Atypical Processing of Gaze Cues and Faces Explains Comorbidity between Autism Spectrum Disorder (ASD) and Attention Deficit/Hyperactivity Disorder (ADHD) / Madeleine J. GROOM in Journal of Autism and Developmental Disorders, 47-5 (May 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-5 (May 2017) . - p.1496-1509 Titre : Atypical Processing of Gaze Cues and Faces Explains Comorbidity between Autism Spectrum Disorder (ASD) and Attention Deficit/Hyperactivity Disorder (ADHD) Type de document : Texte imprimé et/ou numérique Auteurs : Madeleine J. GROOM, Auteur ; Puja KOCHHAR, Auteur ; Antonia HAMILTON, Auteur ; Elizabeth B. LIDDLE, Auteur ; Marina SIMEOU, Auteur ; Chris HOLLIS, Auteur Article en page(s) : p.1496-1509 Langues : Anglais (eng) Mots-clés : ASD  ADHD  ERPs  Comorbidity  Gaze cueing  Face processing Index. décimale : PER Périodiques Résumé : This study investigated the neurobiological basis of comorbidity between autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). We compared children with ASD, ADHD or ADHD+ASD and typically developing controls (CTRL) on behavioural and electrophysiological correlates of gaze cue and face processing. We measured effects of ASD, ADHD and their interaction on the EDAN, an ERP marker of orienting visual attention towards a spatially cued location and the N170, a right-hemisphere lateralised ERP linked to face processing. We identified atypical gaze cue and face processing in children with ASD and ADHD+ASD compared with the ADHD and CTRL groups. The findings indicate a neurobiological basis for the presence of comorbid ASD symptoms in ADHD. Further research using larger samples is needed. En ligne : http://dx.doi.org/10.1007/s10803-017-3078-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305 [article] Atypical Processing of Gaze Cues and Faces Explains Comorbidity between Autism Spectrum Disorder (ASD) and Attention Deficit/Hyperactivity Disorder (ADHD) [Texte imprimé et/ou numérique] / Madeleine J. GROOM, Auteur ; Puja KOCHHAR, Auteur ; Antonia HAMILTON, Auteur ; Elizabeth B. LIDDLE, Auteur ; Marina SIMEOU, Auteur ; Chris HOLLIS, Auteur . - p.1496-1509. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-5 (May 2017) . - p.1496-1509 Mots-clés : ASD  ADHD  ERPs  Comorbidity  Gaze cueing  Face processing Index. décimale : PER Périodiques Résumé : This study investigated the neurobiological basis of comorbidity between autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). We compared children with ASD, ADHD or ADHD+ASD and typically developing controls (CTRL) on behavioural and electrophysiological correlates of gaze cue and face processing. We measured effects of ASD, ADHD and their interaction on the EDAN, an ERP marker of orienting visual attention towards a spatially cued location and the N170, a right-hemisphere lateralised ERP linked to face processing. We identified atypical gaze cue and face processing in children with ASD and ADHD+ASD compared with the ADHD and CTRL groups. The findings indicate a neurobiological basis for the presence of comorbid ASD symptoms in ADHD. Further research using larger samples is needed. En ligne : http://dx.doi.org/10.1007/s10803-017-3078-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305

Commentary: Using QbTest for monitoring pharmacological treatment response in ADHD - are we there yet? / Alessio BELLATO ; Valeria PARLATINI ; Madeleine J. GROOM ; Charlotte L. HALL ; Chris HOLLIS ; Emily SIMONOFF ; Anita THAPAR ; Samuele CORTESE in Journal of Child Psychology and Psychiatry, 66-2 (February 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-2 (February 2025) . - p.266-270 Titre : Commentary: Using QbTest for monitoring pharmacological treatment response in ADHD - are we there yet? : Journal of Child Psychology and Psychiatry Type de document : Texte imprimé et/ou numérique Auteurs : Alessio BELLATO, Auteur ; Valeria PARLATINI, Auteur ; Madeleine J. GROOM, Auteur ; Charlotte L. HALL, Auteur ; Chris HOLLIS, Auteur ; Emily SIMONOFF, Auteur ; Anita THAPAR, Auteur ; Samuele CORTESE, Auteur Article en page(s) : p.266-270 Langues : Anglais (eng) Mots-clés : ADHD  activity level  biomarkers  continuous performance test  outcome  pharmacotherapy Index. décimale : PER Périodiques Résumé : Individuals with attention-deficit/hyperactivity disorder (ADHD) exhibit varied responses to pharmacological treatments (e.g. stimulants and non-stimulants). Accurately and promptly detecting treatment-related improvements, response failure, or deterioration poses significant challenges, as current monitoring primarily relies on subjective ratings. In this commentary, we critically evaluate the evidence supporting the use of QbTest for objectively monitoring ADHD treatment response in clinical practice. We also offer recommendations for future research, advocating for rigorous clinical trials and longitudinal studies to further explore the potential utilisation of QbTest and other tools for monitoring treatment responses in individuals with ADHD. En ligne : https://doi.org/10.1111/jcpp.14071 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545 [article] Commentary: Using QbTest for monitoring pharmacological treatment response in ADHD - are we there yet? : Journal of Child Psychology and Psychiatry [Texte imprimé et/ou numérique] / Alessio BELLATO, Auteur ; Valeria PARLATINI, Auteur ; Madeleine J. GROOM, Auteur ; Charlotte L. HALL, Auteur ; Chris HOLLIS, Auteur ; Emily SIMONOFF, Auteur ; Anita THAPAR, Auteur ; Samuele CORTESE, Auteur . - p.266-270. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-2 (February 2025) . - p.266-270 Mots-clés : ADHD  activity level  biomarkers  continuous performance test  outcome  pharmacotherapy Index. décimale : PER Périodiques Résumé : Individuals with attention-deficit/hyperactivity disorder (ADHD) exhibit varied responses to pharmacological treatments (e.g. stimulants and non-stimulants). Accurately and promptly detecting treatment-related improvements, response failure, or deterioration poses significant challenges, as current monitoring primarily relies on subjective ratings. In this commentary, we critically evaluate the evidence supporting the use of QbTest for objectively monitoring ADHD treatment response in clinical practice. We also offer recommendations for future research, advocating for rigorous clinical trials and longitudinal studies to further explore the potential utilisation of QbTest and other tools for monitoring treatment responses in individuals with ADHD. En ligne : https://doi.org/10.1111/jcpp.14071 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545

Electrophysiological indices of abnormal error-processing in adolescents with attention deficit hyperactivity disorder (ADHD) / Madeleine J. GROOM in Journal of Child Psychology and Psychiatry, 51-1 (January 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-1 (January 2010) . - p.66-76 Titre : Electrophysiological indices of abnormal error-processing in adolescents with attention deficit hyperactivity disorder (ADHD) Type de document : Texte imprimé et/ou numérique Auteurs : Madeleine J. GROOM, Auteur ; John D. CAHILL, Auteur ; Alan T. BATES, Auteur ; Georgina M. JACKSON, Auteur ; Timothy G. CALTON, Auteur ; Peter F. LIDDLE, Auteur ; Chris HOLLIS, Auteur Année de publication : 2010 Article en page(s) : p.66-76 Langues : Anglais (eng) Mots-clés : ADHD electrophysiology ERN cognitive-control adolescence Index. décimale : PER Périodiques Résumé : Background: Impaired cognitive control has been frequently observed in children and young people with attention deficit hyperactivity disorder (ADHD) and might underlie the excessive hyperactivity and impulsivity in this population. We investigated behavioural and electrophysiological indices relevant to one domain of cognitive control; namely error processing. Methods: Adolescents aged 14 to 17 with ADHD (n = 23) and a typically developing control group (HC; n = 19) performed a visual go/no-go task. Electro-encephalography (EEG) data were collected simultaneously and response-locked error trials were averaged to derive two event-related potentials, the error-related negativity (ERN) and error positivity (Pe). Evoked theta power and inter-trial phase coherence (ITC) were measured in two time windows ('early' and 'late') equivalent to those used for detection of the ERN and Pe. Results: Analysis revealed normal ERN amplitude and a statistical trend for smaller Pe amplitude at a fronto-central electrode site in the ADHD group. The group also showed significant reductions in late evoked theta power and early and late theta ITC. Relationships between behavioural measures and ITC were different between groups, particularly for post-error slowing, a measure of strategic response adjustment on trials immediately following an error. Conclusions: The results reveal abnormalities in behavioural and electrophysiological indices of error processing in adolescents with ADHD and suggest that ITC is more sensitive than traditional ERP measures to error-processing abnormalities. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02128.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=940 [article] Electrophysiological indices of abnormal error-processing in adolescents with attention deficit hyperactivity disorder (ADHD) [Texte imprimé et/ou numérique] / Madeleine J. GROOM, Auteur ; John D. CAHILL, Auteur ; Alan T. BATES, Auteur ; Georgina M. JACKSON, Auteur ; Timothy G. CALTON, Auteur ; Peter F. LIDDLE, Auteur ; Chris HOLLIS, Auteur . - 2010 . - p.66-76. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-1 (January 2010) . - p.66-76 Mots-clés : ADHD electrophysiology ERN cognitive-control adolescence Index. décimale : PER Périodiques Résumé : Background: Impaired cognitive control has been frequently observed in children and young people with attention deficit hyperactivity disorder (ADHD) and might underlie the excessive hyperactivity and impulsivity in this population. We investigated behavioural and electrophysiological indices relevant to one domain of cognitive control; namely error processing. Methods: Adolescents aged 14 to 17 with ADHD (n = 23) and a typically developing control group (HC; n = 19) performed a visual go/no-go task. Electro-encephalography (EEG) data were collected simultaneously and response-locked error trials were averaged to derive two event-related potentials, the error-related negativity (ERN) and error positivity (Pe). Evoked theta power and inter-trial phase coherence (ITC) were measured in two time windows ('early' and 'late') equivalent to those used for detection of the ERN and Pe. Results: Analysis revealed normal ERN amplitude and a statistical trend for smaller Pe amplitude at a fronto-central electrode site in the ADHD group. The group also showed significant reductions in late evoked theta power and early and late theta ITC. Relationships between behavioural measures and ITC were different between groups, particularly for post-error slowing, a measure of strategic response adjustment on trials immediately following an error. Conclusions: The results reveal abnormalities in behavioural and electrophysiological indices of error processing in adolescents with ADHD and suggest that ITC is more sensitive than traditional ERP measures to error-processing abnormalities. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02128.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=940

Heart Rate Variability in Children and Adolescents with Autism, ADHD and Co-occurring Autism and ADHD, During Passive and Active Experimental Conditions / Alessio BELLATO in Journal of Autism and Developmental Disorders, 52-11 (November 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4679-4691 Titre : Heart Rate Variability in Children and Adolescents with Autism, ADHD and Co-occurring Autism and ADHD, During Passive and Active Experimental Conditions Type de document : Texte imprimé et/ou numérique Auteurs : Alessio BELLATO, Auteur ; Iti ARORA, Auteur ; Puja KOCHHAR, Auteur ; Danielle ROPAR, Auteur ; Chris HOLLIS, Auteur ; Madeleine J. GROOM, Auteur Article en page(s) : p.4679-4691 Langues : Anglais (eng) Mots-clés : Adolescent  Attention Deficit Disorder with Hyperactivity/psychology  Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Autonomic Nervous System  Child  Heart Rate/physiology  Humans  Adhd  Autism  Cognitive function  Comorbidity  Heart rate variability Index. décimale : PER Périodiques Résumé : Despite overlaps in clinical symptomatology, autism and ADHD may be associated with opposite autonomic arousal profiles which might partly explain altered cognitive and global functioning. We investigated autonomic arousal in 106 children/adolescents with autism, ADHD, co-occurring autism/ADHD, and neurotypical controls. Heart rate variability was recorded during resting-state, a 'passive' auditory oddball task and an 'active' response conflict task. Autistic children showed hyper-arousal during the active task, while those with ADHD showed hypo-arousal during resting-state and the passive task. Irrespective of diagnosis, children characterised by hyper-arousal showed more severe autistic symptomatology, increased anxiety and reduced global functioning than those displaying hypo-arousal, suggesting the importance of considering individual autonomic arousal profiles for differential diagnosis of autism/ADHD and when developing personalised interventions. En ligne : http://dx.doi.org/10.1007/s10803-021-05244-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 [article] Heart Rate Variability in Children and Adolescents with Autism, ADHD and Co-occurring Autism and ADHD, During Passive and Active Experimental Conditions [Texte imprimé et/ou numérique] / Alessio BELLATO, Auteur ; Iti ARORA, Auteur ; Puja KOCHHAR, Auteur ; Danielle ROPAR, Auteur ; Chris HOLLIS, Auteur ; Madeleine J. GROOM, Auteur . - p.4679-4691. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4679-4691 Mots-clés : Adolescent  Attention Deficit Disorder with Hyperactivity/psychology  Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Autonomic Nervous System  Child  Heart Rate/physiology  Humans  Adhd  Autism  Cognitive function  Comorbidity  Heart rate variability Index. décimale : PER Périodiques Résumé : Despite overlaps in clinical symptomatology, autism and ADHD may be associated with opposite autonomic arousal profiles which might partly explain altered cognitive and global functioning. We investigated autonomic arousal in 106 children/adolescents with autism, ADHD, co-occurring autism/ADHD, and neurotypical controls. Heart rate variability was recorded during resting-state, a 'passive' auditory oddball task and an 'active' response conflict task. Autistic children showed hyper-arousal during the active task, while those with ADHD showed hypo-arousal during resting-state and the passive task. Irrespective of diagnosis, children characterised by hyper-arousal showed more severe autistic symptomatology, increased anxiety and reduced global functioning than those displaying hypo-arousal, suggesting the importance of considering individual autonomic arousal profiles for differential diagnosis of autism/ADHD and when developing personalised interventions. En ligne : http://dx.doi.org/10.1007/s10803-021-05244-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489

Motivational incentives and methylphenidate enhance electrophysiological correlates of error monitoring in children with attention deficit/hyperactivity disorder / Madeleine J. GROOM in Journal of Child Psychology and Psychiatry, 54-8 (August 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-8 (August 2013) . - p.836-845 Titre : Motivational incentives and methylphenidate enhance electrophysiological correlates of error monitoring in children with attention deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Madeleine J. GROOM, Auteur ; Elizabeth B. LIDDLE, Auteur ; Gaia SCERIF, Auteur ; Peter F. LIDDLE, Auteur ; Martin J. BATTY, Auteur ; Mario LIOTTI, Auteur ; Chris HOLLIS, Auteur Article en page(s) : p.836-845 Langues : Anglais (eng) Mots-clés : ADHD  electrophysiology  error monitoring  motivation  methylphenidate  stimulant medication Index. décimale : PER Périodiques Résumé : Background Children with attention deficit hyperactivity disorder (ADHD) are characterised by developmentally inappropriate levels of hyperactivity, impulsivity and/or inattention and are particularly impaired when performing tasks that require a high level of cognitive control. Methylphenidate (MPH) and motivational incentives may help improve cognitive control by enhancing the ability to monitor response accuracy and regulate performance accordingly. Methods Twenty-eight children with DSM-IV ADHD (combined type) aged 9–15 years and pairwise-matched typically developing children (CTRL) performed a go/no-go task in which the incentives attached to performance on no-go trials were manipulated. The ADHD group performed the task off and on their usual dose of MPH. CTRL children performed the task twice but were never medicated. EEG data were recorded simultaneously and two electrophysiological indices of error monitoring, the error-related negativity (ERN) and error positivity (Pe) were measured. Amplitudes of each ERP were compared between diagnostic groups (CTRL, ADHD), medication days (Off MPH, On MPH) and motivational conditions (baseline – low incentive, reward, response cost). Results Error rates were lower in the reward and response cost conditions compared with baseline across diagnostic groups and medication days. ERN and Pe amplitudes were significantly reduced in ADHD compared with CTRL, and were significantly enhanced by MPH. Incentives significantly increased ERN and Pe amplitudes in the ADHD group but had no effect in CTRL. The effects of incentives did not interact with the effects of MPH on either ERP. Effect sizes were computed and revealed larger effects of MPH than incentives on ERN and Pe amplitudes. Conclusions The findings reveal independent effects of motivational incentives and MPH on two electrophysiological markers of error monitoring in children with ADHD, suggesting that each may be important tools for enhancing or restoring cognitive control in these children. En ligne : http://dx.doi.org/10.1111/jcpp.12069 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210 [article] Motivational incentives and methylphenidate enhance electrophysiological correlates of error monitoring in children with attention deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Madeleine J. GROOM, Auteur ; Elizabeth B. LIDDLE, Auteur ; Gaia SCERIF, Auteur ; Peter F. LIDDLE, Auteur ; Martin J. BATTY, Auteur ; Mario LIOTTI, Auteur ; Chris HOLLIS, Auteur . - p.836-845. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-8 (August 2013) . - p.836-845 Mots-clés : ADHD  electrophysiology  error monitoring  motivation  methylphenidate  stimulant medication Index. décimale : PER Périodiques Résumé : Background Children with attention deficit hyperactivity disorder (ADHD) are characterised by developmentally inappropriate levels of hyperactivity, impulsivity and/or inattention and are particularly impaired when performing tasks that require a high level of cognitive control. Methylphenidate (MPH) and motivational incentives may help improve cognitive control by enhancing the ability to monitor response accuracy and regulate performance accordingly. Methods Twenty-eight children with DSM-IV ADHD (combined type) aged 9–15 years and pairwise-matched typically developing children (CTRL) performed a go/no-go task in which the incentives attached to performance on no-go trials were manipulated. The ADHD group performed the task off and on their usual dose of MPH. CTRL children performed the task twice but were never medicated. EEG data were recorded simultaneously and two electrophysiological indices of error monitoring, the error-related negativity (ERN) and error positivity (Pe) were measured. Amplitudes of each ERP were compared between diagnostic groups (CTRL, ADHD), medication days (Off MPH, On MPH) and motivational conditions (baseline – low incentive, reward, response cost). Results Error rates were lower in the reward and response cost conditions compared with baseline across diagnostic groups and medication days. ERN and Pe amplitudes were significantly reduced in ADHD compared with CTRL, and were significantly enhanced by MPH. Incentives significantly increased ERN and Pe amplitudes in the ADHD group but had no effect in CTRL. The effects of incentives did not interact with the effects of MPH on either ERP. Effect sizes were computed and revealed larger effects of MPH than incentives on ERN and Pe amplitudes. Conclusions The findings reveal independent effects of motivational incentives and MPH on two electrophysiological markers of error monitoring in children with ADHD, suggesting that each may be important tools for enhancing or restoring cognitive control in these children. En ligne : http://dx.doi.org/10.1111/jcpp.12069 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210

Practitioner Review: Clinical utility of the QbTest for the assessment and diagnosis of attention-deficit/hyperactivity disorder - a systematic review and meta-analysis / Charlotte L. HALL ; Madeleine J. GROOM ; Emily SIMONOFF ; Anita THAPAR ; Chris HOLLIS ; Samuele CORTESE in Journal of Child Psychology and Psychiatry, 65-6 (June 2024)  

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Task-related default mode network modulation and inhibitory control in ADHD: effects of motivation and methylphenidate / Elizabeth B. LIDDLE in Journal of Child Psychology and Psychiatry, 52-7 (July 2011)  

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