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Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems / E. S. CARLSON in Journal of Neurodevelopmental Disorders, 2-3 (September 2010)
[article]
Titre : Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems Type de document : Texte imprimé et/ou numérique Auteurs : E. S. CARLSON, Auteur ; S. J. FRETHAM, Auteur ; E. UNGER, Auteur ; M. O'CONNOR, Auteur ; A. PETRYK, Auteur ; T. SCHALLERT, Auteur ; R. RAO, Auteur ; I. TKAC, Auteur ; Michael K. GEORGIEFF, Auteur Article en page(s) : p.133-43 Langues : Anglais (eng) Mots-clés : DMT1, Slc11a2, Nuclear magnetic resonance spectroscopy Hippocampus Iron deficiency Memory systems Morris water maze Procedural memory Spatial memory Striatum Index. décimale : PER Périodiques Résumé : UNLABELLED: Iron deficiency (ID) is the most common gestational micronutrient deficiency in the world, targets the fetal hippocampus and striatum and results in long-term behavioral abnormalities. These structures primarily mediate spatial and procedural memory, respectively, in the rodent but have interconnections that result in competition or cooperation during cognitive tasks. We determined whether ID-induced impairment of one alters the function of the other by genetically inducing a 40% reduction of hippocampus iron content in late fetal life in mice and measuring dorsal striatal gene expression and metabolism and the behavioral balance between the two memory systems in adulthood. Slc11a2(hipp/hipp) mice had similar striatum iron content, but 18% lower glucose and 44% lower lactate levels, a 30% higher phosphocreatine:creatine ratio, and reduced iron transporter gene expression compared to wild type (WT) littermates, implying reduced striatal metabolic function. Slc11a2(hipp/hipp) mice had longer mean escape times on a cued task paradigm implying impaired procedural memory. Nevertheless, when hippocampal and striatal memory systems were placed in competition using a Morris Water Maze task that alternates spatial navigation and visual cued responses during training, and forces a choice between hippocampal and striatal strategies during probe trials, Slc11a2(hipp/hipp) mice used the hippocampus-dependent response less often (25%) and the visual cued response more often (75%) compared to WT littermates that used both strategies approximately equally. Hippocampal ID not only reduces spatial recognition memory performance but also affects systems that support procedural memory, suggesting an altered balance between memory systems. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11689-010-9049-0) contains supplementary material, which is available to authorized users. En ligne : http://dx.doi.org/10.1007/s11689-010-9049-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342
in Journal of Neurodevelopmental Disorders > 2-3 (September 2010) . - p.133-43[article] Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems [Texte imprimé et/ou numérique] / E. S. CARLSON, Auteur ; S. J. FRETHAM, Auteur ; E. UNGER, Auteur ; M. O'CONNOR, Auteur ; A. PETRYK, Auteur ; T. SCHALLERT, Auteur ; R. RAO, Auteur ; I. TKAC, Auteur ; Michael K. GEORGIEFF, Auteur . - p.133-43.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 2-3 (September 2010) . - p.133-43
Mots-clés : DMT1, Slc11a2, Nuclear magnetic resonance spectroscopy Hippocampus Iron deficiency Memory systems Morris water maze Procedural memory Spatial memory Striatum Index. décimale : PER Périodiques Résumé : UNLABELLED: Iron deficiency (ID) is the most common gestational micronutrient deficiency in the world, targets the fetal hippocampus and striatum and results in long-term behavioral abnormalities. These structures primarily mediate spatial and procedural memory, respectively, in the rodent but have interconnections that result in competition or cooperation during cognitive tasks. We determined whether ID-induced impairment of one alters the function of the other by genetically inducing a 40% reduction of hippocampus iron content in late fetal life in mice and measuring dorsal striatal gene expression and metabolism and the behavioral balance between the two memory systems in adulthood. Slc11a2(hipp/hipp) mice had similar striatum iron content, but 18% lower glucose and 44% lower lactate levels, a 30% higher phosphocreatine:creatine ratio, and reduced iron transporter gene expression compared to wild type (WT) littermates, implying reduced striatal metabolic function. Slc11a2(hipp/hipp) mice had longer mean escape times on a cued task paradigm implying impaired procedural memory. Nevertheless, when hippocampal and striatal memory systems were placed in competition using a Morris Water Maze task that alternates spatial navigation and visual cued responses during training, and forces a choice between hippocampal and striatal strategies during probe trials, Slc11a2(hipp/hipp) mice used the hippocampus-dependent response less often (25%) and the visual cued response more often (75%) compared to WT littermates that used both strategies approximately equally. Hippocampal ID not only reduces spatial recognition memory performance but also affects systems that support procedural memory, suggesting an altered balance between memory systems. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11689-010-9049-0) contains supplementary material, which is available to authorized users. En ligne : http://dx.doi.org/10.1007/s11689-010-9049-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342 Early-life adversity is associated with poor iron status in infancy / Patricia EAST ; Estela BLANCO ; Jenalee R. DOOM ; Raquel A. BURROWS ; Paulina CORREA-BURROWS ; Betsy LOZOFF ; Sheila GAHAGAN in Development and Psychopathology, 35-4 (October 2023)
[article]
Titre : Early-life adversity is associated with poor iron status in infancy Type de document : Texte imprimé et/ou numérique Auteurs : Patricia EAST, Auteur ; Estela BLANCO, Auteur ; Jenalee R. DOOM, Auteur ; Raquel A. BURROWS, Auteur ; Paulina CORREA-BURROWS, Auteur ; Betsy LOZOFF, Auteur ; Sheila GAHAGAN, Auteur Article en page(s) : p.1856-1867 Langues : Anglais (eng) Mots-clés : early-life adversity infancy iron deficiency nutrition stress Index. décimale : PER Périodiques Résumé : Exposure to early-life adversity (ELA) and iron deficiency early in life are known risk factors for suboptimal brain and socioemotional development. Iron deficiency may arise from and co-occur with ELA, which could negatively affect development. In the present study, we investigated whether ELA is associated with iron deficiency in infants receiving no iron supplementation. This study is a secondary analysis of extant data collected in the 1990s; participants were healthy infants from working-class communities in Santiago, Chile (N = 534, 45.5% female). We measured stressful life events, maternal depression, and low home support for child development during infancy and assessed iron status when the infant was 12 months old. Slightly more than half of the infants were iron-deficient (51%), and 25.8% were iron-deficient anemic at 12 months. Results indicated that ELA was associated with lower iron levels and iron deficiency at 12 months. The findings are consistent with animal and human prenatal models of stress and iron status and provide evidence of the association between postnatal ELA and iron status in humans. The findings also highlight a nutritional pathway by which ELA may impact development and present a nutritionally-focused avenue for future research on ELA and psychopathology. En ligne : https://dx.doi.org/10.1017/S0954579422000517 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515
in Development and Psychopathology > 35-4 (October 2023) . - p.1856-1867[article] Early-life adversity is associated with poor iron status in infancy [Texte imprimé et/ou numérique] / Patricia EAST, Auteur ; Estela BLANCO, Auteur ; Jenalee R. DOOM, Auteur ; Raquel A. BURROWS, Auteur ; Paulina CORREA-BURROWS, Auteur ; Betsy LOZOFF, Auteur ; Sheila GAHAGAN, Auteur . - p.1856-1867.
Langues : Anglais (eng)
in Development and Psychopathology > 35-4 (October 2023) . - p.1856-1867
Mots-clés : early-life adversity infancy iron deficiency nutrition stress Index. décimale : PER Périodiques Résumé : Exposure to early-life adversity (ELA) and iron deficiency early in life are known risk factors for suboptimal brain and socioemotional development. Iron deficiency may arise from and co-occur with ELA, which could negatively affect development. In the present study, we investigated whether ELA is associated with iron deficiency in infants receiving no iron supplementation. This study is a secondary analysis of extant data collected in the 1990s; participants were healthy infants from working-class communities in Santiago, Chile (N = 534, 45.5% female). We measured stressful life events, maternal depression, and low home support for child development during infancy and assessed iron status when the infant was 12 months old. Slightly more than half of the infants were iron-deficient (51%), and 25.8% were iron-deficient anemic at 12 months. Results indicated that ELA was associated with lower iron levels and iron deficiency at 12 months. The findings are consistent with animal and human prenatal models of stress and iron status and provide evidence of the association between postnatal ELA and iron status in humans. The findings also highlight a nutritional pathway by which ELA may impact development and present a nutritionally-focused avenue for future research on ELA and psychopathology. En ligne : https://dx.doi.org/10.1017/S0954579422000517 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515