Are Stimulants Useful in ASC? / L. Eugene ARNOLD

Public ISBD in Autism Spectrum Conditions / Sven BÖLTE Titre : Are Stimulants Useful in ASC? Type de document : texte imprimé Auteurs : L. Eugene ARNOLD, Auteur ; Michael G. AMAN, Auteur ; Benjamin L. HANDEN, Auteur Année de publication : 2011 Importance : p.217-219 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139 in Autism Spectrum Conditions / Sven BÖLTE Are Stimulants Useful in ASC? [texte imprimé] / L. Eugene ARNOLD, Auteur ; Michael G. AMAN, Auteur ; Benjamin L. HANDEN, Auteur . - 2011 . - p.217-219. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139

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Assessing general cognitive and adaptive abilities in adults with Down syndrome: a systematic review / S. HAMBURG in Journal of Neurodevelopmental Disorders, 11-1 (December 2019)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 20 p. Titre : Assessing general cognitive and adaptive abilities in adults with Down syndrome: a systematic review Type de document : texte imprimé Auteurs : S. HAMBURG, Auteur ; B. LOWE, Auteur ; C.M. STARTIN, Auteur ; C. PADILLA, Auteur ; A. COPPUS, Auteur ; Wendy SILVERMAN, Auteur ; J. FORTEA, Auteur ; S. ZAMAN, Auteur ; E. HEAD, Auteur ; Benjamin L. HANDEN, Auteur ; I. LOTT, Auteur ; Weihong SONG, Auteur ; A. STRYDOM, Auteur Article en page(s) : 20 p. Langues : Anglais (eng) Mots-clés : Ab  Adaptive ability  Adaptive behaviour  Cognition  Down syndrome  General ability  Iq  Intelligence Index. décimale : PER Périodiques Résumé : BACKGROUND: Measures of general cognitive and adaptive ability in adults with Down syndrome (DS) used by previous studies vary substantially. This review summarises the different ability measures used previously, focusing on tests of intelligence quotient (IQ) and adaptive behaviour (AB), and where possible examines floor effects and differences between DS subpopulations. We aimed to use information regarding existing measures to provide recommendations for individual researchers and the DS research community. RESULTS: Nineteen studies reporting IQ test data met inclusion for this review, with 17 different IQ tests used. Twelve of these IQ tests were used in only one study while five were used in two different studies. Eleven studies reporting AB test data met inclusion for this review, with seven different AB tests used. The only AB scales to be used by more than one study were the Vineland Adaptive Behaviour Scale (VABS; used by three studies) and the Vineland Adaptive Behavior Scale 2nd Edition (VABS-II; used by two studies). A variety of additional factors were identified which make comparison of test scores between studies problematic, including different score types provided between studies (e.g. raw scores compared to age-equivalent scores) and different participant inclusion criteria (e.g. whether individuals with cognitive decline were excluded). Floor effects were common for IQ tests (particularly for standardised test scores). Data exists to suggest that floor effects may be minimised by the use of raw test scores rather than standardised test scores. Raw scores may, therefore, be particularly useful in longitudinal studies to track change in cognitive ability over time. CONCLUSIONS: Studies assessing general ability in adults with DS are likely to benefit from the use of both IQ and AB scales. The DS research community may benefit from the development of reporting standards for IQ and AB data, and from the sharing of raw study data enabling further in-depth investigation of issues highlighted by this review. En ligne : https://dx.doi.org/10.1186/s11689-019-9279-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] Assessing general cognitive and adaptive abilities in adults with Down syndrome: a systematic review [texte imprimé] / S. HAMBURG, Auteur ; B. LOWE, Auteur ; C.M. STARTIN, Auteur ; C. PADILLA, Auteur ; A. COPPUS, Auteur ; Wendy SILVERMAN, Auteur ; J. FORTEA, Auteur ; S. ZAMAN, Auteur ; E. HEAD, Auteur ; Benjamin L. HANDEN, Auteur ; I. LOTT, Auteur ; Weihong SONG, Auteur ; A. STRYDOM, Auteur . - 20 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 20 p. Mots-clés : Ab  Adaptive ability  Adaptive behaviour  Cognition  Down syndrome  General ability  Iq  Intelligence Index. décimale : PER Périodiques Résumé : BACKGROUND: Measures of general cognitive and adaptive ability in adults with Down syndrome (DS) used by previous studies vary substantially. This review summarises the different ability measures used previously, focusing on tests of intelligence quotient (IQ) and adaptive behaviour (AB), and where possible examines floor effects and differences between DS subpopulations. We aimed to use information regarding existing measures to provide recommendations for individual researchers and the DS research community. RESULTS: Nineteen studies reporting IQ test data met inclusion for this review, with 17 different IQ tests used. Twelve of these IQ tests were used in only one study while five were used in two different studies. Eleven studies reporting AB test data met inclusion for this review, with seven different AB tests used. The only AB scales to be used by more than one study were the Vineland Adaptive Behaviour Scale (VABS; used by three studies) and the Vineland Adaptive Behavior Scale 2nd Edition (VABS-II; used by two studies). A variety of additional factors were identified which make comparison of test scores between studies problematic, including different score types provided between studies (e.g. raw scores compared to age-equivalent scores) and different participant inclusion criteria (e.g. whether individuals with cognitive decline were excluded). Floor effects were common for IQ tests (particularly for standardised test scores). Data exists to suggest that floor effects may be minimised by the use of raw test scores rather than standardised test scores. Raw scores may, therefore, be particularly useful in longitudinal studies to track change in cognitive ability over time. CONCLUSIONS: Studies assessing general ability in adults with DS are likely to benefit from the use of both IQ and AB scales. The DS research community may benefit from the development of reporting standards for IQ and AB data, and from the sharing of raw study data enabling further in-depth investigation of issues highlighted by this review. En ligne : https://dx.doi.org/10.1186/s11689-019-9279-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

Brief Report: A Double-Blind, Placebo-Controlled, Crossover, Proof-of-Concept Study of Minocycline in Autism Spectrum Disorder / Craig ERICKSON in Journal of Autism and Developmental Disorders, 55-9 (September 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-9 (September 2025) . - p.3387-3394 Titre : Brief Report: A Double-Blind, Placebo-Controlled, Crossover, Proof-of-Concept Study of Minocycline in Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Craig ERICKSON, Auteur ; Rebecca C. SHAFFER, Auteur ; Meredith WILL, Auteur ; Lauren M. SCHMITT, Auteur ; Paul S. HORN, Auteur ; Kathy HIRST, Auteur ; Ernest V. PEDAPATI, Auteur ; Nicole OBER, Auteur ; Rameshwari V. TUMULURU, Auteur ; Benjamin L. HANDEN, Auteur ; David Q. BEVERSDORF, Auteur Article en page(s) : p.3387-3394 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Neuroinflammatory mechanisms have been implicated in the pathophysiology of autism spectrum disorder (ASD). Minocycline is a matrix metalloproteinase inhibitor 9 (MMP9) inhibitor tetracycline antibiotic with known anti-inflammatory properties. In preclinical animal models of ASD, minocycline has demonstrated potential positive effects on phenotypes that may have relevance to ASD. We conducted the first placebo-controlled study of minocycline in ASD. This double-blind, placebo-controlled crossover trial employed four week treatment periods with a two week washout period. Twenty-four 12-22 year olds (mean age 17.4 years; range 12.9-22.5 years) with ASD were enrolled. Overall minocycline was well tolerated. No minocycline-associated clinical changes were noted with treatment on any performance or clinician or caregiver completed measures were noted. We hypothesize that either minocycline does not have potential therapeutic effects in ASD or our project was underpowered to define potential subject subgroups who may potentially respond positively to this drug. En ligne : https://doi.org/10.1007/s10803-023-06132-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=566 [article] Brief Report: A Double-Blind, Placebo-Controlled, Crossover, Proof-of-Concept Study of Minocycline in Autism Spectrum Disorder [texte imprimé] / Craig ERICKSON, Auteur ; Rebecca C. SHAFFER, Auteur ; Meredith WILL, Auteur ; Lauren M. SCHMITT, Auteur ; Paul S. HORN, Auteur ; Kathy HIRST, Auteur ; Ernest V. PEDAPATI, Auteur ; Nicole OBER, Auteur ; Rameshwari V. TUMULURU, Auteur ; Benjamin L. HANDEN, Auteur ; David Q. BEVERSDORF, Auteur . - p.3387-3394. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-9 (September 2025) . - p.3387-3394 Index. décimale : PER Périodiques Résumé : Neuroinflammatory mechanisms have been implicated in the pathophysiology of autism spectrum disorder (ASD). Minocycline is a matrix metalloproteinase inhibitor 9 (MMP9) inhibitor tetracycline antibiotic with known anti-inflammatory properties. In preclinical animal models of ASD, minocycline has demonstrated potential positive effects on phenotypes that may have relevance to ASD. We conducted the first placebo-controlled study of minocycline in ASD. This double-blind, placebo-controlled crossover trial employed four week treatment periods with a two week washout period. Twenty-four 12-22 year olds (mean age 17.4 years; range 12.9-22.5 years) with ASD were enrolled. Overall minocycline was well tolerated. No minocycline-associated clinical changes were noted with treatment on any performance or clinician or caregiver completed measures were noted. We hypothesize that either minocycline does not have potential therapeutic effects in ASD or our project was underpowered to define potential subject subgroups who may potentially respond positively to this drug. En ligne : https://doi.org/10.1007/s10803-023-06132-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=566

Differences in verbal and nonverbal IQ test scores in children with autism spectrum disorder / Sabrina N. GRONDHUIS in Research in Autism Spectrum Disorders, 49 (May 2018)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 49 (May 2018) . - p.47-55 Titre : Differences in verbal and nonverbal IQ test scores in children with autism spectrum disorder Type de document : texte imprimé Auteurs : Sabrina N. GRONDHUIS, Auteur ; Luc LECAVALIER, Auteur ; L. Eugene ARNOLD, Auteur ; Benjamin L. HANDEN, Auteur ; Lawrence SCAHILL, Auteur ; Christopher J. MCDOUGLE, Auteur ; Michael G. AMAN, Auteur Article en page(s) : p.47-55 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  ASD  Intelligence  IQ  Language  Assessment Index. décimale : PER Périodiques Résumé : Background Intelligence tests are a fundamental component of diagnostic assessments for children with suspected autism spectrum disorder (ASD). There are many assessments available, but scores across tests may not be comparable in children with ASD. Method Eighty children (68 boys) age 4–14 years with ASD completed the Stanford-Binet Intelligence Scales, 5th Edition (SB5), a verbal measure of intelligence, and the Leiter International Performance Scale – Revised (Leiter-R), a nonverbal measure of intelligence. Results Although discrepancies went in both directions, we found significantly higher mean scores on the Leiter-R than SB5 (9.6 point difference). Children younger than 8 years had more pronounced discrepancies (13.8 points vs. 3.5 points for >8 years), and children with less-developed language skills had greater discrepancies (13.1 points vs. 5.8 points for higher language skills). Conclusion This suggests these IQ tests are not interchangeable and language demands may produce different results that could impact clinician interpretation. Both clinicians and researchers should be aware of the likely impact of adopting primarily verbal vs. nonverbal tests when assessing children with ASD, especially those with less language. En ligne : https://doi.org/10.1016/j.rasd.2018.02.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=340 [article] Differences in verbal and nonverbal IQ test scores in children with autism spectrum disorder [texte imprimé] / Sabrina N. GRONDHUIS, Auteur ; Luc LECAVALIER, Auteur ; L. Eugene ARNOLD, Auteur ; Benjamin L. HANDEN, Auteur ; Lawrence SCAHILL, Auteur ; Christopher J. MCDOUGLE, Auteur ; Michael G. AMAN, Auteur . - p.47-55. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 49 (May 2018) . - p.47-55 Mots-clés : Autism spectrum disorder  ASD  Intelligence  IQ  Language  Assessment Index. décimale : PER Périodiques Résumé : Background Intelligence tests are a fundamental component of diagnostic assessments for children with suspected autism spectrum disorder (ASD). There are many assessments available, but scores across tests may not be comparable in children with ASD. Method Eighty children (68 boys) age 4–14 years with ASD completed the Stanford-Binet Intelligence Scales, 5th Edition (SB5), a verbal measure of intelligence, and the Leiter International Performance Scale – Revised (Leiter-R), a nonverbal measure of intelligence. Results Although discrepancies went in both directions, we found significantly higher mean scores on the Leiter-R than SB5 (9.6 point difference). Children younger than 8 years had more pronounced discrepancies (13.8 points vs. 3.5 points for >8 years), and children with less-developed language skills had greater discrepancies (13.1 points vs. 5.8 points for higher language skills). Conclusion This suggests these IQ tests are not interchangeable and language demands may produce different results that could impact clinician interpretation. Both clinicians and researchers should be aware of the likely impact of adopting primarily verbal vs. nonverbal tests when assessing children with ASD, especially those with less language. En ligne : https://doi.org/10.1016/j.rasd.2018.02.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=340

Direct observation in a large-scale randomized trial of parent training in children with autism spectrum disorder and disruptive behavior / Naomi SWIEZY in Research in Autism Spectrum Disorders, 89 (November 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 89 (November 2021) . - 101879 Titre : Direct observation in a large-scale randomized trial of parent training in children with autism spectrum disorder and disruptive behavior Type de document : texte imprimé Auteurs : Naomi SWIEZY, Auteur ; Tristram SMITH, Auteur ; Cindy R. JOHNSON, Auteur ; Karen E. BEARSS, Auteur ; Luc LECAVALIER, Auteur ; Rochelle DRILL, Auteur ; Danielle WARNER, Auteur ; Yanhong DENG, Auteur ; Yunshan XU, Auteur ; James DZIURA, Auteur ; Benjamin L. HANDEN, Auteur ; Lawrence SCAHILL, Auteur Article en page(s) : 101879 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder (ASD)  Direct observation  Behavioral assessment  Behavioral intervention  Randomized Control Trial (RCT)  Parent and caregiver training Index. décimale : PER Périodiques Résumé : A direct observation strategy (Standardized Observation Analogue Procedure, SOAP) was used in a large-scale randomized trial of parent training versus parent education in young children with autism spectrum disorder (ASD) and disruptive behavior. The 16-minute SOAP, modified from an earlier version of this same measure, included parentchild interaction to assess child behavior in a clinical laboratory setting. Despite study entry criteria for all child participants requiring moderate levels of disruptive behavior in this project, 126 of 168 children with complete SOAP data at baseline showed no disruptive behavior on this measure. Although the primary purpose of the study was to determine whether the SOAP could detect differences between the two conditions (i.e.,parent training (PT) and parent education (PE)), baseline observation data was not consistent with parent ratings at baseline or subsequent follow up visits, leaving little room to demonstrate improvement with this observation measure. This and the challenging, time-consuming and resource intensive effort involved in using such a measure in a large randomized scale trial, raises fundamental questions about the validity of the SOAP as an outcome measure in such a study. Further consideration related to the feasibility and practicality of using direct observation as a primary measure in larger scale efforts overall are also discussed. En ligne : https://doi.org/10.1016/j.rasd.2021.101879 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Direct observation in a large-scale randomized trial of parent training in children with autism spectrum disorder and disruptive behavior [texte imprimé] / Naomi SWIEZY, Auteur ; Tristram SMITH, Auteur ; Cindy R. JOHNSON, Auteur ; Karen E. BEARSS, Auteur ; Luc LECAVALIER, Auteur ; Rochelle DRILL, Auteur ; Danielle WARNER, Auteur ; Yanhong DENG, Auteur ; Yunshan XU, Auteur ; James DZIURA, Auteur ; Benjamin L. HANDEN, Auteur ; Lawrence SCAHILL, Auteur . - 101879. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 89 (November 2021) . - 101879 Mots-clés : Autism spectrum disorder (ASD)  Direct observation  Behavioral assessment  Behavioral intervention  Randomized Control Trial (RCT)  Parent and caregiver training Index. décimale : PER Périodiques Résumé : A direct observation strategy (Standardized Observation Analogue Procedure, SOAP) was used in a large-scale randomized trial of parent training versus parent education in young children with autism spectrum disorder (ASD) and disruptive behavior. The 16-minute SOAP, modified from an earlier version of this same measure, included parentchild interaction to assess child behavior in a clinical laboratory setting. Despite study entry criteria for all child participants requiring moderate levels of disruptive behavior in this project, 126 of 168 children with complete SOAP data at baseline showed no disruptive behavior on this measure. Although the primary purpose of the study was to determine whether the SOAP could detect differences between the two conditions (i.e.,parent training (PT) and parent education (PE)), baseline observation data was not consistent with parent ratings at baseline or subsequent follow up visits, leaving little room to demonstrate improvement with this observation measure. This and the challenging, time-consuming and resource intensive effort involved in using such a measure in a large randomized scale trial, raises fundamental questions about the validity of the SOAP as an outcome measure in such a study. Further consideration related to the feasibility and practicality of using direct observation as a primary measure in larger scale efforts overall are also discussed. En ligne : https://doi.org/10.1016/j.rasd.2021.101879 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

A Double-Blind, Placebo-Controlled Trial of Oral Human Immunoglobulin for Gastrointestinal Dysfunction in Children with Autistic Disorder / Benjamin L. HANDEN in Journal of Autism and Developmental Disorders, 39-5 (May 2009)  

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Factors associated with DSM-5 severity level ratings for autism spectrum disorder / Micah O. MAZUREK in Autism, 23-2 (February 2019)  

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Measuring Anxiety as a Treatment Endpoint in Youth with Autism Spectrum Disorder / Luc LECAVALIER in Journal of Autism and Developmental Disorders, 44-5 (May 2014)  

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Measuring repetitive behaviors as a treatment endpoint in youth with autism spectrum disorder / Lawrence SCAHILL in Autism, 19-1 (January 2015)  

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A multisite trial of atomoxetine and parent training in children with autism spectrum disorders: Rationale and design challenges / Laura SILVERMAN in Research in Autism Spectrum Disorders, 8-7 (July 2014)  

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Parent Stress in a Randomized Clinical Trial of Atomoxetine and Parent Training for Children with Autism Spectrum Disorder / L. LECAVALIER in Journal of Autism and Developmental Disorders, 48-4 (April 2018)  

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Parent Training for Disruptive Behavior. The RUBI Autism Network, Clinician Manual / Karen E. BEARSS

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Parent Training for Disruptive Behavior. The RUBI Autism Network, Parent Workbook / Karen E. BEARSS

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A Pilot Study of Parent Training in Young Children with Autism Spectrum Disorders and Disruptive Behavior / Karen E. BEARSS in Journal of Autism and Developmental Disorders, 43-4 (April 2013)  

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Practitioner Review: Psychopharmacology in children and adolescents with mental retardation / Benjamin L. HANDEN in Journal of Child Psychology and Psychiatry, 47-9 (September 2006)  

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