Altered immune function associated with disordered neural connectivity and executive dysfunctions: A neurophysiological study on children with autism spectrum disorders / Yvonne M.Y. HAN in Research in Autism Spectrum Disorders, 7-6 (June 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-6 (June 2013) . - p.662-674 Titre : Altered immune function associated with disordered neural connectivity and executive dysfunctions: A neurophysiological study on children with autism spectrum disorders Type de document : texte imprimé Auteurs : Yvonne M.Y. HAN, Auteur ; Agnes S. CHAN, Auteur ; Sophia L. SZE, Auteur ; Mei-chun CHEUNG, Auteur ; Chun Kwok WONG, Auteur ; Joseph M.K. LAM, Auteur ; Priscilla M.K. POON, Auteur Article en page(s) : p.662-674 Langues : Anglais (eng) Mots-clés : EEG coherence  Immunologic function  Executive dysfunction  Autism  Children Index. décimale : PER Périodiques Résumé : Previous studies have shown that children with autism spectrum disorders (ASDs) have impaired executive function, disordered neural connectivity, and abnormal immunologic function. The present study examined whether these abnormalities were associated. Seventeen high-functioning (HFA) and 17 low-functioning (LFA) children with ASD, aged 8–17 years, participated voluntarily in the study. The two groups of children were compared on their general intelligence in terms of IQ; executive function as measured by the Hong Kong List Learning Test, D2 Test of Concentration, Five Point Test, Children's Color Trail Test, Tower of California Test, and Go/No-Go task; a non-executive task as measured by the Picture Completion Task; neural connectivity as measured by theta coherence in the anterior and posterior regions; and immunologic function as measured by the level of circulating CD3+ CD8+ suppressor/cytotoxic T lymphocytes in a blood sample. Results on executive function showed that LFA children performed significantly poorer than HFA children as shown on their lower Executive Composite as well as individual executive function scores. However, there was no group difference on the Picture Completion Task. Results on neural connectivity showed that LFA children demonstrated a different pattern of electroencephalography (EEG) coherence from HFA children as shown in the significantly elevated theta coherence in the anterior network, as well as at the left intra-hemispheric (LA-LP) and right-to-left inter-hemisphere (RA-LP) connections of LFA children. In immunologic function, results showed that LFA children had significantly elevated level of suppressor/cytotoxic T lymphocytes (CD3+ CD8+) (p lt; 0.05). In addition, the executive dysfunction, disordered neural connectivity, and abnormal immunologic function were found to be associated. These results provided some initial evidence to support the notion that immunologic factors are associated with neuronal damage, measureable by EEG coherence and manifested as executive dysfunctions. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.02.011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=199 [article] Altered immune function associated with disordered neural connectivity and executive dysfunctions: A neurophysiological study on children with autism spectrum disorders [texte imprimé] / Yvonne M.Y. HAN, Auteur ; Agnes S. CHAN, Auteur ; Sophia L. SZE, Auteur ; Mei-chun CHEUNG, Auteur ; Chun Kwok WONG, Auteur ; Joseph M.K. LAM, Auteur ; Priscilla M.K. POON, Auteur . - p.662-674. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 7-6 (June 2013) . - p.662-674 Mots-clés : EEG coherence  Immunologic function  Executive dysfunction  Autism  Children Index. décimale : PER Périodiques Résumé : Previous studies have shown that children with autism spectrum disorders (ASDs) have impaired executive function, disordered neural connectivity, and abnormal immunologic function. The present study examined whether these abnormalities were associated. Seventeen high-functioning (HFA) and 17 low-functioning (LFA) children with ASD, aged 8–17 years, participated voluntarily in the study. The two groups of children were compared on their general intelligence in terms of IQ; executive function as measured by the Hong Kong List Learning Test, D2 Test of Concentration, Five Point Test, Children's Color Trail Test, Tower of California Test, and Go/No-Go task; a non-executive task as measured by the Picture Completion Task; neural connectivity as measured by theta coherence in the anterior and posterior regions; and immunologic function as measured by the level of circulating CD3+ CD8+ suppressor/cytotoxic T lymphocytes in a blood sample. Results on executive function showed that LFA children performed significantly poorer than HFA children as shown on their lower Executive Composite as well as individual executive function scores. However, there was no group difference on the Picture Completion Task. Results on neural connectivity showed that LFA children demonstrated a different pattern of electroencephalography (EEG) coherence from HFA children as shown in the significantly elevated theta coherence in the anterior network, as well as at the left intra-hemispheric (LA-LP) and right-to-left inter-hemisphere (RA-LP) connections of LFA children. In immunologic function, results showed that LFA children had significantly elevated level of suppressor/cytotoxic T lymphocytes (CD3+ CD8+) (p lt; 0.05). In addition, the executive dysfunction, disordered neural connectivity, and abnormal immunologic function were found to be associated. These results provided some initial evidence to support the notion that immunologic factors are associated with neuronal damage, measureable by EEG coherence and manifested as executive dysfunctions. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.02.011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=199

Covid-19, social restrictions, and mental distress among young people: a UK longitudinal, population-based study / Gemma KNOWLES in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1392-1404 Titre : Covid-19, social restrictions, and mental distress among young people: a UK longitudinal, population-based study Type de document : texte imprimé Auteurs : Gemma KNOWLES, Auteur ; Charlotte GAYER-ANDERSON, Auteur ; Alice TURNER, Auteur ; Lynsey DORN, Auteur ; Joseph M.K. LAM, Auteur ; Samantha DAVIS, Auteur ; Rachel BLAKEY, Auteur ; Katie LOWIS, Auteur ; SCHOOLS WORKING GROUP, Auteur ; YOUNG PERSONS ADVISORY GROUP, Auteur ; Vanessa PINFOLD, Auteur ; Natalie CREARY, Auteur ; Jacqui DYER, Auteur ; Stephani L. HATCH, Auteur ; George B. PLOUBIDIS, Auteur ; Kamaldeep BHUI, Auteur ; Seeromanie HARDING, Auteur ; Craig MORGAN, Auteur Article en page(s) : p.1392-1404 Langues : Anglais (eng) Mots-clés : Adolescent  Male  Female  Humans  Child  covid-19  Communicable Disease Control  Pandemics  Mental Disorders/epidemiology  Mental Health  Covid-19  adolescence  cohort  mental distress Index. décimale : PER Périodiques Résumé : BACKGROUND: Adolescence is a critical period for social and emotional development. We sought to examine the impacts of Covid-19 and related social restrictions and school closures on adolescent mental health, particularly among disadvantaged, marginalised, and vulnerable groups. METHODS: We analysed four waves of data - 3 pre-Covid-19 (2016-2019) and 1 mid-Covid-19 (May-Aug 2020; n, 1074; 12-18 years old,>80% minority ethnic groups, 25% free school meals) from REACH (Resilience, Ethnicity, and AdolesCent Mental Health), an adolescent cohort based in inner-London, United Kingdom. Mental health was assessed using validated measures at each time point. We estimated temporal trends in mental distress and examined variations in changes in distress, pre- to mid-Covid-19, by social group, and by pre- and mid-pandemic risks. RESULTS: We found no evidence of an overall increase in mental distress midpandemic (15.9%, 95% CI: 13.0, 19.4) compared with prepandemic (around 18%). However, there were variations in changes in mental distress by subgroups. There were modest variations by social group and by pre-Covid risks (e.g., a small increase in distress among girls (b [unstandardised beta coefficient] 0.42 [-0.19, 1.03]); a small decrease among boys (b - 0.59 [-1.37, 0.19]); p for interaction .007). The most notable variations were by midpandemic risks: that is, broadly, increases in distress among those reporting negative circumstances and impacts (e.g., in finances, housing, social support and relationships, and daily routines) and decreases in distress among those reporting positive impacts. CONCLUSIONS: We found strong evidence that mental distress increased among young people who were most negatively impacted by Covid-19 and by related social restrictions during the first lockdown in the United Kingdom. En ligne : http://dx.doi.org/10.1111/jcpp.13586 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Covid-19, social restrictions, and mental distress among young people: a UK longitudinal, population-based study [texte imprimé] / Gemma KNOWLES, Auteur ; Charlotte GAYER-ANDERSON, Auteur ; Alice TURNER, Auteur ; Lynsey DORN, Auteur ; Joseph M.K. LAM, Auteur ; Samantha DAVIS, Auteur ; Rachel BLAKEY, Auteur ; Katie LOWIS, Auteur ; SCHOOLS WORKING GROUP, Auteur ; YOUNG PERSONS ADVISORY GROUP, Auteur ; Vanessa PINFOLD, Auteur ; Natalie CREARY, Auteur ; Jacqui DYER, Auteur ; Stephani L. HATCH, Auteur ; George B. PLOUBIDIS, Auteur ; Kamaldeep BHUI, Auteur ; Seeromanie HARDING, Auteur ; Craig MORGAN, Auteur . - p.1392-1404. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1392-1404 Mots-clés : Adolescent  Male  Female  Humans  Child  covid-19  Communicable Disease Control  Pandemics  Mental Disorders/epidemiology  Mental Health  Covid-19  adolescence  cohort  mental distress Index. décimale : PER Périodiques Résumé : BACKGROUND: Adolescence is a critical period for social and emotional development. We sought to examine the impacts of Covid-19 and related social restrictions and school closures on adolescent mental health, particularly among disadvantaged, marginalised, and vulnerable groups. METHODS: We analysed four waves of data - 3 pre-Covid-19 (2016-2019) and 1 mid-Covid-19 (May-Aug 2020; n, 1074; 12-18 years old,>80% minority ethnic groups, 25% free school meals) from REACH (Resilience, Ethnicity, and AdolesCent Mental Health), an adolescent cohort based in inner-London, United Kingdom. Mental health was assessed using validated measures at each time point. We estimated temporal trends in mental distress and examined variations in changes in distress, pre- to mid-Covid-19, by social group, and by pre- and mid-pandemic risks. RESULTS: We found no evidence of an overall increase in mental distress midpandemic (15.9%, 95% CI: 13.0, 19.4) compared with prepandemic (around 18%). However, there were variations in changes in mental distress by subgroups. There were modest variations by social group and by pre-Covid risks (e.g., a small increase in distress among girls (b [unstandardised beta coefficient] 0.42 [-0.19, 1.03]); a small decrease among boys (b - 0.59 [-1.37, 0.19]); p for interaction .007). The most notable variations were by midpandemic risks: that is, broadly, increases in distress among those reporting negative circumstances and impacts (e.g., in finances, housing, social support and relationships, and daily routines) and decreases in distress among those reporting positive impacts. CONCLUSIONS: We found strong evidence that mental distress increased among young people who were most negatively impacted by Covid-19 and by related social restrictions during the first lockdown in the United Kingdom. En ligne : http://dx.doi.org/10.1111/jcpp.13586 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Lymphocyte subset alterations related to executive function deficits and repetitive stereotyped behavior in autism / Yvonne M.Y. HAN in Research in Autism Spectrum Disorders, 5-1 (January-March 2011)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.486-494 Titre : Lymphocyte subset alterations related to executive function deficits and repetitive stereotyped behavior in autism Type de document : texte imprimé Auteurs : Yvonne M.Y. HAN, Auteur ; Agnes S. CHAN, Auteur ; Mei-chun CHEUNG, Auteur ; Winnie Wing-man LEUNG, Auteur ; Chun Kwok WONG, Auteur ; Joseph M.K. LAM, Auteur Année de publication : 2011 Article en page(s) : p.486-494 Langues : Anglais (eng) Mots-clés : Immune-function Neuropsychological-function Autism Index. décimale : PER Périodiques Résumé : Increasing evidence suggests that immunological factors are involved in the pathogenesis of autism spectrum disorders (ASD). The present study examined whether immunological abnormalities are associated with cognitive deficits in children with ASD. Eighteen high-functioning (HFA) and 19 low-functioning (LFA) children with ASD, aged 8–17 years, were assessed on cognitive functioning using IQ tests and executive functions tests including the Five Point test, Children Color Trail-making Test, D2 Test of Concentration, Tower of California Test; Hong Kong List Learning Test, and Go/No-Go test. They were also assessed on autoimmune symptoms, reported by their parents; and immunological measures including T lymphocytes (CD3+), B lymphocytes (CD19+), T helper lymphocytes (CD3+CD4+), suppressor/cytotoxic T lymphocytes (CD3+CD8+), and natural killer (NK) cells (CD3−CD16+ and/or CD56+). LFA children showed greater deficits in executive functions as well as higher levels of total lymphocyte, T lymphocyte and suppressor/cytotoxic T lymphocyte levels than HFA children (all p < 0.05). Their executive functions were also significantly associated with the three lymphocyte levels (all p < 0.05). These findings support the notion that altered immune functions may act on the neural tissues of individuals with ASD, which in turn leads to their cognitive dysfunctions. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.06.013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111 [article] Lymphocyte subset alterations related to executive function deficits and repetitive stereotyped behavior in autism [texte imprimé] / Yvonne M.Y. HAN, Auteur ; Agnes S. CHAN, Auteur ; Mei-chun CHEUNG, Auteur ; Winnie Wing-man LEUNG, Auteur ; Chun Kwok WONG, Auteur ; Joseph M.K. LAM, Auteur . - 2011 . - p.486-494. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.486-494 Mots-clés : Immune-function Neuropsychological-function Autism Index. décimale : PER Périodiques Résumé : Increasing evidence suggests that immunological factors are involved in the pathogenesis of autism spectrum disorders (ASD). The present study examined whether immunological abnormalities are associated with cognitive deficits in children with ASD. Eighteen high-functioning (HFA) and 19 low-functioning (LFA) children with ASD, aged 8–17 years, were assessed on cognitive functioning using IQ tests and executive functions tests including the Five Point test, Children Color Trail-making Test, D2 Test of Concentration, Tower of California Test; Hong Kong List Learning Test, and Go/No-Go test. They were also assessed on autoimmune symptoms, reported by their parents; and immunological measures including T lymphocytes (CD3+), B lymphocytes (CD19+), T helper lymphocytes (CD3+CD4+), suppressor/cytotoxic T lymphocytes (CD3+CD8+), and natural killer (NK) cells (CD3−CD16+ and/or CD56+). LFA children showed greater deficits in executive functions as well as higher levels of total lymphocyte, T lymphocyte and suppressor/cytotoxic T lymphocyte levels than HFA children (all p < 0.05). Their executive functions were also significantly associated with the three lymphocyte levels (all p < 0.05). These findings support the notion that altered immune functions may act on the neural tissues of individuals with ASD, which in turn leads to their cognitive dysfunctions. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.06.013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111

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