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The p factor: genetic analyses support a general dimension of psychopathology in childhood and adolescence / Andrea G. ALLEGRINI in Journal of Child Psychology and Psychiatry, 61-1 (January 2020)
[article]
Titre : The p factor: genetic analyses support a general dimension of psychopathology in childhood and adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Andrea G. ALLEGRINI, Auteur ; Rosa CHEESMAN, Auteur ; K. RIMFELD, Auteur ; S. SELZAM, Auteur ; J. B. PINGAULT, Auteur ; T. C. ELEY, Auteur ; R. PLOMIN, Auteur Article en page(s) : p.30-39 Langues : Anglais (eng) Mots-clés : Childhood psychopathology behavioural genetics genomics Index. décimale : PER Périodiques Résumé : BACKGROUND: Diverse behaviour problems in childhood correlate phenotypically, suggesting a general dimension of psychopathology that has been called the p factor. The shared genetic architecture between childhood psychopathology traits also supports a genetic p. This study systematically investigates the manifestation of this common dimension across self-, parent- and teacher-rated measures in childhood and adolescence. METHODS: The sample included 7,026 twin pairs from the Twins Early Development Study (TEDS). First, we employed multivariate twin models to estimate common genetic and environmental influences on p based on diverse measures of behaviour problems rated by children, parents and teachers at ages 7, 9, 12 and 16 (depressive traits, emotional problems, peer problems, autism traits, hyperactivity, antisocial behaviour, conduct problems and psychopathic tendencies). Second, to assess the stability of genetic and environmental influences on p across time, we conducted longitudinal twin modelling of the first phenotypic principal components of childhood psychopathological measures across each of the four ages. Third, we created a genetic p factor in 7,026 unrelated genotyped individuals based on eight polygenic scores for psychiatric disorders to estimate how a general polygenic predisposition to mostly adult psychiatric disorders relates to childhood p. RESULTS: Behaviour problems were consistently correlated phenotypically and genetically across ages and raters. The p factor is substantially heritable (50%-60%) and manifests consistently across diverse ages and raters. However, residual variation in the common factor models indicates unique contributions as well. Genetic correlations of p components across childhood and adolescence suggest stability over time (49%-78%). A polygenic general psychopathology factor derived from studies of psychiatric disorders consistently predicted a general phenotypic p factor across development (0.3%-0.9%). CONCLUSIONS: Diverse forms of psychopathology generally load on a common p factor, which is highly heritable. There are substantial genetic influences on the stability of p across childhood. Our analyses indicate genetic overlap between general risk for psychiatric disorders in adulthood and p in childhood, even as young as age 7. The p factor has far-reaching implications for genomic research and, eventually, for diagnosis and treatment of behaviour problems. En ligne : http://dx.doi.org/10.1111/jcpp.13113 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=413
in Journal of Child Psychology and Psychiatry > 61-1 (January 2020) . - p.30-39[article] The p factor: genetic analyses support a general dimension of psychopathology in childhood and adolescence [Texte imprimé et/ou numérique] / Andrea G. ALLEGRINI, Auteur ; Rosa CHEESMAN, Auteur ; K. RIMFELD, Auteur ; S. SELZAM, Auteur ; J. B. PINGAULT, Auteur ; T. C. ELEY, Auteur ; R. PLOMIN, Auteur . - p.30-39.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-1 (January 2020) . - p.30-39
Mots-clés : Childhood psychopathology behavioural genetics genomics Index. décimale : PER Périodiques Résumé : BACKGROUND: Diverse behaviour problems in childhood correlate phenotypically, suggesting a general dimension of psychopathology that has been called the p factor. The shared genetic architecture between childhood psychopathology traits also supports a genetic p. This study systematically investigates the manifestation of this common dimension across self-, parent- and teacher-rated measures in childhood and adolescence. METHODS: The sample included 7,026 twin pairs from the Twins Early Development Study (TEDS). First, we employed multivariate twin models to estimate common genetic and environmental influences on p based on diverse measures of behaviour problems rated by children, parents and teachers at ages 7, 9, 12 and 16 (depressive traits, emotional problems, peer problems, autism traits, hyperactivity, antisocial behaviour, conduct problems and psychopathic tendencies). Second, to assess the stability of genetic and environmental influences on p across time, we conducted longitudinal twin modelling of the first phenotypic principal components of childhood psychopathological measures across each of the four ages. Third, we created a genetic p factor in 7,026 unrelated genotyped individuals based on eight polygenic scores for psychiatric disorders to estimate how a general polygenic predisposition to mostly adult psychiatric disorders relates to childhood p. RESULTS: Behaviour problems were consistently correlated phenotypically and genetically across ages and raters. The p factor is substantially heritable (50%-60%) and manifests consistently across diverse ages and raters. However, residual variation in the common factor models indicates unique contributions as well. Genetic correlations of p components across childhood and adolescence suggest stability over time (49%-78%). A polygenic general psychopathology factor derived from studies of psychiatric disorders consistently predicted a general phenotypic p factor across development (0.3%-0.9%). CONCLUSIONS: Diverse forms of psychopathology generally load on a common p factor, which is highly heritable. There are substantial genetic influences on the stability of p across childhood. Our analyses indicate genetic overlap between general risk for psychiatric disorders in adulthood and p in childhood, even as young as age 7. The p factor has far-reaching implications for genomic research and, eventually, for diagnosis and treatment of behaviour problems. En ligne : http://dx.doi.org/10.1111/jcpp.13113 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=413 The parent–infant dyad and the construction of the subjective self / Peter FONAGY in Journal of Child Psychology and Psychiatry, 48-3/4 (March/April 2007)
[article]
Titre : The parent–infant dyad and the construction of the subjective self Type de document : Texte imprimé et/ou numérique Auteurs : Peter FONAGY, Auteur ; György GERGELY, Auteur ; Mary TARGET, Auteur Année de publication : 2007 Article en page(s) : p.288–328 Langues : Anglais (eng) Mots-clés : Attachment mentalisation theory-of-mind social development social-cognition self pedagogical-stance Index. décimale : PER Périodiques Résumé : Developmental psychology and psychopathology has in the past been more concerned with the quality of self-representation than with the development of the subjective agency which underpins our experience of feeling, thought and action, a key function of mentalisation. This review begins by contrasting a Cartesian view of pre-wired introspective subjectivity with a constructionist model based on the assumption of an innate contingency detector which orients the infant towards aspects of the social world that react congruently and in a specifically cued informative manner that expresses and facilitates the assimilation of cultural knowledge. Research on the neural mechanisms associated with mentalisation and social influences on its development are reviewed. It is suggested that the infant focuses on the attachment figure as a source of reliable information about the world. The construction of the sense of a subjective self is then an aspect of acquiring knowledge about the world through the caregiver's pedagogical communicative displays which in this context focuses on the child's thoughts and feelings. We argue that a number of possible mechanisms, including complementary activation of attachment and mentalisation, the disruptive effect of maltreatment on parent–child communication, the biobehavioural overlap of cues for learning and cues for attachment, may have a role in ensuring that the quality of relationship with the caregiver influences the development of the child's experience of thoughts and feelings. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01727.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=950
in Journal of Child Psychology and Psychiatry > 48-3/4 (March/April 2007) . - p.288–328[article] The parent–infant dyad and the construction of the subjective self [Texte imprimé et/ou numérique] / Peter FONAGY, Auteur ; György GERGELY, Auteur ; Mary TARGET, Auteur . - 2007 . - p.288–328.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 48-3/4 (March/April 2007) . - p.288–328
Mots-clés : Attachment mentalisation theory-of-mind social development social-cognition self pedagogical-stance Index. décimale : PER Périodiques Résumé : Developmental psychology and psychopathology has in the past been more concerned with the quality of self-representation than with the development of the subjective agency which underpins our experience of feeling, thought and action, a key function of mentalisation. This review begins by contrasting a Cartesian view of pre-wired introspective subjectivity with a constructionist model based on the assumption of an innate contingency detector which orients the infant towards aspects of the social world that react congruently and in a specifically cued informative manner that expresses and facilitates the assimilation of cultural knowledge. Research on the neural mechanisms associated with mentalisation and social influences on its development are reviewed. It is suggested that the infant focuses on the attachment figure as a source of reliable information about the world. The construction of the sense of a subjective self is then an aspect of acquiring knowledge about the world through the caregiver's pedagogical communicative displays which in this context focuses on the child's thoughts and feelings. We argue that a number of possible mechanisms, including complementary activation of attachment and mentalisation, the disruptive effect of maltreatment on parent–child communication, the biobehavioural overlap of cues for learning and cues for attachment, may have a role in ensuring that the quality of relationship with the caregiver influences the development of the child's experience of thoughts and feelings. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01727.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=950 The Parent Interview for Autism-Clinical Version (PIA-CV): A Measure of Behavioral Change for Young Children with Autism / Wendy L. STONE in Autism, 7-1 (March 2003)
[article]
Titre : The Parent Interview for Autism-Clinical Version (PIA-CV): A Measure of Behavioral Change for Young Children with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Wendy L. STONE, Auteur ; Elaine E. COONROD, Auteur ; Stacie L. POZDOL, Auteur ; Lauren M. TURNER, Auteur Article en page(s) : p.9-30 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The Parent Interview for Autism-Clinical Version (PIA-CV) was developed to measure autism symptom severity across a wide range of behavioral domains. Two studies were conducted to examine the psychometric properties of the PIA-CV for a sample of children under 3 years old. Results of study 1 revealed adequate internal consistency for nine of the 11 PIA-CV dimensions, as well as significant group differences on social-communication domains between 2- year-old children with autism and a developmentally matched sample. Study 2 examined the association between changes in PIA-CV scores and changes in autism symptomatology from age 2 to age 4. Results revealed that changes on PIA-CV dimensions assessing social and communication skills were associated with clinically significant behavioral and diagnostic improvements. These findings support the utility of the PIA-CV for obtaining ecologically valid information from parents and for measuring behavioral change in young children with autism. En ligne : http://dx.doi.org/10.1177/1362361303007001003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=209
in Autism > 7-1 (March 2003) . - p.9-30[article] The Parent Interview for Autism-Clinical Version (PIA-CV): A Measure of Behavioral Change for Young Children with Autism [Texte imprimé et/ou numérique] / Wendy L. STONE, Auteur ; Elaine E. COONROD, Auteur ; Stacie L. POZDOL, Auteur ; Lauren M. TURNER, Auteur . - p.9-30.
Langues : Anglais (eng)
in Autism > 7-1 (March 2003) . - p.9-30
Index. décimale : PER Périodiques Résumé : The Parent Interview for Autism-Clinical Version (PIA-CV) was developed to measure autism symptom severity across a wide range of behavioral domains. Two studies were conducted to examine the psychometric properties of the PIA-CV for a sample of children under 3 years old. Results of study 1 revealed adequate internal consistency for nine of the 11 PIA-CV dimensions, as well as significant group differences on social-communication domains between 2- year-old children with autism and a developmentally matched sample. Study 2 examined the association between changes in PIA-CV scores and changes in autism symptomatology from age 2 to age 4. Results revealed that changes on PIA-CV dimensions assessing social and communication skills were associated with clinically significant behavioral and diagnostic improvements. These findings support the utility of the PIA-CV for obtaining ecologically valid information from parents and for measuring behavioral change in young children with autism. En ligne : http://dx.doi.org/10.1177/1362361303007001003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=209 The parenting experiences and needs of Asian primary caregivers of children with autism: A meta-synthesis / Shefaly SHOREY in Autism, 24-3 (April 2020)
[article]
Titre : The parenting experiences and needs of Asian primary caregivers of children with autism: A meta-synthesis Type de document : Texte imprimé et/ou numérique Auteurs : Shefaly SHOREY, Auteur ; Esperanza D. NG, Auteur ; Gorill HAUGAN, Auteur ; Evelyn LAW, Auteur Article en page(s) : p.591-604 Langues : Anglais (eng) Mots-clés : Asian Asperger syndrome autism spectrum disorder autistic disorder caregivers child parenting review Index. décimale : PER Périodiques Résumé : Parents of children with autism are faced with higher risks of unemployment, divorce, and poorer mental health than parents of children with other disorders. Such parenting stress can be further exacerbated by cultural and environmental factors such as the more conservative and collectivistic Asian values. Therefore, this review identifies and synthesizes literature on the parenting experiences and needs of Asian primary caregivers of children with autism using a critical interpretive method. A qualitative meta-summary was conducted. Seven electronic databases (CINAHL, Embase, ProQuest, PsycINFO, PubMed, Scopus, and Web of Science) were searched from each database's date of inception to November 2018. In total, 44 studies were included in this review. Thirteen studies examined Asian immigrant parents' experiences, and 31 studies were done among Asia-based parents. Six domains were identified: "personal parenting journey"; "adaptation and coping strategies"; "family, community, and social support"; "experiences with healthcare, education, and social services"; "future hopes and recommendations"; and "unique experiences of immigrants." The distinctive influence of religious beliefs, cultural values, and environmental factors on Asian parenting experiences were discussed, and recommendations were proposed to better meet the needs of parents with autistic children. En ligne : http://dx.doi.org/10.1177/1362361319886513 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422
in Autism > 24-3 (April 2020) . - p.591-604[article] The parenting experiences and needs of Asian primary caregivers of children with autism: A meta-synthesis [Texte imprimé et/ou numérique] / Shefaly SHOREY, Auteur ; Esperanza D. NG, Auteur ; Gorill HAUGAN, Auteur ; Evelyn LAW, Auteur . - p.591-604.
Langues : Anglais (eng)
in Autism > 24-3 (April 2020) . - p.591-604
Mots-clés : Asian Asperger syndrome autism spectrum disorder autistic disorder caregivers child parenting review Index. décimale : PER Périodiques Résumé : Parents of children with autism are faced with higher risks of unemployment, divorce, and poorer mental health than parents of children with other disorders. Such parenting stress can be further exacerbated by cultural and environmental factors such as the more conservative and collectivistic Asian values. Therefore, this review identifies and synthesizes literature on the parenting experiences and needs of Asian primary caregivers of children with autism using a critical interpretive method. A qualitative meta-summary was conducted. Seven electronic databases (CINAHL, Embase, ProQuest, PsycINFO, PubMed, Scopus, and Web of Science) were searched from each database's date of inception to November 2018. In total, 44 studies were included in this review. Thirteen studies examined Asian immigrant parents' experiences, and 31 studies were done among Asia-based parents. Six domains were identified: "personal parenting journey"; "adaptation and coping strategies"; "family, community, and social support"; "experiences with healthcare, education, and social services"; "future hopes and recommendations"; and "unique experiences of immigrants." The distinctive influence of religious beliefs, cultural values, and environmental factors on Asian parenting experiences were discussed, and recommendations were proposed to better meet the needs of parents with autistic children. En ligne : http://dx.doi.org/10.1177/1362361319886513 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 The Passionate Mind / Martin GORE in Good Autism Practice - GAP, 12-2 (October 2011)
[article]
Titre : The Passionate Mind Type de document : Texte imprimé et/ou numérique Auteurs : Martin GORE, Auteur Année de publication : 2011 Article en page(s) : p.93 Langues : Anglais (eng) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=149
in Good Autism Practice - GAP > 12-2 (October 2011) . - p.93[article] The Passionate Mind [Texte imprimé et/ou numérique] / Martin GORE, Auteur . - 2011 . - p.93.
Langues : Anglais (eng)
in Good Autism Practice - GAP > 12-2 (October 2011) . - p.93
Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=149 The passionate mind : how people with autism learn / Damian MILTON in Good Autism Practice - GAP, 12-1 (May 2011)
PermalinkThe past achievements and future promises of developmental psychopathology: the coming of age of a discipline / Dante CICCHETTI in Journal of Child Psychology and Psychiatry, 50-1-2 (January/February 2009)
PermalinkThe pathogenesis of progressive cavitation of the spinal cord / Henry H. SHERK in Developmental Medicine & Child Neurology, 26-4 (August 1984)
PermalinkThe pathomechanics of gait in Duchenne muscular dystrophy / David H. SUTHERLAND in Developmental Medicine & Child Neurology, 23-1 (February 1981)
PermalinkThe pathophysiology of restricted repetitive behavior / M. LEWIS in Journal of Neurodevelopmental Disorders, 1-2 (June 2009)
PermalinkThe pattern and problems of spina bifida cystica at Ibadan, Nigeria / Adelola ADELOYE in Developmental Medicine & Child Neurology, S25 (1971)
PermalinkThe pattern of congenital renal anomalies associated with neural-tube defects / Gillian M. HUNT in Developmental Medicine & Child Neurology, 29-1 (February 1987)
PermalinkThe PDA Paradox: The Highs and Lows of My Life on a Little-known Part of the Autism Spectrum / Harry THOMPSON in Good Autism Practice - GAP, 20-1 (May 2019)
PermalinkThe peer relationships of girls with ASD at school: comparison to boys and girls with and without ASD / Michelle DEAN in Journal of Child Psychology and Psychiatry, 55-11 (November 2014)
PermalinkThe Perceived Social Context Modulates Rule Learning in Autism / H. LU in Journal of Autism and Developmental Disorders, 49-11 (November 2019)
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