6 recherche sur le mot-clé 'randomized clinical trial'

A Feasibility Randomized Clinical Trial of a Structured Function-Based Intervention for Elopement in Children with Autism Spectrum Disorder / Mindy C. SCHEITHAUER in Journal of Autism and Developmental Disorders, 51-8 (August 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2866-2875 Titre : A Feasibility Randomized Clinical Trial of a Structured Function-Based Intervention for Elopement in Children with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Mindy C. SCHEITHAUER, Auteur ; Nathan A. CALL, Auteur ; Joanna E. LOMAS MEVERS, Auteur ; Courtney E. MCCRACKEN, Auteur ; Lawrence SCAHILL, Auteur Article en page(s) : p.2866-2875 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/psychology/therapy  Behavior Therapy/methods  Child  Child, Preschool  Feasibility Studies  Female  Humans  Male  Parents/psychology  Treatment Refusal/psychology  Applied behavior analysis  Autism spectrum disorder  Elopement  Intervention  Randomized clinical trial  Treatment Index. décimale : PER Périodiques Résumé : Elopement is a common and dangerous concern in autism spectrum disorder (ASD). There is evidence that behavior analytic treatments can successfully treat elopement, but the research is limited due to small samples and treatment components varying across studies. The current study evaluated the feasibility of studying a manualized intervention for elopement, based on strategies from single-subject research, in a randomized clinical trial with 24 individuals with ASD. Results demonstrated that recruitment was feasible; the manual was acceptable to parents; and therapists followed the manual with high-integrity. Initial efficacy results measured by the Aberrant Behavior Checklist, Clinical Global Impression Scale, and a Home Elopement Safety Checklist suggested improvement in the treatment group that should be studied in future research. En ligne : http://dx.doi.org/10.1007/s10803-020-04753-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] A Feasibility Randomized Clinical Trial of a Structured Function-Based Intervention for Elopement in Children with Autism Spectrum Disorder [texte imprimé] / Mindy C. SCHEITHAUER, Auteur ; Nathan A. CALL, Auteur ; Joanna E. LOMAS MEVERS, Auteur ; Courtney E. MCCRACKEN, Auteur ; Lawrence SCAHILL, Auteur . - p.2866-2875. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2866-2875 Mots-clés : Autism Spectrum Disorder/psychology/therapy  Behavior Therapy/methods  Child  Child, Preschool  Feasibility Studies  Female  Humans  Male  Parents/psychology  Treatment Refusal/psychology  Applied behavior analysis  Autism spectrum disorder  Elopement  Intervention  Randomized clinical trial  Treatment Index. décimale : PER Périodiques Résumé : Elopement is a common and dangerous concern in autism spectrum disorder (ASD). There is evidence that behavior analytic treatments can successfully treat elopement, but the research is limited due to small samples and treatment components varying across studies. The current study evaluated the feasibility of studying a manualized intervention for elopement, based on strategies from single-subject research, in a randomized clinical trial with 24 individuals with ASD. Results demonstrated that recruitment was feasible; the manual was acceptable to parents; and therapists followed the manual with high-integrity. Initial efficacy results measured by the Aberrant Behavior Checklist, Clinical Global Impression Scale, and a Home Elopement Safety Checklist suggested improvement in the treatment group that should be studied in future research. En ligne : http://dx.doi.org/10.1007/s10803-020-04753-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

A Parent-Mediated Intervention That Targets Responsive Parental Behaviors Increases Attachment Behaviors in Children with ASD: Results from a Randomized Clinical Trial / Michael SILLER in Journal of Autism and Developmental Disorders, 44-7 (July 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-7 (July 2014) . - p.1720-1732 Titre : A Parent-Mediated Intervention That Targets Responsive Parental Behaviors Increases Attachment Behaviors in Children with ASD: Results from a Randomized Clinical Trial Type de document : texte imprimé Auteurs : Michael SILLER, Auteur ; Meghan SWANSON, Auteur ; Alan H. GERBER, Auteur ; Ted HUTMAN, Auteur ; Marian SIGMAN, Auteur Article en page(s) : p.1720-1732 Langues : Anglais (eng) Mots-clés : Autism  Randomized clinical trial  Parent child communication  Attachment  Intervention Index. décimale : PER Périodiques Résumé : The current study is a randomized clinical trial evaluating the efficacy of Focused Playtime Intervention (FPI) in a sample of 70 children with Autism Spectrum Disorder. This parent-mediated intervention has previously been shown to significantly increase responsive parental communication (Siller et al. in J Autism Dev Disord 43:540–555, 2013a). The current analyses focus on children’s attachment related outcomes. Results revealed that children who were randomly assigned to FPI showed bigger increases in attachment-related behaviors, compared to children assigned to the control condition. Significant treatment effects of FPI were found for both an observational measure of attachment-related behaviors elicited during a brief separation-reunion episode and a questionnaire measure evaluating parental perceptions of child attachment. The theoretical and clinical implications of these findings are discussed. En ligne : http://dx.doi.org/10.1007/s10803-014-2049-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236 [article] A Parent-Mediated Intervention That Targets Responsive Parental Behaviors Increases Attachment Behaviors in Children with ASD: Results from a Randomized Clinical Trial [texte imprimé] / Michael SILLER, Auteur ; Meghan SWANSON, Auteur ; Alan H. GERBER, Auteur ; Ted HUTMAN, Auteur ; Marian SIGMAN, Auteur . - p.1720-1732. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-7 (July 2014) . - p.1720-1732 Mots-clés : Autism  Randomized clinical trial  Parent child communication  Attachment  Intervention Index. décimale : PER Périodiques Résumé : The current study is a randomized clinical trial evaluating the efficacy of Focused Playtime Intervention (FPI) in a sample of 70 children with Autism Spectrum Disorder. This parent-mediated intervention has previously been shown to significantly increase responsive parental communication (Siller et al. in J Autism Dev Disord 43:540–555, 2013a). The current analyses focus on children’s attachment related outcomes. Results revealed that children who were randomly assigned to FPI showed bigger increases in attachment-related behaviors, compared to children assigned to the control condition. Significant treatment effects of FPI were found for both an observational measure of attachment-related behaviors elicited during a brief separation-reunion episode and a questionnaire measure evaluating parental perceptions of child attachment. The theoretical and clinical implications of these findings are discussed. En ligne : http://dx.doi.org/10.1007/s10803-014-2049-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236

A Parent-Mediated Intervention to Increase Responsive Parental Behaviors and Child Communication in Children with ASD: A Randomized Clinical Trial / Michael SILLER in Journal of Autism and Developmental Disorders, 43-3 (March 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-3 (March 2013) . - p.540-555 Titre : A Parent-Mediated Intervention to Increase Responsive Parental Behaviors and Child Communication in Children with ASD: A Randomized Clinical Trial Type de document : texte imprimé Auteurs : Michael SILLER, Auteur ; Ted HUTMAN, Auteur ; Marian SIGMAN, Auteur Article en page(s) : p.540-555 Langues : Anglais (eng) Mots-clés : Autism  Randomized clinical trial  Parent child communication  Language  Intervention Index. décimale : PER Périodiques Résumé : Longitudinal research has demonstrated that responsive parental behaviors reliably predict subsequent language gains in children with autism spectrum disorder. To investigate the underlying causal mechanisms, we conducted a randomized clinical trial of an experimental intervention (Focused Playtime Intervention, FPI) that aims to enhance responsive parental communication (N = 70). Results showed a significant treatment effect of FPI on responsive parental behaviors. Findings also revealed a conditional effect of FPI on children’s expressive language outcomes at 12-month follow up, suggesting that children with baseline language skills below 12 months (n = 24) are most likely to benefit from FPI. Parents of children with more advanced language skills may require intervention strategies that go beyond FPI’s focus on responsive communication. En ligne : http://dx.doi.org/10.1007/s10803-012-1584-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192 [article] A Parent-Mediated Intervention to Increase Responsive Parental Behaviors and Child Communication in Children with ASD: A Randomized Clinical Trial [texte imprimé] / Michael SILLER, Auteur ; Ted HUTMAN, Auteur ; Marian SIGMAN, Auteur . - p.540-555. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-3 (March 2013) . - p.540-555 Mots-clés : Autism  Randomized clinical trial  Parent child communication  Language  Intervention Index. décimale : PER Périodiques Résumé : Longitudinal research has demonstrated that responsive parental behaviors reliably predict subsequent language gains in children with autism spectrum disorder. To investigate the underlying causal mechanisms, we conducted a randomized clinical trial of an experimental intervention (Focused Playtime Intervention, FPI) that aims to enhance responsive parental communication (N = 70). Results showed a significant treatment effect of FPI on responsive parental behaviors. Findings also revealed a conditional effect of FPI on children’s expressive language outcomes at 12-month follow up, suggesting that children with baseline language skills below 12 months (n = 24) are most likely to benefit from FPI. Parents of children with more advanced language skills may require intervention strategies that go beyond FPI’s focus on responsive communication. En ligne : http://dx.doi.org/10.1007/s10803-012-1584-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192

Vitamin D supplementation in the first 2 years and autism spectrum traits at 6–8 years – a randomized clinical trial / Samuel SANDBOGE in Journal of Child Psychology and Psychiatry, 67-7 (July 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-7 (July 2026) . - p.1004-1014 Titre : Vitamin D supplementation in the first 2 years and autism spectrum traits at 6–8 years – a randomized clinical trial Type de document : texte imprimé Auteurs : Samuel SANDBOGE, Auteur ; Vilja SEPPÄLÄ, Auteur ; Sakari LINTULA, Auteur ; Elisa HOLMLUND-SUILA, Auteur ; Helena HAUTA-ALUS, Auteur ; Eero KAJANTIE, Auteur ; Outi MÄKITIE, Auteur ; Sture ANDERSSON, Auteur ; Katri RAIKKONEN, Auteur ; Kati HEINONEN, Auteur Article en page(s) : p.1004-1014 Langues : Anglais (eng) Mots-clés : Vitamin D  neurodevelopment  randomized clinical trial  autism spectrum disorder Index. décimale : PER Périodiques Résumé : Background Early life vitamin D levels may be associated with autism spectrum disorder (ASD) and related traits, but causality is unknown. We examine whether higher-than-standard vitamin D3 supplementation during the first 2?years, as well as higher pregnancy and childhood 25-hydroxyvitamin D (25(OH)D) levels and their trajectories, are associated with lower ASD trait scores at ages 6?8?years in a non-clinical cohort. Methods This secondary analysis of the double-blind randomized clinical trial vitamin D intervention in infants (VIDI) comprised 366 Finnish children aged 6?8?years, 177 of whom were randomized to receive 400-IU and 189 to receive 1,200-IU daily oral vitamin D3 supplementation between ages 2?weeks and 2?years. ASD-related traits were assessed at mean age 7.2?years (SD 0.4) using the parent-reported Autism Spectrum Screening Questionnaire (ASSQ). Predictor variables were supplementation group, 25(OH)D concentrations measured during pregnancy and at ages 1 and 2?years, as well as 25(OH)D trajectories (high vs. low) derived from these time points. Results None of the predictor variables of interest were associated with the outcome in the full sample. After sex stratification, among boys, 25(OH)D concentrations at 1 and 2?years were inversely associated with ASSQ scores (mean difference ?0.2 of normalized SD score (95% CI ?0.3 to ?0.1, p?=?.003) and??0.2 (95% CI ?0.3 to ?0.05, p?=?.01) per 10?ng/mL 25(OH)D) after adjustment for age, breastfeeding, parental education, maternal depressive symptoms, and season of 25(OH)D assessment as was belonging to the higher 25(OH)D trajectory, ?0.45 SD (95% CI ?0.79 to ?0.10, p?=?.01). Conclusions We found no indication that higher-than-normal vitamin D3 supplementation between ages 0 and 2?years decreases ASD-related trait scores at ages 6?8?years. Sex-stratified analysis suggested an inverse association, among boys, between early life 25(OH)D concentrations and ASD-related traits, warranting further studies on potential causal direction and sex specificity of associations. En ligne : https://doi.org/10.1111/jcpp.70110 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=588 [article] Vitamin D supplementation in the first 2 years and autism spectrum traits at 6–8 years – a randomized clinical trial [texte imprimé] / Samuel SANDBOGE, Auteur ; Vilja SEPPÄLÄ, Auteur ; Sakari LINTULA, Auteur ; Elisa HOLMLUND-SUILA, Auteur ; Helena HAUTA-ALUS, Auteur ; Eero KAJANTIE, Auteur ; Outi MÄKITIE, Auteur ; Sture ANDERSSON, Auteur ; Katri RAIKKONEN, Auteur ; Kati HEINONEN, Auteur . - p.1004-1014. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-7 (July 2026) . - p.1004-1014 Mots-clés : Vitamin D  neurodevelopment  randomized clinical trial  autism spectrum disorder Index. décimale : PER Périodiques Résumé : Background Early life vitamin D levels may be associated with autism spectrum disorder (ASD) and related traits, but causality is unknown. We examine whether higher-than-standard vitamin D3 supplementation during the first 2?years, as well as higher pregnancy and childhood 25-hydroxyvitamin D (25(OH)D) levels and their trajectories, are associated with lower ASD trait scores at ages 6?8?years in a non-clinical cohort. Methods This secondary analysis of the double-blind randomized clinical trial vitamin D intervention in infants (VIDI) comprised 366 Finnish children aged 6?8?years, 177 of whom were randomized to receive 400-IU and 189 to receive 1,200-IU daily oral vitamin D3 supplementation between ages 2?weeks and 2?years. ASD-related traits were assessed at mean age 7.2?years (SD 0.4) using the parent-reported Autism Spectrum Screening Questionnaire (ASSQ). Predictor variables were supplementation group, 25(OH)D concentrations measured during pregnancy and at ages 1 and 2?years, as well as 25(OH)D trajectories (high vs. low) derived from these time points. Results None of the predictor variables of interest were associated with the outcome in the full sample. After sex stratification, among boys, 25(OH)D concentrations at 1 and 2?years were inversely associated with ASSQ scores (mean difference ?0.2 of normalized SD score (95% CI ?0.3 to ?0.1, p?=?.003) and??0.2 (95% CI ?0.3 to ?0.05, p?=?.01) per 10?ng/mL 25(OH)D) after adjustment for age, breastfeeding, parental education, maternal depressive symptoms, and season of 25(OH)D assessment as was belonging to the higher 25(OH)D trajectory, ?0.45 SD (95% CI ?0.79 to ?0.10, p?=?.01). Conclusions We found no indication that higher-than-normal vitamin D3 supplementation between ages 0 and 2?years decreases ASD-related trait scores at ages 6?8?years. Sex-stratified analysis suggested an inverse association, among boys, between early life 25(OH)D concentrations and ASD-related traits, warranting further studies on potential causal direction and sex specificity of associations. En ligne : https://doi.org/10.1111/jcpp.70110 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=588

A Randomized Trial of Caregiver-Mediated Function-Based Elopement Treatment for Autistic Children / Mindy C. SCHEITHAUER in Autism, 29-8 (August 2025)  

Public ISBD [article]  inAutism > 29-8 (August 2025) . - p.1973-1986 Titre : A Randomized Trial of Caregiver-Mediated Function-Based Elopement Treatment for Autistic Children Type de document : texte imprimé Auteurs : Mindy C. SCHEITHAUER, Auteur ; Joanna E. LOMAS MEVERS, Auteur ; Lawrence SCAHILL, Auteur ; Sarah Slocum FREEMAN, Auteur ; Colin MUETHING, Auteur ; Chelsea ROCK, Auteur ; Scott E. GILLESPIE, Auteur ; Laura JOHNSON, Auteur ; Nathan A. CALL, Auteur Article en page(s) : p.1973-1986 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  elopement  function-based treatment  interventions-psychosocial/behavioral  randomized clinical trial Index. décimale : PER Périodiques Résumé : Elopement is a common and dangerous behavior among autistic children. Behavioral treatments can reduce elopement, but most evidence comes from small-N evaluations in specialized settings with strategies varying across studies. The current study compared the efficacy of the caregiver-mediated function-based elopement treatment to parent education program (PEP) in a 16-week randomized clinical trial of 76 autistic children (age = 4-12 years). Function-based elopement treatment involves 12 weekly appointments aimed at improving safety, identifying the function of elopement, and implementing subsequent function-based treatment strategies. No group differences were observed on the Aberrant Behavior Checklist-Hyperactivity (primary outcome). Significant improvement from baseline to endpoint in function-based elopement treatment compared to parent education program participants was observed for secondary outcomes, including caregiver ratings of safety measures (p < 0.01), severity of elopement based on the Elopement Questionnaire (p < 0.01), and caregiver-collected data on elopement (p < 0.01). The Clinical Global Impression-Improvement Scale (CGI-I) rated by a treatment-blind evaluator found 31.6% of function-based elopement treatment participants improved compared to 2.6% in parent education program (p = 0.001). Improvements were maintained at a 28-week follow-up. Attrition was 5.26%, and no significant adverse events were deemed related to treatment. Function-based elopement treatment was superior to parent education program on elopement-specific outcomes and appears safe and acceptable.Lay Abstract Many autistic children exhibit wandering or running away from supervision (i.e. elopement), which can include leaving the house in the middle of the night or getting lost from a parent in a crowded location. Elopement can result in injury when the child is not supervised and is incredibly stressful for parents. Research suggests that behavioral intervention can help with elopement. However, most studies include only a few children. In addition, treatment strategies differ across studies, making it difficult to compare outcomes. The function-based elopement treatment has compiled strategies across different studies to build a 12-session treatment manual that can be followed by clinicians. The manual guides the therapist on the delivery of parent-training strategies to improve the child?s safety and reduce elopement. We compared function-based elopement treatment to a control condition where parents met weekly with a clinician for more general parent training. Children whose parents received function-based elopement treatment showed greater improvement in elopement than children whose parents received more general parent education. This result suggests that the treatment works. Further study is needed to move function-based elopement treatment into clinical practice. En ligne : https://journals.sagepub.com/doi/abs/10.1177/13623613251330388 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564 [article] A Randomized Trial of Caregiver-Mediated Function-Based Elopement Treatment for Autistic Children [texte imprimé] / Mindy C. SCHEITHAUER, Auteur ; Joanna E. LOMAS MEVERS, Auteur ; Lawrence SCAHILL, Auteur ; Sarah Slocum FREEMAN, Auteur ; Colin MUETHING, Auteur ; Chelsea ROCK, Auteur ; Scott E. GILLESPIE, Auteur ; Laura JOHNSON, Auteur ; Nathan A. CALL, Auteur . - p.1973-1986. Langues : Anglais (eng) in Autism > 29-8 (August 2025) . - p.1973-1986 Mots-clés : autism spectrum disorders  elopement  function-based treatment  interventions-psychosocial/behavioral  randomized clinical trial Index. décimale : PER Périodiques Résumé : Elopement is a common and dangerous behavior among autistic children. Behavioral treatments can reduce elopement, but most evidence comes from small-N evaluations in specialized settings with strategies varying across studies. The current study compared the efficacy of the caregiver-mediated function-based elopement treatment to parent education program (PEP) in a 16-week randomized clinical trial of 76 autistic children (age = 4-12 years). Function-based elopement treatment involves 12 weekly appointments aimed at improving safety, identifying the function of elopement, and implementing subsequent function-based treatment strategies. No group differences were observed on the Aberrant Behavior Checklist-Hyperactivity (primary outcome). Significant improvement from baseline to endpoint in function-based elopement treatment compared to parent education program participants was observed for secondary outcomes, including caregiver ratings of safety measures (p < 0.01), severity of elopement based on the Elopement Questionnaire (p < 0.01), and caregiver-collected data on elopement (p < 0.01). The Clinical Global Impression-Improvement Scale (CGI-I) rated by a treatment-blind evaluator found 31.6% of function-based elopement treatment participants improved compared to 2.6% in parent education program (p = 0.001). Improvements were maintained at a 28-week follow-up. Attrition was 5.26%, and no significant adverse events were deemed related to treatment. Function-based elopement treatment was superior to parent education program on elopement-specific outcomes and appears safe and acceptable.Lay Abstract Many autistic children exhibit wandering or running away from supervision (i.e. elopement), which can include leaving the house in the middle of the night or getting lost from a parent in a crowded location. Elopement can result in injury when the child is not supervised and is incredibly stressful for parents. Research suggests that behavioral intervention can help with elopement. However, most studies include only a few children. In addition, treatment strategies differ across studies, making it difficult to compare outcomes. The function-based elopement treatment has compiled strategies across different studies to build a 12-session treatment manual that can be followed by clinicians. The manual guides the therapist on the delivery of parent-training strategies to improve the child?s safety and reduce elopement. We compared function-based elopement treatment to a control condition where parents met weekly with a clinician for more general parent training. Children whose parents received function-based elopement treatment showed greater improvement in elopement than children whose parents received more general parent education. This result suggests that the treatment works. Further study is needed to move function-based elopement treatment into clinical practice. En ligne : https://journals.sagepub.com/doi/abs/10.1177/13623613251330388 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564

Personalized at-home neurofeedback compared to long-acting methylphenidate in children with ADHD: NEWROFEED, a European randomized noninferiority trial / Diane PURPER-OUAKIL in Journal of Child Psychology and Psychiatry, 63-2 (February 2022)  

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