Complexity analysis of head movements in autistic toddlers / Pradeep Raj KRISHNAPPA BABU in Journal of Child Psychology and Psychiatry, 64-1 (January 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-1 (January 2023) . - p.156-166 Titre : Complexity analysis of head movements in autistic toddlers Type de document : Texte imprimé et/ou numérique Auteurs : Pradeep Raj KRISHNAPPA BABU, Auteur ; J. Matias DI MARTINO, Auteur ; Zhuoqing CHANG, Auteur ; Sam PEROCHON, Auteur ; Rachel AIELLO, Auteur ; Kimberly L.H. CARPENTER, Auteur ; Scott COMPTON, Auteur ; Naomi DAVIS, Auteur ; Lauren FRANZ, Auteur ; Steven ESPINOSA, Auteur ; Jacqueline FLOWERS, Auteur ; Geraldine DAWSON, Auteur ; Guillermo SAPIRO, Auteur Article en page(s) : p.156-166 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Early differences in sensorimotor functioning have been documented in young autistic children and infants who are later diagnosed with autism. Previous research has demonstrated that autistic toddlers exhibit more frequent head movement when viewing dynamic audiovisual stimuli, compared to neurotypical toddlers. To further explore this behavioral characteristic, in this study, computer vision (CV) analysis was used to measure several aspects of head movement dynamics of autistic and neurotypical toddlers while they watched a set of brief movies with social and nonsocial content presented on a tablet. Methods Data were collected from 457 toddlers, 17-36 months old, during their well-child visit to four pediatric primary care clinics. Forty-one toddlers were subsequently diagnosed with autism. An application (app) displayed several brief movies on a tablet, and the toddlers watched these movies while sitting on their caregiver's lap. The front-facing camera in the tablet recorded the toddlers' behavioral responses. CV was used to measure the participants' head movement rate, movement acceleration, and complexity using multiscale entropy. Results Autistic toddlers exhibited significantly higher rate, acceleration, and complexity in their head movements while watching the movies compared to neurotypical toddlers, regardless of the type of movie content (social vs. nonsocial). The combined features of head movement acceleration and complexity reliably distinguished the autistic and neurotypical toddlers. Conclusions Autistic toddlers exhibit differences in their head movement dynamics when viewing audiovisual stimuli. Higher complexity of their head movements suggests that their movements were less predictable and less stable compared to neurotypical toddlers. CV offers a scalable means of detecting subtle differences in head movement dynamics, which may be helpful in identifying early behaviors associated with autism and providing insight into the nature of sensorimotor differences associated with autism. En ligne : https://doi.org/10.1111/jcpp.13681 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Complexity analysis of head movements in autistic toddlers [Texte imprimé et/ou numérique] / Pradeep Raj KRISHNAPPA BABU, Auteur ; J. Matias DI MARTINO, Auteur ; Zhuoqing CHANG, Auteur ; Sam PEROCHON, Auteur ; Rachel AIELLO, Auteur ; Kimberly L.H. CARPENTER, Auteur ; Scott COMPTON, Auteur ; Naomi DAVIS, Auteur ; Lauren FRANZ, Auteur ; Steven ESPINOSA, Auteur ; Jacqueline FLOWERS, Auteur ; Geraldine DAWSON, Auteur ; Guillermo SAPIRO, Auteur . - p.156-166. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-1 (January 2023) . - p.156-166 Index. décimale : PER Périodiques Résumé : Background Early differences in sensorimotor functioning have been documented in young autistic children and infants who are later diagnosed with autism. Previous research has demonstrated that autistic toddlers exhibit more frequent head movement when viewing dynamic audiovisual stimuli, compared to neurotypical toddlers. To further explore this behavioral characteristic, in this study, computer vision (CV) analysis was used to measure several aspects of head movement dynamics of autistic and neurotypical toddlers while they watched a set of brief movies with social and nonsocial content presented on a tablet. Methods Data were collected from 457 toddlers, 17-36 months old, during their well-child visit to four pediatric primary care clinics. Forty-one toddlers were subsequently diagnosed with autism. An application (app) displayed several brief movies on a tablet, and the toddlers watched these movies while sitting on their caregiver's lap. The front-facing camera in the tablet recorded the toddlers' behavioral responses. CV was used to measure the participants' head movement rate, movement acceleration, and complexity using multiscale entropy. Results Autistic toddlers exhibited significantly higher rate, acceleration, and complexity in their head movements while watching the movies compared to neurotypical toddlers, regardless of the type of movie content (social vs. nonsocial). The combined features of head movement acceleration and complexity reliably distinguished the autistic and neurotypical toddlers. Conclusions Autistic toddlers exhibit differences in their head movement dynamics when viewing audiovisual stimuli. Higher complexity of their head movements suggests that their movements were less predictable and less stable compared to neurotypical toddlers. CV offers a scalable means of detecting subtle differences in head movement dynamics, which may be helpful in identifying early behaviors associated with autism and providing insight into the nature of sensorimotor differences associated with autism. En ligne : https://doi.org/10.1111/jcpp.13681 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Computer Vision Analysis of Caregiver-Child Interactions in Children with Neurodevelopmental Disorders: A Preliminary Report / Dmitry Yu ISAEV in Journal of Autism and Developmental Disorders, 54-6 (June 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-6 (June 2024) . - p.2286-2297 Titre : Computer Vision Analysis of Caregiver-Child Interactions in Children with Neurodevelopmental Disorders: A Preliminary Report Type de document : Texte imprimé et/ou numérique Auteurs : Dmitry Yu ISAEV, Auteur ; Maura SABATOS-DEVITO, Auteur ; J. Matias DI MARTINO, Auteur ; Kimberly CARPENTER, Auteur ; Rachel AIELLO, Auteur ; Scott COMPTON, Auteur ; Naomi DAVIS, Auteur ; Lauren FRANZ, Auteur ; Connor SULLIVAN, Auteur ; Geraldine DAWSON, Auteur ; Guillermo SAPIRO, Auteur Article en page(s) : p.2286-2297 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We report preliminary results of computer vision analysis of caregiver-child interactions during free play with children diagnosed with autism (N = 29, 41-91 months), attention-deficit/hyperactivity disorder (ADHD, N = 22, 48-100 months), or combined autism?+?ADHD (N = 20, 56-98 months), and neurotypical children (NT, N = 7, 55-95 months). We conducted micro-analytic analysis of 'reaching to a toy,' as a proxy for initiating or responding to a toy play bout. Dyadic analysis revealed two clusters of interaction patterns, which differed in frequency of 'reaching to a toy' and caregivers' contingent responding to the child?s reach for a toy by also reaching for a toy. Children in dyads with higher caregiver responsiveness had less developed language, communication, and socialization skills. Clusters were not associated with diagnostic groups. These results hold promise for automated methods of characterizing caregiver responsiveness in dyadic interactions for assessment and outcome monitoring in clinical trials. En ligne : https://doi.org/10.1007/s10803-023-05973-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=530 [article] Computer Vision Analysis of Caregiver-Child Interactions in Children with Neurodevelopmental Disorders: A Preliminary Report [Texte imprimé et/ou numérique] / Dmitry Yu ISAEV, Auteur ; Maura SABATOS-DEVITO, Auteur ; J. Matias DI MARTINO, Auteur ; Kimberly CARPENTER, Auteur ; Rachel AIELLO, Auteur ; Scott COMPTON, Auteur ; Naomi DAVIS, Auteur ; Lauren FRANZ, Auteur ; Connor SULLIVAN, Auteur ; Geraldine DAWSON, Auteur ; Guillermo SAPIRO, Auteur . - p.2286-2297. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-6 (June 2024) . - p.2286-2297 Index. décimale : PER Périodiques Résumé : We report preliminary results of computer vision analysis of caregiver-child interactions during free play with children diagnosed with autism (N = 29, 41-91 months), attention-deficit/hyperactivity disorder (ADHD, N = 22, 48-100 months), or combined autism?+?ADHD (N = 20, 56-98 months), and neurotypical children (NT, N = 7, 55-95 months). We conducted micro-analytic analysis of 'reaching to a toy,' as a proxy for initiating or responding to a toy play bout. Dyadic analysis revealed two clusters of interaction patterns, which differed in frequency of 'reaching to a toy' and caregivers' contingent responding to the child?s reach for a toy by also reaching for a toy. Children in dyads with higher caregiver responsiveness had less developed language, communication, and socialization skills. Clusters were not associated with diagnostic groups. These results hold promise for automated methods of characterizing caregiver responsiveness in dyadic interactions for assessment and outcome monitoring in clinical trials. En ligne : https://doi.org/10.1007/s10803-023-05973-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=530

Distinct trajectories of long-term symptom severity in pediatric obsessive-compulsive disorder during and after stepped-care treatment / Sanne JENSEN in Journal of Child Psychology and Psychiatry, 61-9 (September 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.969-978 Titre : Distinct trajectories of long-term symptom severity in pediatric obsessive-compulsive disorder during and after stepped-care treatment Type de document : Texte imprimé et/ou numérique Auteurs : Sanne JENSEN, Auteur ; Davíð R. M. A. HØJGAARD, Auteur ; Katja A HYBEL, Auteur ; Erik Lykke MORTENSEN, Auteur ; Gudmundur SKARPHEDINSSON, Auteur ; Karin MELIN, Auteur ; Tord IVARSSON, Auteur ; Judith Becker NISSEN, Auteur ; Bernhard WEIDLE, Auteur ; Robert VALDERHAUG, Auteur ; Nor Christian TORP, Auteur ; Kitty DAHL, Auteur ; Scott COMPTON, Auteur ; Per Hove THOMSEN, Auteur Article en page(s) : p.969-978 Langues : Anglais (eng) Mots-clés : Obsessive-compulsive disorder  children and adolescents  latent class growth analysis  longitudinal study  outcome predictors  stepped-care treatment  trajectories Index. décimale : PER Périodiques Résumé : BACKGROUND: First-line treatments for pediatric obsessive-compulsive disorder (OCD) include exposure-based cognitive-behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs). No studies have thus far identified distinct classes and associated predictors of long-term symptom severity during and after treatment. Yet, these could form the basis for more personalized treatment in pediatric OCD. METHOD: The study included 269 OCD patients aged 7-17 years from the Nordic Long-term OCD Treatment Study (NordLOTS). All participants received stepped-care treatment starting with 14 weekly sessions of manualized CBT. Nonresponders were randomized to either prolonged CBT or SSRIs. Symptom severity was assessed using the Children's Yale-Brown Obsessive-Compulsive Scale at seven time points from pre- to post-treatment and over a three-year follow-up. Latent class growth analysis (LCGA) was performed to identify latent classes of symptom severity trajectories. Univariate and multivariate analyses were used to detect differences between classes and identify predictors of trajectory class membership including several clinical and demographic variables. TRIAL REGISTRY: Nordic Long-term Obsessive-Compulsive Disorder (OCD) Treatment Study; www.controlled-trials.com; ISRCTN66385119. RESULTS: Three LCGA classes were identified: (a) acute, sustained responders (54.6%); (b) slow, continued responders (23.4%); and (c) limited long-term responders (21.9%). Class membership was predicted by distinct baseline characteristics pertaining to age, symptom severity, contamination/cleaning and anxiety symptoms. CONCLUSIONS: The LCGA suggests three distinct trajectory classes of long-term symptom severity during and after treatment in pediatric OCD with different clinical profiles at pretreatment. The results point to required clinical attention for adolescent patients with contamination/cleaning and anxiety symptoms who do not show convincing responses to first-line treatment even though they may have reached the established cutoff for treatment response. En ligne : http://dx.doi.org/10.1111/jcpp.13155 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 [article] Distinct trajectories of long-term symptom severity in pediatric obsessive-compulsive disorder during and after stepped-care treatment [Texte imprimé et/ou numérique] / Sanne JENSEN, Auteur ; Davíð R. M. A. HØJGAARD, Auteur ; Katja A HYBEL, Auteur ; Erik Lykke MORTENSEN, Auteur ; Gudmundur SKARPHEDINSSON, Auteur ; Karin MELIN, Auteur ; Tord IVARSSON, Auteur ; Judith Becker NISSEN, Auteur ; Bernhard WEIDLE, Auteur ; Robert VALDERHAUG, Auteur ; Nor Christian TORP, Auteur ; Kitty DAHL, Auteur ; Scott COMPTON, Auteur ; Per Hove THOMSEN, Auteur . - p.969-978. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.969-978 Mots-clés : Obsessive-compulsive disorder  children and adolescents  latent class growth analysis  longitudinal study  outcome predictors  stepped-care treatment  trajectories Index. décimale : PER Périodiques Résumé : BACKGROUND: First-line treatments for pediatric obsessive-compulsive disorder (OCD) include exposure-based cognitive-behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs). No studies have thus far identified distinct classes and associated predictors of long-term symptom severity during and after treatment. Yet, these could form the basis for more personalized treatment in pediatric OCD. METHOD: The study included 269 OCD patients aged 7-17 years from the Nordic Long-term OCD Treatment Study (NordLOTS). All participants received stepped-care treatment starting with 14 weekly sessions of manualized CBT. Nonresponders were randomized to either prolonged CBT or SSRIs. Symptom severity was assessed using the Children's Yale-Brown Obsessive-Compulsive Scale at seven time points from pre- to post-treatment and over a three-year follow-up. Latent class growth analysis (LCGA) was performed to identify latent classes of symptom severity trajectories. Univariate and multivariate analyses were used to detect differences between classes and identify predictors of trajectory class membership including several clinical and demographic variables. TRIAL REGISTRY: Nordic Long-term Obsessive-Compulsive Disorder (OCD) Treatment Study; www.controlled-trials.com; ISRCTN66385119. RESULTS: Three LCGA classes were identified: (a) acute, sustained responders (54.6%); (b) slow, continued responders (23.4%); and (c) limited long-term responders (21.9%). Class membership was predicted by distinct baseline characteristics pertaining to age, symptom severity, contamination/cleaning and anxiety symptoms. CONCLUSIONS: The LCGA suggests three distinct trajectory classes of long-term symptom severity during and after treatment in pediatric OCD with different clinical profiles at pretreatment. The results point to required clinical attention for adolescent patients with contamination/cleaning and anxiety symptoms who do not show convincing responses to first-line treatment even though they may have reached the established cutoff for treatment response. En ligne : http://dx.doi.org/10.1111/jcpp.13155 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430

Relationship between quantitative digital behavioral features and clinical profiles in young autistic children / Marika COFFMAN in Autism Research, 16-7 (July 2023)  

Public ISBD [article]  inAutism Research > 16-7 (July 2023) . - p.1360-1374 Titre : Relationship between quantitative digital behavioral features and clinical profiles in young autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Marika COFFMAN, Auteur ; J. Matias DI MARTINO, Auteur ; Rachel AIELLO, Auteur ; Kimberly L. H. CARPENTER, Auteur ; Zhuoqing CHANG, Auteur ; Scott COMPTON, Auteur ; Brian EICHNER, Auteur ; Steve ESPINOSA, Auteur ; Jacqueline FLOWERS, Auteur ; Lauren FRANZ, Auteur ; Sam PEROCHON, Auteur ; Pradeep Raj KRISHNAPPA BABU, Auteur ; Guillermo SAPIRO, Auteur ; Geraldine DAWSON, Auteur Article en page(s) : p.1360-1374 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Early behavioral markers for autism include differences in social attention and orienting in response to one's name when called, and differences in body movements and motor abilities. More efficient, scalable, objective, and reliable measures of these behaviors could improve early screening for autism. This study evaluated whether objective and quantitative measures of autism-related behaviors elicited from an app (SenseToKnow) administered on a smartphone or tablet and measured via computer vision analysis (CVA) are correlated with standardized caregiver-report and clinician administered measures of autism-related behaviors and cognitive, language, and motor abilities. This is an essential step in establishing the concurrent validity of a digital phenotyping approach. In a sample of 485 toddlers, 43 of whom were diagnosed with autism, we found that CVA-based gaze variables related to social attention were associated with the level of autism-related behaviors. Two language-related behaviors measured via the app, attention to people during a conversation and responding to one's name being called, were associated with children's language skills. Finally, performance during a bubble popping game was associated with fine motor skills. These findings provide initial support for the concurrent validity of the SenseToKnow app and its potential utility in identifying clinical profiles associated with autism. Future research is needed to determine whether the app can be used as an autism screening tool, can reliably stratify autism-related behaviors, and measure changes in autism-related behaviors over time. En ligne : https://doi.org/10.1002/aur.2955 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510 [article] Relationship between quantitative digital behavioral features and clinical profiles in young autistic children [Texte imprimé et/ou numérique] / Marika COFFMAN, Auteur ; J. Matias DI MARTINO, Auteur ; Rachel AIELLO, Auteur ; Kimberly L. H. CARPENTER, Auteur ; Zhuoqing CHANG, Auteur ; Scott COMPTON, Auteur ; Brian EICHNER, Auteur ; Steve ESPINOSA, Auteur ; Jacqueline FLOWERS, Auteur ; Lauren FRANZ, Auteur ; Sam PEROCHON, Auteur ; Pradeep Raj KRISHNAPPA BABU, Auteur ; Guillermo SAPIRO, Auteur ; Geraldine DAWSON, Auteur . - p.1360-1374. Langues : Anglais (eng) in Autism Research > 16-7 (July 2023) . - p.1360-1374 Index. décimale : PER Périodiques Résumé : Abstract Early behavioral markers for autism include differences in social attention and orienting in response to one's name when called, and differences in body movements and motor abilities. More efficient, scalable, objective, and reliable measures of these behaviors could improve early screening for autism. This study evaluated whether objective and quantitative measures of autism-related behaviors elicited from an app (SenseToKnow) administered on a smartphone or tablet and measured via computer vision analysis (CVA) are correlated with standardized caregiver-report and clinician administered measures of autism-related behaviors and cognitive, language, and motor abilities. This is an essential step in establishing the concurrent validity of a digital phenotyping approach. In a sample of 485 toddlers, 43 of whom were diagnosed with autism, we found that CVA-based gaze variables related to social attention were associated with the level of autism-related behaviors. Two language-related behaviors measured via the app, attention to people during a conversation and responding to one's name being called, were associated with children's language skills. Finally, performance during a bubble popping game was associated with fine motor skills. These findings provide initial support for the concurrent validity of the SenseToKnow app and its potential utility in identifying clinical profiles associated with autism. Future research is needed to determine whether the app can be used as an autism screening tool, can reliably stratify autism-related behaviors, and measure changes in autism-related behaviors over time. En ligne : https://doi.org/10.1002/aur.2955 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510

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