Are numerical impairments syndrome specific? Evidence from Williams syndrome and Down's syndrome / Sarah J. PATERSON in Journal of Child Psychology and Psychiatry, 47-2 (February 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-2 (February 2006) . - p.190–204 Titre : Are numerical impairments syndrome specific? Evidence from Williams syndrome and Down's syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Sarah J. PATERSON, Auteur ; Luisa GIRELLI, Auteur ; Brian BUTTERWORTH, Auteur ; Annette KARMILOFF-SMITH, Auteur Année de publication : 2006 Article en page(s) : p.190–204 Langues : Anglais (eng) Mots-clés : Williams-syndrome Down's-syndrome number-development adults infants Index. décimale : PER Périodiques Résumé : Background: Several theorists maintain that exact number abilities rely on language-relevant processes whereas approximate number calls on visuo-spatial skills. We chose two genetic disorders, Williams syndrome and Down's syndrome, which differ in their relative abilities in verbal versus spatial skills, to examine this hypothesis. Five experiments assessed number skills in these two genetic syndromes and in their mental age (MA) and chronological age (CA) matched controls. Methods: Experiment 1 used a preferential looking paradigm with infants and toddlers to measure sensitivity to changes in numerosity. Experiment 2 measured reaction times in older children and adults in a numerosity comparison task with dots in a random pattern. Experiment 3 comprised a number battery that measured various forms of counting and simple arithmetic. Results: The WS infants displayed a level of performance equal to that of their CA-controls, whereas the DS infants failed to reach even the level of their MA-controls. By contrast, the older DS children and adults outstripped the older WS group in their numerosity abilities, with different patterns of errors in the two clinical groups. Conclusions: Differences in the infant and adult number phenotypes between these two genetic disorders are discussed with reference to the processing styles used by each group and how these might impact on their developmental trajectories. Theoretically, we highlight our contention that one cannot infer the infant starting state from the adult end state. Rather, the development process itself must be taken into account. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01460.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=717 [article] Are numerical impairments syndrome specific? Evidence from Williams syndrome and Down's syndrome [Texte imprimé et/ou numérique] / Sarah J. PATERSON, Auteur ; Luisa GIRELLI, Auteur ; Brian BUTTERWORTH, Auteur ; Annette KARMILOFF-SMITH, Auteur . - 2006 . - p.190–204. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-2 (February 2006) . - p.190–204 Mots-clés : Williams-syndrome Down's-syndrome number-development adults infants Index. décimale : PER Périodiques Résumé : Background: Several theorists maintain that exact number abilities rely on language-relevant processes whereas approximate number calls on visuo-spatial skills. We chose two genetic disorders, Williams syndrome and Down's syndrome, which differ in their relative abilities in verbal versus spatial skills, to examine this hypothesis. Five experiments assessed number skills in these two genetic syndromes and in their mental age (MA) and chronological age (CA) matched controls. Methods: Experiment 1 used a preferential looking paradigm with infants and toddlers to measure sensitivity to changes in numerosity. Experiment 2 measured reaction times in older children and adults in a numerosity comparison task with dots in a random pattern. Experiment 3 comprised a number battery that measured various forms of counting and simple arithmetic. Results: The WS infants displayed a level of performance equal to that of their CA-controls, whereas the DS infants failed to reach even the level of their MA-controls. By contrast, the older DS children and adults outstripped the older WS group in their numerosity abilities, with different patterns of errors in the two clinical groups. Conclusions: Differences in the infant and adult number phenotypes between these two genetic disorders are discussed with reference to the processing styles used by each group and how these might impact on their developmental trajectories. Theoretically, we highlight our contention that one cannot infer the infant starting state from the adult end state. Rather, the development process itself must be taken into account. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01460.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=717

Autism spectrum disorder screening with the CBCL/11/2-5: Findings for young children at high risk for autism spectrum disorder / L. A. RESCORLA in Autism, 23-1 (January 2019)  

Public ISBD [article]  inAutism > 23-1 (January 2019) . - p.29-38 Titre : Autism spectrum disorder screening with the CBCL/11/2-5: Findings for young children at high risk for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : L. A. RESCORLA, Auteur ; Breanna WINDER-PATEL, Auteur ; Sarah J. PATERSON, Auteur ; J. PANDEY, Auteur ; J. J. WOLFF, Auteur ; Robert T. SCHULTZ, Auteur ; J. PIVEN, Auteur Article en page(s) : p.29-38 Langues : Anglais (eng) Mots-clés : autism spectrum disorder screening  baby sibling paradigm  CBCL/11/2-5  Diagnostic and Statistical Manual of Mental Disorders-Pervasive  Developmental Problems scale  familial high-risk  modified checklist  rating-scales  toddlers  identification  cbcl  Psychology Index. décimale : PER Périodiques Résumé : The screening power of the CBCL/11/2-5's Withdrawn and Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems (DSM-PDP) scales to identify children diagnosed with autism spectrum disorder at 24 months was tested in a longitudinal, familial high-risk study. Participants were 56 children at high risk for autism spectrum disorder due to an affected older sibling (high-risk group) and 26 low-risk children with a typically developing older sibling (low-risk group). At 24 months, 13 of the 56 high-risk children were diagnosed with autism spectrum disorder, whereas the other 43 were not. The high-risk children diagnosed with autism spectrum disorder group had significantly higher scores on the CBCL/11/2-5's Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems and Withdrawn scales than children in the low-risk and high-risk children not diagnosed with autism spectrum disorder groups (eta p2>0.50). Receiver operating characteristic analyses yielded very high area under the curve values (0.91 and 0.89), and a cut point of T > 60 yielded sensitivity of 77% and specificity of 97% to 99% between the high-risk children diagnosed with autism spectrum disorder and the combination of low-risk and high-risk children not diagnosed with autism spectrum disorder. Consistent with several previous studies, the CBCL/11/2-5's Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems scale and the Withdrawn syndrome differentiated well between children diagnosed with autism spectrum disorder and those not diagnosed. En ligne : http://dx.doi.org/10.1177/1362361317718482 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=379 [article] Autism spectrum disorder screening with the CBCL/11/2-5: Findings for young children at high risk for autism spectrum disorder [Texte imprimé et/ou numérique] / L. A. RESCORLA, Auteur ; Breanna WINDER-PATEL, Auteur ; Sarah J. PATERSON, Auteur ; J. PANDEY, Auteur ; J. J. WOLFF, Auteur ; Robert T. SCHULTZ, Auteur ; J. PIVEN, Auteur . - p.29-38. Langues : Anglais (eng) in Autism > 23-1 (January 2019) . - p.29-38 Mots-clés : autism spectrum disorder screening  baby sibling paradigm  CBCL/11/2-5  Diagnostic and Statistical Manual of Mental Disorders-Pervasive  Developmental Problems scale  familial high-risk  modified checklist  rating-scales  toddlers  identification  cbcl  Psychology Index. décimale : PER Périodiques Résumé : The screening power of the CBCL/11/2-5's Withdrawn and Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems (DSM-PDP) scales to identify children diagnosed with autism spectrum disorder at 24 months was tested in a longitudinal, familial high-risk study. Participants were 56 children at high risk for autism spectrum disorder due to an affected older sibling (high-risk group) and 26 low-risk children with a typically developing older sibling (low-risk group). At 24 months, 13 of the 56 high-risk children were diagnosed with autism spectrum disorder, whereas the other 43 were not. The high-risk children diagnosed with autism spectrum disorder group had significantly higher scores on the CBCL/11/2-5's Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems and Withdrawn scales than children in the low-risk and high-risk children not diagnosed with autism spectrum disorder groups (eta p2>0.50). Receiver operating characteristic analyses yielded very high area under the curve values (0.91 and 0.89), and a cut point of T > 60 yielded sensitivity of 77% and specificity of 97% to 99% between the high-risk children diagnosed with autism spectrum disorder and the combination of low-risk and high-risk children not diagnosed with autism spectrum disorder. Consistent with several previous studies, the CBCL/11/2-5's Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems scale and the Withdrawn syndrome differentiated well between children diagnosed with autism spectrum disorder and those not diagnosed. En ligne : http://dx.doi.org/10.1177/1362361317718482 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=379

Development and validation of a streamlined autism case confirmation approach for use in epidemiologic risk factor research in prospective cohorts / Craig J. NEWSCHAFFER in Autism Research, 10-3 (March 2017)  

Public ISBD [article]  inAutism Research > 10-3 (March 2017) . - p.485-501 Titre : Development and validation of a streamlined autism case confirmation approach for use in epidemiologic risk factor research in prospective cohorts Type de document : Texte imprimé et/ou numérique Auteurs : Craig J. NEWSCHAFFER, Auteur ; Emily SCHRIVER, Auteur ; Lindsay BERRIGAN, Auteur ; Rebecca LANDA, Auteur ; Wendy L. STONE, Auteur ; Somer L. BISHOP, Auteur ; Diane BURKOM, Auteur ; Anne GOLDEN, Auteur ; Lisa IBANEZ, Auteur ; Alice KUO, Auteur ; Kimberly D. LAKES, Auteur ; Daniel S. MESSINGER, Auteur ; Sarah J. PATERSON, Auteur ; Zachary WARREN, Auteur Article en page(s) : p.485-501 Langues : Anglais (eng) Mots-clés : autism  ASD  case-confirmation  epidemiology  diagnosis  novel assessments Index. décimale : PER Périodiques Résumé : The cost associated with incorporating standardized observational assessments and diagnostic interviews in large-scale epidemiologic studies of autism spectrum disorders (ASD) risk factors can be substantial. Streamlined approaches for confirming ASD case status would benefit these studies. We conducted a multi-site, cross-sectional criterion validity study in a convenience sample of 382 three-year olds scheduled for neurodevelopmental evaluation. ASD case classification as determined by three novel assessment instruments (the Early Video-guided Autism Screener E-VAS; the Autism Symptom Interview, ASI; the Screening Tool for Autism in Toddlers Expanded, STAT-E) each designed to be administered in less than 30 minutes by lay staff, was compared to ADOS scores and DSM-based diagnostic assessment from a qualified clinician. Sensitivity and specificity of each instrument alone and in combination were estimated. Alternative cutpoints were identified under different criteria and two-stage cross validation was used to avoid overfitting. Findings were interpreted in the context of a large, prospective pregnancy cohort study utilizing a two-stage approach to case identification. Under initial cutpoints, sensitivity ranged from 0.63 to 0.92 and specificity from 0.35 to 0.70. Cutpoints giving equal weight to sensitivity and specificity resulted in sensitivity estimates ranging from 0.45 to 0.83 and specificity ranging from 0.49 to 0.86. Several strategies were well-suited for application as a second-stage case-confirmation. These included the STAT-E alone and the parallel administration of both the E-VAS and the ASI. Use of more streamlined methods of case-confirmation in large-scale prospective cohort epidemiologic investigations of ASD risk factors appears feasible. En ligne : http://dx.doi.org/10.1002/aur.1659 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Development and validation of a streamlined autism case confirmation approach for use in epidemiologic risk factor research in prospective cohorts [Texte imprimé et/ou numérique] / Craig J. NEWSCHAFFER, Auteur ; Emily SCHRIVER, Auteur ; Lindsay BERRIGAN, Auteur ; Rebecca LANDA, Auteur ; Wendy L. STONE, Auteur ; Somer L. BISHOP, Auteur ; Diane BURKOM, Auteur ; Anne GOLDEN, Auteur ; Lisa IBANEZ, Auteur ; Alice KUO, Auteur ; Kimberly D. LAKES, Auteur ; Daniel S. MESSINGER, Auteur ; Sarah J. PATERSON, Auteur ; Zachary WARREN, Auteur . - p.485-501. Langues : Anglais (eng) in Autism Research > 10-3 (March 2017) . - p.485-501 Mots-clés : autism  ASD  case-confirmation  epidemiology  diagnosis  novel assessments Index. décimale : PER Périodiques Résumé : The cost associated with incorporating standardized observational assessments and diagnostic interviews in large-scale epidemiologic studies of autism spectrum disorders (ASD) risk factors can be substantial. Streamlined approaches for confirming ASD case status would benefit these studies. We conducted a multi-site, cross-sectional criterion validity study in a convenience sample of 382 three-year olds scheduled for neurodevelopmental evaluation. ASD case classification as determined by three novel assessment instruments (the Early Video-guided Autism Screener E-VAS; the Autism Symptom Interview, ASI; the Screening Tool for Autism in Toddlers Expanded, STAT-E) each designed to be administered in less than 30 minutes by lay staff, was compared to ADOS scores and DSM-based diagnostic assessment from a qualified clinician. Sensitivity and specificity of each instrument alone and in combination were estimated. Alternative cutpoints were identified under different criteria and two-stage cross validation was used to avoid overfitting. Findings were interpreted in the context of a large, prospective pregnancy cohort study utilizing a two-stage approach to case identification. Under initial cutpoints, sensitivity ranged from 0.63 to 0.92 and specificity from 0.35 to 0.70. Cutpoints giving equal weight to sensitivity and specificity resulted in sensitivity estimates ranging from 0.45 to 0.83 and specificity ranging from 0.49 to 0.86. Several strategies were well-suited for application as a second-stage case-confirmation. These included the STAT-E alone and the parallel administration of both the E-VAS and the ASI. Use of more streamlined methods of case-confirmation in large-scale prospective cohort epidemiologic investigations of ASD risk factors appears feasible. En ligne : http://dx.doi.org/10.1002/aur.1659 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Language delay aggregates in toddler siblings of children with autism spectrum disorder / N. MARRUS in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 29 p. Titre : Language delay aggregates in toddler siblings of children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : N. MARRUS, Auteur ; L. P. HALL, Auteur ; Sarah J. PATERSON, Auteur ; J. T. ELISON, Auteur ; J. J. WOLFF, Auteur ; M. R. SWANSON, Auteur ; Julia PARISH-MORRIS, Auteur ; A. T. EGGEBRECHT, Auteur ; J. R. PRUETT, Auteur ; Heather C. HAZLETT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Stephen R. DAGER, Auteur ; A. M. ESTES, Auteur ; Robert T. SCHULTZ, Auteur ; Kelly N. BOTTERON, Auteur ; J. PIVEN, Auteur ; John N. CONSTANTINO, Auteur Année de publication : 2018 Article en page(s) : 29 p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Development  Endophenotype  Infant sibling  Language Index. décimale : PER Périodiques Résumé : BACKGROUND: Language delay is extremely common in children with autism spectrum disorder (ASD), yet it is unclear whether measurable variation in early language is associated with genetic liability for ASD. Assessment of language development in unaffected siblings of children with ASD can inform whether decreased early language ability aggregates with inherited risk for ASD and serves as an ASD endophenotype. METHODS: We implemented two approaches: (1) a meta-analysis of studies comparing language delay, a categorical indicator of language function, and language scores, a continuous metric, in unaffected toddlers at high and low familial risk for ASD, and (2) a parallel analysis of 350 unaffected 24-month-olds in the Infant Brain Imaging Study (IBIS), a prospective study of infants at high and low familial risk for ASD. An advantage of the former was its detection of group differences from pooled data across unique samples; an advantage of the latter was its sensitivity in quantifying early manifestations of language delay while accounting for covariates within a single large sample. RESULTS: Meta-analysis showed that high-risk siblings without ASD (HR-noASD) were three to four times more likely to exhibit language delay versus low-risk siblings without ASD (LR-noASD) and had lower mean receptive and expressive language scores. Analyses of IBIS data corroborated that language delay, specifically receptive language delay, was more frequent in the HR-noASD (n = 235) versus LR-noASD group (n = 115). IBIS language scores were continuously and unimodally distributed, with a pathological shift towards decreased language function in HR-noASD siblings. The elevated inherited risk for ASD was associated with lower receptive and expressive language scores when controlling for sociodemographic factors. For receptive but not expressive language, the effect of risk group remained significant even when controlling for nonverbal cognition. CONCLUSIONS: Greater frequency of language delay and a lower distribution of language scores in high-risk, unaffected toddler-aged siblings support decreased early language ability as an endophenotype for ASD, with a more pronounced effect for receptive versus expressive language. Further characterization of language development is warranted to refine genetic investigations of ASD and to elucidate factors influencing the progression of core autistic traits and related symptoms. En ligne : http://dx.doi.org/10.1186/s11689-018-9247-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] Language delay aggregates in toddler siblings of children with autism spectrum disorder [Texte imprimé et/ou numérique] / N. MARRUS, Auteur ; L. P. HALL, Auteur ; Sarah J. PATERSON, Auteur ; J. T. ELISON, Auteur ; J. J. WOLFF, Auteur ; M. R. SWANSON, Auteur ; Julia PARISH-MORRIS, Auteur ; A. T. EGGEBRECHT, Auteur ; J. R. PRUETT, Auteur ; Heather C. HAZLETT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Stephen R. DAGER, Auteur ; A. M. ESTES, Auteur ; Robert T. SCHULTZ, Auteur ; Kelly N. BOTTERON, Auteur ; J. PIVEN, Auteur ; John N. CONSTANTINO, Auteur . - 2018 . - 29 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 29 p. Mots-clés : Autism spectrum disorder  Development  Endophenotype  Infant sibling  Language Index. décimale : PER Périodiques Résumé : BACKGROUND: Language delay is extremely common in children with autism spectrum disorder (ASD), yet it is unclear whether measurable variation in early language is associated with genetic liability for ASD. Assessment of language development in unaffected siblings of children with ASD can inform whether decreased early language ability aggregates with inherited risk for ASD and serves as an ASD endophenotype. METHODS: We implemented two approaches: (1) a meta-analysis of studies comparing language delay, a categorical indicator of language function, and language scores, a continuous metric, in unaffected toddlers at high and low familial risk for ASD, and (2) a parallel analysis of 350 unaffected 24-month-olds in the Infant Brain Imaging Study (IBIS), a prospective study of infants at high and low familial risk for ASD. An advantage of the former was its detection of group differences from pooled data across unique samples; an advantage of the latter was its sensitivity in quantifying early manifestations of language delay while accounting for covariates within a single large sample. RESULTS: Meta-analysis showed that high-risk siblings without ASD (HR-noASD) were three to four times more likely to exhibit language delay versus low-risk siblings without ASD (LR-noASD) and had lower mean receptive and expressive language scores. Analyses of IBIS data corroborated that language delay, specifically receptive language delay, was more frequent in the HR-noASD (n = 235) versus LR-noASD group (n = 115). IBIS language scores were continuously and unimodally distributed, with a pathological shift towards decreased language function in HR-noASD siblings. The elevated inherited risk for ASD was associated with lower receptive and expressive language scores when controlling for sociodemographic factors. For receptive but not expressive language, the effect of risk group remained significant even when controlling for nonverbal cognition. CONCLUSIONS: Greater frequency of language delay and a lower distribution of language scores in high-risk, unaffected toddler-aged siblings support decreased early language ability as an endophenotype for ASD, with a more pronounced effect for receptive versus expressive language. Further characterization of language development is warranted to refine genetic investigations of ASD and to elucidate factors influencing the progression of core autistic traits and related symptoms. En ligne : http://dx.doi.org/10.1186/s11689-018-9247-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

Longitudinal patterns of repetitive behavior in toddlers with autism / Jason J. WOLFF in Journal of Child Psychology and Psychiatry, 55-8 (August 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-8 (August 2014) . - p.945-953 Titre : Longitudinal patterns of repetitive behavior in toddlers with autism Type de document : Texte imprimé et/ou numérique Auteurs : Jason J. WOLFF, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; Jed T. ELISON, Auteur ; Annette M. ESTES, Auteur ; Hongbin GU, Auteur ; Heather C. HAZLETT, Auteur ; Juhi PANDEY, Auteur ; Sarah J. PATERSON, Auteur ; Robert T. SCHULTZ, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Joseph PIVEN, Auteur ; THE IBIS NETWORK,, Auteur Article en page(s) : p.945-953 Langues : Anglais (eng) Mots-clés : Autism  repetitive behavior  high-risk siblings Index. décimale : PER Périodiques Résumé : Background Recent evidence suggests that restricted and repetitive behaviors may differentiate children who develop autism spectrum disorder (ASD) by late infancy. How these core symptoms manifest early in life, particularly among infants at high risk for the disorder, is not well characterized. Methods Prospective, longitudinal parent-report data (Repetitive Behavior Scales-Revised) were collected for 190 high-risk toddlers and 60 low-risk controls from 12 to 24 months of age. Forty-one high-risk children were classified with ASD at age 2. Profiles of repetitive behavior were compared between groups using generalized estimating equations. Results Longitudinal profiles for children diagnosed with ASD differed significantly from high- and low-risk children without the disorder on all measures of repetitive behavior. High-risk toddlers without ASD were intermediate to low risk and ASD positive counterparts. Toddlers with ASD showed significantly higher rates of repetitive behavior across subtypes at the 12-month time point. Repetitive behaviors were significantly correlated with adaptive behavior and socialization scores among children with ASD at 24 months of age, but were largely unrelated to measures of general cognitive ability. Conclusions These findings suggest that as early as 12 months of age, a broad range of repetitive behaviors are highly elevated in children who go on to develop ASD. While some degree of repetitive behavior is elemental to typical early development, the extent of these behaviors among children who develop ASD appears highly atypical. En ligne : http://dx.doi.org/10.1111/jcpp.12207 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=237 [article] Longitudinal patterns of repetitive behavior in toddlers with autism [Texte imprimé et/ou numérique] / Jason J. WOLFF, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; Jed T. ELISON, Auteur ; Annette M. ESTES, Auteur ; Hongbin GU, Auteur ; Heather C. HAZLETT, Auteur ; Juhi PANDEY, Auteur ; Sarah J. PATERSON, Auteur ; Robert T. SCHULTZ, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Joseph PIVEN, Auteur ; THE IBIS NETWORK,, Auteur . - p.945-953. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-8 (August 2014) . - p.945-953 Mots-clés : Autism  repetitive behavior  high-risk siblings Index. décimale : PER Périodiques Résumé : Background Recent evidence suggests that restricted and repetitive behaviors may differentiate children who develop autism spectrum disorder (ASD) by late infancy. How these core symptoms manifest early in life, particularly among infants at high risk for the disorder, is not well characterized. Methods Prospective, longitudinal parent-report data (Repetitive Behavior Scales-Revised) were collected for 190 high-risk toddlers and 60 low-risk controls from 12 to 24 months of age. Forty-one high-risk children were classified with ASD at age 2. Profiles of repetitive behavior were compared between groups using generalized estimating equations. Results Longitudinal profiles for children diagnosed with ASD differed significantly from high- and low-risk children without the disorder on all measures of repetitive behavior. High-risk toddlers without ASD were intermediate to low risk and ASD positive counterparts. Toddlers with ASD showed significantly higher rates of repetitive behavior across subtypes at the 12-month time point. Repetitive behaviors were significantly correlated with adaptive behavior and socialization scores among children with ASD at 24 months of age, but were largely unrelated to measures of general cognitive ability. Conclusions These findings suggest that as early as 12 months of age, a broad range of repetitive behaviors are highly elevated in children who go on to develop ASD. While some degree of repetitive behavior is elemental to typical early development, the extent of these behaviors among children who develop ASD appears highly atypical. En ligne : http://dx.doi.org/10.1111/jcpp.12207 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=237

The Importance of Temperament for Understanding Early Manifestations of Autism Spectrum Disorder in High-Risk Infants / Sarah J. PATERSON in Journal of Autism and Developmental Disorders, 49-7 (July 2019)  

Permalink

---

1 (1 - 6 / 6)