice to parents. Participants who were receiving at least one privately funded service were more likely to have at least one service delivered directly to their child. Parents' most preferred delivery method for all early intervention services, except parent education programs, involved a professional working directly with their child. En ligne : http://dx.doi.org/10.1007/s10803-020-04777-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 Evidence against poor semantic encoding in individuals with autism / Andrew J. O. WHITEHOUSE in Autism, 11-3 (May 2007)
[article]
Titre : Evidence against poor semantic encoding in individuals with autism Type de document : Texte imprimé et/ou numérique Auteurs : Andrew J. O. WHITEHOUSE, Auteur ; Murray T. MAYBERY, Auteur ; Kevin DURKIN, Auteur Année de publication : 2007 Article en page(s) : p.241-254 Langues : Anglais (eng) Mots-clés : Autism Memory Phonological-encoding Semantic-encoding Index. décimale : PER Périodiques Résumé : This article tests the hypothesis that individuals with autism poorly encode verbal information to the semantic level of processing, instead paying greater attention to phonological attributes. Participants undertook a novel explicit verbal recall task. Twenty children with autism were compared with 20 matched typically developing children. On each trial, 20 words were presented individually on a computer screen. Half of the items were related through having either a common semantic theme, or a common phonological feature. Following a filler task, the participants were presented with a cue and asked to recall items consistent with the cue. No differences between the autism and comparison groups were found in either the semantic or the phonological condition. A follow-up comparison revealed that the participants with autism showed comparable levels of recall to an additional group of children matched in chronological age. The findings do not support the idea of a developmental delay in semantic encoding in children with autism. En ligne : http://dx.doi.org/10.1177/1362361307076860 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=112
in Autism > 11-3 (May 2007) . - p.241-254[article] Evidence against poor semantic encoding in individuals with autism [Texte imprimé et/ou numérique] / Andrew J. O. WHITEHOUSE, Auteur ; Murray T. MAYBERY, Auteur ; Kevin DURKIN, Auteur . - 2007 . - p.241-254.
Langues : Anglais (eng)
in Autism > 11-3 (May 2007) . - p.241-254
Mots-clés : Autism Memory Phonological-encoding Semantic-encoding Index. décimale : PER Périodiques Résumé : This article tests the hypothesis that individuals with autism poorly encode verbal information to the semantic level of processing, instead paying greater attention to phonological attributes. Participants undertook a novel explicit verbal recall task. Twenty children with autism were compared with 20 matched typically developing children. On each trial, 20 words were presented individually on a computer screen. Half of the items were related through having either a common semantic theme, or a common phonological feature. Following a filler task, the participants were presented with a cue and asked to recall items consistent with the cue. No differences between the autism and comparison groups were found in either the semantic or the phonological condition. A follow-up comparison revealed that the participants with autism showed comparable levels of recall to an additional group of children matched in chronological age. The findings do not support the idea of a developmental delay in semantic encoding in children with autism. En ligne : http://dx.doi.org/10.1177/1362361307076860 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=112 Evidence for Distinct Cognitive Profiles in Autism Spectrum Disorders and Specific Language Impairment / Lauren J. TAYLOR in Journal of Autism and Developmental Disorders, 44-1 (January 2014)
PermalinkEvidence of a reduction over time in the behavioral severity of autistic disorder diagnoses / Andrew J. O. WHITEHOUSE in Autism Research, 10-1 (January 2017)
PermalinkExamining parent use of specific intervention techniques during a 12-week training program based on the Early Start Denver Model / Hannah WADDINGTON in Autism, 24-2 (February 2020)
PermalinkFacial asymmetry in parents of children on the autism spectrum / D. W. TAN in Autism Research, 14-11 (November 2021)
PermalinkGaps in Current Autism Research: The Thoughts of the Autism Research Editorial Board and Associate Editors / David G. AMARAL in Autism Research, 12-5 (May 2019)
PermalinkGet it right, make it easy, see it all: Viewpoints of autistic individuals and parents of autistic individuals about the autism diagnostic process in Australia / Emily D’ARCY in Research in Autism Spectrum Disorders, 85 (July 2021)
PermalinkIncreased facial asymmetry in autism spectrum conditions is associated with symptom presentation / Maryam BOUTRUS in Autism Research, 12-12 (December)
PermalinkInner speech impairments in autism / Andrew J. O. WHITEHOUSE in Journal of Child Psychology and Psychiatry, 47-8 (August 2006)
PermalinkInvestigating associations between birth order and autism diagnostic phenotypes / Gail A. ALVARES in Journal of Child Psychology and Psychiatry, 62-8 (August 2021)
PermalinkInvestigating facial phenotype in autism spectrum conditions: The importance of a hypothesis driven approach / Maryam BOUTRUS in Autism Research, 10-12 (December 2017)
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