9 recherche sur le mot-clé 'Language delay'

Sex-specific associations between umbilical cord blood testosterone levels and language delay in early childhood / Andrew J. O. WHITEHOUSE in Journal of Child Psychology and Psychiatry, 53-7 (July 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-7 (July 2012) . - p.726-734 Titre : Sex-specific associations between umbilical cord blood testosterone levels and language delay in early childhood Type de document : Texte imprimé et/ou numérique Auteurs : Andrew J. O. WHITEHOUSE, Auteur ; Eugen MATTES, Auteur Année de publication : 2012 Article en page(s) : p.726-734 Langues : Anglais (eng) Mots-clés : Testosterone  language delay  sex-difference  developmental language disorder  Raine study Index. décimale : PER Périodiques Résumé : Background:  Preliminary evidence suggests that prenatal testosterone exposure may be associated with language delay. However, no study has examined a large sample of children at multiple time-points. Methods:  Umbilical cord blood samples were obtained at 861 births and analysed for bioavailable testosterone (BioT) concentrations. When participating offspring were 1, 2 and 3 years of age, parents of 767 children (males = 395; females = 372) completed the Infant Monitoring Questionnaire (IMQ), which measures Communication, Gross Motor, Fine Motor, Adaptive and Personal–Social development. Cut-off scores are available for each scale at each age to identify children with ‘clinically significant’ developmental delays. Chi-square analyses and generalized estimating equations examined longitudinal associations between sex-specific quartiles of BioT concentrations and the rate of developmental delay. Results:  Significantly more males than females had language delay (Communication scale) at age 1, 2 and 3 years (p-values ≤. 01). Males were also more likely to be classified as delayed on the Fine-Motor (p = .04) and Personal–Social (p < .01) scales at age 3 years. Chi-square analyses found a significant difference between BioT quartiles in the rate of language delay (but not Fine-Motor and Personal–Social delay) for males (age 3) and females (age 1 and 3). Generalized estimating equations, incorporating a range of sociodemographic and obstetric variables, found that males in the highest BioT quartile were at increased risk for a clinically significant language delay during the first 3 years of life, with an odds ratio (OR) of 2.47 (95% CI: 1.12, 5.47). By contrast, increasing levels of BioT reduced the risk of language delay among females (Quartile 2: OR = 0.23, 95% CI: 0.09, 0.59; Quartile 4: 0.46, 95% CI: 0.21, 0.99). Conclusion:  These data suggest that high prenatal testosterone levels are a risk factor for language delay in males, but may be a protective factor for females. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02523.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166 [article] Sex-specific associations between umbilical cord blood testosterone levels and language delay in early childhood [Texte imprimé et/ou numérique] / Andrew J. O. WHITEHOUSE, Auteur ; Eugen MATTES, Auteur . - 2012 . - p.726-734. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-7 (July 2012) . - p.726-734 Mots-clés : Testosterone  language delay  sex-difference  developmental language disorder  Raine study Index. décimale : PER Périodiques Résumé : Background:  Preliminary evidence suggests that prenatal testosterone exposure may be associated with language delay. However, no study has examined a large sample of children at multiple time-points. Methods:  Umbilical cord blood samples were obtained at 861 births and analysed for bioavailable testosterone (BioT) concentrations. When participating offspring were 1, 2 and 3 years of age, parents of 767 children (males = 395; females = 372) completed the Infant Monitoring Questionnaire (IMQ), which measures Communication, Gross Motor, Fine Motor, Adaptive and Personal–Social development. Cut-off scores are available for each scale at each age to identify children with ‘clinically significant’ developmental delays. Chi-square analyses and generalized estimating equations examined longitudinal associations between sex-specific quartiles of BioT concentrations and the rate of developmental delay. Results:  Significantly more males than females had language delay (Communication scale) at age 1, 2 and 3 years (p-values ≤. 01). Males were also more likely to be classified as delayed on the Fine-Motor (p = .04) and Personal–Social (p < .01) scales at age 3 years. Chi-square analyses found a significant difference between BioT quartiles in the rate of language delay (but not Fine-Motor and Personal–Social delay) for males (age 3) and females (age 1 and 3). Generalized estimating equations, incorporating a range of sociodemographic and obstetric variables, found that males in the highest BioT quartile were at increased risk for a clinically significant language delay during the first 3 years of life, with an odds ratio (OR) of 2.47 (95% CI: 1.12, 5.47). By contrast, increasing levels of BioT reduced the risk of language delay among females (Quartile 2: OR = 0.23, 95% CI: 0.09, 0.59; Quartile 4: 0.46, 95% CI: 0.21, 0.99). Conclusion:  These data suggest that high prenatal testosterone levels are a risk factor for language delay in males, but may be a protective factor for females. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02523.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166

Haploinsufficiency of CMIP in a Girl With Autism Spectrum Disorder and Developmental Delay due to a De Novo Deletion on Chromosome 16q23.2 / Nathalie VAN DER AA in Autism Research, 5-4 (August 2012)  

Public ISBD [article]  inAutism Research > 5-4 (August 2012) . - p.277-81 Titre : Haploinsufficiency of CMIP in a Girl With Autism Spectrum Disorder and Developmental Delay due to a De Novo Deletion on Chromosome 16q23.2 Type de document : Texte imprimé et/ou numérique Auteurs : Nathalie VAN DER AA, Auteur ; Geert VANDEWEYER, Auteur ; Edwin REYNIERS, Auteur ; Sandra KENIS, Auteur ; Lina DOM, Auteur ; Geert MORTIER, Auteur ; Liesbeth ROOMS, Auteur ; R. Frank KOOY, Auteur Année de publication : 2012 Article en page(s) : p.277-81 Langues : Anglais (eng) Mots-clés : language delay  autism  ASD  CMIP  intellectual disability Index. décimale : PER Périodiques Résumé : In a developmentally delayed girl with an autism spectrum disorder, Single nucleotide polymorphism (SNP) array analysis showed a de novo 280 kb deletion on chromosome 16q23.2 involving two genes, GAN and CMIP. Inactivating mutations in GAN cause the autosomal recessive disorder giant axonal neuropathy, not present in our patient. CMIP was recently implicated in the etiology of specific language impairment by genome-wide association analysis. It modulates phonological short-term memory and hence plays an important role in language acquisition. Overlaps of specific language impairment and autism have been debated in the literature regarding the phenotypical language profile as well as etiology. Our patient illustrates that haploinsufficiency of CMIP may contribute to autism spectrum disorders. Our finding further supports the existence of a genetic overlap in the etiology of specific language impairment and autism. En ligne : http://dx.doi.org/10.1002/aur.1240 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 [article] Haploinsufficiency of CMIP in a Girl With Autism Spectrum Disorder and Developmental Delay due to a De Novo Deletion on Chromosome 16q23.2 [Texte imprimé et/ou numérique] / Nathalie VAN DER AA, Auteur ; Geert VANDEWEYER, Auteur ; Edwin REYNIERS, Auteur ; Sandra KENIS, Auteur ; Lina DOM, Auteur ; Geert MORTIER, Auteur ; Liesbeth ROOMS, Auteur ; R. Frank KOOY, Auteur . - 2012 . - p.277-81. Langues : Anglais (eng) in Autism Research > 5-4 (August 2012) . - p.277-81 Mots-clés : language delay  autism  ASD  CMIP  intellectual disability Index. décimale : PER Périodiques Résumé : In a developmentally delayed girl with an autism spectrum disorder, Single nucleotide polymorphism (SNP) array analysis showed a de novo 280 kb deletion on chromosome 16q23.2 involving two genes, GAN and CMIP. Inactivating mutations in GAN cause the autosomal recessive disorder giant axonal neuropathy, not present in our patient. CMIP was recently implicated in the etiology of specific language impairment by genome-wide association analysis. It modulates phonological short-term memory and hence plays an important role in language acquisition. Overlaps of specific language impairment and autism have been debated in the literature regarding the phenotypical language profile as well as etiology. Our patient illustrates that haploinsufficiency of CMIP may contribute to autism spectrum disorders. Our finding further supports the existence of a genetic overlap in the etiology of specific language impairment and autism. En ligne : http://dx.doi.org/10.1002/aur.1240 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179

Preterm birth and risk for language delays before school entry: A sibling-control study / Imac Maria ZAMBRANA in Development and Psychopathology, 33-1 (February 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-1 (February 2021) . - p.47-52 Titre : Preterm birth and risk for language delays before school entry: A sibling-control study Type de document : Texte imprimé et/ou numérique Auteurs : Imac Maria ZAMBRANA, Auteur ; Margarete E. VOLLRATH, Auteur ; Bo JACOBSSON, Auteur ; Verena SENGPIEL, Auteur ; Eivind YSTROM, Auteur Article en page(s) : p.47-52 Langues : Anglais (eng) Mots-clés : cohort study  early childhood  language delay  preterm birth  sibling control study Index. décimale : PER Périodiques Résumé : We investigated whether children born preterm are at risk for language delay using a sibling-control design in the Norwegian Mother and Child Cohort Study (MoBa), conducted by the Norwegian Institute of Public Health. Participants included 26,769 siblings born between gestational weeks 23 and 42. Language delay was assessed when the children were 1.5, 3, and 5 years old. To adjust for familial risk factors, comparisons were conducted between preterm and full-term siblings. Pregnancy-specific risk factors were controlled for by means of observed variables. Findings showed that preterm children born before week 37 had increased risk for language delays at 1.5 years. At 3 and 5 years, only children born before week 34 had increased risk for language delay. Children born weeks 29-33 and before week 29 had increased risk for language delay at 1.5 years (RR = 4.51, 95% CI [3.45, 5.88]; RR = 10.32, 95% CI [6.7, 15.80]), 3 years (RR = 1.50, 95% CI [1.02, 2.21]; RR = 2.78, 95% CI [1.09, 7.07]), and 5 years (RR = 1.63, 95% CI [1.06, 2.51]; RR = 2.98, 95% CI [0.87, 10.26]), respectively. In conclusion, children born preterm are at risk for language delays, with familial confounders only explaining a moderate share of the association. This suggests a cause-effect relationship between early preterm birth and risk for language delay in preschool children. En ligne : http://dx.doi.org/10.1017/s0954579419001536 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442 [article] Preterm birth and risk for language delays before school entry: A sibling-control study [Texte imprimé et/ou numérique] / Imac Maria ZAMBRANA, Auteur ; Margarete E. VOLLRATH, Auteur ; Bo JACOBSSON, Auteur ; Verena SENGPIEL, Auteur ; Eivind YSTROM, Auteur . - p.47-52. Langues : Anglais (eng) in Development and Psychopathology > 33-1 (February 2021) . - p.47-52 Mots-clés : cohort study  early childhood  language delay  preterm birth  sibling control study Index. décimale : PER Périodiques Résumé : We investigated whether children born preterm are at risk for language delay using a sibling-control design in the Norwegian Mother and Child Cohort Study (MoBa), conducted by the Norwegian Institute of Public Health. Participants included 26,769 siblings born between gestational weeks 23 and 42. Language delay was assessed when the children were 1.5, 3, and 5 years old. To adjust for familial risk factors, comparisons were conducted between preterm and full-term siblings. Pregnancy-specific risk factors were controlled for by means of observed variables. Findings showed that preterm children born before week 37 had increased risk for language delays at 1.5 years. At 3 and 5 years, only children born before week 34 had increased risk for language delay. Children born weeks 29-33 and before week 29 had increased risk for language delay at 1.5 years (RR = 4.51, 95% CI [3.45, 5.88]; RR = 10.32, 95% CI [6.7, 15.80]), 3 years (RR = 1.50, 95% CI [1.02, 2.21]; RR = 2.78, 95% CI [1.09, 7.07]), and 5 years (RR = 1.63, 95% CI [1.06, 2.51]; RR = 2.98, 95% CI [0.87, 10.26]), respectively. In conclusion, children born preterm are at risk for language delays, with familial confounders only explaining a moderate share of the association. This suggests a cause-effect relationship between early preterm birth and risk for language delay in preschool children. En ligne : http://dx.doi.org/10.1017/s0954579419001536 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442

The Effects of Early Language on Age at Diagnosis and Functioning at School Age in Children with Autism Spectrum Disorder / Anthony GOODWIN in Journal of Autism and Developmental Disorders, 47-7 (July 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-7 (July 2017) . - p.2176-2188 Titre : The Effects of Early Language on Age at Diagnosis and Functioning at School Age in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Anthony GOODWIN, Auteur ; Nicole L. MATTHEWS, Auteur ; Christopher J. SMITH, Auteur Article en page(s) : p.2176-2188 Langues : Anglais (eng) Mots-clés : Adaptive functioning  Age at diagnosis  ASD  IQ  Language delay  Language milestones  Symptom severity Index. décimale : PER Périodiques Résumé : Research suggests that toddlers with no language delay (NLD) should have better outcomes than those with language delay (LD). However, the predictive utility of language milestones relative to co-varying factors such as age at diagnosis, IQ, and ASD symptomatology is unclear. This study compared school-aged children with ASD and NLD (n?=?59) to a well-matched group with ASD and LD (n?=?59). The LD group was diagnosed at younger ages and their historical ASD symptoms were more severe than the NLD group. The groups were similar in current ASD symptoms and adaptive functioning at school age. Language milestones were correlated with adaptive functioning, but IQ and social symptoms of ASD were stronger predictors of functioning at school age. Therefore, language milestones may not be the best indicators of prognosis for children who are diagnosed after toddlerhood. En ligne : https://doi.org/10.1007/s10803-017-3133-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=314 [article] The Effects of Early Language on Age at Diagnosis and Functioning at School Age in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Anthony GOODWIN, Auteur ; Nicole L. MATTHEWS, Auteur ; Christopher J. SMITH, Auteur . - p.2176-2188. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-7 (July 2017) . - p.2176-2188 Mots-clés : Adaptive functioning  Age at diagnosis  ASD  IQ  Language delay  Language milestones  Symptom severity Index. décimale : PER Périodiques Résumé : Research suggests that toddlers with no language delay (NLD) should have better outcomes than those with language delay (LD). However, the predictive utility of language milestones relative to co-varying factors such as age at diagnosis, IQ, and ASD symptomatology is unclear. This study compared school-aged children with ASD and NLD (n?=?59) to a well-matched group with ASD and LD (n?=?59). The LD group was diagnosed at younger ages and their historical ASD symptoms were more severe than the NLD group. The groups were similar in current ASD symptoms and adaptive functioning at school age. Language milestones were correlated with adaptive functioning, but IQ and social symptoms of ASD were stronger predictors of functioning at school age. Therefore, language milestones may not be the best indicators of prognosis for children who are diagnosed after toddlerhood. En ligne : https://doi.org/10.1007/s10803-017-3133-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=314

The gesture–language association over time in toddlers with and without language delays / Stacy S. MANWARING in Autism & Developmental Language Impairments, 4 (January-December 2019)  

Public ISBD [article]  inAutism & Developmental Language Impairments > 4 (January-December 2019) Titre : The gesture–language association over time in toddlers with and without language delays Type de document : Texte imprimé et/ou numérique Auteurs : Stacy S. MANWARING, Auteur ; Lauren SWINEFORD, Auteur ; Danielle L. MEAD, Auteur ; Chih-Ching YEH, Auteur ; Yue ZHANG, Auteur ; Audrey THURM, Auteur Langues : Anglais (eng) Mots-clés : Gesture  deictic  language delay  autism spectrum disorder Index. décimale : PER Périodiques Résumé : Background and aimsYoung children with language delays or other factors that heighten risk for autism spectrum disorder often show reduced gesture use. In particular, deictic gestures such as pointing and showing are reported to be deficient in young children with autism spectrum disorder, and their use has been found to predict expressive vocabulary development. The first aim of this study was to examine the production of two types of gestures (deictic and conventional) for two communicative functions (behavior regulation and joint attention) across two observational contexts in a sample of 18-month-old toddlers with significant language delays compared to typical controls. The second aim was to examine if and how gesture use (type and communicative function) at 18 months is associated with later receptive and expressive language.MethodsToddlers with significant language delays (n=30) or typical development (n=62) were drawn from longitudinal studies of early language delay as a risk factor for autism spectrum disorder. Toddlers identified with early language delay were classified based on a diagnosis of autism spectrum disorder (n=12) or non-autism spectrum disorder (n=18) after an evaluation at 36 months. Gestures were coded from video recordings of the Communication and Symbolic Behavior Scales Developmental Profile?Behavior Sample and a naturalistic parent?child interaction obtained at 18 months. Language outcomes included receptive and expressive age equivalents from the Mullen Scales of Early Learning and the number of words produced on the MacArthur?Bates Communicative Development Inventories.ResultsAt 18 months, toddlers with language delay showed reduced deictic and conventional gesture use in both the Communication and Symbolic Behavior Scales Developmental Profile?Behavior Sample and parent?child interaction compared to toddlers with typical development. Within the language delay group, toddlers with an autism spectrum disorder diagnosis at outcome also produced significantly fewer deictic gestures than those without an autism spectrum disorder diagnosis across both communicative functions and observational contexts. While all groups of toddlers gestured more in the Communication and Symbolic Behavior Scales Developmental Profile?Behavior Sample, the mean difference in gesture use between the Communication and Symbolic Behavior Scales Developmental Profile?Behavior Sample and parent?child interaction was significantly larger in toddlers with typical development than language delay for deictic gestures, as compared to the difference between the two contexts for conventional gestures. In the combined sample, a significant association was found between deictic gestures used in the Communication and Symbolic Behavior Scales Developmental Profile?Behavior Sample and change in the number of words produced from 18 to 36 months, accounting for significant demographic and developmental confounders.ConclusionsFindings show that early language delay is associated with reduced deictic and conventional gestures across observational contexts. Importantly, deictic gesture use, but not conventional, was associated with the development of expressive language in toddlers with and without language delays.ImplicationsDeictic gestures play an important role in the development of expressive language in toddlers, including those with language delays. Assessment of young children with language delays should include evaluation of types of gestures used and communicative function of gestures, with assessments utilizing communicative temptations yielding higher rates of gesture production. Directly targeting both gesture type and function in early intervention may be important in facilitating the development of language. En ligne : https://doi.org/10.1177/2396941519845545 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] The gesture–language association over time in toddlers with and without language delays [Texte imprimé et/ou numérique] / Stacy S. MANWARING, Auteur ; Lauren SWINEFORD, Auteur ; Danielle L. MEAD, Auteur ; Chih-Ching YEH, Auteur ; Yue ZHANG, Auteur ; Audrey THURM, Auteur. Langues : Anglais (eng) in Autism & Developmental Language Impairments > 4 (January-December 2019) Mots-clés : Gesture  deictic  language delay  autism spectrum disorder Index. décimale : PER Périodiques Résumé : Background and aimsYoung children with language delays or other factors that heighten risk for autism spectrum disorder often show reduced gesture use. In particular, deictic gestures such as pointing and showing are reported to be deficient in young children with autism spectrum disorder, and their use has been found to predict expressive vocabulary development. The first aim of this study was to examine the production of two types of gestures (deictic and conventional) for two communicative functions (behavior regulation and joint attention) across two observational contexts in a sample of 18-month-old toddlers with significant language delays compared to typical controls. The second aim was to examine if and how gesture use (type and communicative function) at 18 months is associated with later receptive and expressive language.MethodsToddlers with significant language delays (n=30) or typical development (n=62) were drawn from longitudinal studies of early language delay as a risk factor for autism spectrum disorder. Toddlers identified with early language delay were classified based on a diagnosis of autism spectrum disorder (n=12) or non-autism spectrum disorder (n=18) after an evaluation at 36 months. Gestures were coded from video recordings of the Communication and Symbolic Behavior Scales Developmental Profile?Behavior Sample and a naturalistic parent?child interaction obtained at 18 months. Language outcomes included receptive and expressive age equivalents from the Mullen Scales of Early Learning and the number of words produced on the MacArthur?Bates Communicative Development Inventories.ResultsAt 18 months, toddlers with language delay showed reduced deictic and conventional gesture use in both the Communication and Symbolic Behavior Scales Developmental Profile?Behavior Sample and parent?child interaction compared to toddlers with typical development. Within the language delay group, toddlers with an autism spectrum disorder diagnosis at outcome also produced significantly fewer deictic gestures than those without an autism spectrum disorder diagnosis across both communicative functions and observational contexts. While all groups of toddlers gestured more in the Communication and Symbolic Behavior Scales Developmental Profile?Behavior Sample, the mean difference in gesture use between the Communication and Symbolic Behavior Scales Developmental Profile?Behavior Sample and parent?child interaction was significantly larger in toddlers with typical development than language delay for deictic gestures, as compared to the difference between the two contexts for conventional gestures. In the combined sample, a significant association was found between deictic gestures used in the Communication and Symbolic Behavior Scales Developmental Profile?Behavior Sample and change in the number of words produced from 18 to 36 months, accounting for significant demographic and developmental confounders.ConclusionsFindings show that early language delay is associated with reduced deictic and conventional gestures across observational contexts. Importantly, deictic gesture use, but not conventional, was associated with the development of expressive language in toddlers with and without language delays.ImplicationsDeictic gestures play an important role in the development of expressive language in toddlers, including those with language delays. Assessment of young children with language delays should include evaluation of types of gestures used and communicative function of gestures, with assessments utilizing communicative temptations yielding higher rates of gesture production. Directly targeting both gesture type and function in early intervention may be important in facilitating the development of language. En ligne : https://doi.org/10.1177/2396941519845545 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

Associations Between Language Development and Skin Conductance Responses to Faces and Eye Gaze in Children with Autism Spectrum Disorder / Steven D. STAGG in Journal of Autism and Developmental Disorders, 43-10 (October 2013)  

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Assessment of presentation patterns, clinical severity, and sensorial mechanism of tip-toe behavior in severe ASD subjects with intellectual disability: A cohort observational study / Giulio VALAGUSSA in Autism Research, 10-9 (September 2017)  

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Age of First Words Predicts Cognitive Ability and Adaptive Skills in Children with ASD / Jessica MAYO in Journal of Autism and Developmental Disorders, 43-2 (February 2013)  

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Validation of Autism Diagnosis and Clinical Data in the SPARK Cohort / Eric FOMBONNE in Journal of Autism and Developmental Disorders, 52-8 (August 2022)  

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