Automated recognition of spontaneous facial expression in individuals with autism spectrum disorder: parsing response variability / Abigail BANGERTER in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) . - 31 p. Titre : Automated recognition of spontaneous facial expression in individuals with autism spectrum disorder: parsing response variability Type de document : Texte imprimé et/ou numérique Auteurs : Abigail BANGERTER, Auteur ; Meenakshi CHATTERJEE, Auteur ; Joseph MANFREDONIA, Auteur ; Nikolay V. MANYAKOV, Auteur ; Seth NESS, Auteur ; Matthew A. BOICE, Auteur ; Andrew SKALKIN, Auteur ; Matthew S GOODWIN, Auteur ; Geraldine DAWSON, Auteur ; Robert HENDREN, Auteur ; Bennett L. LEVENTHAL, Auteur ; Frederick SHIC, Auteur ; Gahan PANDINA, Auteur Article en page(s) : 31 p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Emotional regulation  Emotions  Facial expression  Impulsive behavior  LLC, and may hold company equity. AS was an employee of Janssen Research &  Development at the time of the study. MSG has received research and consulting  funding from Janssen Research & Development. GD is on the Scientific Advisory Boards  of Janssen Research & Development  Akili, Inc.  LabCorp, Inc.  and Roche  Pharmaceutical Company  is a consultant for Apple, Inc  Gerson Lehrman Group  Guidepoint, Inc.  and Axial Ventures  has received grant funding from Janssen  Research & Development  and is the CEO of DASIO, LLC. GD receives royalties from  Guilford Press, Springer, and Oxford University Press. RH received reimbursement for  consultation from Janssen Research & Development. BL has received research grant  funding from the NIH  is a consultant to Janssen Research & Development, the  Illinois Children’s Healthcare Foundation  and is a board member of the Brain  Research Foundation. FS is on the Scientific Advisory Board, is a consultant to and  received grant funding from Janssen Research & Development, and has also received  grant funding from Roche. Index. décimale : PER Périodiques Résumé : BACKGROUND: Reduction or differences in facial expression are a core diagnostic feature of autism spectrum disorder (ASD), yet evidence regarding the extent of this discrepancy is limited and inconsistent. Use of automated facial expression detection technology enables accurate and efficient tracking of facial expressions that has potential to identify individual response differences. METHODS: Children and adults with ASD (N = 124) and typically developing (TD, N = 41) were shown short clips of "funny videos." Using automated facial analysis software, we investigated differences between ASD and TD groups and within the ASD group in evidence of facial action unit (AU) activation related to the expression of positive facial expression, in particular, a smile. RESULTS: Individuals with ASD on average showed less evidence of facial AUs (AU12, AU6) relating to positive facial expression, compared to the TD group (p < .05, r = -?0.17). Using Gaussian mixture model for clustering, we identified two distinct distributions within the ASD group, which were then compared to the TD group. One subgroup (n = 35), termed "over-responsive," expressed more intense positive facial expressions in response to the videos than the TD group (p < .001, r = 0.31). The second subgroup (n = 89), ("under-responsive"), displayed fewer, less intense positive facial expressions in response to videos than the TD group (p < .001; r = -?0.36). The over-responsive subgroup differed from the under-responsive subgroup in age and caregiver-reported impulsivity (p < .05, r = 0.21). Reduced expression in the under-responsive, but not the over-responsive group, was related to caregiver-reported social withdrawal (p < .01, r = -?0.3). LIMITATIONS: This exploratory study does not account for multiple comparisons, and future work will have to ascertain the strength and reproducibility of all results. Reduced displays of positive facial expressions do not mean individuals with ASD do not experience positive emotions. CONCLUSIONS: Individuals with ASD differed from the TD group in their facial expressions of positive emotion in response to "funny videos." Identification of subgroups based on response may help in parsing heterogeneity in ASD and enable targeting of treatment based on subtypes. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02299700. Registration date: November 24, 2014. En ligne : http://dx.doi.org/10.1186/s13229-020-00327-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 [article] Automated recognition of spontaneous facial expression in individuals with autism spectrum disorder: parsing response variability [Texte imprimé et/ou numérique] / Abigail BANGERTER, Auteur ; Meenakshi CHATTERJEE, Auteur ; Joseph MANFREDONIA, Auteur ; Nikolay V. MANYAKOV, Auteur ; Seth NESS, Auteur ; Matthew A. BOICE, Auteur ; Andrew SKALKIN, Auteur ; Matthew S GOODWIN, Auteur ; Geraldine DAWSON, Auteur ; Robert HENDREN, Auteur ; Bennett L. LEVENTHAL, Auteur ; Frederick SHIC, Auteur ; Gahan PANDINA, Auteur . - 31 p. Langues : Anglais (eng) in Molecular Autism > 11 (2020) . - 31 p. Mots-clés : Autism spectrum disorder  Emotional regulation  Emotions  Facial expression  Impulsive behavior  LLC, and may hold company equity. AS was an employee of Janssen Research &  Development at the time of the study. MSG has received research and consulting  funding from Janssen Research & Development. GD is on the Scientific Advisory Boards  of Janssen Research & Development  Akili, Inc.  LabCorp, Inc.  and Roche  Pharmaceutical Company  is a consultant for Apple, Inc  Gerson Lehrman Group  Guidepoint, Inc.  and Axial Ventures  has received grant funding from Janssen  Research & Development  and is the CEO of DASIO, LLC. GD receives royalties from  Guilford Press, Springer, and Oxford University Press. RH received reimbursement for  consultation from Janssen Research & Development. BL has received research grant  funding from the NIH  is a consultant to Janssen Research & Development, the  Illinois Children’s Healthcare Foundation  and is a board member of the Brain  Research Foundation. FS is on the Scientific Advisory Board, is a consultant to and  received grant funding from Janssen Research & Development, and has also received  grant funding from Roche. Index. décimale : PER Périodiques Résumé : BACKGROUND: Reduction or differences in facial expression are a core diagnostic feature of autism spectrum disorder (ASD), yet evidence regarding the extent of this discrepancy is limited and inconsistent. Use of automated facial expression detection technology enables accurate and efficient tracking of facial expressions that has potential to identify individual response differences. METHODS: Children and adults with ASD (N = 124) and typically developing (TD, N = 41) were shown short clips of "funny videos." Using automated facial analysis software, we investigated differences between ASD and TD groups and within the ASD group in evidence of facial action unit (AU) activation related to the expression of positive facial expression, in particular, a smile. RESULTS: Individuals with ASD on average showed less evidence of facial AUs (AU12, AU6) relating to positive facial expression, compared to the TD group (p < .05, r = -?0.17). Using Gaussian mixture model for clustering, we identified two distinct distributions within the ASD group, which were then compared to the TD group. One subgroup (n = 35), termed "over-responsive," expressed more intense positive facial expressions in response to the videos than the TD group (p < .001, r = 0.31). The second subgroup (n = 89), ("under-responsive"), displayed fewer, less intense positive facial expressions in response to videos than the TD group (p < .001; r = -?0.36). The over-responsive subgroup differed from the under-responsive subgroup in age and caregiver-reported impulsivity (p < .05, r = 0.21). Reduced expression in the under-responsive, but not the over-responsive group, was related to caregiver-reported social withdrawal (p < .01, r = -?0.3). LIMITATIONS: This exploratory study does not account for multiple comparisons, and future work will have to ascertain the strength and reproducibility of all results. Reduced displays of positive facial expressions do not mean individuals with ASD do not experience positive emotions. CONCLUSIONS: Individuals with ASD differed from the TD group in their facial expressions of positive emotion in response to "funny videos." Identification of subgroups based on response may help in parsing heterogeneity in ASD and enable targeting of treatment based on subtypes. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02299700. Registration date: November 24, 2014. En ligne : http://dx.doi.org/10.1186/s13229-020-00327-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427

Automatic Recognition of Posed Facial Expression of Emotion in Individuals with Autism Spectrum Disorder / J. MANFREDONIA in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.279-293 Titre : Automatic Recognition of Posed Facial Expression of Emotion in Individuals with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : J. MANFREDONIA, Auteur ; Abigail BANGERTER, Auteur ; N. V. MANYAKOV, Auteur ; S. NESS, Auteur ; D. LEWIN, Auteur ; A. SKALKIN, Auteur ; Matthew A. BOICE, Auteur ; M. S. GOODWIN, Auteur ; G. DAWSON, Auteur ; R. HENDREN, Auteur ; B. LEVENTHAL, Auteur ; F. SHIC, Auteur ; Gahan PANDINA, Auteur Article en page(s) : p.279-293 Langues : Anglais (eng) Mots-clés : Asd  Automated  Emotion  Expression  Facet  Facial Index. décimale : PER Périodiques Résumé : Facial expression is impaired in autism spectrum disorder (ASD), but rarely systematically studied. We focus on the ability of individuals with ASD to produce facial expressions of emotions in response to a verbal prompt. We used the Janssen Autism Knowledge Engine (JAKE((R))), including automated facial expression analysis software (FACET) to measure facial expressions in individuals with ASD (n = 144) and a typically developing (TD) comparison group (n = 41). Differences in ability to produce facial expressions were observed between ASD and TD groups, demonstrated by activation of facial action units (happy, scared, surprised, disgusted, but not angry or sad). Activation of facial action units correlated with parent-reported social communication skills. This approach has potential for diagnostic and response to intervention measures.Trial Registration NCT02299700. En ligne : http://dx.doi.org/10.1007/s10803-018-3757-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377 [article] Automatic Recognition of Posed Facial Expression of Emotion in Individuals with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / J. MANFREDONIA, Auteur ; Abigail BANGERTER, Auteur ; N. V. MANYAKOV, Auteur ; S. NESS, Auteur ; D. LEWIN, Auteur ; A. SKALKIN, Auteur ; Matthew A. BOICE, Auteur ; M. S. GOODWIN, Auteur ; G. DAWSON, Auteur ; R. HENDREN, Auteur ; B. LEVENTHAL, Auteur ; F. SHIC, Auteur ; Gahan PANDINA, Auteur . - p.279-293. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.279-293 Mots-clés : Asd  Automated  Emotion  Expression  Facet  Facial Index. décimale : PER Périodiques Résumé : Facial expression is impaired in autism spectrum disorder (ASD), but rarely systematically studied. We focus on the ability of individuals with ASD to produce facial expressions of emotions in response to a verbal prompt. We used the Janssen Autism Knowledge Engine (JAKE((R))), including automated facial expression analysis software (FACET) to measure facial expressions in individuals with ASD (n = 144) and a typically developing (TD) comparison group (n = 41). Differences in ability to produce facial expressions were observed between ASD and TD groups, demonstrated by activation of facial action units (happy, scared, surprised, disgusted, but not angry or sad). Activation of facial action units correlated with parent-reported social communication skills. This approach has potential for diagnostic and response to intervention measures.Trial Registration NCT02299700. En ligne : http://dx.doi.org/10.1007/s10803-018-3757-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377

Clinical Validation of the Autism Behavior Inventory: Caregiver-Rated Assessment of Core and Associated Symptoms of Autism Spectrum Disorder / Abigail BANGERTER in Journal of Autism and Developmental Disorders, 50-6 (June 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-6 (June 2020) . - p.2090-2101 Titre : Clinical Validation of the Autism Behavior Inventory: Caregiver-Rated Assessment of Core and Associated Symptoms of Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Abigail BANGERTER, Auteur ; Seth NESS, Auteur ; David LEWIN, Auteur ; Michael G. AMAN, Auteur ; Anna J. ESBENSEN, Auteur ; Matthew S GOODWIN, Auteur ; Geraldine DAWSON, Auteur ; Robert HENDREN, Auteur ; Bennett L. LEVENTHAL, Auteur ; Fred SHIC, Auteur ; Mark OPLER, Auteur ; Kai Fai HO, Auteur ; Gahan PANDINA, Auteur Article en page(s) : p.2090-2101 Langues : Anglais (eng) Mots-clés : Assessment  Autism spectrum disorder  Caregiver-reported outcomes  Clinical trials  Rating scales and instruments  hold company stocks/stock options. Anna Esbensen has consulted with Roche on outcome  measures in Down syndrome and ProPhase LLC. Robert Hendren received reimbursement  for consultation from Janssen Research & Development, LLC. Michael Aman has received  research contracts, consulted with, served on advisory boards, or done investigator  training for AMO Pharma, Bracket, CogState, Inc., CogState Clinical Trials, Ltd.,  Coronado Biosciences, Forest Research, Hoffman-La Roche, Lumos Pharma, MedAvante,  Inc., Ovid Therapeutics  ProPhase LLC, Supernus Pharmaceuticals, Zynerba  Pharmaceuticals, and Yamo Pharmaceuticals. He receives royalties from Slosson  Educational Publications. Geraldine Dawson is on the Scientific Advisory Boards of  Janssen Research and Development, LabCorp, and Akili, Inc., a consultant to Roche  has received grant funding from Janssen Research and Development, LLC and  PerkinElmer  and, receives royalties from Guilford Press and Oxford University  Press. Index. décimale : PER Périodiques Résumé : There is a need for measures to track symptom change in autism spectrum disorder (ASD). We conducted a validation study on a revised version of the Autism Behavior Inventory (ABI), and a short form (ABI-S). Caregivers of individuals (6-54 years) with confirmed diagnoses of ASD (N?=?144) completed the ABI and other rating scales at 4 time points. Scale consistency for each domain, 3-5 day test-retest reliability, and construct validity, determined by comparison to pre-specified scales, were all good. Change in the ABI was congruent with changes in other instruments. Collectively, results suggest incipient suitability of the ABI as a measure of changes in core and associated symptoms of ASD.Trial Registration NCT02299700. En ligne : http://dx.doi.org/10.1007/s10803-019-03965-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425 [article] Clinical Validation of the Autism Behavior Inventory: Caregiver-Rated Assessment of Core and Associated Symptoms of Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Abigail BANGERTER, Auteur ; Seth NESS, Auteur ; David LEWIN, Auteur ; Michael G. AMAN, Auteur ; Anna J. ESBENSEN, Auteur ; Matthew S GOODWIN, Auteur ; Geraldine DAWSON, Auteur ; Robert HENDREN, Auteur ; Bennett L. LEVENTHAL, Auteur ; Fred SHIC, Auteur ; Mark OPLER, Auteur ; Kai Fai HO, Auteur ; Gahan PANDINA, Auteur . - p.2090-2101. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-6 (June 2020) . - p.2090-2101 Mots-clés : Assessment  Autism spectrum disorder  Caregiver-reported outcomes  Clinical trials  Rating scales and instruments  hold company stocks/stock options. Anna Esbensen has consulted with Roche on outcome  measures in Down syndrome and ProPhase LLC. Robert Hendren received reimbursement  for consultation from Janssen Research & Development, LLC. Michael Aman has received  research contracts, consulted with, served on advisory boards, or done investigator  training for AMO Pharma, Bracket, CogState, Inc., CogState Clinical Trials, Ltd.,  Coronado Biosciences, Forest Research, Hoffman-La Roche, Lumos Pharma, MedAvante,  Inc., Ovid Therapeutics  ProPhase LLC, Supernus Pharmaceuticals, Zynerba  Pharmaceuticals, and Yamo Pharmaceuticals. He receives royalties from Slosson  Educational Publications. Geraldine Dawson is on the Scientific Advisory Boards of  Janssen Research and Development, LabCorp, and Akili, Inc., a consultant to Roche  has received grant funding from Janssen Research and Development, LLC and  PerkinElmer  and, receives royalties from Guilford Press and Oxford University  Press. Index. décimale : PER Périodiques Résumé : There is a need for measures to track symptom change in autism spectrum disorder (ASD). We conducted a validation study on a revised version of the Autism Behavior Inventory (ABI), and a short form (ABI-S). Caregivers of individuals (6-54 years) with confirmed diagnoses of ASD (N?=?144) completed the ABI and other rating scales at 4 time points. Scale consistency for each domain, 3-5 day test-retest reliability, and construct validity, determined by comparison to pre-specified scales, were all good. Change in the ABI was congruent with changes in other instruments. Collectively, results suggest incipient suitability of the ABI as a measure of changes in core and associated symptoms of ASD.Trial Registration NCT02299700. En ligne : http://dx.doi.org/10.1007/s10803-019-03965-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425

Context Modulates Attention to Faces in Dynamic Social Scenes in Children and Adults with Autism Spectrum Disorder / Dzmitry A. KALIUKHOVICH in Journal of Autism and Developmental Disorders, 52-10 (October 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-10 (October 2022) . - p.4219-4232 Titre : Context Modulates Attention to Faces in Dynamic Social Scenes in Children and Adults with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Dzmitry A. KALIUKHOVICH, Auteur ; Nikolay V. MANYAKOV, Auteur ; Abigail BANGERTER, Auteur ; Gahan PANDINA, Auteur Article en page(s) : p.4219-4232 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Biomarkers  Eye-tracking  Faces  Social attention  stocks/stock options. The authors have no relevant non-financial interests to  disclose. Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) have been found to view social scenes differently compared to typically developing (TD) peers, but results can vary depending on context and age. We used eye-tracking in children and adults (age 6-63) to assess allocation of visual attention in a dynamic social orientation paradigm previously used only in younger children. The ASD group (n=94) looked less at the actor's face compared to TD (n=38) when they were engaged in activity (mean percentage of looking time, ASD=30.7% vs TD=34.9%; Cohen's d=0.56; p value<0.03) or looking at a moving toy (24.5% vs 33.2%; d=0.65; p value<0.001). Findings indicate that there are qualitative differences in allocation of visual attention to social stimuli across ages in ASD.ClinicalTrials.gov identifier: NCT02668991. En ligne : http://dx.doi.org/10.1007/s10803-021-05279-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Context Modulates Attention to Faces in Dynamic Social Scenes in Children and Adults with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Dzmitry A. KALIUKHOVICH, Auteur ; Nikolay V. MANYAKOV, Auteur ; Abigail BANGERTER, Auteur ; Gahan PANDINA, Auteur . - p.4219-4232. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-10 (October 2022) . - p.4219-4232 Mots-clés : Autism spectrum disorder  Biomarkers  Eye-tracking  Faces  Social attention  stocks/stock options. The authors have no relevant non-financial interests to  disclose. Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) have been found to view social scenes differently compared to typically developing (TD) peers, but results can vary depending on context and age. We used eye-tracking in children and adults (age 6-63) to assess allocation of visual attention in a dynamic social orientation paradigm previously used only in younger children. The ASD group (n=94) looked less at the actor's face compared to TD (n=38) when they were engaged in activity (mean percentage of looking time, ASD=30.7% vs TD=34.9%; Cohen's d=0.56; p value<0.03) or looking at a moving toy (24.5% vs 33.2%; d=0.65; p value<0.001). Findings indicate that there are qualitative differences in allocation of visual attention to social stimuli across ages in ASD.ClinicalTrials.gov identifier: NCT02668991. En ligne : http://dx.doi.org/10.1007/s10803-021-05279-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

Social attention to activities in children and adults with autism spectrum disorder: effects of context and age / Dzmitry A. KALIUKHOVICH in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) . - 79 p. Titre : Social attention to activities in children and adults with autism spectrum disorder: effects of context and age Type de document : Texte imprimé et/ou numérique Auteurs : Dzmitry A. KALIUKHOVICH, Auteur ; Nikolay V. MANYAKOV, Auteur ; Abigail BANGERTER, Auteur ; Seth NESS, Auteur ; Andrew SKALKIN, Auteur ; Matthew S GOODWIN, Auteur ; Geraldine DAWSON, Auteur ; Robert L. HENDREN, Auteur ; Bennett L. LEVENTHAL, Auteur ; Caitlin M. HUDAC, Auteur ; Jessica BRADSHAW, Auteur ; Frederick SHIC, Auteur ; Gahan PANDINA, Auteur Article en page(s) : 79 p. Langues : Anglais (eng) Mots-clés : Activity monitoring  Autism spectrum disorder  Biomarkers  Eye tracking  Social attention  Skalkin (at the time of study conduct), and Gahan Pandina are employees of Janssen  Research & Development, LLC and hold company stocks/stock options. Matthew Goodwin  has received research and consulting funding from Janssen Research & Development,  LLC. Geraldine Dawson is on the Scientific Advisory Boards of Janssen Research and  Development, Akili, Inc., LabCorp, Inc., and Roche Pharmaceutical Company, a  consultant for Apple, Inc, Gerson Lehrman Group, Guidepoint, Inc., Teva  Pharmaceuticals, Tris Pharma, Inc., and Axial Ventures, has received grant funding  from Janssen Research and Development, and is CEO of DASIO, LLC. Dawson has  developed technology that has been licensed and Dawson and Duke University have  benefited financially. Dawson receives royalties from Guilford Press, Springer, and  Oxford University Press. Robert Hendren received reimbursement for consultation from  Janssen Research & Development, LLC. Bennett Leventhal has received research grant  funding from the NIH, is a consultant to Janssen Research and Development, LLC and  the Illinois Children’s Healthcare Foundation, and is a board member of the Brain  Research Foundation. Frederick Shic is on the Scientific Advisory Board of and is a  consultant to Janssen Research and Development, LLC, and has received grant funding  from Janssen Research and Development LLC, and Roche. Index. décimale : PER Périodiques Résumé : BACKGROUND: Diminished visual monitoring of faces and activities of others is an early feature of autism spectrum disorder (ASD). It is uncertain whether deficits in activity monitoring, identified using a homogeneous set of stimuli, persist throughout the lifespan in ASD, and thus, whether they could serve as a biological indicator ("biomarker") of ASD. We investigated differences in visual attention during activity monitoring in children and adult participants with autism compared to a control group of participants without autism. METHODS: Eye movements of participants with autism (n?=?122; mean age [SD]?=?14.5 [8.0] years) and typically developing (TD) controls (n?=?40, age?=?16.4 [13.3] years) were recorded while they viewed a series of videos depicting two female actors conversing while interacting with their hands over a shared task. Actors either continuously focused their gaze on each other's face (mutual gaze) or on the shared activity area (shared focus). Mean percentage looking time was computed for the activity area, actors' heads, and their bodies. RESULTS: Compared to TD participants, participants with ASD looked longer at the activity area (mean % looking time: 58.5% vs. 53.8%, p??60] limited the ability to include individuals with substantial intellectual disability. CONCLUSIONS: Differences in attention to faces could constitute a feature discriminative between individuals with and without ASD across the lifespan, whereas between-group differences in looking at activities may shift with development. These findings may have applications in the search for underlying biological indicators specific to ASD. Trial registration ClinicalTrials.gov identifier NCT02668991. En ligne : http://dx.doi.org/10.1186/s13229-020-00388-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] Social attention to activities in children and adults with autism spectrum disorder: effects of context and age [Texte imprimé et/ou numérique] / Dzmitry A. KALIUKHOVICH, Auteur ; Nikolay V. MANYAKOV, Auteur ; Abigail BANGERTER, Auteur ; Seth NESS, Auteur ; Andrew SKALKIN, Auteur ; Matthew S GOODWIN, Auteur ; Geraldine DAWSON, Auteur ; Robert L. HENDREN, Auteur ; Bennett L. LEVENTHAL, Auteur ; Caitlin M. HUDAC, Auteur ; Jessica BRADSHAW, Auteur ; Frederick SHIC, Auteur ; Gahan PANDINA, Auteur . - 79 p. Langues : Anglais (eng) in Molecular Autism > 11 (2020) . - 79 p. Mots-clés : Activity monitoring  Autism spectrum disorder  Biomarkers  Eye tracking  Social attention  Skalkin (at the time of study conduct), and Gahan Pandina are employees of Janssen  Research & Development, LLC and hold company stocks/stock options. Matthew Goodwin  has received research and consulting funding from Janssen Research & Development,  LLC. Geraldine Dawson is on the Scientific Advisory Boards of Janssen Research and  Development, Akili, Inc., LabCorp, Inc., and Roche Pharmaceutical Company, a  consultant for Apple, Inc, Gerson Lehrman Group, Guidepoint, Inc., Teva  Pharmaceuticals, Tris Pharma, Inc., and Axial Ventures, has received grant funding  from Janssen Research and Development, and is CEO of DASIO, LLC. Dawson has  developed technology that has been licensed and Dawson and Duke University have  benefited financially. Dawson receives royalties from Guilford Press, Springer, and  Oxford University Press. Robert Hendren received reimbursement for consultation from  Janssen Research & Development, LLC. Bennett Leventhal has received research grant  funding from the NIH, is a consultant to Janssen Research and Development, LLC and  the Illinois Children’s Healthcare Foundation, and is a board member of the Brain  Research Foundation. Frederick Shic is on the Scientific Advisory Board of and is a  consultant to Janssen Research and Development, LLC, and has received grant funding  from Janssen Research and Development LLC, and Roche. Index. décimale : PER Périodiques Résumé : BACKGROUND: Diminished visual monitoring of faces and activities of others is an early feature of autism spectrum disorder (ASD). It is uncertain whether deficits in activity monitoring, identified using a homogeneous set of stimuli, persist throughout the lifespan in ASD, and thus, whether they could serve as a biological indicator ("biomarker") of ASD. We investigated differences in visual attention during activity monitoring in children and adult participants with autism compared to a control group of participants without autism. METHODS: Eye movements of participants with autism (n?=?122; mean age [SD]?=?14.5 [8.0] years) and typically developing (TD) controls (n?=?40, age?=?16.4 [13.3] years) were recorded while they viewed a series of videos depicting two female actors conversing while interacting with their hands over a shared task. Actors either continuously focused their gaze on each other's face (mutual gaze) or on the shared activity area (shared focus). Mean percentage looking time was computed for the activity area, actors' heads, and their bodies. RESULTS: Compared to TD participants, participants with ASD looked longer at the activity area (mean % looking time: 58.5% vs. 53.8%, p??60] limited the ability to include individuals with substantial intellectual disability. CONCLUSIONS: Differences in attention to faces could constitute a feature discriminative between individuals with and without ASD across the lifespan, whereas between-group differences in looking at activities may shift with development. These findings may have applications in the search for underlying biological indicators specific to ASD. Trial registration ClinicalTrials.gov identifier NCT02668991. En ligne : http://dx.doi.org/10.1186/s13229-020-00388-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

Visual Exploration in Autism Spectrum Disorder: Exploring Age Differences and Dynamic Features Using Recurrence Quantification Analysis / N. V. MANYAKOV in Autism Research, 11-11 (November 2018)  

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Visual Preference for Biological Motion in Children and Adults with Autism Spectrum Disorder: An Eye-Tracking Study / Dzmitry A. KALIUKHOVICH in Journal of Autism and Developmental Disorders, 51-7 (July 2021)  

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