5 recherche sur le mot-clé 'neuroplasticity'

Neural mechanisms of behavioral change in young adults with high?functioning autism receiving virtual reality social cognition training: A pilot study / Y. J. Daniel YANG in Autism Research, 11-5 (May 2018)  

Public ISBD [article]  inAutism Research > 11-5 (May 2018) . - p.713-725 Titre : Neural mechanisms of behavioral change in young adults with high?functioning autism receiving virtual reality social cognition training: A pilot study Type de document : Texte imprimé et/ou numérique Auteurs : Y. J. Daniel YANG, Auteur ; Tandra T. ALLEN, Auteur ; Sebiha M. ABDULLAHI, Auteur ; Kevin A. PELPHREY, Auteur ; Fred R. VOLKMAR, Auteur ; Sandra B. CHAPMAN, Auteur Article en page(s) : p.713-725 Langues : Anglais (eng) Mots-clés : neuroplasticity  adults with autism  emotion recognition  theory of mind  clinical trials  computerized treatment  virtual reality Index. décimale : PER Périodiques Résumé : Measuring treatment efficacy in individuals with Autism Spectrum Disorder (ASD) relies primarily on behaviors, with limited evidence as to the neural mechanisms underlying these behavioral gains. This pilot study addresses this void by investigating neural and behavioral changes in a Phase I trial in young adults with high?functioning ASD who received an evidence?based behavioral intervention, Virtual Reality?Social Cognition Training over 5 weeks for a total of 10 hr. The participants were tested pre? and post?training with a validated biological/social versus scrambled/nonsocial motion neuroimaging task, previously shown to activate regions within the social brain networks. Three significant brain?behavior changes were identified. First, the right posterior superior temporal sulcus, a hub for socio?cognitive processing, showed increased brain activation to social versus nonsocial stimuli in individuals with greater gains on a theory?of?mind measure. Second, the left inferior frontal gyrus, a region for socio?emotional processing, tracked individual gains in emotion recognition with decreased activation to social versus nonsocial stimuli. Finally, the left superior parietal lobule, a region for visual attention, showed significantly decreased activation to nonsocial versus social stimuli across all participants, where heightened attention to nonsocial contingencies has been considered a disabling aspect of ASD. This study provides, albeit preliminary, some of the first evidence of the harnessable neuroplasticity in adults with ASD through an age?appropriate intervention in brain regions tightly linked to social abilities. This pilot trial motivates future efforts to develop and test social interventions to improve behaviors and supporting brain networks in adults with ASD. Autism Res 2018, 11: 713?725. ? 2018 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. Lay Summary This study addresses how the behavioral changes after treatment for ASD reflect underlying brain changes. Before and after receiving VR?SCT, young adults with high?functioning ASD passively viewed biological motion stimuli in a MRI scanner, tapping changes in the social brain network. The results reveal neuroplasticity in this age population, extending the window of opportunity for interventions to impact social competency in adults with ASD. En ligne : https://doi.org/10.1002/aur.1941 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363 [article] Neural mechanisms of behavioral change in young adults with high?functioning autism receiving virtual reality social cognition training: A pilot study [Texte imprimé et/ou numérique] / Y. J. Daniel YANG, Auteur ; Tandra T. ALLEN, Auteur ; Sebiha M. ABDULLAHI, Auteur ; Kevin A. PELPHREY, Auteur ; Fred R. VOLKMAR, Auteur ; Sandra B. CHAPMAN, Auteur . - p.713-725. Langues : Anglais (eng) in Autism Research > 11-5 (May 2018) . - p.713-725 Mots-clés : neuroplasticity  adults with autism  emotion recognition  theory of mind  clinical trials  computerized treatment  virtual reality Index. décimale : PER Périodiques Résumé : Measuring treatment efficacy in individuals with Autism Spectrum Disorder (ASD) relies primarily on behaviors, with limited evidence as to the neural mechanisms underlying these behavioral gains. This pilot study addresses this void by investigating neural and behavioral changes in a Phase I trial in young adults with high?functioning ASD who received an evidence?based behavioral intervention, Virtual Reality?Social Cognition Training over 5 weeks for a total of 10 hr. The participants were tested pre? and post?training with a validated biological/social versus scrambled/nonsocial motion neuroimaging task, previously shown to activate regions within the social brain networks. Three significant brain?behavior changes were identified. First, the right posterior superior temporal sulcus, a hub for socio?cognitive processing, showed increased brain activation to social versus nonsocial stimuli in individuals with greater gains on a theory?of?mind measure. Second, the left inferior frontal gyrus, a region for socio?emotional processing, tracked individual gains in emotion recognition with decreased activation to social versus nonsocial stimuli. Finally, the left superior parietal lobule, a region for visual attention, showed significantly decreased activation to nonsocial versus social stimuli across all participants, where heightened attention to nonsocial contingencies has been considered a disabling aspect of ASD. This study provides, albeit preliminary, some of the first evidence of the harnessable neuroplasticity in adults with ASD through an age?appropriate intervention in brain regions tightly linked to social abilities. This pilot trial motivates future efforts to develop and test social interventions to improve behaviors and supporting brain networks in adults with ASD. Autism Res 2018, 11: 713?725. ? 2018 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. Lay Summary This study addresses how the behavioral changes after treatment for ASD reflect underlying brain changes. Before and after receiving VR?SCT, young adults with high?functioning ASD passively viewed biological motion stimuli in a MRI scanner, tapping changes in the social brain network. The results reveal neuroplasticity in this age population, extending the window of opportunity for interventions to impact social competency in adults with ASD. En ligne : https://doi.org/10.1002/aur.1941 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363

Brain-Derived Neurotrophic Factor Levels in Autism: A Systematic Review and Meta-Analysis / Amene SAGHAZADEH in Journal of Autism and Developmental Disorders, 47-4 (April 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-4 (April 2017) . - p.1018-1029 Titre : Brain-Derived Neurotrophic Factor Levels in Autism: A Systematic Review and Meta-Analysis Type de document : Texte imprimé et/ou numérique Auteurs : Amene SAGHAZADEH, Auteur ; Nima REZAEI, Auteur Article en page(s) : p.1018-1029 Langues : Anglais (eng) Mots-clés : Autism  Brain-derived neurotrophic factor  Meta-analysis  Neuroplasticity  Systematic review Index. décimale : PER Périodiques Résumé : Brain-derived neurotrophic factor (BDNF) plays an important role in activity-dependent synaptic plasticity. Altered blood BDNF levels have been frequently identified in people with autism spectrum disorders (ASD). There are however wide discrepancies in the evidence. Therefore, we performed the present systematic review and meta-analysis aimed at qualitative and quantitative synthesis of studies that measured blood BDNF levels in ASD and control subjects. Observational studies were identified through electronic database searching and also hand-searching of reference lists of relevant articles. A total of 183 papers were initially identified for review and eventually twenty studies were included in the meta-analysis. A meta-analysis of blood BDNF in 887 patients with ASD and 901 control subjects demonstrated significantly higher BDNF levels in ASD compared to controls with the SMD of 0.47 (95% CI 0.07–0.86, p?=?0.02). In addition subgroup meta-analyses were performed based on the BDNF specimen. The present meta-analysis study led to conclusion that BDNF might play role in autism initiation/ propagation and therefore it can be considered as a possible biomarker of ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-3024-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Brain-Derived Neurotrophic Factor Levels in Autism: A Systematic Review and Meta-Analysis [Texte imprimé et/ou numérique] / Amene SAGHAZADEH, Auteur ; Nima REZAEI, Auteur . - p.1018-1029. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-4 (April 2017) . - p.1018-1029 Mots-clés : Autism  Brain-derived neurotrophic factor  Meta-analysis  Neuroplasticity  Systematic review Index. décimale : PER Périodiques Résumé : Brain-derived neurotrophic factor (BDNF) plays an important role in activity-dependent synaptic plasticity. Altered blood BDNF levels have been frequently identified in people with autism spectrum disorders (ASD). There are however wide discrepancies in the evidence. Therefore, we performed the present systematic review and meta-analysis aimed at qualitative and quantitative synthesis of studies that measured blood BDNF levels in ASD and control subjects. Observational studies were identified through electronic database searching and also hand-searching of reference lists of relevant articles. A total of 183 papers were initially identified for review and eventually twenty studies were included in the meta-analysis. A meta-analysis of blood BDNF in 887 patients with ASD and 901 control subjects demonstrated significantly higher BDNF levels in ASD compared to controls with the SMD of 0.47 (95% CI 0.07–0.86, p?=?0.02). In addition subgroup meta-analyses were performed based on the BDNF specimen. The present meta-analysis study led to conclusion that BDNF might play role in autism initiation/ propagation and therefore it can be considered as a possible biomarker of ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-3024-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Hidden talents in harsh environments / Bruce J. ELLIS in Development and Psychopathology, 34-1 (February 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-1 (February 2022) . - p.95-113 Titre : Hidden talents in harsh environments Type de document : Texte imprimé et/ou numérique Auteurs : Bruce J. ELLIS, Auteur ; Laura S. ABRAMS, Auteur ; Ann S. MASTEN, Auteur ; Robert J. STERNBERG, Auteur ; Nim TOTTENHAM, Auteur ; Willem E. FRANKENHUIS, Auteur Article en page(s) : p.95-113 Langues : Anglais (eng) Mots-clés : adaptive intelligence  adjudicated youth  developmental adaptation to stress  educational interventions  neuroplasticity  resilience  stress-adapted skills Index. décimale : PER Périodiques Résumé : Although early-life adversity can undermine healthy development, children growing up in harsh environments may develop intact, or even enhanced, skills for solving problems in high-adversity contexts (i.e., ?hidden talents?). Here we situate the hidden talents model within a larger interdisciplinary framework. Summarizing theory and research on hidden talents, we propose that stress-adapted skills represent a form of adaptive intelligence that enables individuals to function within the constraints of harsh, unpredictable environments. We discuss the alignment of the hidden talents model with current knowledge about human brain development following early adversity; examine potential applications of this perspective to multiple sectors concerned with youth from harsh environments, including education, social services, and juvenile justice; and compare the hidden talents model with contemporary developmental resilience models. We conclude that the hidden talents approach offers exciting new directions for research on developmental adaptations to childhood adversity, with translational implications for leveraging stress-adapted skills to more effectively tailor education, jobs, and interventions to fit the needs and potentials of individuals from a diverse range of life circumstances. This approach affords a well-rounded view of people who live with adversity that avoids stigma and communicates a novel, distinctive, and strength-based message. En ligne : http://dx.doi.org/10.1017/s0954579420000887 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] Hidden talents in harsh environments [Texte imprimé et/ou numérique] / Bruce J. ELLIS, Auteur ; Laura S. ABRAMS, Auteur ; Ann S. MASTEN, Auteur ; Robert J. STERNBERG, Auteur ; Nim TOTTENHAM, Auteur ; Willem E. FRANKENHUIS, Auteur . - p.95-113. Langues : Anglais (eng) in Development and Psychopathology > 34-1 (February 2022) . - p.95-113 Mots-clés : adaptive intelligence  adjudicated youth  developmental adaptation to stress  educational interventions  neuroplasticity  resilience  stress-adapted skills Index. décimale : PER Périodiques Résumé : Although early-life adversity can undermine healthy development, children growing up in harsh environments may develop intact, or even enhanced, skills for solving problems in high-adversity contexts (i.e., ?hidden talents?). Here we situate the hidden talents model within a larger interdisciplinary framework. Summarizing theory and research on hidden talents, we propose that stress-adapted skills represent a form of adaptive intelligence that enables individuals to function within the constraints of harsh, unpredictable environments. We discuss the alignment of the hidden talents model with current knowledge about human brain development following early adversity; examine potential applications of this perspective to multiple sectors concerned with youth from harsh environments, including education, social services, and juvenile justice; and compare the hidden talents model with contemporary developmental resilience models. We conclude that the hidden talents approach offers exciting new directions for research on developmental adaptations to childhood adversity, with translational implications for leveraging stress-adapted skills to more effectively tailor education, jobs, and interventions to fit the needs and potentials of individuals from a diverse range of life circumstances. This approach affords a well-rounded view of people who live with adversity that avoids stigma and communicates a novel, distinctive, and strength-based message. En ligne : http://dx.doi.org/10.1017/s0954579420000887 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

Social brain circuitry and social cognition in infants born preterm / A. FENOGLIO in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.27 Titre : Social brain circuitry and social cognition in infants born preterm Type de document : Texte imprimé et/ou numérique Auteurs : A. FENOGLIO, Auteur ; Michael K. GEORGIEFF, Auteur ; J. T. ELISON, Auteur Article en page(s) : p.27 Langues : Anglais (eng) Mots-clés : Neurodevelopment  Neuroplasticity  Prematurity  Social brain  Social cognition Index. décimale : PER Périodiques Résumé : Preterm birth is associated with an increased risk of adverse neurologic, psychiatric, and cognitive outcomes. The brain circuits involved in processing social information are critical to all of these domains, but little work has been done to examine whether and how these circuits may be especially sensitive to prematurity. This paper contains a brief summary of some of the cognitive, psychiatric, and social outcomes associated with prematurity, followed by a description of findings from the modest body of research into social-cognitive development in infants and children born preterm. Next, findings from studies of structural and functional brain development in infants born preterm are reviewed, with an eye toward the distinctive role of the brain circuits implicated in social functioning. The goal of this review is to investigate the extent to which the putative "social brain" may have particular developmental susceptibilities to the insults associated with preterm birth, and the role of early social-cognitive development in later neurodevelopmental outcomes. Much work has been done to characterize neurobehavioral outcomes in the preterm population, but future research must incorporate both brain and behavioral measures to identify early biomarkers linked to later emerging social-cognitive clinical impairment in order to guide effective, targeted intervention. En ligne : http://dx.doi.org/10.1186/s11689-017-9206-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350 [article] Social brain circuitry and social cognition in infants born preterm [Texte imprimé et/ou numérique] / A. FENOGLIO, Auteur ; Michael K. GEORGIEFF, Auteur ; J. T. ELISON, Auteur . - p.27. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.27 Mots-clés : Neurodevelopment  Neuroplasticity  Prematurity  Social brain  Social cognition Index. décimale : PER Périodiques Résumé : Preterm birth is associated with an increased risk of adverse neurologic, psychiatric, and cognitive outcomes. The brain circuits involved in processing social information are critical to all of these domains, but little work has been done to examine whether and how these circuits may be especially sensitive to prematurity. This paper contains a brief summary of some of the cognitive, psychiatric, and social outcomes associated with prematurity, followed by a description of findings from the modest body of research into social-cognitive development in infants and children born preterm. Next, findings from studies of structural and functional brain development in infants born preterm are reviewed, with an eye toward the distinctive role of the brain circuits implicated in social functioning. The goal of this review is to investigate the extent to which the putative "social brain" may have particular developmental susceptibilities to the insults associated with preterm birth, and the role of early social-cognitive development in later neurodevelopmental outcomes. Much work has been done to characterize neurobehavioral outcomes in the preterm population, but future research must incorporate both brain and behavioral measures to identify early biomarkers linked to later emerging social-cognitive clinical impairment in order to guide effective, targeted intervention. En ligne : http://dx.doi.org/10.1186/s11689-017-9206-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350

Social brain circuitry and social cognition in infants born preterm / A. FENOGLIO in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.27 Titre : Social brain circuitry and social cognition in infants born preterm Type de document : Texte imprimé et/ou numérique Auteurs : A. FENOGLIO, Auteur ; Michael K. GEORGIEFF, Auteur ; J. T. ELISON, Auteur Article en page(s) : p.27 Langues : Anglais (eng) Mots-clés : Neurodevelopment  Neuroplasticity  Prematurity  Social brain  Social cognition Index. décimale : PER Périodiques Résumé : Preterm birth is associated with an increased risk of adverse neurologic, psychiatric, and cognitive outcomes. The brain circuits involved in processing social information are critical to all of these domains, but little work has been done to examine whether and how these circuits may be especially sensitive to prematurity. This paper contains a brief summary of some of the cognitive, psychiatric, and social outcomes associated with prematurity, followed by a description of findings from the modest body of research into social-cognitive development in infants and children born preterm. Next, findings from studies of structural and functional brain development in infants born preterm are reviewed, with an eye toward the distinctive role of the brain circuits implicated in social functioning. The goal of this review is to investigate the extent to which the putative "social brain" may have particular developmental susceptibilities to the insults associated with preterm birth, and the role of early social-cognitive development in later neurodevelopmental outcomes. Much work has been done to characterize neurobehavioral outcomes in the preterm population, but future research must incorporate both brain and behavioral measures to identify early biomarkers linked to later emerging social-cognitive clinical impairment in order to guide effective, targeted intervention. En ligne : http://dx.doi.org/10.1186/s11689-017-9206-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350 [article] Social brain circuitry and social cognition in infants born preterm [Texte imprimé et/ou numérique] / A. FENOGLIO, Auteur ; Michael K. GEORGIEFF, Auteur ; J. T. ELISON, Auteur . - p.27. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.27 Mots-clés : Neurodevelopment  Neuroplasticity  Prematurity  Social brain  Social cognition Index. décimale : PER Périodiques Résumé : Preterm birth is associated with an increased risk of adverse neurologic, psychiatric, and cognitive outcomes. The brain circuits involved in processing social information are critical to all of these domains, but little work has been done to examine whether and how these circuits may be especially sensitive to prematurity. This paper contains a brief summary of some of the cognitive, psychiatric, and social outcomes associated with prematurity, followed by a description of findings from the modest body of research into social-cognitive development in infants and children born preterm. Next, findings from studies of structural and functional brain development in infants born preterm are reviewed, with an eye toward the distinctive role of the brain circuits implicated in social functioning. The goal of this review is to investigate the extent to which the putative "social brain" may have particular developmental susceptibilities to the insults associated with preterm birth, and the role of early social-cognitive development in later neurodevelopmental outcomes. Much work has been done to characterize neurobehavioral outcomes in the preterm population, but future research must incorporate both brain and behavioral measures to identify early biomarkers linked to later emerging social-cognitive clinical impairment in order to guide effective, targeted intervention. En ligne : http://dx.doi.org/10.1186/s11689-017-9206-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350