Combining multivariate genomic approaches to elucidate the comorbidity between autism spectrum disorder and attention deficit hyperactivity disorder / H. PEYRE in Journal of Child Psychology and Psychiatry, 62-11 (November 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1285-1296 Titre : Combining multivariate genomic approaches to elucidate the comorbidity between autism spectrum disorder and attention deficit hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : H. PEYRE, Auteur ; T. SCHOELER, Auteur ; C. LIU, Auteur ; C. M. WILLIAMS, Auteur ; N. HOERTEL, Auteur ; A. HAVDAHL, Auteur ; J. B. PINGAULT, Auteur Article en page(s) : p.1285-1296 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity/epidemiology/genetics  Autism Spectrum Disorder/epidemiology/genetics  Comorbidity  Genome-Wide Association Study  Genomics  Humans  Paired Box Transcription Factors/genetics  Polymorphism, Single Nucleotide  Repressor Proteins/genetics  Autism spectrum disorder  Gwas  Snp  attention deficit hyperactivity disorder  colocalization  common genetic variants  comorbidity  genomic structural equation modelling Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are two highly heritable neurodevelopmental disorders. Several lines of evidence point towards the presence of shared genetic factors underlying ASD and ADHD. We conducted genomic analyses of common risk variants (i.e. single nucleotide polymorphisms, SNPs) shared by ASD and ADHD, and those specific to each disorder. METHODS: With the summary data from two GWAS, one on ASD (N = 46,350) and another on ADHD (N = 55,374) individuals, we used genomic structural equation modelling and colocalization analysis to identify SNPs shared by ASD and ADHD and SNPs specific to each disorder. Functional genomic analyses were then conducted on shared and specific common genetic variants. Finally, we performed a bidirectional Mendelian randomization analysis to test whether the shared genetic risk between ASD and ADHD was interpretable in terms of reciprocal relationships between ASD and ADHD. RESULTS: We found that 37.5% of the SNPs associated with ASD (at p < 1e-6) colocalized with ADHD SNPs and that 19.6% of the SNPs associated with ADHD colocalized with ASD SNPs. We identified genes mapped to SNPs that are specific to ASD or ADHD and that are shared by ASD and ADHD, including two novel genes INSM1 and PAX1. Our bidirectional Mendelian randomization analyses indicated that the risk of ASD was associated with an increased risk of ADHD and vice versa. CONCLUSIONS: Using multivariate genomic analyses, the present study uncovers shared and specific genetic variants associated with ASD and ADHD. Further functional investigation of genes mapped to those shared variants may help identify pathophysiological pathways and new targets for treatment. En ligne : http://dx.doi.org/10.1111/jcpp.13479 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Combining multivariate genomic approaches to elucidate the comorbidity between autism spectrum disorder and attention deficit hyperactivity disorder [Texte imprimé et/ou numérique] / H. PEYRE, Auteur ; T. SCHOELER, Auteur ; C. LIU, Auteur ; C. M. WILLIAMS, Auteur ; N. HOERTEL, Auteur ; A. HAVDAHL, Auteur ; J. B. PINGAULT, Auteur . - p.1285-1296. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1285-1296 Mots-clés : Attention Deficit Disorder with Hyperactivity/epidemiology/genetics  Autism Spectrum Disorder/epidemiology/genetics  Comorbidity  Genome-Wide Association Study  Genomics  Humans  Paired Box Transcription Factors/genetics  Polymorphism, Single Nucleotide  Repressor Proteins/genetics  Autism spectrum disorder  Gwas  Snp  attention deficit hyperactivity disorder  colocalization  common genetic variants  comorbidity  genomic structural equation modelling Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are two highly heritable neurodevelopmental disorders. Several lines of evidence point towards the presence of shared genetic factors underlying ASD and ADHD. We conducted genomic analyses of common risk variants (i.e. single nucleotide polymorphisms, SNPs) shared by ASD and ADHD, and those specific to each disorder. METHODS: With the summary data from two GWAS, one on ASD (N = 46,350) and another on ADHD (N = 55,374) individuals, we used genomic structural equation modelling and colocalization analysis to identify SNPs shared by ASD and ADHD and SNPs specific to each disorder. Functional genomic analyses were then conducted on shared and specific common genetic variants. Finally, we performed a bidirectional Mendelian randomization analysis to test whether the shared genetic risk between ASD and ADHD was interpretable in terms of reciprocal relationships between ASD and ADHD. RESULTS: We found that 37.5% of the SNPs associated with ASD (at p < 1e-6) colocalized with ADHD SNPs and that 19.6% of the SNPs associated with ADHD colocalized with ASD SNPs. We identified genes mapped to SNPs that are specific to ASD or ADHD and that are shared by ASD and ADHD, including two novel genes INSM1 and PAX1. Our bidirectional Mendelian randomization analyses indicated that the risk of ASD was associated with an increased risk of ADHD and vice versa. CONCLUSIONS: Using multivariate genomic analyses, the present study uncovers shared and specific genetic variants associated with ASD and ADHD. Further functional investigation of genes mapped to those shared variants may help identify pathophysiological pathways and new targets for treatment. En ligne : http://dx.doi.org/10.1111/jcpp.13479 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Épidémiologie des troubles de la lecture en France : une comparaison du DSM-5 et de la CIM-11 / Franck RAMUS in Approche Neuropsychologique des Apprentissages chez l'Enfant - A.N.A.E., 175 (Décembre 2021)

Public ISBD [article]  inApproche Neuropsychologique des Apprentissages chez l'Enfant - A.N.A.E. > 175 (Décembre 2021) . - p.639-649 Titre : Épidémiologie des troubles de la lecture en France : une comparaison du DSM-5 et de la CIM-11 Type de document : Texte imprimé et/ou numérique Auteurs : Franck RAMUS, Auteur ; C. DI FOLCO, Auteur ; A. GUEZ, Auteur ; H. PEYRE, Auteur Article en page(s) : p.639-649 Langues : Français (fre) Mots-clés : Trouble de lecture  Prévalence  QI  DSM-5  lCD-1 1 Index. décimale : PER Périodiques Résumé : La présente étude effectue une comparaison systématique entre DSM-5 et CIM-1 1 des critères diagnostiques du trouble de la lecture, dans une population représentative d'élèves français de 6 (n 25000). Elle explore quantitativement les conséquences d'utiliser le DSM-5 ou la CIM-1 1, et des différentes manières d'implémenter chaque critère diagnostique. En utilisant un test de compréhension en lecture pour évaluer les capacités de lecture, un ensemble raisonnable de critères et de seuils aboutit à une prévalence de 6,6 % selon le DSM-5 et de 3,5 % selon la CIM-1 1. Les facteurs qui ont le plus grand impact sur la prévalence sont le critère relatif au décalage entre lecture et 01, et le critère d'interférence avec la performance scolaire. Comparés à la population de référence, les élèves avec trouble de lecture avaient une plus forte probabilité d'être des garçons, d'être en secteur d'éducation prioritaire, et d'avoir des scores plus faibles en niveau socioéconomique, en 01 et en mathématiques. Nos résultats montrent que le choix de classification et la manière précise d'opérationnaliser chaque critère diagnostique peuvent avoir un impact important sur le diagnostic. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=472 [article] Épidémiologie des troubles de la lecture en France : une comparaison du DSM-5 et de la CIM-11 [Texte imprimé et/ou numérique] / Franck RAMUS, Auteur ; C. DI FOLCO, Auteur ; A. GUEZ, Auteur ; H. PEYRE, Auteur . - p.639-649. Langues : Français (fre) in Approche Neuropsychologique des Apprentissages chez l'Enfant - A.N.A.E. > 175 (Décembre 2021) . - p.639-649 Mots-clés : Trouble de lecture  Prévalence  QI  DSM-5  lCD-1 1 Index. décimale : PER Périodiques Résumé : La présente étude effectue une comparaison systématique entre DSM-5 et CIM-1 1 des critères diagnostiques du trouble de la lecture, dans une population représentative d'élèves français de 6 (n 25000). Elle explore quantitativement les conséquences d'utiliser le DSM-5 ou la CIM-1 1, et des différentes manières d'implémenter chaque critère diagnostique. En utilisant un test de compréhension en lecture pour évaluer les capacités de lecture, un ensemble raisonnable de critères et de seuils aboutit à une prévalence de 6,6 % selon le DSM-5 et de 3,5 % selon la CIM-1 1. Les facteurs qui ont le plus grand impact sur la prévalence sont le critère relatif au décalage entre lecture et 01, et le critère d'interférence avec la performance scolaire. Comparés à la population de référence, les élèves avec trouble de lecture avaient une plus forte probabilité d'être des garçons, d'être en secteur d'éducation prioritaire, et d'avoir des scores plus faibles en niveau socioéconomique, en 01 et en mathématiques. Nos résultats montrent que le choix de classification et la manière précise d'opérationnaliser chaque critère diagnostique peuvent avoir un impact important sur le diagnostic. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=472

Fever during pregnancy as a risk factor for neurodevelopmental disorders: results from a systematic review and meta-analysis / S. ANTOUN in Molecular Autism, 12 (2021)  

Public ISBD [article]  inMolecular Autism > 12 (2021) . - 60 p. Titre : Fever during pregnancy as a risk factor for neurodevelopmental disorders: results from a systematic review and meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : S. ANTOUN, Auteur ; P. ELLUL, Auteur ; H. PEYRE, Auteur ; M. ROSENZWAJG, Auteur ; P. GRESSENS, Auteur ; D. KLATZMANN, Auteur ; R. DELORME, Auteur Article en page(s) : 60 p. Langues : Anglais (eng) Mots-clés : Autism  Children  Immunology  Maternal immune activation Index. décimale : PER Périodiques Résumé : BACKGROUND: Fever during pregnancy is a relatively common and most often trivial event. However, under specific conditions, it could affect significantly fetal brain development. Few studies, with inconsistent results, investigated whether fever, regardless the pathogen, could represent a risk factor for neurodevelopmental disorders (NDD) in the offspring. We aimed to explore further this question by performing a systematic review and meta-analysis. METHODS: Peer-reviewed studies exploring the occurrence of NDD in offspring after a fetal exposure to maternal fever were included. We specifically considered the impact of fever severity and duration, taking into consideration some confounding variables such as the use of antipyretic during pregnancy, the trimester in which the fever arose, the maternal age or smoking at time of gestation. MEDLINE, EMBASE, PsycINFO, Cochrane and Web of Science were searched without language restriction. PRISMA recommendations were followed. Odds ratio (OR) were pooled using random-effects meta-analysis. Heterogeneity in effect size across studies was studied using random-effects meta-regression analysis. (PROSPERO CRD42020182801). RESULTS: We finally considered ten studies gathering a total of 10,304 children with NDD. Among them, 1394 were exposed to fever during pregnancy. The selected studies were divided into 5 case-control studies and 5 cohort studies. Maternal exposure to fever during pregnancy increased the risk of NDD in offspring with an OR of 1.24 [95% CI: 1.12-1.38]. Secondary analysis revealed an increased risk for NDD when fever occurred during the first trimester of gestation [OR 1.13-95% CI: 1.02-1.26]. LIMITATIONS: We excluded studies that considered infections with no evidence of fever. Another potential limitation may be the possible heterogeneity between study designs (cohorts and case-control). CONCLUSION: Additional evidence supported the association between fever during pregnancy and increased risk for NDD in offspring. Careful monitoring should be considered for children born from mothers with a febrile episode during pregnancy (specifically during the first trimester). En ligne : http://dx.doi.org/10.1186/s13229-021-00464-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] Fever during pregnancy as a risk factor for neurodevelopmental disorders: results from a systematic review and meta-analysis [Texte imprimé et/ou numérique] / S. ANTOUN, Auteur ; P. ELLUL, Auteur ; H. PEYRE, Auteur ; M. ROSENZWAJG, Auteur ; P. GRESSENS, Auteur ; D. KLATZMANN, Auteur ; R. DELORME, Auteur . - 60 p. Langues : Anglais (eng) in Molecular Autism > 12 (2021) . - 60 p. Mots-clés : Autism  Children  Immunology  Maternal immune activation Index. décimale : PER Périodiques Résumé : BACKGROUND: Fever during pregnancy is a relatively common and most often trivial event. However, under specific conditions, it could affect significantly fetal brain development. Few studies, with inconsistent results, investigated whether fever, regardless the pathogen, could represent a risk factor for neurodevelopmental disorders (NDD) in the offspring. We aimed to explore further this question by performing a systematic review and meta-analysis. METHODS: Peer-reviewed studies exploring the occurrence of NDD in offspring after a fetal exposure to maternal fever were included. We specifically considered the impact of fever severity and duration, taking into consideration some confounding variables such as the use of antipyretic during pregnancy, the trimester in which the fever arose, the maternal age or smoking at time of gestation. MEDLINE, EMBASE, PsycINFO, Cochrane and Web of Science were searched without language restriction. PRISMA recommendations were followed. Odds ratio (OR) were pooled using random-effects meta-analysis. Heterogeneity in effect size across studies was studied using random-effects meta-regression analysis. (PROSPERO CRD42020182801). RESULTS: We finally considered ten studies gathering a total of 10,304 children with NDD. Among them, 1394 were exposed to fever during pregnancy. The selected studies were divided into 5 case-control studies and 5 cohort studies. Maternal exposure to fever during pregnancy increased the risk of NDD in offspring with an OR of 1.24 [95% CI: 1.12-1.38]. Secondary analysis revealed an increased risk for NDD when fever occurred during the first trimester of gestation [OR 1.13-95% CI: 1.02-1.26]. LIMITATIONS: We excluded studies that considered infections with no evidence of fever. Another potential limitation may be the possible heterogeneity between study designs (cohorts and case-control). CONCLUSION: Additional evidence supported the association between fever during pregnancy and increased risk for NDD in offspring. Careful monitoring should be considered for children born from mothers with a febrile episode during pregnancy (specifically during the first trimester). En ligne : http://dx.doi.org/10.1186/s13229-021-00464-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459

Maternal immigrant status and signs of neurodevelopmental problems in early childhood: The French representative ELFE birth cohort / H. SCHMENGLER in Autism Research, 12-12 (December)  

Public ISBD [article]  inAutism Research > 12-12 (December) . - p.1845-1859 Titre : Maternal immigrant status and signs of neurodevelopmental problems in early childhood: The French representative ELFE birth cohort Type de document : Texte imprimé et/ou numérique Auteurs : H. SCHMENGLER, Auteur ; F. EL-KHOURY LESUEUR, Auteur ; A. YERMACHENKO, Auteur ; M. TAINE, Auteur ; D. COHEN, Auteur ; H. PEYRE, Auteur ; C. SAINT-GEORGES, Auteur ; X. THIERRY, Auteur ; M. MELCHIOR, Auteur Année de publication : 2019 Article en page(s) : p.1845-1859 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  child development  developmental disabilities  immigrants  language Index. décimale : PER Périodiques Résumé : A growing body of evidence suggests that children of immigrants may have increased risks of neurodevelopmental disorders. However, evidence based on parent report and on very young children is lacking. We therefore investigated the association between maternal immigrant status and early signs of neurodevelopmental problems in a population-based sample of 2-year-old children using standardized parent-report instruments. We used data from the French representative Etude Longitudinale Francaise depuis l'Enfance birth cohort, initiated in 2011. The study sample included 9,900 children of nonimmigrant French, 1,403 children of second, and 1,171 children of first generation immigrant women followed-up to age 2 years. Neurodevelopment was assessed using the Modified Checklist for Autism in Toddlers (M-CHAT) and an adaptation of the MacArthur-Bates Communicative Development Inventories (MB-CDI). In fully adjusted linear regression models, maternal immigrant status was associated with M-CHAT scores, with stronger associations in children of first (beta-coefficient: 0.19; 95% CI 0.08-0.29) than second generation immigrants (0.09; 0.01-0.17). This association was especially strong among children of first generation immigrant mothers native of North Africa (vs. nonimmigrant French: 0.33; 0.16-0.49) and French-speaking Sub-Saharan Africa (0.26; 0.07-0.45). MB-CDI scores were lowest among children of first generation immigrant mothers, particularly from mostly non-francophone regions. Children of first generation immigrant mothers were most likely to have simultaneously low MB-CDI and high M-CHAT scores. Our findings suggest that maternal immigrant status is associated with early signs of neurodevelopmental difficulties, with strong variations according to maternal region of origin. Further research is necessary to test whether these associations persist and to determine the underlying mechanisms. Autism Res 2019, 12: 1845-1859. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We asked immigrant and nonimmigrant mothers in France about early signs of neurodevelopmental problems in their 2-year-old children. Overall, we found that children of immigrants may be at higher risk of showing these early warning signs, as compared to children of nonimmigrants. This is in line with previous studies, which were based on doctors' diagnoses at later ages. However, our results differed depending on the mothers' regions of origin. We found the highest risks in children of first generation immigrants from North and French-speaking Sub-Saharan Africa, who also seemed especially at risk of neurodevelopmental problems combined with low language development. En ligne : http://dx.doi.org/10.1002/aur.2181 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=413 [article] Maternal immigrant status and signs of neurodevelopmental problems in early childhood: The French representative ELFE birth cohort [Texte imprimé et/ou numérique] / H. SCHMENGLER, Auteur ; F. EL-KHOURY LESUEUR, Auteur ; A. YERMACHENKO, Auteur ; M. TAINE, Auteur ; D. COHEN, Auteur ; H. PEYRE, Auteur ; C. SAINT-GEORGES, Auteur ; X. THIERRY, Auteur ; M. MELCHIOR, Auteur . - 2019 . - p.1845-1859. Langues : Anglais (eng) in Autism Research > 12-12 (December) . - p.1845-1859 Mots-clés : autism spectrum disorder  child development  developmental disabilities  immigrants  language Index. décimale : PER Périodiques Résumé : A growing body of evidence suggests that children of immigrants may have increased risks of neurodevelopmental disorders. However, evidence based on parent report and on very young children is lacking. We therefore investigated the association between maternal immigrant status and early signs of neurodevelopmental problems in a population-based sample of 2-year-old children using standardized parent-report instruments. We used data from the French representative Etude Longitudinale Francaise depuis l'Enfance birth cohort, initiated in 2011. The study sample included 9,900 children of nonimmigrant French, 1,403 children of second, and 1,171 children of first generation immigrant women followed-up to age 2 years. Neurodevelopment was assessed using the Modified Checklist for Autism in Toddlers (M-CHAT) and an adaptation of the MacArthur-Bates Communicative Development Inventories (MB-CDI). In fully adjusted linear regression models, maternal immigrant status was associated with M-CHAT scores, with stronger associations in children of first (beta-coefficient: 0.19; 95% CI 0.08-0.29) than second generation immigrants (0.09; 0.01-0.17). This association was especially strong among children of first generation immigrant mothers native of North Africa (vs. nonimmigrant French: 0.33; 0.16-0.49) and French-speaking Sub-Saharan Africa (0.26; 0.07-0.45). MB-CDI scores were lowest among children of first generation immigrant mothers, particularly from mostly non-francophone regions. Children of first generation immigrant mothers were most likely to have simultaneously low MB-CDI and high M-CHAT scores. Our findings suggest that maternal immigrant status is associated with early signs of neurodevelopmental difficulties, with strong variations according to maternal region of origin. Further research is necessary to test whether these associations persist and to determine the underlying mechanisms. Autism Res 2019, 12: 1845-1859. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We asked immigrant and nonimmigrant mothers in France about early signs of neurodevelopmental problems in their 2-year-old children. Overall, we found that children of immigrants may be at higher risk of showing these early warning signs, as compared to children of nonimmigrants. This is in line with previous studies, which were based on doctors' diagnoses at later ages. However, our results differed depending on the mothers' regions of origin. We found the highest risks in children of first generation immigrants from North and French-speaking Sub-Saharan Africa, who also seemed especially at risk of neurodevelopmental problems combined with low language development. En ligne : http://dx.doi.org/10.1002/aur.2181 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=413

Regulatory T lymphocytes/Th17 lymphocytes imbalance in autism spectrum disorders: evidence from a meta-analysis / P. ELLUL in Molecular Autism, 12 (2021)  

Public ISBD [article]  inMolecular Autism > 12 (2021) . - 68 p. Titre : Regulatory T lymphocytes/Th17 lymphocytes imbalance in autism spectrum disorders: evidence from a meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : P. ELLUL, Auteur ; M. ROSENZWAJG, Auteur ; H. PEYRE, Auteur ; G. FOURCADE, Auteur ; E. MARIOTTI-FERRANDIZ, Auteur ; V. TREBOSSEN, Auteur ; D. KLATZMANN, Auteur ; R. DELORME, Auteur Article en page(s) : 68 p. Langues : Anglais (eng) Mots-clés : Asd  Immunology  Peripheral blood  Regulatory T lymphocyte  Th17 lymphocytes Index. décimale : PER Périodiques Résumé : BACKGROUND: Immune system dysfunction has been proposed to play a critical role in the pathophysiology of autism spectrum disorders (ASD). Conflicting reports of lymphocyte subpopulation abnormalities have been described in numerous studies of patients with ASD. To better define lymphocytes abnormalities in ASD, we performed a meta-analysis of the lymphocyte profiles from subjects with ASD. METHODS: We used the PRISMA recommendations to query PubMed, Embase, PsychoINFO, BIOSIS, Science Direct, Cochrane CENTRAL, and Clinicaltrials.gov for terms related to clinical diagnosis of ASD and to lymphocytes' populations. We selected studies exploring lymphocyte subpopulations in children with ASD. The search protocol has been registered in the international Prospective Register of Systematic Reviews (CRD42019121473). RESULTS: We selected 13 studies gathering 388 ASD patients and 326 healthy controls. A significant decrease in the CD4+?lymphocyte was found in ASD patients compared to controls [-?1.51 (95% CI?-?2.99;?-?0.04) p?=?0.04] (I(2)?=?96% [95% CI 94.6, 97.7], p? En ligne : http://dx.doi.org/10.1186/s13229-021-00472-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] Regulatory T lymphocytes/Th17 lymphocytes imbalance in autism spectrum disorders: evidence from a meta-analysis [Texte imprimé et/ou numérique] / P. ELLUL, Auteur ; M. ROSENZWAJG, Auteur ; H. PEYRE, Auteur ; G. FOURCADE, Auteur ; E. MARIOTTI-FERRANDIZ, Auteur ; V. TREBOSSEN, Auteur ; D. KLATZMANN, Auteur ; R. DELORME, Auteur . - 68 p. Langues : Anglais (eng) in Molecular Autism > 12 (2021) . - 68 p. Mots-clés : Asd  Immunology  Peripheral blood  Regulatory T lymphocyte  Th17 lymphocytes Index. décimale : PER Périodiques Résumé : BACKGROUND: Immune system dysfunction has been proposed to play a critical role in the pathophysiology of autism spectrum disorders (ASD). Conflicting reports of lymphocyte subpopulation abnormalities have been described in numerous studies of patients with ASD. To better define lymphocytes abnormalities in ASD, we performed a meta-analysis of the lymphocyte profiles from subjects with ASD. METHODS: We used the PRISMA recommendations to query PubMed, Embase, PsychoINFO, BIOSIS, Science Direct, Cochrane CENTRAL, and Clinicaltrials.gov for terms related to clinical diagnosis of ASD and to lymphocytes' populations. We selected studies exploring lymphocyte subpopulations in children with ASD. The search protocol has been registered in the international Prospective Register of Systematic Reviews (CRD42019121473). RESULTS: We selected 13 studies gathering 388 ASD patients and 326 healthy controls. A significant decrease in the CD4+?lymphocyte was found in ASD patients compared to controls [-?1.51 (95% CI?-?2.99;?-?0.04) p?=?0.04] (I(2)?=?96% [95% CI 94.6, 97.7], p? En ligne : http://dx.doi.org/10.1186/s13229-021-00472-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459

Trustworthiness and Dominance Personality Traits' Judgments in Adults with Autism Spectrum Disorder / A. LATIMIER in Journal of Autism and Developmental Disorders, 49-11 (November 2019)  

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