3 recherche sur le mot-clé 'Schizophrenia spectrum disorders'

Task-based functional neural correlates of social cognition across autism and schizophrenia spectrum disorders / Lindsay D. OLIVER in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 37p. Titre : Task-based functional neural correlates of social cognition across autism and schizophrenia spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Lindsay D. OLIVER, Auteur ; Iska MOXON-EMRE, Auteur ; Colin HAWCO, Auteur ; Erin W. DICKIE, Auteur ; Arla DAKLI, Auteur ; Rachael E. LYON, Auteur ; Peter SZATMARI, Auteur ; John D. HALTIGAN, Auteur ; Anna GOLDENBERG, Auteur ; Ayesha G. RASHIDI, Auteur ; Vinh TAN, Auteur ; Maria T. SECARA, Auteur ; Pushpal DESARKAR, Auteur ; George FOUSSIAS, Auteur ; Robert W. BUCHANAN, Auteur ; Anil K. MALHOTRA, Auteur ; Meng-Chuan LAI, Auteur ; Aristotle N VOINESKOS, Auteur ; Stephanie H. AMEIS, Auteur Article en page(s) : 37p. Langues : Anglais (eng) Mots-clés : Humans  Social Cognition  Male  Female  Adult  Magnetic Resonance Imaging  Adolescent  Young Adult  Brain/diagnostic imaging/physiopathology  Schizophrenia/physiopathology/diagnostic imaging  Autism Spectrum Disorder/physiopathology/diagnostic imaging/psychology  Autistic Disorder/physiopathology/psychology  Brain Mapping  Case-Control Studies  Autism  Schizophrenia spectrum disorders  Social cognition  fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism and schizophrenia spectrum disorders (SSDs) both feature atypical social cognition. Despite evidence for comparable group-level performance in lower-level emotion processing and higher-level mentalizing, limited research has examined the neural basis of social cognition across these conditions. Our goal was to compare the neural correlates of social cognition in autism, SSDs, and typically developing controls (TDCs). METHODS: Data came from two harmonized studies in individuals diagnosed with autism or SSDs and TDCs (aged 16-35 years), including behavioral social cognitive metrics and two functional magnetic resonance imaging (fMRI) tasks: a social mirroring Imitate/Observe (ImObs) task and the Empathic Accuracy (EA) task. Group-level comparisons, and transdiagnostic analyses incorporating social cognitive performance, were run using FSL's PALM for each task, covarying for age and sex (1000 permutations, thresholded at p < 0.05 FWE-corrected). Exploratory region of interest (ROI)-based analyses were also conducted. RESULTS: ImObs and EA analyses included 164 and 174 participants, respectively (autism N = 56/59, SSD N = 50/56, TDC N = 58/59). EA and both lower- and higher-level social cognition scores differed across groups. While canonical social cognitive networks were activated, no significant whole-brain or ROI-based group-level differences in neural correlates for either task were detected. Transdiagnostically, neural activity during the EA task, but not the ImObs task, was associated with lower- and higher-level social cognitive performance. LIMITATIONS: Despite attempting to match our groups on age, sex, and race, significant group differences remained. Power to detect regional brain differences is also influenced by sample size and multiple comparisons in whole-brain analyses. Our findings may not generalize to autism and SSD individuals with co-occurring intellectual disabilities. CONCLUSIONS: The lack of whole-brain and ROI-based group-level differences identified and the dimensional EA brain-behavior relationship observed across our sample suggest that the EA task may be well-suited to target engagement in novel intervention testing. Our results also emphasize the potential utility of cross-condition approaches to better understand social cognition across autism and SSDs. En ligne : https://dx.doi.org/10.1186/s13229-024-00615-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Task-based functional neural correlates of social cognition across autism and schizophrenia spectrum disorders [Texte imprimé et/ou numérique] / Lindsay D. OLIVER, Auteur ; Iska MOXON-EMRE, Auteur ; Colin HAWCO, Auteur ; Erin W. DICKIE, Auteur ; Arla DAKLI, Auteur ; Rachael E. LYON, Auteur ; Peter SZATMARI, Auteur ; John D. HALTIGAN, Auteur ; Anna GOLDENBERG, Auteur ; Ayesha G. RASHIDI, Auteur ; Vinh TAN, Auteur ; Maria T. SECARA, Auteur ; Pushpal DESARKAR, Auteur ; George FOUSSIAS, Auteur ; Robert W. BUCHANAN, Auteur ; Anil K. MALHOTRA, Auteur ; Meng-Chuan LAI, Auteur ; Aristotle N VOINESKOS, Auteur ; Stephanie H. AMEIS, Auteur . - 37p. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 37p. Mots-clés : Humans  Social Cognition  Male  Female  Adult  Magnetic Resonance Imaging  Adolescent  Young Adult  Brain/diagnostic imaging/physiopathology  Schizophrenia/physiopathology/diagnostic imaging  Autism Spectrum Disorder/physiopathology/diagnostic imaging/psychology  Autistic Disorder/physiopathology/psychology  Brain Mapping  Case-Control Studies  Autism  Schizophrenia spectrum disorders  Social cognition  fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism and schizophrenia spectrum disorders (SSDs) both feature atypical social cognition. Despite evidence for comparable group-level performance in lower-level emotion processing and higher-level mentalizing, limited research has examined the neural basis of social cognition across these conditions. Our goal was to compare the neural correlates of social cognition in autism, SSDs, and typically developing controls (TDCs). METHODS: Data came from two harmonized studies in individuals diagnosed with autism or SSDs and TDCs (aged 16-35 years), including behavioral social cognitive metrics and two functional magnetic resonance imaging (fMRI) tasks: a social mirroring Imitate/Observe (ImObs) task and the Empathic Accuracy (EA) task. Group-level comparisons, and transdiagnostic analyses incorporating social cognitive performance, were run using FSL's PALM for each task, covarying for age and sex (1000 permutations, thresholded at p < 0.05 FWE-corrected). Exploratory region of interest (ROI)-based analyses were also conducted. RESULTS: ImObs and EA analyses included 164 and 174 participants, respectively (autism N = 56/59, SSD N = 50/56, TDC N = 58/59). EA and both lower- and higher-level social cognition scores differed across groups. While canonical social cognitive networks were activated, no significant whole-brain or ROI-based group-level differences in neural correlates for either task were detected. Transdiagnostically, neural activity during the EA task, but not the ImObs task, was associated with lower- and higher-level social cognitive performance. LIMITATIONS: Despite attempting to match our groups on age, sex, and race, significant group differences remained. Power to detect regional brain differences is also influenced by sample size and multiple comparisons in whole-brain analyses. Our findings may not generalize to autism and SSD individuals with co-occurring intellectual disabilities. CONCLUSIONS: The lack of whole-brain and ROI-based group-level differences identified and the dimensional EA brain-behavior relationship observed across our sample suggest that the EA task may be well-suited to target engagement in novel intervention testing. Our results also emphasize the potential utility of cross-condition approaches to better understand social cognition across autism and SSDs. En ligne : https://dx.doi.org/10.1186/s13229-024-00615-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

Spanish Validation of the Autism Quotient Short Form Questionnaire for Adults with Autism Spectrum Disorder / J. LUGO-MARIN in Journal of Autism and Developmental Disorders, 49-11 (November 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-11 (November 2019) . - p.4375-4389 Titre : Spanish Validation of the Autism Quotient Short Form Questionnaire for Adults with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : J. LUGO-MARIN, Auteur ; Emiliano DIEZ VILLORIA, Auteur ; M. MAGÁN-MAGANTO, Auteur ; L. PEREZ-MENDEZ, Auteur ; M. ALVIANI, Auteur ; J. A. DE LA FUENTE-PORTERO, Auteur ; Ricardo CANAL-BEDIA, Auteur Article en page(s) : p.4375-4389 Langues : Anglais (eng) Mots-clés : Asd  Autism Spectrum Quotient  Diagnosis  Factor analysis  Reliability  Schizophrenia spectrum disorders  Validity Index. décimale : PER Périodiques Résumé : The objective of this study was to adapt and validate the abbreviated version of the "Autism-Spectrum Quotient" (AQ-Short) in a sample of Spanish native adults. A total of 46 individuals with ASD, 41 ASD-relatives, 17 patients with schizophrenia spectrum disorders and 190 non-clinical adults were administered the Spanish version of the AQ-Short. The results of the confirmatory factorial analysis found two high-order factors (Social Behaviour and Numbers/Patterns) and four subscales (Social Skills, Routines, Switching and Imagination). The reliability analysis showed very good internal structure and test-retest reliability. The AQ-Short also showed moderate convergent validity with ADOS-2. Differences by group were found in the ASD group when compared to other groups. Gender differences were only found in the non-clinical group. En ligne : http://dx.doi.org/10.1007/s10803-019-04127-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 [article] Spanish Validation of the Autism Quotient Short Form Questionnaire for Adults with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / J. LUGO-MARIN, Auteur ; Emiliano DIEZ VILLORIA, Auteur ; M. MAGÁN-MAGANTO, Auteur ; L. PEREZ-MENDEZ, Auteur ; M. ALVIANI, Auteur ; J. A. DE LA FUENTE-PORTERO, Auteur ; Ricardo CANAL-BEDIA, Auteur . - p.4375-4389. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-11 (November 2019) . - p.4375-4389 Mots-clés : Asd  Autism Spectrum Quotient  Diagnosis  Factor analysis  Reliability  Schizophrenia spectrum disorders  Validity Index. décimale : PER Périodiques Résumé : The objective of this study was to adapt and validate the abbreviated version of the "Autism-Spectrum Quotient" (AQ-Short) in a sample of Spanish native adults. A total of 46 individuals with ASD, 41 ASD-relatives, 17 patients with schizophrenia spectrum disorders and 190 non-clinical adults were administered the Spanish version of the AQ-Short. The results of the confirmatory factorial analysis found two high-order factors (Social Behaviour and Numbers/Patterns) and four subscales (Social Skills, Routines, Switching and Imagination). The reliability analysis showed very good internal structure and test-retest reliability. The AQ-Short also showed moderate convergent validity with ADOS-2. Differences by group were found in the ASD group when compared to other groups. Gender differences were only found in the non-clinical group. En ligne : http://dx.doi.org/10.1007/s10803-019-04127-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

Neurocognitive characteristics of psychotic symptoms in young adults with high functioning autism / Romina RINALDI in Research in Autism Spectrum Disorders, 17 (September 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 17 (September 2015) . - p.135-141 Titre : Neurocognitive characteristics of psychotic symptoms in young adults with high functioning autism Type de document : Texte imprimé et/ou numérique Auteurs : Romina RINALDI, Auteur ; Elodie JACQUET, Auteur ; Laurent LEFEBVRE, Auteur Année de publication : 2015 Article en page(s) : p.135-141 Langues : Anglais (eng) Mots-clés : High functioning autism  Psychosis  Schizophrenia spectrum disorders  Cognition Index. décimale : PER Périodiques Résumé : Abstract Autism and schizophrenia are severe neurodevelopmental disorders. Recent findings from several studies suggest that these disorders share some common features at the biological, psychosocial and cognitive level. We have chosen to focus on a specific subgroup of autism spectrum disorders (ASD), individuals with high functioning autism (HFA), owing notably to the specific difficulties associated with differential diagnosis between individuals with autism and schizophrenia spectrum disorders (SSD) in the case of normal intelligence. In particular, we sought to investigate the extent to which neuropsychological and neurocognitive components could be specific in diagnosed participants with HFA who later developed SSD symptoms. We assessed a group of participants with HFA diagnosis and a group of participants who had first received an HFA diagnostic then were diagnosed with schizophrenia spectrum disorder during late adolescence. Results show that interference management is the most likely variable to discriminate the two groups. The findings are discussed in terms of similarities or discrepancies between ASD or SSD-like processes and clinical implications. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.06.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263 [article] Neurocognitive characteristics of psychotic symptoms in young adults with high functioning autism [Texte imprimé et/ou numérique] / Romina RINALDI, Auteur ; Elodie JACQUET, Auteur ; Laurent LEFEBVRE, Auteur . - 2015 . - p.135-141. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 17 (September 2015) . - p.135-141 Mots-clés : High functioning autism  Psychosis  Schizophrenia spectrum disorders  Cognition Index. décimale : PER Périodiques Résumé : Abstract Autism and schizophrenia are severe neurodevelopmental disorders. Recent findings from several studies suggest that these disorders share some common features at the biological, psychosocial and cognitive level. We have chosen to focus on a specific subgroup of autism spectrum disorders (ASD), individuals with high functioning autism (HFA), owing notably to the specific difficulties associated with differential diagnosis between individuals with autism and schizophrenia spectrum disorders (SSD) in the case of normal intelligence. In particular, we sought to investigate the extent to which neuropsychological and neurocognitive components could be specific in diagnosed participants with HFA who later developed SSD symptoms. We assessed a group of participants with HFA diagnosis and a group of participants who had first received an HFA diagnostic then were diagnosed with schizophrenia spectrum disorder during late adolescence. Results show that interference management is the most likely variable to discriminate the two groups. The findings are discussed in terms of similarities or discrepancies between ASD or SSD-like processes and clinical implications. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.06.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263