38 recherche sur le mot-clé 'heterogeneity'

Heterogeneity and plasticity in the development of language: a 17-year follow-up of children referred early for possible autism / Andrew PICKLES in Journal of Child Psychology and Psychiatry, 55-12 (December 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1354-1362 Titre : Heterogeneity and plasticity in the development of language: a 17-year follow-up of children referred early for possible autism Type de document : Texte imprimé et/ou numérique Auteurs : Andrew PICKLES, Auteur ; Deborah K. ANDERSON, Auteur ; Catherine LORD, Auteur Article en page(s) : p.1354-1362 Langues : Anglais (eng) Mots-clés : Early intervention  heterogeneity  language impairment  plasticity Index. décimale : PER Périodiques Résumé : Background Delayed, abnormal language is a common feature of autism and language therapy often a significant component of recommended treatment. However, as with other disorders with a language component, we know surprisingly little about the language trajectories and how varied these might be across different children. Thus, we know little about how and when language problems might resolve, whether there are periods of relative stability or lack of change and what periods might offer more favourable circumstances for intervention. Methods Expressive and receptive language was measured on six occasions between age 2 and 19 on a cohort of 192 children initially referred for autism. Latent class growth models were fitted to characterize the patterns of heterogeneous development. Results Latent class growth analysis identified seven classes. Between age 6 and 19, all classes tracked in parallel. Between ages 2 and 6, development was more heterogeneous with considerable variation in relative progress. In all groups, receptive and expressive language developed very largely in tandem. Conclusions The results confirmed previous analysis of children with specific language impairment where progress beyond age 6 was remarkably uniform. Greater variation was evident before this age with some groups making clearly better or worse progress compared to others. While this developmental heterogeneity may simply be a reflection of variation in preexisting and unchanging biological disposition, it may also reflect, at least in part, greater sensitivity in the early years to environments that are more or less supportive of language development. These findings contribute to the case for the importance of early intervention. En ligne : http://dx.doi.org/10.1111/jcpp.12269 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2439 [article] Heterogeneity and plasticity in the development of language: a 17-year follow-up of children referred early for possible autism [Texte imprimé et/ou numérique] / Andrew PICKLES, Auteur ; Deborah K. ANDERSON, Auteur ; Catherine LORD, Auteur . - p.1354-1362. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1354-1362 Mots-clés : Early intervention  heterogeneity  language impairment  plasticity Index. décimale : PER Périodiques Résumé : Background Delayed, abnormal language is a common feature of autism and language therapy often a significant component of recommended treatment. However, as with other disorders with a language component, we know surprisingly little about the language trajectories and how varied these might be across different children. Thus, we know little about how and when language problems might resolve, whether there are periods of relative stability or lack of change and what periods might offer more favourable circumstances for intervention. Methods Expressive and receptive language was measured on six occasions between age 2 and 19 on a cohort of 192 children initially referred for autism. Latent class growth models were fitted to characterize the patterns of heterogeneous development. Results Latent class growth analysis identified seven classes. Between age 6 and 19, all classes tracked in parallel. Between ages 2 and 6, development was more heterogeneous with considerable variation in relative progress. In all groups, receptive and expressive language developed very largely in tandem. Conclusions The results confirmed previous analysis of children with specific language impairment where progress beyond age 6 was remarkably uniform. Greater variation was evident before this age with some groups making clearly better or worse progress compared to others. While this developmental heterogeneity may simply be a reflection of variation in preexisting and unchanging biological disposition, it may also reflect, at least in part, greater sensitivity in the early years to environments that are more or less supportive of language development. These findings contribute to the case for the importance of early intervention. En ligne : http://dx.doi.org/10.1111/jcpp.12269 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2439

Heterogeneity in caregiving-related early adversity: Creating stable dimensions and subtypes / Aki NIKOLAIDIS in Development and Psychopathology, 34-2 (May 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-2 (May 2022) . - 621-634 Titre : Heterogeneity in caregiving-related early adversity: Creating stable dimensions and subtypes Type de document : Texte imprimé et/ou numérique Auteurs : Aki NIKOLAIDIS, Auteur ; Charlotte HELENIAK, Auteur ; Andrea FIELDS, Auteur ; Paul A. BLOOM, Auteur ; Michelle VANTIEGHEM, Auteur ; Anna VANNUCCI, Auteur ; Nicolas L. CAMACHO, Auteur ; Tricia CHOY, Auteur ; Lisa GIBSON, Auteur ; Chelsea HARMON, Auteur ; Syntia S. HADIS, Auteur ; Ian J. DOUGLAS, Auteur ; Michael P. MILHAM, Auteur ; Nim TOTTENHAM, Auteur Article en page(s) : 621-634 Langues : Anglais (eng) Mots-clés : caregiving related early adversities  heterogeneity  prediction  subtyping Index. décimale : PER Périodiques Résumé : Early psychosocial adversities exist at many levels, including caregiving-related, extrafamilial, and sociodemographic, which despite their high interrelatedness may have unique impacts on development. In this paper, we focus on caregiving-related early adversities (crEAs) and parse the heterogeneity of crEAs via data reduction techniques that identify experiential cooccurrences. Using network science, we characterized crEA cooccurrences to represent the comorbidity of crEA experiences across a sample of school-age children (n = 258; 6?12 years old) with a history of crEAs. crEA dimensions (variable level) and crEA subtypes (subject level) were identified using parallel factor analysis/principal component analysis and graph-based Louvain community detection. Bagging enhancement with cross-validation provided estimates of robustness. These data-driven dimensions/subtypes showed evidence of stability, transcended traditional sociolegally defined groups, were more homogenous than sociolegally defined groups, and reduced statistical correlations with sociodemographic factors. Finally, random forests showed both unique and common predictive importance of the crEA dimensions/subtypes for childhood mental health symptoms and academic skills. These data-driven outcomes provide additional tools and recommendations for crEA data reduction to inform precision medicine efforts in this area. En ligne : http://dx.doi.org/10.1017/s0954579421001668 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4744 [article] Heterogeneity in caregiving-related early adversity: Creating stable dimensions and subtypes [Texte imprimé et/ou numérique] / Aki NIKOLAIDIS, Auteur ; Charlotte HELENIAK, Auteur ; Andrea FIELDS, Auteur ; Paul A. BLOOM, Auteur ; Michelle VANTIEGHEM, Auteur ; Anna VANNUCCI, Auteur ; Nicolas L. CAMACHO, Auteur ; Tricia CHOY, Auteur ; Lisa GIBSON, Auteur ; Chelsea HARMON, Auteur ; Syntia S. HADIS, Auteur ; Ian J. DOUGLAS, Auteur ; Michael P. MILHAM, Auteur ; Nim TOTTENHAM, Auteur . - 621-634. Langues : Anglais (eng) in Development and Psychopathology > 34-2 (May 2022) . - 621-634 Mots-clés : caregiving related early adversities  heterogeneity  prediction  subtyping Index. décimale : PER Périodiques Résumé : Early psychosocial adversities exist at many levels, including caregiving-related, extrafamilial, and sociodemographic, which despite their high interrelatedness may have unique impacts on development. In this paper, we focus on caregiving-related early adversities (crEAs) and parse the heterogeneity of crEAs via data reduction techniques that identify experiential cooccurrences. Using network science, we characterized crEA cooccurrences to represent the comorbidity of crEA experiences across a sample of school-age children (n = 258; 6?12 years old) with a history of crEAs. crEA dimensions (variable level) and crEA subtypes (subject level) were identified using parallel factor analysis/principal component analysis and graph-based Louvain community detection. Bagging enhancement with cross-validation provided estimates of robustness. These data-driven dimensions/subtypes showed evidence of stability, transcended traditional sociolegally defined groups, were more homogenous than sociolegally defined groups, and reduced statistical correlations with sociodemographic factors. Finally, random forests showed both unique and common predictive importance of the crEA dimensions/subtypes for childhood mental health symptoms and academic skills. These data-driven outcomes provide additional tools and recommendations for crEA data reduction to inform precision medicine efforts in this area. En ligne : http://dx.doi.org/10.1017/s0954579421001668 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4744

Heterogeneity of social cognitive performance in autism and schizophrenia / Michal HAJDUK in Autism Research, 15-8 (August 2022)  

Public ISBD [article]  inAutism Research > 15-8 (August 2022) . - p.1522-1534 Titre : Heterogeneity of social cognitive performance in autism and schizophrenia Type de document : Texte imprimé et/ou numérique Auteurs : Michal HAJDUK, Auteur ; Amy E. PINKHAM, Auteur ; David L. PENN, Auteur ; Philip D. HARVEY, Auteur ; Noah J. SASSON, Auteur Article en page(s) : p.1522-1534 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder/psychology  Autistic Disorder/psychology  Cognition  Humans  Intellectual Disability  Male  Schizophrenia/complications  Social Behavior  Social Cognition  Young Adult  autism spectrum disorders  cluster  heterogeneity  schizophrenia Index. décimale : PER Périodiques Résumé : Autistic adults and those with schizophrenia (SCZ) demonstrate similar levels of reduced social cognitive performance at the group level, but it is unclear whether these patterns are relatively consistent or highly variable within and between the two conditions. Seventy-two adults with SCZ (52 male, M(age)  = 28.2years) and 94 with diagnoses on the autism spectrum (83 male, M(age)  = 24.2years) without intellectual disability completed a comprehensive social cognitive battery. Latent profile analysis identified four homogeneous subgroups that were compared on their diagnosis, independent living skills, neurocognition, and symptomatology. Two groups showed normative performance across most social cognitive tasks but were differentiated by one having significantly higher hostility and blaming biases. Autistic participants were more likely to demonstrate fully normative performance (46.8%) than participants with SCZ, whereas normative performance in SCZ was more likely to co-occur with increased hostility and blaming biases (36.1%). Approximately 43% of participants in the full sample were classified into the remaining two groups showing low or very low performance. These participants tended to perform worse on neurocognitive tests and have lower IQ and fewer independent living skills. The prevalence of low performance on social cognitive tasks was comparable across clinical groups. However, nearly half of autistic participants demonstrated normative social cognitive performance, challenging assumptions that reduced social cognitive performance is inherent to the condition. Subgrouping also revealed a meaningful distinction between the clinical groups: participants with SCZ were more likely to demonstrate hostility biases than autistic participants, even when social cognitive performance was otherwise in the typical range. LAY SUMMARY: Social cognition refers to the perception and interpretation of social information. Previous research has shown that both autistic people and those with schizophrenia demonstrate reduced performance on traditional social cognitive tasks, which we replicate here at the group level. However, we also found that almost half of autistic participants performed in the normal range. Over a third of participants with schizophrenia did as well, but for them this performance was accompanied by a hostility bias not commonly found in the autistic sample. Taken together, findings challenge assumptions that difficulties in social cognition are a uniform characteristic of these clinical conditions in those without intellectual disability. En ligne : http://dx.doi.org/10.1002/aur.2730 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4836 [article] Heterogeneity of social cognitive performance in autism and schizophrenia [Texte imprimé et/ou numérique] / Michal HAJDUK, Auteur ; Amy E. PINKHAM, Auteur ; David L. PENN, Auteur ; Philip D. HARVEY, Auteur ; Noah J. SASSON, Auteur . - p.1522-1534. Langues : Anglais (eng) in Autism Research > 15-8 (August 2022) . - p.1522-1534 Mots-clés : Adult  Autism Spectrum Disorder/psychology  Autistic Disorder/psychology  Cognition  Humans  Intellectual Disability  Male  Schizophrenia/complications  Social Behavior  Social Cognition  Young Adult  autism spectrum disorders  cluster  heterogeneity  schizophrenia Index. décimale : PER Périodiques Résumé : Autistic adults and those with schizophrenia (SCZ) demonstrate similar levels of reduced social cognitive performance at the group level, but it is unclear whether these patterns are relatively consistent or highly variable within and between the two conditions. Seventy-two adults with SCZ (52 male, M(age)  = 28.2years) and 94 with diagnoses on the autism spectrum (83 male, M(age)  = 24.2years) without intellectual disability completed a comprehensive social cognitive battery. Latent profile analysis identified four homogeneous subgroups that were compared on their diagnosis, independent living skills, neurocognition, and symptomatology. Two groups showed normative performance across most social cognitive tasks but were differentiated by one having significantly higher hostility and blaming biases. Autistic participants were more likely to demonstrate fully normative performance (46.8%) than participants with SCZ, whereas normative performance in SCZ was more likely to co-occur with increased hostility and blaming biases (36.1%). Approximately 43% of participants in the full sample were classified into the remaining two groups showing low or very low performance. These participants tended to perform worse on neurocognitive tests and have lower IQ and fewer independent living skills. The prevalence of low performance on social cognitive tasks was comparable across clinical groups. However, nearly half of autistic participants demonstrated normative social cognitive performance, challenging assumptions that reduced social cognitive performance is inherent to the condition. Subgrouping also revealed a meaningful distinction between the clinical groups: participants with SCZ were more likely to demonstrate hostility biases than autistic participants, even when social cognitive performance was otherwise in the typical range. LAY SUMMARY: Social cognition refers to the perception and interpretation of social information. Previous research has shown that both autistic people and those with schizophrenia demonstrate reduced performance on traditional social cognitive tasks, which we replicate here at the group level. However, we also found that almost half of autistic participants performed in the normal range. Over a third of participants with schizophrenia did as well, but for them this performance was accompanied by a hostility bias not commonly found in the autistic sample. Taken together, findings challenge assumptions that difficulties in social cognition are a uniform characteristic of these clinical conditions in those without intellectual disability. En ligne : http://dx.doi.org/10.1002/aur.2730 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4836

Heterogeneity of Visual Preferences for Biological and Repetitive Movements in Children With Autism Spectrum Disorder / Tianbi LI in Autism Research, 14-1 (January 2021)  

Public ISBD [article]  inAutism Research > 14-1 (January 2021) . - p.102-111 Titre : Heterogeneity of Visual Preferences for Biological and Repetitive Movements in Children With Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Tianbi LI, Auteur ; Yewei LI, Auteur ; Yixiao HU, Auteur ; Yuyin WANG, Auteur ; Cheuk Man LAM, Auteur ; Wei NI, Auteur ; Xueqin WANG, Auteur ; Li YI, Auteur Article en page(s) : p.102-111 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  eye movement  heterogeneity  repetitive behavior  visual biological movement  visual preference Index. décimale : PER Périodiques Résumé : Previous studies have repeatedly reported atypical visual preferences to repetitive movements and deficient perception of biological movements in individuals with autism spectrum disorder (ASD). However, limited research has investigated the heterogeneity of the visual preferences in individuals with ASD. In the current study, we explored the visual preferences to different movement types (repetitive, biological, and random) in children with ASD using a paired preferential looking paradigm. Thirty-nine children with ASD and 37 typically developing (TD) children participated in our study, with their eye movements recorded as the index of visual preferences. We examined the differences of visual preferences between the ASD and TD group, and the heterogeneity of visual preferences within the ASD group. We found group differences between children with ASD and TD children: Overall, the ASD group preferred repetitive movements while the TD group preferred biological movements. We also detected heterogeneity of visual preferences within the ASD group: Although the majority of children with ASD preferred repetitive movements as previous studies reported, 9 out of 39 children with ASD preferred biological movements similarly as their TD peers. Moreover, the visual preference patterns were correlated with autistic symptoms, especially the socio-communicative impairments. Our study provided evidence of heterogeneity of visual attention and main visual preference to repetitive movements in children with ASD. The findings add to the body of literature of the heterogeneous behavioral symptoms and the atypical visual preferences in individuals with ASD. LAY SUMMARY: The current study examined visual preferences to biological, repetitive, and random movements in children with Autism Spectrum Disorder (ASD). We showed a pair of two videos representing two types of movements (random, repetitive, or biological movements) to children with ASD and typically developing children. We found the main visual preferences for repetitive movements and heterogeneity of visual attention within the ASD group. Our findings provide theoretical and methodological implications for future study of the heterogeneity in the ASD population. En ligne : http://dx.doi.org/10.1002/aur.2366 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4416 [article] Heterogeneity of Visual Preferences for Biological and Repetitive Movements in Children With Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Tianbi LI, Auteur ; Yewei LI, Auteur ; Yixiao HU, Auteur ; Yuyin WANG, Auteur ; Cheuk Man LAM, Auteur ; Wei NI, Auteur ; Xueqin WANG, Auteur ; Li YI, Auteur . - p.102-111. Langues : Anglais (eng) in Autism Research > 14-1 (January 2021) . - p.102-111 Mots-clés : autism spectrum disorder  eye movement  heterogeneity  repetitive behavior  visual biological movement  visual preference Index. décimale : PER Périodiques Résumé : Previous studies have repeatedly reported atypical visual preferences to repetitive movements and deficient perception of biological movements in individuals with autism spectrum disorder (ASD). However, limited research has investigated the heterogeneity of the visual preferences in individuals with ASD. In the current study, we explored the visual preferences to different movement types (repetitive, biological, and random) in children with ASD using a paired preferential looking paradigm. Thirty-nine children with ASD and 37 typically developing (TD) children participated in our study, with their eye movements recorded as the index of visual preferences. We examined the differences of visual preferences between the ASD and TD group, and the heterogeneity of visual preferences within the ASD group. We found group differences between children with ASD and TD children: Overall, the ASD group preferred repetitive movements while the TD group preferred biological movements. We also detected heterogeneity of visual preferences within the ASD group: Although the majority of children with ASD preferred repetitive movements as previous studies reported, 9 out of 39 children with ASD preferred biological movements similarly as their TD peers. Moreover, the visual preference patterns were correlated with autistic symptoms, especially the socio-communicative impairments. Our study provided evidence of heterogeneity of visual attention and main visual preference to repetitive movements in children with ASD. The findings add to the body of literature of the heterogeneous behavioral symptoms and the atypical visual preferences in individuals with ASD. LAY SUMMARY: The current study examined visual preferences to biological, repetitive, and random movements in children with Autism Spectrum Disorder (ASD). We showed a pair of two videos representing two types of movements (random, repetitive, or biological movements) to children with ASD and typically developing children. We found the main visual preferences for repetitive movements and heterogeneity of visual attention within the ASD group. Our findings provide theoretical and methodological implications for future study of the heterogeneity in the ASD population. En ligne : http://dx.doi.org/10.1002/aur.2366 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4416

Dissecting the phenotypic heterogeneity in sensory features in autism spectrum disorder: a factor mixture modelling approach / J. TILLMANN in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) . - 67 p. Titre : Dissecting the phenotypic heterogeneity in sensory features in autism spectrum disorder: a factor mixture modelling approach Type de document : Texte imprimé et/ou numérique Auteurs : J. TILLMANN, Auteur ; M. ULJAREVIC, Auteur ; D. CRAWLEY, Auteur ; G. DUMAS, Auteur ; E. LOTH, Auteur ; D. MURPHY, Auteur ; Jan K. BUITELAAR, Auteur ; Tony CHARMAN, Auteur Article en page(s) : 67 p. Langues : Anglais (eng) Mots-clés : Anxiety  Autism spectrum disorder  Heterogeneity  Phenotype  Sensory features  Social-communication symptoms  of/and/or speaker for Takeda/Shire, Roche, Medice, Servier and Angelini. He is not  an employee of any of these companies, and not a stock shareholder of any of these  companies. He has no other financial or material support, including expert  testimony, patents and royalties. Julian Tillmann is a consultant to F. Hoffmann-La  Roche. Index. décimale : PER Périodiques Résumé : BACKGROUND: Heterogeneity in the phenotypic presentation of autism spectrum disorder (ASD) is apparent in the profile and the severity of sensory features. Here, we applied factor mixture modelling (FMM) to test a multidimensional factor model of sensory processing in ASD. We aimed to identify homogeneous sensory subgroups in ASD that differ intrinsically in their severity along continuous factor scores. We also investigated sensory subgroups in relation to clinical variables: sex, age, IQ, social-communication symptoms, restricted and repetitive behaviours, adaptive functioning and symptoms of anxiety and attention-deficit/hyperactivity disorder. METHODS: Three hundred thirty-two children and adults with ASD between the ages of 6 and 30?years with IQs varying between 40 and 148 were included. First, three different confirmatory factor models were fit to the 38 items of the Short Sensory Profile (SSP). Then, latent class models (with two-to-six subgroups) were evaluated. The best performing factor model, the 7-factor structure, was subsequently used in two FMMs that varied in the number of subgroups: a two-subgroup, seven-factor model and a three-subgroup and seven-factor model. RESULTS: The 'three-subgroup/seven-factor' FMM was superior to all other models based on different fit criteria. Identified subgroups differed in sensory severity from severe, moderate to low. Accounting for the potential confounding effects of age and IQ, participants in these sensory subgroups had different levels of social-communicative symptoms, restricted and repetitive behaviours, adaptive functioning skills and symptoms of inattention and anxiety. LIMITATIONS: Results were derived using a single parent-report measure of sensory features, the SSP, which limits the generalisability of findings. CONCLUSION: Sensory features can be best described by three homogeneous sensory subgroups that differ in sensory severity gradients along seven continuous factor scores. Identified sensory subgroups were further differentiated by the severity of core and co-occurring symptoms, and level of adaptive functioning, providing novel evidence on the associated clinical correlates of sensory subgroups. These sensory subgroups provide a platform to further interrogate the neurobiological and genetic correlates of altered sensory processing in ASD. En ligne : http://dx.doi.org/10.1186/s13229-020-00367-w Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4333 [article] Dissecting the phenotypic heterogeneity in sensory features in autism spectrum disorder: a factor mixture modelling approach [Texte imprimé et/ou numérique] / J. TILLMANN, Auteur ; M. ULJAREVIC, Auteur ; D. CRAWLEY, Auteur ; G. DUMAS, Auteur ; E. LOTH, Auteur ; D. MURPHY, Auteur ; Jan K. BUITELAAR, Auteur ; Tony CHARMAN, Auteur . - 67 p. Langues : Anglais (eng) in Molecular Autism > 11 (2020) . - 67 p. Mots-clés : Anxiety  Autism spectrum disorder  Heterogeneity  Phenotype  Sensory features  Social-communication symptoms  of/and/or speaker for Takeda/Shire, Roche, Medice, Servier and Angelini. He is not  an employee of any of these companies, and not a stock shareholder of any of these  companies. He has no other financial or material support, including expert  testimony, patents and royalties. Julian Tillmann is a consultant to F. Hoffmann-La  Roche. Index. décimale : PER Périodiques Résumé : BACKGROUND: Heterogeneity in the phenotypic presentation of autism spectrum disorder (ASD) is apparent in the profile and the severity of sensory features. Here, we applied factor mixture modelling (FMM) to test a multidimensional factor model of sensory processing in ASD. We aimed to identify homogeneous sensory subgroups in ASD that differ intrinsically in their severity along continuous factor scores. We also investigated sensory subgroups in relation to clinical variables: sex, age, IQ, social-communication symptoms, restricted and repetitive behaviours, adaptive functioning and symptoms of anxiety and attention-deficit/hyperactivity disorder. METHODS: Three hundred thirty-two children and adults with ASD between the ages of 6 and 30?years with IQs varying between 40 and 148 were included. First, three different confirmatory factor models were fit to the 38 items of the Short Sensory Profile (SSP). Then, latent class models (with two-to-six subgroups) were evaluated. The best performing factor model, the 7-factor structure, was subsequently used in two FMMs that varied in the number of subgroups: a two-subgroup, seven-factor model and a three-subgroup and seven-factor model. RESULTS: The 'three-subgroup/seven-factor' FMM was superior to all other models based on different fit criteria. Identified subgroups differed in sensory severity from severe, moderate to low. Accounting for the potential confounding effects of age and IQ, participants in these sensory subgroups had different levels of social-communicative symptoms, restricted and repetitive behaviours, adaptive functioning skills and symptoms of inattention and anxiety. LIMITATIONS: Results were derived using a single parent-report measure of sensory features, the SSP, which limits the generalisability of findings. CONCLUSION: Sensory features can be best described by three homogeneous sensory subgroups that differ in sensory severity gradients along seven continuous factor scores. Identified sensory subgroups were further differentiated by the severity of core and co-occurring symptoms, and level of adaptive functioning, providing novel evidence on the associated clinical correlates of sensory subgroups. These sensory subgroups provide a platform to further interrogate the neurobiological and genetic correlates of altered sensory processing in ASD. En ligne : http://dx.doi.org/10.1186/s13229-020-00367-w Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4333

Editorial: Distinguishing between the challenges posed by surface and deep forms of heterogeneity to diagnostic systems: do we need a new approach to subtyping of child and adolescent psychiatric disorders / Edmund J. S. SONUGA-BARKE in Journal of Child Psychology and Psychiatry, 57-1 (January 2016)  

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Examining Phenotypical Heterogeneity in Language Abilities in Chinese-Speaking Children with Autism: A Naturalistic Sampling Approach / Xue-Ke SONG in Journal of Autism and Developmental Disorders, 52-5 (May 2022)  

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Research Review: Brain network connectivity and the heterogeneity of depression in adolescence - a precision mental health perspective / Rajpreet CHAHAL in Journal of Child Psychology and Psychiatry, 61-12 (December 2020)  

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The longitudinal heterogeneity of autistic traits: A systematic review / Richard PENDER in Research in Autism Spectrum Disorders, 79 (November 2020)  

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Commentary: Integrating callous and unemotional traits into the definition of antisocial behaviour – a commentary on Frick et al. (2014) / Richard ROWE in Journal of Child Psychology and Psychiatry, 55-6 (June 2014)  

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