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Recognition of scared faces and the serotonin transporter gene in young children: the Generation R Study / Eszter SZEKELY in Journal of Child Psychology and Psychiatry, 52-12 (December 2011)
[article]
Titre : Recognition of scared faces and the serotonin transporter gene in young children: the Generation R Study Type de document : Texte imprimé et/ou numérique Auteurs : Eszter SZEKELY, Auteur ; Catherine M. HERBA, Auteur ; Pascal P. ARP, Auteur ; André G. UITTERLINDEN, Auteur ; Vincent W.V. JADDOE, Auteur ; Albert HOFMAN, Auteur ; Frank C. VERHULST, Auteur ; James J. HUDZIAK, Auteur ; Henning TIEMEIER, Auteur Année de publication : 2011 Article en page(s) : p.1279-1286 Langues : Anglais (eng) Mots-clés : Serotonin transporter gene emotion processing facial expression fear children Index. décimale : PER Périodiques Résumé : Background: Previous research highlights the significance of a functional polymorphism located in the promoter region (5-HTTLPR) of the serotonin transporter gene in emotional behaviour. This study examined the effect of the 5-HTTLPR polymorphism on emotion processing in a large number of healthy preschoolers.
Methods: The 5-HTTLPR genotype was classified in 605 children as homozygous for the short allele (SS), homozygous for the long allele (LL), or heterozygous (LS). Emotion-processing was assessed using age-appropriate computer tasks where children matched happy, sad, angry, and fearful facial expressions preceded by a shape-matching task to assess basic matching ability.
Results: We found that young children could differentiate between emotion categories (F = 12.1, p < .001). The effect of 5-HTTLPR genotype depended on the emotion category presented (F = 2.3, p = .031). This effect was explained by the finding that SS children were less accurate at recognising fearful faces than LL or LS children (F = 5.3, p = .005). We did not find any significant differences as a result of 5-HTTLPR genotype for happy, sad or angry expressions (p > .05).
Conclusions: Results indicate that 5-HTTLPR allele status selectively impacts the processing of fearful but not other facial expressions. This pattern is already apparent in very young typically developing children. Results may signal an early vulnerability for affective problems before disorders emerge.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02423.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146
in Journal of Child Psychology and Psychiatry > 52-12 (December 2011) . - p.1279-1286[article] Recognition of scared faces and the serotonin transporter gene in young children: the Generation R Study [Texte imprimé et/ou numérique] / Eszter SZEKELY, Auteur ; Catherine M. HERBA, Auteur ; Pascal P. ARP, Auteur ; André G. UITTERLINDEN, Auteur ; Vincent W.V. JADDOE, Auteur ; Albert HOFMAN, Auteur ; Frank C. VERHULST, Auteur ; James J. HUDZIAK, Auteur ; Henning TIEMEIER, Auteur . - 2011 . - p.1279-1286.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 52-12 (December 2011) . - p.1279-1286
Mots-clés : Serotonin transporter gene emotion processing facial expression fear children Index. décimale : PER Périodiques Résumé : Background: Previous research highlights the significance of a functional polymorphism located in the promoter region (5-HTTLPR) of the serotonin transporter gene in emotional behaviour. This study examined the effect of the 5-HTTLPR polymorphism on emotion processing in a large number of healthy preschoolers.
Methods: The 5-HTTLPR genotype was classified in 605 children as homozygous for the short allele (SS), homozygous for the long allele (LL), or heterozygous (LS). Emotion-processing was assessed using age-appropriate computer tasks where children matched happy, sad, angry, and fearful facial expressions preceded by a shape-matching task to assess basic matching ability.
Results: We found that young children could differentiate between emotion categories (F = 12.1, p < .001). The effect of 5-HTTLPR genotype depended on the emotion category presented (F = 2.3, p = .031). This effect was explained by the finding that SS children were less accurate at recognising fearful faces than LL or LS children (F = 5.3, p = .005). We did not find any significant differences as a result of 5-HTTLPR genotype for happy, sad or angry expressions (p > .05).
Conclusions: Results indicate that 5-HTTLPR allele status selectively impacts the processing of fearful but not other facial expressions. This pattern is already apparent in very young typically developing children. Results may signal an early vulnerability for affective problems before disorders emerge.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02423.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146 Psychomotor agitation and mood instability in patients with autism spectrum disorders: A possible effect of SLC6A4 gene? / Jaqueline Bohrer SCHUCH in Research in Autism Spectrum Disorders, 26 (June 2016)
[article]
Titre : Psychomotor agitation and mood instability in patients with autism spectrum disorders: A possible effect of SLC6A4 gene? Type de document : Texte imprimé et/ou numérique Auteurs : Jaqueline Bohrer SCHUCH, Auteur ; Diana MÜLLER, Auteur ; Renata Giuliani ENDRES, Auteur ; Cleonice Alves BOSA, Auteur ; Dânae LONGO, Auteur ; Lavinia SCHULER-FACCINI, Auteur ; Josiane RANZAN, Auteur ; Michele Michelin BECKER, Auteur ; Rudimar dos Santos RIESGO, Auteur ; Tatiana ROMAN, Auteur Article en page(s) : p.48-56 Langues : Anglais (eng) Mots-clés : ASD Serotonin transporter gene Clinical symptoms Sex differences Association Family-based test Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions characterized by impairments in communication and social interaction and repetitive and stereotyped behaviors. Serotoninergic transmission has been suggested as an important neuronal pathway in ASD. In this study, we analyzed four polymorphisms (5HTTLPR, rs2066713, STin2, rs1042173; 5? ? 3? end) at the serotonin transporter gene (SLC6A4) in a sample of 209 ASD children and their biological parents. Both single markers and haplotypes were tested for association with ASD diagnosis and with clinical symptoms (aggression, echolalia, seizures, mood instability, psychomotor agitation, repetitive behaviors and sleep disorders) commonly present in ASD patients. The family-based analyses showed a significant result for one haplotype (H4: S-G-12R-T), which did not hold in global analyses. In male patients, a nominal association between the rs1042173 GG genotype and a diminished psychomotor agitation was observed; a trend for an association between the 5HTTLPR LaLa genotype and mood instability was also verified. Through interesting results that are mainly related to clinical manifestations and gender differences, our study adds to knowledge of ASD. Future investigations may corroborate the relevance of our data to upcoming clinical and pharmacological interventions. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.03.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285
in Research in Autism Spectrum Disorders > 26 (June 2016) . - p.48-56[article] Psychomotor agitation and mood instability in patients with autism spectrum disorders: A possible effect of SLC6A4 gene? [Texte imprimé et/ou numérique] / Jaqueline Bohrer SCHUCH, Auteur ; Diana MÜLLER, Auteur ; Renata Giuliani ENDRES, Auteur ; Cleonice Alves BOSA, Auteur ; Dânae LONGO, Auteur ; Lavinia SCHULER-FACCINI, Auteur ; Josiane RANZAN, Auteur ; Michele Michelin BECKER, Auteur ; Rudimar dos Santos RIESGO, Auteur ; Tatiana ROMAN, Auteur . - p.48-56.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 26 (June 2016) . - p.48-56
Mots-clés : ASD Serotonin transporter gene Clinical symptoms Sex differences Association Family-based test Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions characterized by impairments in communication and social interaction and repetitive and stereotyped behaviors. Serotoninergic transmission has been suggested as an important neuronal pathway in ASD. In this study, we analyzed four polymorphisms (5HTTLPR, rs2066713, STin2, rs1042173; 5? ? 3? end) at the serotonin transporter gene (SLC6A4) in a sample of 209 ASD children and their biological parents. Both single markers and haplotypes were tested for association with ASD diagnosis and with clinical symptoms (aggression, echolalia, seizures, mood instability, psychomotor agitation, repetitive behaviors and sleep disorders) commonly present in ASD patients. The family-based analyses showed a significant result for one haplotype (H4: S-G-12R-T), which did not hold in global analyses. In male patients, a nominal association between the rs1042173 GG genotype and a diminished psychomotor agitation was observed; a trend for an association between the 5HTTLPR LaLa genotype and mood instability was also verified. Through interesting results that are mainly related to clinical manifestations and gender differences, our study adds to knowledge of ASD. Future investigations may corroborate the relevance of our data to upcoming clinical and pharmacological interventions. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.03.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285 Maternal neglect and the serotonin system are associated with daytime sleep in infant rhesus monkeys / Alexander BAXTER in Development and Psychopathology, 32-1 (February 2020)
[article]
Titre : Maternal neglect and the serotonin system are associated with daytime sleep in infant rhesus monkeys Type de document : Texte imprimé et/ou numérique Auteurs : Alexander BAXTER, Auteur ; Elizabeth K. WOOD, Auteur ; Christina S. BARR, Auteur ; Daniel B. KAY, Auteur ; Stephen J. SUOMI, Auteur ; J. Dee HIGLEY, Auteur Article en page(s) : p.1-10 Langues : Anglais (eng) Mots-clés : 5-hydroxyindoleacetic acid development infant sleep maternal neglect serotonin transporter gene Index. décimale : PER Périodiques Résumé : Environmental and biological factors contribute to sleep development during infancy. Parenting plays a particularly important role in modulating infant sleep, potentially via the serotonin system, which is itself involved in regulating infant sleep. We hypothesized that maternal neglect and serotonin system dysregulation would be associated with daytime sleep in infant rhesus monkeys. Subjects were nursery-reared infant rhesus macaques (n = 287). During the first month of life, daytime sleep-wake states were rated bihourly (0800-2100). Infants were considered neglected (n = 16) if before nursery-rearing, their mother repeatedly failed to retrieve them. Serotonin transporter genotype and concentrations of cerebrospinal fluid 5-hydroxyindoleacetic acid (5-HIAA) were used as markers of central serotonin system functioning. t tests showed that neglected infants were observed sleeping less frequently, weighed less, and had higher 5-HIAA than non-neglected nursery-reared infants. Regression revealed that serotonin transporter genotype moderated the relationship between 5-HIAA and daytime sleep: in subjects possessing the Ls genotype, there was a positive correlation between 5-HIAA and daytime sleep, whereas in subjects possessing the LL genotype there was no association. These results highlight the pivotal roles that parents and the serotonin system play in sleep development. Daytime sleep alterations observed in neglected infants may partially derive from serotonin system dysregulation. En ligne : http://dx.doi.org/10.1017/s0954579418001359 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415
in Development and Psychopathology > 32-1 (February 2020) . - p.1-10[article] Maternal neglect and the serotonin system are associated with daytime sleep in infant rhesus monkeys [Texte imprimé et/ou numérique] / Alexander BAXTER, Auteur ; Elizabeth K. WOOD, Auteur ; Christina S. BARR, Auteur ; Daniel B. KAY, Auteur ; Stephen J. SUOMI, Auteur ; J. Dee HIGLEY, Auteur . - p.1-10.
Langues : Anglais (eng)
in Development and Psychopathology > 32-1 (February 2020) . - p.1-10
Mots-clés : 5-hydroxyindoleacetic acid development infant sleep maternal neglect serotonin transporter gene Index. décimale : PER Périodiques Résumé : Environmental and biological factors contribute to sleep development during infancy. Parenting plays a particularly important role in modulating infant sleep, potentially via the serotonin system, which is itself involved in regulating infant sleep. We hypothesized that maternal neglect and serotonin system dysregulation would be associated with daytime sleep in infant rhesus monkeys. Subjects were nursery-reared infant rhesus macaques (n = 287). During the first month of life, daytime sleep-wake states were rated bihourly (0800-2100). Infants were considered neglected (n = 16) if before nursery-rearing, their mother repeatedly failed to retrieve them. Serotonin transporter genotype and concentrations of cerebrospinal fluid 5-hydroxyindoleacetic acid (5-HIAA) were used as markers of central serotonin system functioning. t tests showed that neglected infants were observed sleeping less frequently, weighed less, and had higher 5-HIAA than non-neglected nursery-reared infants. Regression revealed that serotonin transporter genotype moderated the relationship between 5-HIAA and daytime sleep: in subjects possessing the Ls genotype, there was a positive correlation between 5-HIAA and daytime sleep, whereas in subjects possessing the LL genotype there was no association. These results highlight the pivotal roles that parents and the serotonin system play in sleep development. Daytime sleep alterations observed in neglected infants may partially derive from serotonin system dysregulation. En ligne : http://dx.doi.org/10.1017/s0954579418001359 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415