41 recherche sur le mot-clé 'heterogeneity'

Heterogeneity and plasticity in the development of language: a 17-year follow-up of children referred early for possible autism / Andrew PICKLES in Journal of Child Psychology and Psychiatry, 55-12 (December 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1354-1362 Titre : Heterogeneity and plasticity in the development of language: a 17-year follow-up of children referred early for possible autism Type de document : Texte imprimé et/ou numérique Auteurs : Andrew PICKLES, Auteur ; Deborah K. ANDERSON, Auteur ; Catherine LORD, Auteur Article en page(s) : p.1354-1362 Langues : Anglais (eng) Mots-clés : Early intervention  heterogeneity  language impairment  plasticity Index. décimale : PER Périodiques Résumé : Background Delayed, abnormal language is a common feature of autism and language therapy often a significant component of recommended treatment. However, as with other disorders with a language component, we know surprisingly little about the language trajectories and how varied these might be across different children. Thus, we know little about how and when language problems might resolve, whether there are periods of relative stability or lack of change and what periods might offer more favourable circumstances for intervention. Methods Expressive and receptive language was measured on six occasions between age 2 and 19 on a cohort of 192 children initially referred for autism. Latent class growth models were fitted to characterize the patterns of heterogeneous development. Results Latent class growth analysis identified seven classes. Between age 6 and 19, all classes tracked in parallel. Between ages 2 and 6, development was more heterogeneous with considerable variation in relative progress. In all groups, receptive and expressive language developed very largely in tandem. Conclusions The results confirmed previous analysis of children with specific language impairment where progress beyond age 6 was remarkably uniform. Greater variation was evident before this age with some groups making clearly better or worse progress compared to others. While this developmental heterogeneity may simply be a reflection of variation in preexisting and unchanging biological disposition, it may also reflect, at least in part, greater sensitivity in the early years to environments that are more or less supportive of language development. These findings contribute to the case for the importance of early intervention. En ligne : http://dx.doi.org/10.1111/jcpp.12269 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] Heterogeneity and plasticity in the development of language: a 17-year follow-up of children referred early for possible autism [Texte imprimé et/ou numérique] / Andrew PICKLES, Auteur ; Deborah K. ANDERSON, Auteur ; Catherine LORD, Auteur . - p.1354-1362. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1354-1362 Mots-clés : Early intervention  heterogeneity  language impairment  plasticity Index. décimale : PER Périodiques Résumé : Background Delayed, abnormal language is a common feature of autism and language therapy often a significant component of recommended treatment. However, as with other disorders with a language component, we know surprisingly little about the language trajectories and how varied these might be across different children. Thus, we know little about how and when language problems might resolve, whether there are periods of relative stability or lack of change and what periods might offer more favourable circumstances for intervention. Methods Expressive and receptive language was measured on six occasions between age 2 and 19 on a cohort of 192 children initially referred for autism. Latent class growth models were fitted to characterize the patterns of heterogeneous development. Results Latent class growth analysis identified seven classes. Between age 6 and 19, all classes tracked in parallel. Between ages 2 and 6, development was more heterogeneous with considerable variation in relative progress. In all groups, receptive and expressive language developed very largely in tandem. Conclusions The results confirmed previous analysis of children with specific language impairment where progress beyond age 6 was remarkably uniform. Greater variation was evident before this age with some groups making clearly better or worse progress compared to others. While this developmental heterogeneity may simply be a reflection of variation in preexisting and unchanging biological disposition, it may also reflect, at least in part, greater sensitivity in the early years to environments that are more or less supportive of language development. These findings contribute to the case for the importance of early intervention. En ligne : http://dx.doi.org/10.1111/jcpp.12269 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

Heterogeneity in autism spectrum disorder explained by social-communicative and restricted repetitive behavior balance subgroups / Manisha UDHNANI ; Luc LECAVALIER in Research in Autism Spectrum Disorders, 114 (June 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 114 (June 2024) . - p.102387 Titre : Heterogeneity in autism spectrum disorder explained by social-communicative and restricted repetitive behavior balance subgroups Type de document : Texte imprimé et/ou numérique Auteurs : Manisha UDHNANI, Auteur ; Luc LECAVALIER, Auteur Année de publication : 2024 Article en page(s) : p.102387 Langues : Anglais (eng) Mots-clés : Autism  ASD  Social communication  Restricted repetitive behavior  Subgroup  Heterogeneity Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is characterized by phenotypic heterogeneity when it comes to the symptom profiles in the social communication (SC) and restricted repetitive behaviors (RRB) domain. To date, a two-factor (i.e., SC and RRB)/three-class model has been empirically shown to be the best fit in explaining the variability. The purpose of the study is to confirm the potential of previously introduced model, the SC-RRB balance subgroups, and investigate the phenotypic characteristics of these subgroups using a large well-characterized sample of autistic youth. Method The final sample extracted from the Simons Simplex Collection (SSC) consisted of 2744 autistic youth aged 4 - 18 years. We adopted the SC-RRB balance modeling used in Bertelsen et al. (2021) where subgroups were labeled based on the within-person difference between SC difficulties and level of RRB. A latent profile analysis (LPA) was conducted to validate the presence of the SC-RRB balance subgroups. Results Data revealed similar SC and RRB scores to previous research. Significant differences in the demographic variables and core autism symptoms across SC-RRB balance subgroups were identified. The LPA indicated presence of three profiles with similar patterns. Conclusions We confirmed the potential of SC-RRB balance modeling in discriminating relatively homogeneous ASD subgroups. In addition to replicating previous findings in an independent sample, our data showed novel findings regarding sex, IQ, and specific ASD symptoms. Stratifying ASD into homogenous groups in a top-down approach could direct future research into unraveling differential pathogenesis and response to treatment. En ligne : https://doi.org/10.1016/j.rasd.2024.102387 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=529 [article] Heterogeneity in autism spectrum disorder explained by social-communicative and restricted repetitive behavior balance subgroups [Texte imprimé et/ou numérique] / Manisha UDHNANI, Auteur ; Luc LECAVALIER, Auteur . - 2024 . - p.102387. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 114 (June 2024) . - p.102387 Mots-clés : Autism  ASD  Social communication  Restricted repetitive behavior  Subgroup  Heterogeneity Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is characterized by phenotypic heterogeneity when it comes to the symptom profiles in the social communication (SC) and restricted repetitive behaviors (RRB) domain. To date, a two-factor (i.e., SC and RRB)/three-class model has been empirically shown to be the best fit in explaining the variability. The purpose of the study is to confirm the potential of previously introduced model, the SC-RRB balance subgroups, and investigate the phenotypic characteristics of these subgroups using a large well-characterized sample of autistic youth. Method The final sample extracted from the Simons Simplex Collection (SSC) consisted of 2744 autistic youth aged 4 - 18 years. We adopted the SC-RRB balance modeling used in Bertelsen et al. (2021) where subgroups were labeled based on the within-person difference between SC difficulties and level of RRB. A latent profile analysis (LPA) was conducted to validate the presence of the SC-RRB balance subgroups. Results Data revealed similar SC and RRB scores to previous research. Significant differences in the demographic variables and core autism symptoms across SC-RRB balance subgroups were identified. The LPA indicated presence of three profiles with similar patterns. Conclusions We confirmed the potential of SC-RRB balance modeling in discriminating relatively homogeneous ASD subgroups. In addition to replicating previous findings in an independent sample, our data showed novel findings regarding sex, IQ, and specific ASD symptoms. Stratifying ASD into homogenous groups in a top-down approach could direct future research into unraveling differential pathogenesis and response to treatment. En ligne : https://doi.org/10.1016/j.rasd.2024.102387 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=529

Heterogeneity in caregiving-related early adversity: Creating stable dimensions and subtypes / Aki NIKOLAIDIS in Development and Psychopathology, 34-2 (May 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-2 (May 2022) . - 621-634 Titre : Heterogeneity in caregiving-related early adversity: Creating stable dimensions and subtypes Type de document : Texte imprimé et/ou numérique Auteurs : Aki NIKOLAIDIS, Auteur ; Charlotte HELENIAK, Auteur ; Andrea FIELDS, Auteur ; Paul A. BLOOM, Auteur ; Michelle VANTIEGHEM, Auteur ; Anna VANNUCCI, Auteur ; Nicolas L. CAMACHO, Auteur ; Tricia CHOY, Auteur ; Lisa GIBSON, Auteur ; Chelsea HARMON, Auteur ; Syntia S. HADIS, Auteur ; Ian J. DOUGLAS, Auteur ; Michael P. MILHAM, Auteur ; Nim TOTTENHAM, Auteur Article en page(s) : 621-634 Langues : Anglais (eng) Mots-clés : caregiving related early adversities  heterogeneity  prediction  subtyping Index. décimale : PER Périodiques Résumé : Early psychosocial adversities exist at many levels, including caregiving-related, extrafamilial, and sociodemographic, which despite their high interrelatedness may have unique impacts on development. In this paper, we focus on caregiving-related early adversities (crEAs) and parse the heterogeneity of crEAs via data reduction techniques that identify experiential cooccurrences. Using network science, we characterized crEA cooccurrences to represent the comorbidity of crEA experiences across a sample of school-age children (n = 258; 6?12 years old) with a history of crEAs. crEA dimensions (variable level) and crEA subtypes (subject level) were identified using parallel factor analysis/principal component analysis and graph-based Louvain community detection. Bagging enhancement with cross-validation provided estimates of robustness. These data-driven dimensions/subtypes showed evidence of stability, transcended traditional sociolegally defined groups, were more homogenous than sociolegally defined groups, and reduced statistical correlations with sociodemographic factors. Finally, random forests showed both unique and common predictive importance of the crEA dimensions/subtypes for childhood mental health symptoms and academic skills. These data-driven outcomes provide additional tools and recommendations for crEA data reduction to inform precision medicine efforts in this area. En ligne : http://dx.doi.org/10.1017/s0954579421001668 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] Heterogeneity in caregiving-related early adversity: Creating stable dimensions and subtypes [Texte imprimé et/ou numérique] / Aki NIKOLAIDIS, Auteur ; Charlotte HELENIAK, Auteur ; Andrea FIELDS, Auteur ; Paul A. BLOOM, Auteur ; Michelle VANTIEGHEM, Auteur ; Anna VANNUCCI, Auteur ; Nicolas L. CAMACHO, Auteur ; Tricia CHOY, Auteur ; Lisa GIBSON, Auteur ; Chelsea HARMON, Auteur ; Syntia S. HADIS, Auteur ; Ian J. DOUGLAS, Auteur ; Michael P. MILHAM, Auteur ; Nim TOTTENHAM, Auteur . - 621-634. Langues : Anglais (eng) in Development and Psychopathology > 34-2 (May 2022) . - 621-634 Mots-clés : caregiving related early adversities  heterogeneity  prediction  subtyping Index. décimale : PER Périodiques Résumé : Early psychosocial adversities exist at many levels, including caregiving-related, extrafamilial, and sociodemographic, which despite their high interrelatedness may have unique impacts on development. In this paper, we focus on caregiving-related early adversities (crEAs) and parse the heterogeneity of crEAs via data reduction techniques that identify experiential cooccurrences. Using network science, we characterized crEA cooccurrences to represent the comorbidity of crEA experiences across a sample of school-age children (n = 258; 6?12 years old) with a history of crEAs. crEA dimensions (variable level) and crEA subtypes (subject level) were identified using parallel factor analysis/principal component analysis and graph-based Louvain community detection. Bagging enhancement with cross-validation provided estimates of robustness. These data-driven dimensions/subtypes showed evidence of stability, transcended traditional sociolegally defined groups, were more homogenous than sociolegally defined groups, and reduced statistical correlations with sociodemographic factors. Finally, random forests showed both unique and common predictive importance of the crEA dimensions/subtypes for childhood mental health symptoms and academic skills. These data-driven outcomes provide additional tools and recommendations for crEA data reduction to inform precision medicine efforts in this area. En ligne : http://dx.doi.org/10.1017/s0954579421001668 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

Heterogeneity in caregiving-related early adversity: Creating stable dimensions and subtypes - CORRIGENDUM / Aki NIKOLAIDIS in Development and Psychopathology, 35-3 (August 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-3 (August 2023) . - p.1570-1570 Titre : Heterogeneity in caregiving-related early adversity: Creating stable dimensions and subtypes - CORRIGENDUM Type de document : Texte imprimé et/ou numérique Auteurs : Aki NIKOLAIDIS, Auteur ; Charlotte HELENIAK, Auteur ; Andrea FIELDS, Auteur ; Paul A. BLOOM, Auteur ; Michelle VANTIEGHEM, Auteur ; Anna VANNUCCI, Auteur ; Nicolas L. CAMACHO, Auteur ; Tricia CHOY, Auteur ; Lisa GIBSON, Auteur ; Chelsea HARMON, Auteur ; Syntia S. HADIS, Auteur ; Ian J. DOUGLAS, Auteur ; Michael P. MILHAM, Auteur ; Nim TOTTENHAM, Auteur Article en page(s) : p.1570-1570 Langues : Anglais (eng) Mots-clés : caregiving related early adversities  heterogeneity  prediction  subtyping Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579422000529 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511 [article] Heterogeneity in caregiving-related early adversity: Creating stable dimensions and subtypes - CORRIGENDUM [Texte imprimé et/ou numérique] / Aki NIKOLAIDIS, Auteur ; Charlotte HELENIAK, Auteur ; Andrea FIELDS, Auteur ; Paul A. BLOOM, Auteur ; Michelle VANTIEGHEM, Auteur ; Anna VANNUCCI, Auteur ; Nicolas L. CAMACHO, Auteur ; Tricia CHOY, Auteur ; Lisa GIBSON, Auteur ; Chelsea HARMON, Auteur ; Syntia S. HADIS, Auteur ; Ian J. DOUGLAS, Auteur ; Michael P. MILHAM, Auteur ; Nim TOTTENHAM, Auteur . - p.1570-1570. Langues : Anglais (eng) in Development and Psychopathology > 35-3 (August 2023) . - p.1570-1570 Mots-clés : caregiving related early adversities  heterogeneity  prediction  subtyping Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579422000529 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511

Heterogeneity of social cognitive performance in autism and schizophrenia / Michal HAJDUK in Autism Research, 15-8 (August 2022)  

Public ISBD [article]  inAutism Research > 15-8 (August 2022) . - p.1522-1534 Titre : Heterogeneity of social cognitive performance in autism and schizophrenia Type de document : Texte imprimé et/ou numérique Auteurs : Michal HAJDUK, Auteur ; Amy E. PINKHAM, Auteur ; David L. PENN, Auteur ; Philip D. HARVEY, Auteur ; Noah J. SASSON, Auteur Article en page(s) : p.1522-1534 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder/psychology  Autistic Disorder/psychology  Cognition  Humans  Intellectual Disability  Male  Schizophrenia/complications  Social Behavior  Social Cognition  Young Adult  autism spectrum disorders  cluster  heterogeneity  schizophrenia Index. décimale : PER Périodiques Résumé : Autistic adults and those with schizophrenia (SCZ) demonstrate similar levels of reduced social cognitive performance at the group level, but it is unclear whether these patterns are relatively consistent or highly variable within and between the two conditions. Seventy-two adults with SCZ (52 male, M(age)  = 28.2years) and 94 with diagnoses on the autism spectrum (83 male, M(age)  = 24.2years) without intellectual disability completed a comprehensive social cognitive battery. Latent profile analysis identified four homogeneous subgroups that were compared on their diagnosis, independent living skills, neurocognition, and symptomatology. Two groups showed normative performance across most social cognitive tasks but were differentiated by one having significantly higher hostility and blaming biases. Autistic participants were more likely to demonstrate fully normative performance (46.8%) than participants with SCZ, whereas normative performance in SCZ was more likely to co-occur with increased hostility and blaming biases (36.1%). Approximately 43% of participants in the full sample were classified into the remaining two groups showing low or very low performance. These participants tended to perform worse on neurocognitive tests and have lower IQ and fewer independent living skills. The prevalence of low performance on social cognitive tasks was comparable across clinical groups. However, nearly half of autistic participants demonstrated normative social cognitive performance, challenging assumptions that reduced social cognitive performance is inherent to the condition. Subgrouping also revealed a meaningful distinction between the clinical groups: participants with SCZ were more likely to demonstrate hostility biases than autistic participants, even when social cognitive performance was otherwise in the typical range. LAY SUMMARY: Social cognition refers to the perception and interpretation of social information. Previous research has shown that both autistic people and those with schizophrenia demonstrate reduced performance on traditional social cognitive tasks, which we replicate here at the group level. However, we also found that almost half of autistic participants performed in the normal range. Over a third of participants with schizophrenia did as well, but for them this performance was accompanied by a hostility bias not commonly found in the autistic sample. Taken together, findings challenge assumptions that difficulties in social cognition are a uniform characteristic of these clinical conditions in those without intellectual disability. En ligne : http://dx.doi.org/10.1002/aur.2730 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483 [article] Heterogeneity of social cognitive performance in autism and schizophrenia [Texte imprimé et/ou numérique] / Michal HAJDUK, Auteur ; Amy E. PINKHAM, Auteur ; David L. PENN, Auteur ; Philip D. HARVEY, Auteur ; Noah J. SASSON, Auteur . - p.1522-1534. Langues : Anglais (eng) in Autism Research > 15-8 (August 2022) . - p.1522-1534 Mots-clés : Adult  Autism Spectrum Disorder/psychology  Autistic Disorder/psychology  Cognition  Humans  Intellectual Disability  Male  Schizophrenia/complications  Social Behavior  Social Cognition  Young Adult  autism spectrum disorders  cluster  heterogeneity  schizophrenia Index. décimale : PER Périodiques Résumé : Autistic adults and those with schizophrenia (SCZ) demonstrate similar levels of reduced social cognitive performance at the group level, but it is unclear whether these patterns are relatively consistent or highly variable within and between the two conditions. Seventy-two adults with SCZ (52 male, M(age)  = 28.2years) and 94 with diagnoses on the autism spectrum (83 male, M(age)  = 24.2years) without intellectual disability completed a comprehensive social cognitive battery. Latent profile analysis identified four homogeneous subgroups that were compared on their diagnosis, independent living skills, neurocognition, and symptomatology. Two groups showed normative performance across most social cognitive tasks but were differentiated by one having significantly higher hostility and blaming biases. Autistic participants were more likely to demonstrate fully normative performance (46.8%) than participants with SCZ, whereas normative performance in SCZ was more likely to co-occur with increased hostility and blaming biases (36.1%). Approximately 43% of participants in the full sample were classified into the remaining two groups showing low or very low performance. These participants tended to perform worse on neurocognitive tests and have lower IQ and fewer independent living skills. The prevalence of low performance on social cognitive tasks was comparable across clinical groups. However, nearly half of autistic participants demonstrated normative social cognitive performance, challenging assumptions that reduced social cognitive performance is inherent to the condition. Subgrouping also revealed a meaningful distinction between the clinical groups: participants with SCZ were more likely to demonstrate hostility biases than autistic participants, even when social cognitive performance was otherwise in the typical range. LAY SUMMARY: Social cognition refers to the perception and interpretation of social information. Previous research has shown that both autistic people and those with schizophrenia demonstrate reduced performance on traditional social cognitive tasks, which we replicate here at the group level. However, we also found that almost half of autistic participants performed in the normal range. Over a third of participants with schizophrenia did as well, but for them this performance was accompanied by a hostility bias not commonly found in the autistic sample. Taken together, findings challenge assumptions that difficulties in social cognition are a uniform characteristic of these clinical conditions in those without intellectual disability. En ligne : http://dx.doi.org/10.1002/aur.2730 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483

Heterogeneity of Visual Preferences for Biological and Repetitive Movements in Children With Autism Spectrum Disorder / Tianbi LI in Autism Research, 14-1 (January 2021)  

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Dissecting the phenotypic heterogeneity in sensory features in autism spectrum disorder: a factor mixture modelling approach / J. TILLMANN in Molecular Autism, 11 (2020)  

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Editorial: Distinguishing between the challenges posed by surface and deep forms of heterogeneity to diagnostic systems: do we need a new approach to subtyping of child and adolescent psychiatric disorders / Edmund J. S. SONUGA-BARKE in Journal of Child Psychology and Psychiatry, 57-1 (January 2016)  

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Examining Phenotypical Heterogeneity in Language Abilities in Chinese-Speaking Children with Autism: A Naturalistic Sampling Approach / Xue-Ke SONG in Journal of Autism and Developmental Disorders, 52-5 (May 2022)  

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Research Review: Brain network connectivity and the heterogeneity of depression in adolescence - a precision mental health perspective / Rajpreet CHAHAL in Journal of Child Psychology and Psychiatry, 61-12 (December 2020)  

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