3 recherche sur le mot-clé 'Autistic Disorder/diagnostic imaging/physiopathology'

White matter microstructure as a potential contributor to differences in resting state alpha activity between neurotypical and autistic children: a longitudinal multimodal imaging study / Heather L. GREEN ; Marybeth MCNAMEE ; Rose E. FRANZEN ; Marissa A. DIPIERO ; Jeffrey I. BERMAN ; Matthew KU ; Luke BLOY ; Song LIU ; Megan AIREY ; Sophia GOLDIN ; Lisa BLASKEY ; Emily S. KUSCHNER ; Mina KIM ; Kimberly KONKA ; Gregory A. MILLER ; J. Christopher EDGAR in Molecular Autism, 16 (2025)  

Public ISBD [article]  inMolecular Autism > 16 (2025) . - 19 Titre : White matter microstructure as a potential contributor to differences in resting state alpha activity between neurotypical and autistic children: a longitudinal multimodal imaging study Type de document : texte imprimé Auteurs : Heather L. GREEN, Auteur ; Marybeth MCNAMEE, Auteur ; Rose E. FRANZEN, Auteur ; Marissa A. DIPIERO, Auteur ; Jeffrey I. BERMAN, Auteur ; Matthew KU, Auteur ; Luke BLOY, Auteur ; Song LIU, Auteur ; Megan AIREY, Auteur ; Sophia GOLDIN, Auteur ; Lisa BLASKEY, Auteur ; Emily S. KUSCHNER, Auteur ; Mina KIM, Auteur ; Kimberly KONKA, Auteur ; Gregory A. MILLER, Auteur ; J. Christopher EDGAR, Auteur Article en page(s) : 19 Langues : Anglais (eng) Mots-clés : Humans  White Matter/diagnostic imaging/pathology  Child  Male  Female  Longitudinal Studies  Magnetoencephalography  Diffusion Tensor Imaging  Multimodal Imaging  Autism Spectrum Disorder/diagnostic imaging/physiopathology  Rest  Alpha Rhythm  Autistic Disorder/diagnostic imaging/physiopathology  Brain/diagnostic imaging/physiopathology/pathology  Autism spectrum disorder  Dti  Maturation  Peak alpha frequency  Human ethics: This study was approved by the Institutional Review Board of  Children?s Hospital of Philadelphia (IRB 15-012531) and performed in accordance  with the Declaration of Helsinki. Parents gave written informed consent and the  children gave verbal and written assent. Index. décimale : PER Périodiques Résumé : We and others have demonstrated the resting-state (RS) peak alpha frequency (PAF) as a potential clinical marker for young children with autism spectrum disorder (ASD), with previous studies observing a higher PAF in school-age children with ASD versus typically developing (TD) children, as well as an association between the RS PAF and measures of processing speed in TD but not ASD. The brain mechanisms associated with these findings are unknown. A few studies have found that in children more mature optic radiation white matter is associated with a higher PAF. Other studies have reported white matter and neural activity associations in TD but not ASD. The present study hypothesized that group differences in the RS PAF are due, in part, to group differences in optic radiation white matter and PAF associations. The maturation of the RS PAF (measured using magnetoencephalography(MEG)), optic radiation white matter (measured using diffusion tensor imaging(DTI)), and associations with processing speed were assessed in a longitudinal cohort of TD and ASD children. Time 1 MEG and DTI measures were obtained at 6-8 years old (59TD and 56ASD) with follow-up brain measures collected?~ 1.5 and ~ 3 years later. The parietal-occipital PAF increased with age in both groups by 0.13 Hz/year, with a main effect of group showing the expected higher PAF in ASD than TD (an average of 0.26 Hz across the 3 time points). Across age, the RS PAF predicted processing speed in TD but not ASD. Finally, more mature optic radiation white matter measures (FA, RD, MD, AD) were associated with a higher PAF in both groups. Present findings provide additional evidence supporting the use of the RS PAF as a brain marker in children with ASD 6-10 years old, and replicate findings of an association between the RS PAF and processing speed in TD but not ASD. The hypothesis that the RS PAF group differences (with ASD leading TD by about 2 years) would be explained by group differences in optic radiation white matter was not supported, with brain structure-function associations indicating that more mature optic radiation white matter is associated with a higher RS PAF in both groups. En ligne : https://dx.doi.org/10.1186/s13229-025-00646-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555 [article] White matter microstructure as a potential contributor to differences in resting state alpha activity between neurotypical and autistic children: a longitudinal multimodal imaging study [texte imprimé] / Heather L. GREEN, Auteur ; Marybeth MCNAMEE, Auteur ; Rose E. FRANZEN, Auteur ; Marissa A. DIPIERO, Auteur ; Jeffrey I. BERMAN, Auteur ; Matthew KU, Auteur ; Luke BLOY, Auteur ; Song LIU, Auteur ; Megan AIREY, Auteur ; Sophia GOLDIN, Auteur ; Lisa BLASKEY, Auteur ; Emily S. KUSCHNER, Auteur ; Mina KIM, Auteur ; Kimberly KONKA, Auteur ; Gregory A. MILLER, Auteur ; J. Christopher EDGAR, Auteur . - 19. Langues : Anglais (eng) in Molecular Autism > 16 (2025) . - 19 Mots-clés : Humans  White Matter/diagnostic imaging/pathology  Child  Male  Female  Longitudinal Studies  Magnetoencephalography  Diffusion Tensor Imaging  Multimodal Imaging  Autism Spectrum Disorder/diagnostic imaging/physiopathology  Rest  Alpha Rhythm  Autistic Disorder/diagnostic imaging/physiopathology  Brain/diagnostic imaging/physiopathology/pathology  Autism spectrum disorder  Dti  Maturation  Peak alpha frequency  Human ethics: This study was approved by the Institutional Review Board of  Children?s Hospital of Philadelphia (IRB 15-012531) and performed in accordance  with the Declaration of Helsinki. Parents gave written informed consent and the  children gave verbal and written assent. Index. décimale : PER Périodiques Résumé : We and others have demonstrated the resting-state (RS) peak alpha frequency (PAF) as a potential clinical marker for young children with autism spectrum disorder (ASD), with previous studies observing a higher PAF in school-age children with ASD versus typically developing (TD) children, as well as an association between the RS PAF and measures of processing speed in TD but not ASD. The brain mechanisms associated with these findings are unknown. A few studies have found that in children more mature optic radiation white matter is associated with a higher PAF. Other studies have reported white matter and neural activity associations in TD but not ASD. The present study hypothesized that group differences in the RS PAF are due, in part, to group differences in optic radiation white matter and PAF associations. The maturation of the RS PAF (measured using magnetoencephalography(MEG)), optic radiation white matter (measured using diffusion tensor imaging(DTI)), and associations with processing speed were assessed in a longitudinal cohort of TD and ASD children. Time 1 MEG and DTI measures were obtained at 6-8 years old (59TD and 56ASD) with follow-up brain measures collected?~ 1.5 and ~ 3 years later. The parietal-occipital PAF increased with age in both groups by 0.13 Hz/year, with a main effect of group showing the expected higher PAF in ASD than TD (an average of 0.26 Hz across the 3 time points). Across age, the RS PAF predicted processing speed in TD but not ASD. Finally, more mature optic radiation white matter measures (FA, RD, MD, AD) were associated with a higher PAF in both groups. Present findings provide additional evidence supporting the use of the RS PAF as a brain marker in children with ASD 6-10 years old, and replicate findings of an association between the RS PAF and processing speed in TD but not ASD. The hypothesis that the RS PAF group differences (with ASD leading TD by about 2 years) would be explained by group differences in optic radiation white matter was not supported, with brain structure-function associations indicating that more mature optic radiation white matter is associated with a higher RS PAF in both groups. En ligne : https://dx.doi.org/10.1186/s13229-025-00646-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555

Superior temporal sulcus folding, functional network connectivity, and autistic-like traits in a non-clinical population / Igor NENADIĆ in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 44p. Titre : Superior temporal sulcus folding, functional network connectivity, and autistic-like traits in a non-clinical population Type de document : texte imprimé Auteurs : Igor NENADIĆ, Auteur ; Yvonne SCHRÖDER, Auteur ; Jonas HOFFMANN, Auteur ; Ulrika EVERMANN, Auteur ; Julia-Katharina PFARR, Auteur ; Aliénor BERGMANN, Auteur ; Daniela Michelle HOHMANN, Auteur ; Boris KEIL, Auteur ; Ahmad ABU-AKEL, Auteur ; Sanna STROTH, Auteur ; Inge KAMP-BECKER, Auteur ; Andreas JANSEN, Auteur ; Sarah GREZELLSCHAK, Auteur ; Tina MELLER, Auteur Article en page(s) : 44p. Langues : Anglais (eng) Mots-clés : Humans  Male  Female  Adult  Temporal Lobe/diagnostic imaging  Magnetic Resonance Imaging  Young Adult  Autistic Disorder/diagnostic imaging/physiopathology  Adolescent  Middle Aged  Nerve Net/diagnostic imaging  Autism Spectrum Disorder/diagnostic imaging/physiopathology  Brain Mapping/methods  Phenotype  Autism quotient (AQ)  Autism spectrum disorder (ASD)  Cortical surface complexity  Interpersonal  Subclinical Index. décimale : PER Périodiques Résumé : BACKGROUND: Autistic-like traits (ALT) are prevalent across the general population and might be linked to some facets of a broader autism spectrum disorder (ASD) phenotype. Recent studies suggest an association of these traits with both genetic and brain structural markers in non-autistic individuals, showing similar spatial location of findings observed in ASD and thus suggesting a potential neurobiological continuum. METHODS: In this study, we first tested an association of ALTs (assessed with the AQ questionnaire) with cortical complexity, a cortical surface marker of early neurodevelopment, and then the association with disrupted functional connectivity. We analysed structural T1-weighted and resting-state functional MRI scans in 250 psychiatrically healthy individuals without a history of early developmental disorders, in a first step using the CAT12 toolbox for cortical complexity analysis and in a second step we used regional cortical complexity findings to apply the CONN toolbox for seed-based functional connectivity analysis. RESULTS: Our findings show a significant negative correlation of both AQ total and AQ attention switching subscores with left superior temporal sulcus (STS) cortical folding complexity, with the former being significantly correlated with STS to left lateral occipital cortex connectivity, while the latter showed significant positive correlation of STS to left inferior/middle frontal gyrus connectivity (n = 233; all p < 0.05, FWE cluster-level corrected). Additional analyses also revealed a significant correlation of AQ attention to detail subscores with STS to left lateral occipital cortex connectivity. LIMITATIONS: Phenotyping might affect association results (e.g. choice of inventories); in addition, our study was limited to subclinical expressions of autistic-like traits. CONCLUSIONS: Our findings provide further evidence for biological correlates of ALT even in the absence of clinical ASD, while establishing a link between structural variation of early developmental origin and functional connectivity. En ligne : https://dx.doi.org/10.1186/s13229-024-00623-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Superior temporal sulcus folding, functional network connectivity, and autistic-like traits in a non-clinical population [texte imprimé] / Igor NENADIĆ, Auteur ; Yvonne SCHRÖDER, Auteur ; Jonas HOFFMANN, Auteur ; Ulrika EVERMANN, Auteur ; Julia-Katharina PFARR, Auteur ; Aliénor BERGMANN, Auteur ; Daniela Michelle HOHMANN, Auteur ; Boris KEIL, Auteur ; Ahmad ABU-AKEL, Auteur ; Sanna STROTH, Auteur ; Inge KAMP-BECKER, Auteur ; Andreas JANSEN, Auteur ; Sarah GREZELLSCHAK, Auteur ; Tina MELLER, Auteur . - 44p. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 44p. Mots-clés : Humans  Male  Female  Adult  Temporal Lobe/diagnostic imaging  Magnetic Resonance Imaging  Young Adult  Autistic Disorder/diagnostic imaging/physiopathology  Adolescent  Middle Aged  Nerve Net/diagnostic imaging  Autism Spectrum Disorder/diagnostic imaging/physiopathology  Brain Mapping/methods  Phenotype  Autism quotient (AQ)  Autism spectrum disorder (ASD)  Cortical surface complexity  Interpersonal  Subclinical Index. décimale : PER Périodiques Résumé : BACKGROUND: Autistic-like traits (ALT) are prevalent across the general population and might be linked to some facets of a broader autism spectrum disorder (ASD) phenotype. Recent studies suggest an association of these traits with both genetic and brain structural markers in non-autistic individuals, showing similar spatial location of findings observed in ASD and thus suggesting a potential neurobiological continuum. METHODS: In this study, we first tested an association of ALTs (assessed with the AQ questionnaire) with cortical complexity, a cortical surface marker of early neurodevelopment, and then the association with disrupted functional connectivity. We analysed structural T1-weighted and resting-state functional MRI scans in 250 psychiatrically healthy individuals without a history of early developmental disorders, in a first step using the CAT12 toolbox for cortical complexity analysis and in a second step we used regional cortical complexity findings to apply the CONN toolbox for seed-based functional connectivity analysis. RESULTS: Our findings show a significant negative correlation of both AQ total and AQ attention switching subscores with left superior temporal sulcus (STS) cortical folding complexity, with the former being significantly correlated with STS to left lateral occipital cortex connectivity, while the latter showed significant positive correlation of STS to left inferior/middle frontal gyrus connectivity (n = 233; all p < 0.05, FWE cluster-level corrected). Additional analyses also revealed a significant correlation of AQ attention to detail subscores with STS to left lateral occipital cortex connectivity. LIMITATIONS: Phenotyping might affect association results (e.g. choice of inventories); in addition, our study was limited to subclinical expressions of autistic-like traits. CONCLUSIONS: Our findings provide further evidence for biological correlates of ALT even in the absence of clinical ASD, while establishing a link between structural variation of early developmental origin and functional connectivity. En ligne : https://dx.doi.org/10.1186/s13229-024-00623-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

Towards robust and replicable sex differences in the intrinsic brain function of autism / Dorothea L. FLORIS in Molecular Autism, 12 (2021)  

Public ISBD [article]  inMolecular Autism > 12 (2021) . - 19 p. Titre : Towards robust and replicable sex differences in the intrinsic brain function of autism Type de document : texte imprimé Auteurs : Dorothea L. FLORIS, Auteur ; José O. A. FILHO, Auteur ; Meng-Chuan LAI, Auteur ; Steve GIAVASIS, Auteur ; Marianne OLDEHINKEL, Auteur ; Maarten MENNES, Auteur ; Tony CHARMAN, Auteur ; Julian TILLMANN, Auteur ; Guillaume DUMAS, Auteur ; Christine ECKER, Auteur ; Flavio DELL'ACQUA, Auteur ; Tobias BANASCHEWSKI, Auteur ; Carolin MOESSNANG, Auteur ; Simon BARON-COHEN, Auteur ; Sarah DURSTON, Auteur ; Eva LOTH, Auteur ; Declan G.M. MURPHY, Auteur ; Jan K. BUITELAAR, Auteur ; Christian F. BECKMANN, Auteur ; Michael P. MILHAM, Auteur ; Adriana DI MARTINO, Auteur Article en page(s) : 19 p. Langues : Anglais (eng) Mots-clés : Adolescent  Autistic Disorder/diagnostic imaging/physiopathology  Brain/diagnostic imaging/physiopathology  Child  Female  Humans  Magnetic Resonance Imaging  Male  Sex Characteristics  Autism spectrum disorder  Replication  Resting-state functional connectivity  Robustness  Sex differences  Voxel-mirrored homotopic connectivity  Responsiveness Scale—Child Version by Organization Speciali, Italy. JKB has been a  consultant to, advisory board member of, and a speaker for Takeda/Shire, Medice,  Roche, and Servier. He is not an employee of any of these companies and not a stock  shareholder of any of these companies. He has no other financial or material  support, including expert testimony, patents, or royalties. CFB is director and  shareholder in SBGneuro Ltd. TC has received consultancy from Roche and Servier and  received book royalties from Guildford Press and Sage. DM has been a consultant to,  and advisory board member, for Roche and Servier. He is not an employee of any of  these companies, and not a stock shareholder of any of these companies. TB served in  an advisory or consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals,  Oberberg GmbH, Shire, and Infectopharm. He received conference support or speaker’s  fee by Lilly, Medice, and Shire. He received royalties from Hogrefe, Kohlhammer, CIP  Medien, Oxford University Press  the present work is unrelated to these  relationships. JT is a consultant to Roche. The remaining authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Marked sex differences in autism prevalence accentuate the need to understand the role of biological sex-related factors in autism. Efforts to unravel sex differences in the brain organization of autism have, however, been challenged by the limited availability of female data. METHODS: We addressed this gap by using a large sample of males and females with autism and neurotypical (NT) control individuals (ABIDE; Autism: 362 males, 82 females; NT: 409 males, 166 females; 7-18 years). Discovery analyses examined main effects of diagnosis, sex and their interaction across five resting-state fMRI (R-fMRI) metrics (voxel-level Z > 3.1, cluster-level P < 0.01, gaussian random field corrected). Secondary analyses assessed the robustness of the results to different pre-processing approaches and their replicability in two independent samples: the EU-AIMS Longitudinal European Autism Project (LEAP) and the Gender Explorations of Neurogenetics and Development to Advance Autism Research. RESULTS: Discovery analyses in ABIDE revealed significant main effects of diagnosis and sex across the intrinsic functional connectivity of the posterior cingulate cortex, regional homogeneity and voxel-mirrored homotopic connectivity (VMHC) in several cortical regions, largely converging in the default network midline. Sex-by-diagnosis interactions were confined to the dorsolateral occipital cortex, with reduced VMHC in females with autism. All findings were robust to different pre-processing steps. Replicability in independent samples varied by R-fMRI measures and effects with the targeted sex-by-diagnosis interaction being replicated in the larger of the two replication samples-EU-AIMS LEAP. LIMITATIONS: Given the lack of a priori harmonization among the discovery and replication datasets available to date, sample-related variation remained and may have affected replicability. CONCLUSIONS: Atypical cross-hemispheric interactions are neurobiologically relevant to autism. They likely result from the combination of sex-dependent and sex-independent factors with a differential effect across functional cortical networks. Systematic assessments of the factors contributing to replicability are needed and necessitate coordinated large-scale data collection across studies. En ligne : http://dx.doi.org/10.1186/s13229-021-00415-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] Towards robust and replicable sex differences in the intrinsic brain function of autism [texte imprimé] / Dorothea L. FLORIS, Auteur ; José O. A. FILHO, Auteur ; Meng-Chuan LAI, Auteur ; Steve GIAVASIS, Auteur ; Marianne OLDEHINKEL, Auteur ; Maarten MENNES, Auteur ; Tony CHARMAN, Auteur ; Julian TILLMANN, Auteur ; Guillaume DUMAS, Auteur ; Christine ECKER, Auteur ; Flavio DELL'ACQUA, Auteur ; Tobias BANASCHEWSKI, Auteur ; Carolin MOESSNANG, Auteur ; Simon BARON-COHEN, Auteur ; Sarah DURSTON, Auteur ; Eva LOTH, Auteur ; Declan G.M. MURPHY, Auteur ; Jan K. BUITELAAR, Auteur ; Christian F. BECKMANN, Auteur ; Michael P. MILHAM, Auteur ; Adriana DI MARTINO, Auteur . - 19 p. Langues : Anglais (eng) in Molecular Autism > 12 (2021) . - 19 p. Mots-clés : Adolescent  Autistic Disorder/diagnostic imaging/physiopathology  Brain/diagnostic imaging/physiopathology  Child  Female  Humans  Magnetic Resonance Imaging  Male  Sex Characteristics  Autism spectrum disorder  Replication  Resting-state functional connectivity  Robustness  Sex differences  Voxel-mirrored homotopic connectivity  Responsiveness Scale—Child Version by Organization Speciali, Italy. JKB has been a  consultant to, advisory board member of, and a speaker for Takeda/Shire, Medice,  Roche, and Servier. He is not an employee of any of these companies and not a stock  shareholder of any of these companies. He has no other financial or material  support, including expert testimony, patents, or royalties. CFB is director and  shareholder in SBGneuro Ltd. TC has received consultancy from Roche and Servier and  received book royalties from Guildford Press and Sage. DM has been a consultant to,  and advisory board member, for Roche and Servier. He is not an employee of any of  these companies, and not a stock shareholder of any of these companies. TB served in  an advisory or consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals,  Oberberg GmbH, Shire, and Infectopharm. He received conference support or speaker’s  fee by Lilly, Medice, and Shire. He received royalties from Hogrefe, Kohlhammer, CIP  Medien, Oxford University Press  the present work is unrelated to these  relationships. JT is a consultant to Roche. The remaining authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Marked sex differences in autism prevalence accentuate the need to understand the role of biological sex-related factors in autism. Efforts to unravel sex differences in the brain organization of autism have, however, been challenged by the limited availability of female data. METHODS: We addressed this gap by using a large sample of males and females with autism and neurotypical (NT) control individuals (ABIDE; Autism: 362 males, 82 females; NT: 409 males, 166 females; 7-18 years). Discovery analyses examined main effects of diagnosis, sex and their interaction across five resting-state fMRI (R-fMRI) metrics (voxel-level Z > 3.1, cluster-level P < 0.01, gaussian random field corrected). Secondary analyses assessed the robustness of the results to different pre-processing approaches and their replicability in two independent samples: the EU-AIMS Longitudinal European Autism Project (LEAP) and the Gender Explorations of Neurogenetics and Development to Advance Autism Research. RESULTS: Discovery analyses in ABIDE revealed significant main effects of diagnosis and sex across the intrinsic functional connectivity of the posterior cingulate cortex, regional homogeneity and voxel-mirrored homotopic connectivity (VMHC) in several cortical regions, largely converging in the default network midline. Sex-by-diagnosis interactions were confined to the dorsolateral occipital cortex, with reduced VMHC in females with autism. All findings were robust to different pre-processing steps. Replicability in independent samples varied by R-fMRI measures and effects with the targeted sex-by-diagnosis interaction being replicated in the larger of the two replication samples-EU-AIMS LEAP. LIMITATIONS: Given the lack of a priori harmonization among the discovery and replication datasets available to date, sample-related variation remained and may have affected replicability. CONCLUSIONS: Atypical cross-hemispheric interactions are neurobiologically relevant to autism. They likely result from the combination of sex-dependent and sex-independent factors with a differential effect across functional cortical networks. Systematic assessments of the factors contributing to replicability are needed and necessitate coordinated large-scale data collection across studies. En ligne : http://dx.doi.org/10.1186/s13229-021-00415-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459