Caregiver-Mediated Early Support Program Delivered Online Versus Care-as-Usual for Infants at Elevated Familial Likelihood for Autism: A Parallel, Assessor Masked, Feasibility Randomized Controlled Trial in India / Shoba S. MEERA in Autism Research, 18-11 (November 2025)  

Public ISBD [article]  inAutism Research > 18-11 (November 2025) . - p.2345-2355 Titre : Caregiver-Mediated Early Support Program Delivered Online Versus Care-as-Usual for Infants at Elevated Familial Likelihood for Autism: A Parallel, Assessor Masked, Feasibility Randomized Controlled Trial in India Type de document : texte imprimé Auteurs : Shoba S. MEERA, Auteur ; Prathyusha VASUKI, Auteur ; Malavi SRIKAR, Auteur ; Reny RAJU, Auteur ; Divya SWAMINATHAN, Auteur ; Shree VOLME, Auteur ; Rachel Elizabeth JOHNSON, Auteur ; Linda R. WATSON, Auteur ; Andrew WHITEHOUSE, Auteur ; Mirko ULJAREVIĆ, Auteur ; Ming Wai WAN, Auteur ; John Vijay SAGAR, Auteur ; Deepa Bhat NAIR, Auteur Article en page(s) : p.2345-2355 Langues : Anglais (eng) Mots-clés : autism  caregiver responsiveness  early intervention  India  infant siblings  LiL' STEPS  online intervention Index. décimale : PER Périodiques Résumé : ABSTRACT LiL' STEPS (Language development n?=?12) using fixed block randomization. While families in the former group received the LiL' STEPS early support program, those in the latter did not avail themselves of any early supports. Assessors were masked to group status. The primary outcome was caregiver sensitive responsiveness, assessed using the Manchester Assessment for Caregiver-Infant Interaction (MACI). Secondary outcomes included caregiver-reported measures of social communication and language. Outcomes were measured at three time points: baseline (T1), 12?weeks post-baseline (T2), and 12?weeks after program completion (T3). Intention-to-treat analyses were performed using linear mixed models. No significant treatment effects were found between baseline (T1) and endpoint (T3) on the primary or secondary outcomes. However, significant, large, positive treatment effects were observed for caregiver sensitive responsiveness (??=?1.48; 95% CI?=?0.51?2.34; d?=?1.15) and dyadic mutuality (??=?1.22; 95% CI?=?0.03?2.15; d?=?1.01) between baseline (T1) and T2, highlighting the need for ongoing support between T2 and T3?a key direction for future large scale efficacy trials. En ligne : https://doi.org/10.1002/aur.70116 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Caregiver-Mediated Early Support Program Delivered Online Versus Care-as-Usual for Infants at Elevated Familial Likelihood for Autism: A Parallel, Assessor Masked, Feasibility Randomized Controlled Trial in India [texte imprimé] / Shoba S. MEERA, Auteur ; Prathyusha VASUKI, Auteur ; Malavi SRIKAR, Auteur ; Reny RAJU, Auteur ; Divya SWAMINATHAN, Auteur ; Shree VOLME, Auteur ; Rachel Elizabeth JOHNSON, Auteur ; Linda R. WATSON, Auteur ; Andrew WHITEHOUSE, Auteur ; Mirko ULJAREVIĆ, Auteur ; Ming Wai WAN, Auteur ; John Vijay SAGAR, Auteur ; Deepa Bhat NAIR, Auteur . - p.2345-2355. Langues : Anglais (eng) in Autism Research > 18-11 (November 2025) . - p.2345-2355 Mots-clés : autism  caregiver responsiveness  early intervention  India  infant siblings  LiL' STEPS  online intervention Index. décimale : PER Périodiques Résumé : ABSTRACT LiL' STEPS (Language development n?=?12) using fixed block randomization. While families in the former group received the LiL' STEPS early support program, those in the latter did not avail themselves of any early supports. Assessors were masked to group status. The primary outcome was caregiver sensitive responsiveness, assessed using the Manchester Assessment for Caregiver-Infant Interaction (MACI). Secondary outcomes included caregiver-reported measures of social communication and language. Outcomes were measured at three time points: baseline (T1), 12?weeks post-baseline (T2), and 12?weeks after program completion (T3). Intention-to-treat analyses were performed using linear mixed models. No significant treatment effects were found between baseline (T1) and endpoint (T3) on the primary or secondary outcomes. However, significant, large, positive treatment effects were observed for caregiver sensitive responsiveness (??=?1.48; 95% CI?=?0.51?2.34; d?=?1.15) and dyadic mutuality (??=?1.22; 95% CI?=?0.03?2.15; d?=?1.01) between baseline (T1) and T2, highlighting the need for ongoing support between T2 and T3?a key direction for future large scale efficacy trials. En ligne : https://doi.org/10.1002/aur.70116 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

Caregiver sensitivity predicts infant language use, and infant language complexity predicts caregiver language complexity, in the context of possible emerging autism / Jodie SMITH in Autism Research, 16-4 (April 2023)  

Public ISBD [article]  inAutism Research > 16-4 (April 2023) . - p.745-756 Titre : Caregiver sensitivity predicts infant language use, and infant language complexity predicts caregiver language complexity, in the context of possible emerging autism Type de document : texte imprimé Auteurs : Jodie SMITH, Auteur ; Lacey CHETCUTI, Auteur ; Lyndel KENNEDY, Auteur ; Kandice J. VARCIN, Auteur ; Vicky SLONIMS, Auteur ; Catherine A. BENT, Auteur ; Jonathan GREEN, Auteur ; Teresa IACONO, Auteur ; Sarah PILLAR, Auteur ; Carol TAYLOR, Auteur ; Ming Wai WAN, Auteur ; Andrew J.O. WHITEHOUSE, Auteur ; Kristelle HUDRY, Auteur ; The AICES TEAM, Auteur Article en page(s) : p.745-756 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract While theory supports bidirectional effects between caregiver sensitivity and language use, and infant language acquisition-both caregiver-to-infant and also infant-to-caregiver effects-empirical research has chiefly explored the former unidirectional path. In the context of infants showing early signs of autism, we investigated prospective bidirectional associations with 6-min free-play interaction samples collected for 103 caregivers and their infants (mean age 12-months; and followed up 6-months later). We anticipated that measures of caregiver sensitivity/language input and infant language would show within-domain temporal stability/continuity, but also that there would be predictive associations from earlier caregiver input to subsequent child language, and vice versa. Caregiver sensitive responsiveness (from the Manchester Assessment of Caregiver-Infant interaction [MACI]) predicted subsequent infant word tokens (i.e., amount of language, coded following the Systematic Analysis of Language Transcripts [SALT]). Further, earlier infant Mean Length of Utterance (MLU; reflecting language complexity, also derived from SALT coding) predicted later caregiver MLU, even when controlling for variability in infant ages and clear within-domain temporal stability/continuity in key measures (i.e., caregiver sensitive responsiveness and infant word tokens; and infant and caregiver MLU). These data add empirical support to theorization on how caregiver input can be both supportive of, and potentially influenced by, infant capacities, when infants have social-communication differences and/or communication/language delays suggestive of possible emerging autism. En ligne : https://doi.org/10.1002/aur.2879 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499 [article] Caregiver sensitivity predicts infant language use, and infant language complexity predicts caregiver language complexity, in the context of possible emerging autism [texte imprimé] / Jodie SMITH, Auteur ; Lacey CHETCUTI, Auteur ; Lyndel KENNEDY, Auteur ; Kandice J. VARCIN, Auteur ; Vicky SLONIMS, Auteur ; Catherine A. BENT, Auteur ; Jonathan GREEN, Auteur ; Teresa IACONO, Auteur ; Sarah PILLAR, Auteur ; Carol TAYLOR, Auteur ; Ming Wai WAN, Auteur ; Andrew J.O. WHITEHOUSE, Auteur ; Kristelle HUDRY, Auteur ; The AICES TEAM, Auteur . - p.745-756. Langues : Anglais (eng) in Autism Research > 16-4 (April 2023) . - p.745-756 Index. décimale : PER Périodiques Résumé : Abstract While theory supports bidirectional effects between caregiver sensitivity and language use, and infant language acquisition-both caregiver-to-infant and also infant-to-caregiver effects-empirical research has chiefly explored the former unidirectional path. In the context of infants showing early signs of autism, we investigated prospective bidirectional associations with 6-min free-play interaction samples collected for 103 caregivers and their infants (mean age 12-months; and followed up 6-months later). We anticipated that measures of caregiver sensitivity/language input and infant language would show within-domain temporal stability/continuity, but also that there would be predictive associations from earlier caregiver input to subsequent child language, and vice versa. Caregiver sensitive responsiveness (from the Manchester Assessment of Caregiver-Infant interaction [MACI]) predicted subsequent infant word tokens (i.e., amount of language, coded following the Systematic Analysis of Language Transcripts [SALT]). Further, earlier infant Mean Length of Utterance (MLU; reflecting language complexity, also derived from SALT coding) predicted later caregiver MLU, even when controlling for variability in infant ages and clear within-domain temporal stability/continuity in key measures (i.e., caregiver sensitive responsiveness and infant word tokens; and infant and caregiver MLU). These data add empirical support to theorization on how caregiver input can be both supportive of, and potentially influenced by, infant capacities, when infants have social-communication differences and/or communication/language delays suggestive of possible emerging autism. En ligne : https://doi.org/10.1002/aur.2879 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499

Infant Neural Sensitivity to Dynamic Eye Gaze Relates to Quality of Parent–Infant Interaction at 7-Months in Infants at Risk for Autism / Mayada ELSABBAGH in Journal of Autism and Developmental Disorders, 45-2 (February 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.283-291 Titre : Infant Neural Sensitivity to Dynamic Eye Gaze Relates to Quality of Parent–Infant Interaction at 7-Months in Infants at Risk for Autism Type de document : texte imprimé Auteurs : Mayada ELSABBAGH, Auteur ; Ruth BRUNO, Auteur ; Ming Wai WAN, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; Jonathan GREEN, Auteur Article en page(s) : p.283-291 Langues : Anglais (eng) Mots-clés : Infant  Autism  Interaction  EEG  Familial risk  Prospective study Index. décimale : PER Périodiques Résumé : Links between brain function measures and quality of parent–child interactions within the early developmental period have been investigated in typical and atypical development. We examined such links in a group of 104 infants with and without a family history for autism in the first year of life. Our findings suggest robust associations between event related potential responses to eye gaze and observed parent–infant interaction measures. In both groups, infants with more positive affect exhibit stronger differentiation to gaze stimuli. This association was observed with the earlier P100 waveform component in the control group but with the later P400 component in infants at-risk. These exploratory findings are critical in paving the way for a better understanding of how infant laboratory measures may relate to overt behavior and how both can be combined in the context of predicting risk or clinical diagnosis in toddlerhood. En ligne : http://dx.doi.org/10.1007/s10803-014-2192-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Infant Neural Sensitivity to Dynamic Eye Gaze Relates to Quality of Parent–Infant Interaction at 7-Months in Infants at Risk for Autism [texte imprimé] / Mayada ELSABBAGH, Auteur ; Ruth BRUNO, Auteur ; Ming Wai WAN, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; Jonathan GREEN, Auteur . - p.283-291. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.283-291 Mots-clés : Infant  Autism  Interaction  EEG  Familial risk  Prospective study Index. décimale : PER Périodiques Résumé : Links between brain function measures and quality of parent–child interactions within the early developmental period have been investigated in typical and atypical development. We examined such links in a group of 104 infants with and without a family history for autism in the first year of life. Our findings suggest robust associations between event related potential responses to eye gaze and observed parent–infant interaction measures. In both groups, infants with more positive affect exhibit stronger differentiation to gaze stimuli. This association was observed with the earlier P100 waveform component in the control group but with the later P400 component in infants at-risk. These exploratory findings are critical in paving the way for a better understanding of how infant laboratory measures may relate to overt behavior and how both can be combined in the context of predicting risk or clinical diagnosis in toddlerhood. En ligne : http://dx.doi.org/10.1007/s10803-014-2192-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

Intervention for Infants at Risk of Developing Autism: A Case Series / Jonathan GREEN in Journal of Autism and Developmental Disorders, 43-11 (November 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2502-2514 Titre : Intervention for Infants at Risk of Developing Autism: A Case Series Type de document : texte imprimé Auteurs : Jonathan GREEN, Auteur ; Ming Wai WAN, Auteur ; Jeanne GUIRAUD, Auteur ; Samina HOLSGROVE, Auteur ; Janet MCNALLY, Auteur ; Vicky SLONIMS, Auteur ; Mayada ELSABBAGH, Auteur ; Tony CHARMAN, Auteur ; Andrew PICKLES, Auteur ; Mark H. JOHNSON, Auteur Article en page(s) : p.2502-2514 Langues : Anglais (eng) Mots-clés : Autism  Intervention  Prodromal  Infancy  Parent–child interaction Index. décimale : PER Périodiques Résumé : Theory and evidence suggest the potential value of prodromal intervention for infants at risk of developing autism. We report an initial case series (n = 8) of a parent-mediated, video-aided and interaction-focused intervention with infant siblings of autistic probands, beginning at 8–10 months of age. We outline the theory and evidence base behind this model and present data on feasibility, acceptability and measures ranging from parent-infant social interaction, to infant atypical behaviors, attention and cognition. The intervention proves to be both feasible and acceptable to families. Measurement across domains was successful and on larger samples promise to be an effective test of whether such an intervention in infancy will modify emergent atypical developmental trajectories in infants at risk for autism. En ligne : http://dx.doi.org/10.1007/s10803-013-1797-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217 [article] Intervention for Infants at Risk of Developing Autism: A Case Series [texte imprimé] / Jonathan GREEN, Auteur ; Ming Wai WAN, Auteur ; Jeanne GUIRAUD, Auteur ; Samina HOLSGROVE, Auteur ; Janet MCNALLY, Auteur ; Vicky SLONIMS, Auteur ; Mayada ELSABBAGH, Auteur ; Tony CHARMAN, Auteur ; Andrew PICKLES, Auteur ; Mark H. JOHNSON, Auteur . - p.2502-2514. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2502-2514 Mots-clés : Autism  Intervention  Prodromal  Infancy  Parent–child interaction Index. décimale : PER Périodiques Résumé : Theory and evidence suggest the potential value of prodromal intervention for infants at risk of developing autism. We report an initial case series (n = 8) of a parent-mediated, video-aided and interaction-focused intervention with infant siblings of autistic probands, beginning at 8–10 months of age. We outline the theory and evidence base behind this model and present data on feasibility, acceptability and measures ranging from parent-infant social interaction, to infant atypical behaviors, attention and cognition. The intervention proves to be both feasible and acceptable to families. Measurement across domains was successful and on larger samples promise to be an effective test of whether such an intervention in infancy will modify emergent atypical developmental trajectories in infants at risk for autism. En ligne : http://dx.doi.org/10.1007/s10803-013-1797-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217

Negative and atypical story content themes depicted by children with behaviour problems / Ming Wai WAN in Journal of Child Psychology and Psychiatry, 51-10 (October 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-10 (October 2010) . - p.1125-1131 Titre : Negative and atypical story content themes depicted by children with behaviour problems Type de document : texte imprimé Auteurs : Ming Wai WAN, Auteur ; Jonathan GREEN, Auteur Année de publication : 2010 Article en page(s) : p.1125-1131 Langues : Anglais (eng) Mots-clés : Conduct-disorder maternal-depression doll-play mother–child-relations story-stems Index. décimale : PER Périodiques Résumé : Keywords:Conduct disorder;maternal depression;doll play;mother–child relations;story stems Background:  Specific thematic content arising from children’s doll play is often considered to give clinically meaningful information regarding their mental state, but has received little systematic enquiry. This exploratory study examined the negative and atypical content themes in the attachment story narratives of children with behaviour problems, and their associations with child symptomatology and parental depressed mood. Method:  Videotaped mother–child attachment doll play completions of 77 children from a clinical sample were blind coded for negative content themes. Mothers completed questionnaires for maternal depression and child behaviour. Results:  Children rating positive for behaviour disorder were more likely to represent maternal injury, role reversal and marked maternal sadness. Severe behavioural symptoms were associated with more pervasive negative themes. Half of the overall sample depicted child accidents and maternal unresponsiveness, whereas child aggression, child anger and maternal absence were rare. Girls with depressed mothers showed an absence of particular negative representations (e.g., child sadness) compared to boys. Conclusions:  Specific atypical themes are associated with the extent of child psychopathology and may be modified by exposure to maternal depressed mood. The methodological limitations in this exploratory study are also discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02239.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=110 [article] Negative and atypical story content themes depicted by children with behaviour problems [texte imprimé] / Ming Wai WAN, Auteur ; Jonathan GREEN, Auteur . - 2010 . - p.1125-1131. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-10 (October 2010) . - p.1125-1131 Mots-clés : Conduct-disorder maternal-depression doll-play mother–child-relations story-stems Index. décimale : PER Périodiques Résumé : Keywords:Conduct disorder;maternal depression;doll play;mother–child relations;story stems Background:  Specific thematic content arising from children’s doll play is often considered to give clinically meaningful information regarding their mental state, but has received little systematic enquiry. This exploratory study examined the negative and atypical content themes in the attachment story narratives of children with behaviour problems, and their associations with child symptomatology and parental depressed mood. Method:  Videotaped mother–child attachment doll play completions of 77 children from a clinical sample were blind coded for negative content themes. Mothers completed questionnaires for maternal depression and child behaviour. Results:  Children rating positive for behaviour disorder were more likely to represent maternal injury, role reversal and marked maternal sadness. Severe behavioural symptoms were associated with more pervasive negative themes. Half of the overall sample depicted child accidents and maternal unresponsiveness, whereas child aggression, child anger and maternal absence were rare. Girls with depressed mothers showed an absence of particular negative representations (e.g., child sadness) compared to boys. Conclusions:  Specific atypical themes are associated with the extent of child psychopathology and may be modified by exposure to maternal depressed mood. The methodological limitations in this exploratory study are also discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02239.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=110

Parent-Child Interactions May Help to Explain Relations Between Parent Characteristics and Clinically Observed Child Autistic Behaviours / Murray T. MAYBERY ; Josephine BARBARO ; Cheryl DISSANAYAKE ; Jonathan GREEN ; Kristelle HUDRY ; Teresa IACONO ; Vicky SLONIMS ; Kandice J. VARCIN ; Ming Wai WAN ; John WRAY ; Andrew J.O. WHITEHOUSE in Journal of Autism and Developmental Disorders, 54-7 (July 2024)  

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Parent-infant interaction trajectories in infants with an elevated likelihood for autism in relation to 3-year clinical outcome / Eirini PAPAGEORGOPOULOU in Autism Research, 17-10 (October 2024)  

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Parent-mediated intervention in infants with an elevated likelihood for autism reduces dwell time during a gaze-following task / Rachael BEDFORD in Autism Research, 17-11 (November 2024)  

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Quality of interaction between at-risk infants and caregiver at 12–15 months is associated with 3-year autism outcome / Ming Wai WAN in Journal of Child Psychology and Psychiatry, 54-7 (July 2013)  

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Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years / Jonathan GREEN in Journal of Child Psychology and Psychiatry, 58-12 (December 2017)  

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Subgroups of Temperament Associated with Social-Emotional Difficulties in Infants with Early Signs of Autism / Lacey CHETCUTI in Autism Research, 13-12 (December 2020)  

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The Role of Negative Affectivity in Concurrent Relations Between Caregiver Psychological Distress and Social-Emotional Difficulties in Infants With Early Signs of Autism / Lacey CHETCUTI in Autism Research, 13-8 (August 2020)  

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Which emerging autism features at 12 months of age are associated with later parent-child interaction? / Chengcheng KE in Research in Autism Spectrum Disorders, 119 (January 2025)  

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