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The potential role of a retrotransposed gene and a long noncoding RNA in regulating an X-linked chromatin gene (KDM5C): Novel epigenetic mechanism in autism / Zohreh TALEBIZADEH in Autism Research, 12-7 (July 2019)
[article]
Titre : The potential role of a retrotransposed gene and a long noncoding RNA in regulating an X-linked chromatin gene (KDM5C): Novel epigenetic mechanism in autism Type de document : Texte imprimé et/ou numérique Auteurs : Zohreh TALEBIZADEH, Auteur ; A. SHAH, Auteur ; L. DITACCHIO, Auteur Année de publication : 2019 Article en page(s) : p.1007-1021 Langues : Anglais (eng) Mots-clés : alternative splicing autism chromatin genes circadian long noncoding RNAs retrotransposons Index. décimale : PER Périodiques Résumé : A growing body of evidence supports the potential role of the circadian system and chromatin remodeling genes in autism. Considering the heterogeneity and gender discrepancy in autism, and the complex nature of the epigenetic landscape, identification of biologically relevant epigenetic factors requires reducing heterogeneity using proper subtyping. For this study, we used X chromosome inactivation (XCI) status in females with autism as an epigenetic marker for subtyping and examined the expression level of members of KDM5, a chromatin remodeling gene family. KDM5 are histone demethylases involved in the circadian molecular machinery. We used human blood samples to characterize alternatively spliced KDM5 isoforms and noticed that KDM5C undergoes a complex splicing process. We also identified a KDM5C isoform (KDM5C-3'UTR-lncRNA) containing a novel 3'UTR originated from a retrotransposed gene (retro-SUV39H2) of an autosomal methyltransferase (SUV39H2). This 3'UTR shows 84% sequence homology with long ncRNAs (lncRNAs) and is located 32 kb downstream of KDM5C. The KDM5C-3'UTR-lncRNA isoform was differentially expressed in autistic females with XCI skewness compared with controls. KDM5C plays a crucial role in balancing histone H3K4 methylation states. The identified retro-SUV39H2 originated lncRNA also shows H3K4 marks. By assessing the expression level of alternatively spliced Kdm5 isoforms at different circadian time-points, we showed that some isoforms follow a circadian oscillation pattern in wild type mouse brain.This study provides the first evidence and a suggestive model for the potential role of retrotransposed elements in autism through linking methylases and demethylases, two functionally complementary components of chromatin remodeling, which may collectively contribute to disease etiology through lncRNAs. Autism Res 2019, 12: 1007-1021. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Genes do not function in isolated conditions and their proper expression level also depends on a mechanism called gene regulation. An example of gene regulation is when changes outside DNA sequences influence the function of autism susceptibility genes. Alternative splicing is one type of gene regulation, which produces several versions of a gene (called variants) that may slightly differ from each other and be expressed at different levels in response to environmental changes. The circadian clock is an essential timing mechanism that enables organisms to maintain internal processes in sync with the dynamic environment brought about by the day-night cycle. The goal of this study was to assess if a subset of females with autism with certain genetic marker had a unique pattern of alternative splicing of three circadian genes. We identified a novel variant that is differentially expressed in this subset. Our study provides a novel subject stratification strategy, and a suggestive model of how biologically relevant components of a gene regulatory process may be linked and, possibly, collectively contribute to the etiology of autism. En ligne : http://dx.doi.org/10.1002/aur.2116 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402
in Autism Research > 12-7 (July 2019) . - p.1007-1021[article] The potential role of a retrotransposed gene and a long noncoding RNA in regulating an X-linked chromatin gene (KDM5C): Novel epigenetic mechanism in autism [Texte imprimé et/ou numérique] / Zohreh TALEBIZADEH, Auteur ; A. SHAH, Auteur ; L. DITACCHIO, Auteur . - 2019 . - p.1007-1021.
Langues : Anglais (eng)
in Autism Research > 12-7 (July 2019) . - p.1007-1021
Mots-clés : alternative splicing autism chromatin genes circadian long noncoding RNAs retrotransposons Index. décimale : PER Périodiques Résumé : A growing body of evidence supports the potential role of the circadian system and chromatin remodeling genes in autism. Considering the heterogeneity and gender discrepancy in autism, and the complex nature of the epigenetic landscape, identification of biologically relevant epigenetic factors requires reducing heterogeneity using proper subtyping. For this study, we used X chromosome inactivation (XCI) status in females with autism as an epigenetic marker for subtyping and examined the expression level of members of KDM5, a chromatin remodeling gene family. KDM5 are histone demethylases involved in the circadian molecular machinery. We used human blood samples to characterize alternatively spliced KDM5 isoforms and noticed that KDM5C undergoes a complex splicing process. We also identified a KDM5C isoform (KDM5C-3'UTR-lncRNA) containing a novel 3'UTR originated from a retrotransposed gene (retro-SUV39H2) of an autosomal methyltransferase (SUV39H2). This 3'UTR shows 84% sequence homology with long ncRNAs (lncRNAs) and is located 32 kb downstream of KDM5C. The KDM5C-3'UTR-lncRNA isoform was differentially expressed in autistic females with XCI skewness compared with controls. KDM5C plays a crucial role in balancing histone H3K4 methylation states. The identified retro-SUV39H2 originated lncRNA also shows H3K4 marks. By assessing the expression level of alternatively spliced Kdm5 isoforms at different circadian time-points, we showed that some isoforms follow a circadian oscillation pattern in wild type mouse brain.This study provides the first evidence and a suggestive model for the potential role of retrotransposed elements in autism through linking methylases and demethylases, two functionally complementary components of chromatin remodeling, which may collectively contribute to disease etiology through lncRNAs. Autism Res 2019, 12: 1007-1021. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Genes do not function in isolated conditions and their proper expression level also depends on a mechanism called gene regulation. An example of gene regulation is when changes outside DNA sequences influence the function of autism susceptibility genes. Alternative splicing is one type of gene regulation, which produces several versions of a gene (called variants) that may slightly differ from each other and be expressed at different levels in response to environmental changes. The circadian clock is an essential timing mechanism that enables organisms to maintain internal processes in sync with the dynamic environment brought about by the day-night cycle. The goal of this study was to assess if a subset of females with autism with certain genetic marker had a unique pattern of alternative splicing of three circadian genes. We identified a novel variant that is differentially expressed in this subset. Our study provides a novel subject stratification strategy, and a suggestive model of how biologically relevant components of a gene regulatory process may be linked and, possibly, collectively contribute to the etiology of autism. En ligne : http://dx.doi.org/10.1002/aur.2116 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402 The Power of Positivity: Predictors of Relationship Satisfaction for Parents of Children with Autism Spectrum Disorder / Naomi V. EKAS in Journal of Autism and Developmental Disorders, 45-7 (July 2015)
[article]
Titre : The Power of Positivity: Predictors of Relationship Satisfaction for Parents of Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Naomi V. EKAS, Auteur ; Lisa TIMMONS, Auteur ; Megan PRUITT, Auteur ; Christine GHILAIN, Auteur ; Michael ALESSANDRI, Auteur Année de publication : 2015 Article en page(s) : p.1997-2007 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Mothers and fathers Relationship satisfaction Dyadic data analysis Social support Coping Benefit finding Index. décimale : PER Périodiques Résumé : The current study uses the actor-partner interdependence model to examine the predictors of relationship satisfaction for mothers and fathers of children with autism spectrum disorder. Sixty-seven couples completed measures of optimism, benefit finding, coping strategies, social support, and relationship satisfaction. Results indicated that parent’s positive strengths predicted better personal relationship satisfaction. Moreover, parents’ benefit finding, use of emotional support, and perceived social support from their partner also predicted their partner’s relationship satisfaction. The results of this study highlight the importance of focusing on positive factors that can enhance relationship quality. Implications for the development of parent-focused interventions are discussed. En ligne : http://dx.doi.org/10.1007/s10803-015-2362-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261
in Journal of Autism and Developmental Disorders > 45-7 (July 2015) . - p.1997-2007[article] The Power of Positivity: Predictors of Relationship Satisfaction for Parents of Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Naomi V. EKAS, Auteur ; Lisa TIMMONS, Auteur ; Megan PRUITT, Auteur ; Christine GHILAIN, Auteur ; Michael ALESSANDRI, Auteur . - 2015 . - p.1997-2007.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-7 (July 2015) . - p.1997-2007
Mots-clés : Autism spectrum disorder Mothers and fathers Relationship satisfaction Dyadic data analysis Social support Coping Benefit finding Index. décimale : PER Périodiques Résumé : The current study uses the actor-partner interdependence model to examine the predictors of relationship satisfaction for mothers and fathers of children with autism spectrum disorder. Sixty-seven couples completed measures of optimism, benefit finding, coping strategies, social support, and relationship satisfaction. Results indicated that parent’s positive strengths predicted better personal relationship satisfaction. Moreover, parents’ benefit finding, use of emotional support, and perceived social support from their partner also predicted their partner’s relationship satisfaction. The results of this study highlight the importance of focusing on positive factors that can enhance relationship quality. Implications for the development of parent-focused interventions are discussed. En ligne : http://dx.doi.org/10.1007/s10803-015-2362-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261 The power of words: Is qualitative research as important as quantitative research in the study of autism? / Sven BÖLTE in Autism, 18-2 (February 2014)
[article]
Titre : The power of words: Is qualitative research as important as quantitative research in the study of autism? Type de document : Texte imprimé et/ou numérique Auteurs : Sven BÖLTE, Auteur Article en page(s) : p.67-68 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1177/1362361313517367 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=223
in Autism > 18-2 (February 2014) . - p.67-68[article] The power of words: Is qualitative research as important as quantitative research in the study of autism? [Texte imprimé et/ou numérique] / Sven BÖLTE, Auteur . - p.67-68.
Langues : Anglais (eng)
in Autism > 18-2 (February 2014) . - p.67-68
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1177/1362361313517367 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=223 The predictive capacity of psychiatric and psychological polygenic risk scores for distinguishing cases in a child and adolescent psychiatric sample from controls / A. G. JANSEN in Journal of Child Psychology and Psychiatry, 62-9 (September 2021)
[article]
Titre : The predictive capacity of psychiatric and psychological polygenic risk scores for distinguishing cases in a child and adolescent psychiatric sample from controls Type de document : Texte imprimé et/ou numérique Auteurs : A. G. JANSEN, Auteur ; P. R. JANSEN, Auteur ; Jeanne E. SAVAGE, Auteur ; J. KRAFT, Auteur ; N. SKARABIS, Auteur ; Tinca J. C. POLDERMAN, Auteur ; G. C. DIELEMAN, Auteur Article en page(s) : p.1079-1089 Langues : Anglais (eng) Mots-clés : Adolescent Adult Aged Aged, 80 and over Anxiety Disorders/epidemiology/genetics Attention Deficit Disorder with Hyperactivity Child Child, Preschool Depressive Disorder, Major Humans Infant Middle Aged Multifactorial Inheritance/genetics Risk Factors Young Adult Genetics comorbidity general P factor neurodevelopmental disorders psychiatry Index. décimale : PER Périodiques Résumé : BACKGROUND: Psychiatric traits are heritable, highly comorbid and genetically correlated, suggesting that genetic effects that are shared across disorders are at play. The aim of the present study is to quantify the predictive capacity of common genetic variation of a variety of traits, as captured by their PRS, to predict case-control status in a child and adolescent psychiatric sample including controls to reveal which traits contribute to the shared genetic risk across disorders. METHOD: Polygenic risk scores (PRS) of 14 traits were used as predictor phenotypes to predict case-control status in a clinical sample. Clinical cases (N = 1,402), age 1-21, diagnostic categories: Autism spectrum disorders (N = 492), Attention-deficit/ hyperactivity disorders (N = 471), Anxiety (N = 293), disruptive behaviors (N = 101), eating disorders (N = 97), OCD (N = 43), Tic disorder (N = 50), Disorder of infancy, childhood or adolescence NOS (N = 65), depression (N = 64), motor, learning and communication disorders (N = 59), Anorexia Nervosa (N = 48), somatoform disorders (N = 47), Trauma/stress (N = 39) and controls (N = 1,448, age 17-84) of European ancestry. First, these 14 PRS were tested in univariate regression analyses. The traits that significantly predicted case-control status were included in a multivariable regression model to investigate the gain in explained variance when leveraging the genetic effects of multiple traits simultaneously. RESULTS: In the univariate analyses, we observed significant associations between clinical status and the PRS of educational attainment (EA), smoking initiation (SI), intelligence, neuroticism, alcohol dependence, ADHD, major depression and anti-social behavior. EA (p-value: 3.53E-20, explained variance: 3.99%, OR: 0.66), and SI (p-value: 4.77E-10, explained variance: 1.91%, OR: 1.33) were the most predictive traits. In the multivariable analysis with these eight significant traits, EA and SI, remained significant predictors. The explained variance of the PRS in the model with these eight traits combined was 5.9%. CONCLUSION: Our study provides more insights into the genetic signal that is shared between childhood and adolescent psychiatric disorders. As such, our findings might guide future studies on psychiatric comorbidity and offer insights into shared etiology between psychiatric disorders. The increase in explained variance when leveraging the genetic signal of different predictor traits supports a multivariable approach to optimize precision accuracy for general psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.13370 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456
in Journal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1079-1089[article] The predictive capacity of psychiatric and psychological polygenic risk scores for distinguishing cases in a child and adolescent psychiatric sample from controls [Texte imprimé et/ou numérique] / A. G. JANSEN, Auteur ; P. R. JANSEN, Auteur ; Jeanne E. SAVAGE, Auteur ; J. KRAFT, Auteur ; N. SKARABIS, Auteur ; Tinca J. C. POLDERMAN, Auteur ; G. C. DIELEMAN, Auteur . - p.1079-1089.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1079-1089
Mots-clés : Adolescent Adult Aged Aged, 80 and over Anxiety Disorders/epidemiology/genetics Attention Deficit Disorder with Hyperactivity Child Child, Preschool Depressive Disorder, Major Humans Infant Middle Aged Multifactorial Inheritance/genetics Risk Factors Young Adult Genetics comorbidity general P factor neurodevelopmental disorders psychiatry Index. décimale : PER Périodiques Résumé : BACKGROUND: Psychiatric traits are heritable, highly comorbid and genetically correlated, suggesting that genetic effects that are shared across disorders are at play. The aim of the present study is to quantify the predictive capacity of common genetic variation of a variety of traits, as captured by their PRS, to predict case-control status in a child and adolescent psychiatric sample including controls to reveal which traits contribute to the shared genetic risk across disorders. METHOD: Polygenic risk scores (PRS) of 14 traits were used as predictor phenotypes to predict case-control status in a clinical sample. Clinical cases (N = 1,402), age 1-21, diagnostic categories: Autism spectrum disorders (N = 492), Attention-deficit/ hyperactivity disorders (N = 471), Anxiety (N = 293), disruptive behaviors (N = 101), eating disorders (N = 97), OCD (N = 43), Tic disorder (N = 50), Disorder of infancy, childhood or adolescence NOS (N = 65), depression (N = 64), motor, learning and communication disorders (N = 59), Anorexia Nervosa (N = 48), somatoform disorders (N = 47), Trauma/stress (N = 39) and controls (N = 1,448, age 17-84) of European ancestry. First, these 14 PRS were tested in univariate regression analyses. The traits that significantly predicted case-control status were included in a multivariable regression model to investigate the gain in explained variance when leveraging the genetic effects of multiple traits simultaneously. RESULTS: In the univariate analyses, we observed significant associations between clinical status and the PRS of educational attainment (EA), smoking initiation (SI), intelligence, neuroticism, alcohol dependence, ADHD, major depression and anti-social behavior. EA (p-value: 3.53E-20, explained variance: 3.99%, OR: 0.66), and SI (p-value: 4.77E-10, explained variance: 1.91%, OR: 1.33) were the most predictive traits. In the multivariable analysis with these eight significant traits, EA and SI, remained significant predictors. The explained variance of the PRS in the model with these eight traits combined was 5.9%. CONCLUSION: Our study provides more insights into the genetic signal that is shared between childhood and adolescent psychiatric disorders. As such, our findings might guide future studies on psychiatric comorbidity and offer insights into shared etiology between psychiatric disorders. The increase in explained variance when leveraging the genetic signal of different predictor traits supports a multivariable approach to optimize precision accuracy for general psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.13370 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 The Predictive Relationship Between Sensory Reactivity and Depressive Symptoms in Young Autistic Children with Few to No Words / Timothy Rossow ; Keren MACLENNAN ; Teresa TAVASSOLI in Journal of Autism and Developmental Disorders, 53-6 (June 2023)
[article]
Titre : The Predictive Relationship Between Sensory Reactivity and Depressive Symptoms in Young Autistic Children with Few to No Words : Journal of Autism and Developmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Timothy Rossow, Auteur ; Keren MACLENNAN, Auteur ; Teresa TAVASSOLI, Auteur Article en page(s) : p.2384-2394 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Depression and sensory reactivity are both common in autism. However, there is little understanding of the predictive relationship between these factors, or the nature of this relationship in autistic children who speak few to no words. This study set out to explore the longitudinal relationship between sensory reactivity and depressive symptoms in 33 young autistic children who speak few to no words. We found positive correlations between depressive symptoms and hyper-reactivity and sensory seeking at both timepoints, and across timepoints. We further found a bidirectional predictive relationship between depressive symptoms and sensory seeking. These results implicate sensory seeking in the development of depressive symptoms in young autistic children who use few to no words. Our findings have important implications for preventative mental health interventions, especially for those with a developmental language delay. En ligne : https://doi.org/10.1007/s10803-022-05528-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=506
in Journal of Autism and Developmental Disorders > 53-6 (June 2023) . - p.2384-2394[article] The Predictive Relationship Between Sensory Reactivity and Depressive Symptoms in Young Autistic Children with Few to No Words : Journal of Autism and Developmental Disorders [Texte imprimé et/ou numérique] / Timothy Rossow, Auteur ; Keren MACLENNAN, Auteur ; Teresa TAVASSOLI, Auteur . - p.2384-2394.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 53-6 (June 2023) . - p.2384-2394
Index. décimale : PER Périodiques Résumé : Depression and sensory reactivity are both common in autism. However, there is little understanding of the predictive relationship between these factors, or the nature of this relationship in autistic children who speak few to no words. This study set out to explore the longitudinal relationship between sensory reactivity and depressive symptoms in 33 young autistic children who speak few to no words. We found positive correlations between depressive symptoms and hyper-reactivity and sensory seeking at both timepoints, and across timepoints. We further found a bidirectional predictive relationship between depressive symptoms and sensory seeking. These results implicate sensory seeking in the development of depressive symptoms in young autistic children who use few to no words. Our findings have important implications for preventative mental health interventions, especially for those with a developmental language delay. En ligne : https://doi.org/10.1007/s10803-022-05528-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=506 The predictive significance of early caregiving experiences for symptoms of psychopathology through midadolescence: Enduring or transient effects? / John D. HALTIGAN in Development and Psychopathology, 25-1 (February 2013)
PermalinkThe Predictive Value of Microcephaly During the First Year of Life for Mental Retardation at Seven Years / H. DOLK in Developmental Medicine & Child Neurology, 33-11 (November 1991)
PermalinkThe Predictive Value of the AQ and the SRS-A in the Diagnosis of ASD in Adults in Clinical Practice / M. L. BEZEMER in Journal of Autism and Developmental Disorders, 51-7 (July 2021)
PermalinkThe predictors of change in reflective parenting therapy: Uncovering the influence of parental reflective functioning and child temperament in predicting the improvement in parent-child relationship and child outcome following DUET group intervention / Naama ATZABA-PORIA in Development and Psychopathology, 35-4 (October 2023)
PermalinkThe presence of migraines and its association with sensory hyperreactivity and anxiety symptomatology in children with autism spectrum disorder / Jillian C SULLIVAN in Autism, 18-6 (August 2014)
PermalinkThe Prevalence and Associations of Psychiatric Disorder in Children in Kerala, South India / Richard HACKETT in Journal of Child Psychology and Psychiatry, 40-5 (July 1999)
PermalinkThe Prevalence and Correlates of Involvement in the Criminal Justice System Among Youth on the Autism Spectrum / Julianna RAVA in Journal of Autism and Developmental Disorders, 47-2 (February 2017)
PermalinkThe prevalence and developmental course of auditory processing differences in autistic children / Bonnie K. LAU in Autism Research, 16-7 (July 2023)
PermalinkThe prevalence and incidence of early-onset dementia among adults with autism spectrum disorder / G. VIVANTI in Autism Research, 14-10 (October 2021)
PermalinkThe Prevalence and Incidence of Mental Ill-Health in Adults with Autism and Intellectual Disabilities / Craig MELVILLE in Journal of Autism and Developmental Disorders, 38-9 (October 2008)
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