Behavioral Phenotype Associations With Resting State EEG Signal Complexity and Power Spectral Density in Fragile X Syndrome / Mélodie PROTEAU-LEMIEUX in Autism Research, 19-3 (March 2026)  

Public ISBD [article]  inAutism Research > 19-3 (March 2026) . - e70194 Titre : Behavioral Phenotype Associations With Resting State EEG Signal Complexity and Power Spectral Density in Fragile X Syndrome Type de document : texte imprimé Auteurs : Mélodie PROTEAU-LEMIEUX, Auteur ; Inga S. KNOTH, Auteur ; Saeideh DAVOUDI, Auteur ; Rae BUCKSER, Auteur ; Charles-Olivier MARTIN, Auteur ; Anne-Marie BÉLANGER, Auteur ; Valérie K. FONTAINE, Auteur ; Hazel Maridith Barlahan BIAG, Auteur ; Leonard ABBEDUTO, Auteur ; Sébastien JACQUEMONT, Auteur ; David HESSL, Auteur ; Randi J. HAGERMAN, Auteur ; Andrea SCHNEIDER, Auteur ; Francois V. BOLDUC, Auteur ; Sarah LIPPE, Auteur Article en page(s) : e70194 Langues : Anglais (eng) Mots-clés : behavior  cognition  EEG  fragile X syndrome  PSD  resting state  signal complexity Index. décimale : PER Périodiques Résumé : ABSTRACT Fragile X Syndrome (FXS), an X-linked genetic condition, is associated with a wide range of phenotypic manifestations, namely intellectual disability (ID), autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and atypical behaviors. Individuals with FXS present robust electrophysiological (EEG) alterations, notably on signal complexity and power spectral density (PSD) resting state measures. To which extent they are associated to specific behavioral phenotypes in the FXS population remains to be comprehensively addressed. This study aimed to investigate the relations between resting state EEG markers and the most frequently observed symptoms in FXS. EEG and behavioral data from 41 individuals with FXS aged between 7 and 34?years old were collected, and correlational approaches were used to analyze the associations between EEG markers and symptomatology. We observed positive associations between complexity in higher scales and non-verbal intelligence quotient (NVIQ). Reduced alpha power, a robust biomarker in FXS, was associated with more social avoidance, a hallmark in FXS. Decreased high gamma power was linked to hyperactive symptoms. Our results suggest powerful relations between known biomarkers and core symptoms in FXS, highlighting that EEG biomarkers correspond to symptom severity which further supports their potential as objective, translational treatment outcome measures. En ligne : https://doi.org/10.1002/aur.70194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Behavioral Phenotype Associations With Resting State EEG Signal Complexity and Power Spectral Density in Fragile X Syndrome [texte imprimé] / Mélodie PROTEAU-LEMIEUX, Auteur ; Inga S. KNOTH, Auteur ; Saeideh DAVOUDI, Auteur ; Rae BUCKSER, Auteur ; Charles-Olivier MARTIN, Auteur ; Anne-Marie BÉLANGER, Auteur ; Valérie K. FONTAINE, Auteur ; Hazel Maridith Barlahan BIAG, Auteur ; Leonard ABBEDUTO, Auteur ; Sébastien JACQUEMONT, Auteur ; David HESSL, Auteur ; Randi J. HAGERMAN, Auteur ; Andrea SCHNEIDER, Auteur ; Francois V. BOLDUC, Auteur ; Sarah LIPPE, Auteur . - e70194. Langues : Anglais (eng) in Autism Research > 19-3 (March 2026) . - e70194 Mots-clés : behavior  cognition  EEG  fragile X syndrome  PSD  resting state  signal complexity Index. décimale : PER Périodiques Résumé : ABSTRACT Fragile X Syndrome (FXS), an X-linked genetic condition, is associated with a wide range of phenotypic manifestations, namely intellectual disability (ID), autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and atypical behaviors. Individuals with FXS present robust electrophysiological (EEG) alterations, notably on signal complexity and power spectral density (PSD) resting state measures. To which extent they are associated to specific behavioral phenotypes in the FXS population remains to be comprehensively addressed. This study aimed to investigate the relations between resting state EEG markers and the most frequently observed symptoms in FXS. EEG and behavioral data from 41 individuals with FXS aged between 7 and 34?years old were collected, and correlational approaches were used to analyze the associations between EEG markers and symptomatology. We observed positive associations between complexity in higher scales and non-verbal intelligence quotient (NVIQ). Reduced alpha power, a robust biomarker in FXS, was associated with more social avoidance, a hallmark in FXS. Decreased high gamma power was linked to hyperactive symptoms. Our results suggest powerful relations between known biomarkers and core symptoms in FXS, highlighting that EEG biomarkers correspond to symptom severity which further supports their potential as objective, translational treatment outcome measures. En ligne : https://doi.org/10.1002/aur.70194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

Brief Report: Sensorimotor Gating in Idiopathic Autism and Autism Associated with Fragile X Syndrome / Jennifer YUHAS in Journal of Autism and Developmental Disorders, 41-2 (February 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-2 (February 2011) . - p.248-253 Titre : Brief Report: Sensorimotor Gating in Idiopathic Autism and Autism Associated with Fragile X Syndrome Type de document : texte imprimé Auteurs : Jennifer YUHAS, Auteur ; Lisa CORDEIRO, Auteur ; Flora TASSONE, Auteur ; Elizabeth C. BALLINGER, Auteur ; Andrea SCHNEIDER, Auteur ; James M. LONG, Auteur ; Edward M. ORNITZ, Auteur ; David HESSL, Auteur Année de publication : 2011 Article en page(s) : p.248-253 Note générale : Article Open Access Langues : Anglais (eng) Mots-clés : PPI  FMR1 gene  Sensorimotor gating  mGluR5  Prepulse inhibition  Startle Index. décimale : PER Périodiques Résumé : Prepulse inhibition (PPI) may useful for exploring the proposed shared neurobiology between idiopathic autism and autism caused by FXS. We compared PPI in four groups: typically developing controls (n = 18), FXS and autism (FXS+A; n = 15), FXS without autism spectrum disorder (FXS−A; n = 17), and idiopathic autism (IA; n = 15). Relative to controls, the FXS+A (p < 0.002) and FXS−A (p < 0.003) groups had impaired PPI. The FXS+A (p < 0.01) and FXS−A (p < 0.03) groups had lower PPI than the IA group. Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating. En ligne : http://dx.doi.org/10.1007/s10803-010-1040-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=117 [article] Brief Report: Sensorimotor Gating in Idiopathic Autism and Autism Associated with Fragile X Syndrome [texte imprimé] / Jennifer YUHAS, Auteur ; Lisa CORDEIRO, Auteur ; Flora TASSONE, Auteur ; Elizabeth C. BALLINGER, Auteur ; Andrea SCHNEIDER, Auteur ; James M. LONG, Auteur ; Edward M. ORNITZ, Auteur ; David HESSL, Auteur . - 2011 . - p.248-253. Article Open Access Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-2 (February 2011) . - p.248-253 Mots-clés : PPI  FMR1 gene  Sensorimotor gating  mGluR5  Prepulse inhibition  Startle Index. décimale : PER Périodiques Résumé : Prepulse inhibition (PPI) may useful for exploring the proposed shared neurobiology between idiopathic autism and autism caused by FXS. We compared PPI in four groups: typically developing controls (n = 18), FXS and autism (FXS+A; n = 15), FXS without autism spectrum disorder (FXS−A; n = 17), and idiopathic autism (IA; n = 15). Relative to controls, the FXS+A (p < 0.002) and FXS−A (p < 0.003) groups had impaired PPI. The FXS+A (p < 0.01) and FXS−A (p < 0.03) groups had lower PPI than the IA group. Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating. En ligne : http://dx.doi.org/10.1007/s10803-010-1040-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=117

Fear Potentiated Startle in Children With Autism Spectrum Disorder: Association With Anxiety Symptoms and Amygdala Volume / David HESSL in Autism Research, 14-3 (March 2021)  

Public ISBD [article]  inAutism Research > 14-3 (March 2021) . - p.450-463 Titre : Fear Potentiated Startle in Children With Autism Spectrum Disorder: Association With Anxiety Symptoms and Amygdala Volume Type de document : texte imprimé Auteurs : David HESSL, Auteur ; Lauren E. LIBERO, Auteur ; Andrea SCHNEIDER, Auteur ; Connor M. KERNS, Auteur ; Breanna WINDER-PATEL, Auteur ; Brianna HEATH, Auteur ; Joshua K. LEE, Auteur ; Cory COLEMAN, Auteur ; Natasha SHARMA, Auteur ; Marjorie SOLOMON, Auteur ; Christine W. NORDAHL, Auteur ; David G. AMARAL, Auteur Article en page(s) : p.450-463 Langues : Anglais (eng) Mots-clés : Mri  anxiety  autism  autistic  fear conditioning Index. décimale : PER Périodiques Résumé : Atypical responses to fearful stimuli and the presence of various forms of anxiety are commonly seen in children with autism spectrum disorder (ASD). The fear potentiated startle paradigm (FPS), which has been studied both in relation to anxiety and as a probe for amygdala function, was carried out in 97 children aged 9-14 years including 48 (12 female) with ASD and 49 (14 female) with typical development (TD). In addition, exploratory analyses were conducted examining the association between FPS and amygdala volume as assessed with magnetic resonance imaging in a subset of the children with ASD with or without an anxiety disorder with available MRI data. While the startle latency was increased in the children with ASD, there was no group difference in FPS. FPS was not significantly associated with traditional Diagnostic and Statistical Manual (DSM) or "autism distinct" forms of anxiety. Within the autism group, FPS was negatively correlated with amygdala volume. Multiple regression analyses revealed that the association between FPS and anxiety severity was significantly moderated by the size of the amygdala, such that the association between FPS and anxiety was significantly more positive in children with larger amygdalas than smaller amygdalas. These findings highlight the heterogeneity of emotional reactivity associated with ASD and the difficulties in establishing biologically meaningful probes of altered brain function. LAY SUMMARY: Many children with autism spectrum disorder (ASD) have additional problems such as anxiety that can greatly impact their lives. How these co-occurring symptoms develop is not well understood. We studied the amygdala, a region of the brain critical for processing fear and a laboratory method called fear potentiated startle for measuring fear conditioning, in children with ASD (with and without an anxiety disorder) and typically developing children. Results showed that the connection between fear conditioning and anxiety is dependent on the size of the amygdala in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2460 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443 [article] Fear Potentiated Startle in Children With Autism Spectrum Disorder: Association With Anxiety Symptoms and Amygdala Volume [texte imprimé] / David HESSL, Auteur ; Lauren E. LIBERO, Auteur ; Andrea SCHNEIDER, Auteur ; Connor M. KERNS, Auteur ; Breanna WINDER-PATEL, Auteur ; Brianna HEATH, Auteur ; Joshua K. LEE, Auteur ; Cory COLEMAN, Auteur ; Natasha SHARMA, Auteur ; Marjorie SOLOMON, Auteur ; Christine W. NORDAHL, Auteur ; David G. AMARAL, Auteur . - p.450-463. Langues : Anglais (eng) in Autism Research > 14-3 (March 2021) . - p.450-463 Mots-clés : Mri  anxiety  autism  autistic  fear conditioning Index. décimale : PER Périodiques Résumé : Atypical responses to fearful stimuli and the presence of various forms of anxiety are commonly seen in children with autism spectrum disorder (ASD). The fear potentiated startle paradigm (FPS), which has been studied both in relation to anxiety and as a probe for amygdala function, was carried out in 97 children aged 9-14 years including 48 (12 female) with ASD and 49 (14 female) with typical development (TD). In addition, exploratory analyses were conducted examining the association between FPS and amygdala volume as assessed with magnetic resonance imaging in a subset of the children with ASD with or without an anxiety disorder with available MRI data. While the startle latency was increased in the children with ASD, there was no group difference in FPS. FPS was not significantly associated with traditional Diagnostic and Statistical Manual (DSM) or "autism distinct" forms of anxiety. Within the autism group, FPS was negatively correlated with amygdala volume. Multiple regression analyses revealed that the association between FPS and anxiety severity was significantly moderated by the size of the amygdala, such that the association between FPS and anxiety was significantly more positive in children with larger amygdalas than smaller amygdalas. These findings highlight the heterogeneity of emotional reactivity associated with ASD and the difficulties in establishing biologically meaningful probes of altered brain function. LAY SUMMARY: Many children with autism spectrum disorder (ASD) have additional problems such as anxiety that can greatly impact their lives. How these co-occurring symptoms develop is not well understood. We studied the amygdala, a region of the brain critical for processing fear and a laboratory method called fear potentiated startle for measuring fear conditioning, in children with ASD (with and without an anxiety disorder) and typically developing children. Results showed that the connection between fear conditioning and anxiety is dependent on the size of the amygdala in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2460 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443

Feasibility, reliability, and clinical validity of the Test of Attentional Performance for Children (KiTAP) in Fragile X syndrome (FXS) / Azia KNOX in Journal of Neurodevelopmental Disorders, 4-1 (December 2012)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.2 Titre : Feasibility, reliability, and clinical validity of the Test of Attentional Performance for Children (KiTAP) in Fragile X syndrome (FXS) Type de document : texte imprimé Auteurs : Azia KNOX, Auteur ; Andrea SCHNEIDER, Auteur ; Floridette ABUCAYAN, Auteur ; Crystal HERVEY, Auteur ; Christina TRAN, Auteur ; David HESSL, Auteur ; Elizabeth BERRY-KRAVIS, Auteur Article en page(s) : p.2 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention and inhibition are core executive-function deficits in FRagile X syndrome (FXS). This pilot study evaluated the feasibility, reproducibility, and clinical relevance of the KiTAP, a computer-based pictorial measure of attention and inhibition with an enchanted-castle theme, in an FXS cohort. METHODS: The 8-subtest KiTAP battery (as many subtests as each could perform) was given to 36 subjects with FXS, of variable age and cognitive/behavioral functioning, and 29 were retested, with an interval of 2 to 4 weeks between sessions. Subjects were rated by parents on the Aberrant Behavior Checklist-Community Edition (ABC-C) and Behavior Assessment System for Children, Second Edition (BASC-2). Feasibility, ceiling and basal effects, and data range and distribution analyses were used to eliminate outliers and invalid data points. Reproducibility of scores was analyzed using intraclass correlation coefficients (ICCs) and validity/clinical relevance was assessed by correlating KiTAP scores with ABC-C and BASC-2 scores. RESULTS: Most of the participants with FXS were able to complete the Alertness, Distractibility, Flexibility, and Go/NoGo subtests.About 50 to 60% completed the Visual Scanning and Vigilance subtests, and 20 to 25% completed the Sustained Attention and Divided Attention subtests. A panel of seven scores from four subtests were identified as feasible for most subjects, lacked excessive ceiling, basal, or learning effects, exhibited an acceptable range and distribution of scores, had good reproducibility (ICC > 0.7), and correlated with behavioral ratings for hyperactivity or attention (P < 0.01). Only minor differences in performance on the KiTAP were seen between mental age-matched cohorts of subjects with FXS and non-FXS intellectual disability. CONCLUSIONS: The KiTAP can be administered to cohorts with FXS over a wide range of function with valid reproducible scores. With additional validation, it could represent a useful outcome measure for assessment of attention/executive-function abilities in clinical trials targeted to these core deficits in FXS. En ligne : http://dx.doi.org/10.1186/1866-1955-4-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344 [article] Feasibility, reliability, and clinical validity of the Test of Attentional Performance for Children (KiTAP) in Fragile X syndrome (FXS) [texte imprimé] / Azia KNOX, Auteur ; Andrea SCHNEIDER, Auteur ; Floridette ABUCAYAN, Auteur ; Crystal HERVEY, Auteur ; Christina TRAN, Auteur ; David HESSL, Auteur ; Elizabeth BERRY-KRAVIS, Auteur . - p.2. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.2 Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention and inhibition are core executive-function deficits in FRagile X syndrome (FXS). This pilot study evaluated the feasibility, reproducibility, and clinical relevance of the KiTAP, a computer-based pictorial measure of attention and inhibition with an enchanted-castle theme, in an FXS cohort. METHODS: The 8-subtest KiTAP battery (as many subtests as each could perform) was given to 36 subjects with FXS, of variable age and cognitive/behavioral functioning, and 29 were retested, with an interval of 2 to 4 weeks between sessions. Subjects were rated by parents on the Aberrant Behavior Checklist-Community Edition (ABC-C) and Behavior Assessment System for Children, Second Edition (BASC-2). Feasibility, ceiling and basal effects, and data range and distribution analyses were used to eliminate outliers and invalid data points. Reproducibility of scores was analyzed using intraclass correlation coefficients (ICCs) and validity/clinical relevance was assessed by correlating KiTAP scores with ABC-C and BASC-2 scores. RESULTS: Most of the participants with FXS were able to complete the Alertness, Distractibility, Flexibility, and Go/NoGo subtests.About 50 to 60% completed the Visual Scanning and Vigilance subtests, and 20 to 25% completed the Sustained Attention and Divided Attention subtests. A panel of seven scores from four subtests were identified as feasible for most subjects, lacked excessive ceiling, basal, or learning effects, exhibited an acceptable range and distribution of scores, had good reproducibility (ICC > 0.7), and correlated with behavioral ratings for hyperactivity or attention (P < 0.01). Only minor differences in performance on the KiTAP were seen between mental age-matched cohorts of subjects with FXS and non-FXS intellectual disability. CONCLUSIONS: The KiTAP can be administered to cohorts with FXS over a wide range of function with valid reproducible scores. With additional validation, it could represent a useful outcome measure for assessment of attention/executive-function abilities in clinical trials targeted to these core deficits in FXS. En ligne : http://dx.doi.org/10.1186/1866-1955-4-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344

Improving IQ measurement in intellectual disabilities using true deviation from population norms / Stephanie M. SANSONE in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.16 Titre : Improving IQ measurement in intellectual disabilities using true deviation from population norms Type de document : texte imprimé Auteurs : Stephanie M. SANSONE, Auteur ; Andrea SCHNEIDER, Auteur ; Erika BICKEL, Auteur ; Elizabeth BERRY-KRAVIS, Auteur ; Christina PRESCOTT, Auteur ; David HESSL, Auteur Article en page(s) : p.16 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Cognitive assessment  Fragile X syndrome  Iq  Intellectual disability Index. décimale : PER Périodiques Résumé : BACKGROUND: Intellectual disability (ID) is characterized by global cognitive deficits, yet the very IQ tests used to assess ID have limited range and precision in this population, especially for more impaired individuals. METHODS: We describe the development and validation of a method of raw z-score transformation (based on general population norms) that ameliorates floor effects and improves the precision of IQ measurement in ID using the Stanford Binet 5 (SB5) in fragile X syndrome (FXS; n = 106), the leading inherited cause of ID, and in individuals with idiopathic autism spectrum disorder (ASD; n = 205). We compared the distributional characteristics and Q-Q plots from the standardized scores with the deviation z-scores. Additionally, we examined the relationship between both scoring methods and multiple criterion measures. RESULTS: We found evidence that substantial and meaningful variation in cognitive ability on standardized IQ tests among individuals with ID is lost when converting raw scores to standardized scaled, index and IQ scores. Use of the deviation z- score method rectifies this problem, and accounts for significant additional variance in criterion validation measures, above and beyond the usual IQ scores. Additionally, individual and group-level cognitive strengths and weaknesses are recovered using deviation scores. CONCLUSION: Traditional methods for generating IQ scores in lower functioning individuals with ID are inaccurate and inadequate, leading to erroneously flat profiles. However assessment of cognitive abilities is substantially improved by measuring true deviation in performance from standardization sample norms. This work has important implications for standardized test development, clinical assessment, and research for which IQ is an important measure of interest in individuals with neurodevelopmental disorders and other forms of cognitive impairment. En ligne : http://dx.doi.org/10.1186/1866-1955-6-16 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346 [article] Improving IQ measurement in intellectual disabilities using true deviation from population norms [texte imprimé] / Stephanie M. SANSONE, Auteur ; Andrea SCHNEIDER, Auteur ; Erika BICKEL, Auteur ; Elizabeth BERRY-KRAVIS, Auteur ; Christina PRESCOTT, Auteur ; David HESSL, Auteur . - p.16. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.16 Mots-clés : Autism spectrum disorder  Cognitive assessment  Fragile X syndrome  Iq  Intellectual disability Index. décimale : PER Périodiques Résumé : BACKGROUND: Intellectual disability (ID) is characterized by global cognitive deficits, yet the very IQ tests used to assess ID have limited range and precision in this population, especially for more impaired individuals. METHODS: We describe the development and validation of a method of raw z-score transformation (based on general population norms) that ameliorates floor effects and improves the precision of IQ measurement in ID using the Stanford Binet 5 (SB5) in fragile X syndrome (FXS; n = 106), the leading inherited cause of ID, and in individuals with idiopathic autism spectrum disorder (ASD; n = 205). We compared the distributional characteristics and Q-Q plots from the standardized scores with the deviation z-scores. Additionally, we examined the relationship between both scoring methods and multiple criterion measures. RESULTS: We found evidence that substantial and meaningful variation in cognitive ability on standardized IQ tests among individuals with ID is lost when converting raw scores to standardized scaled, index and IQ scores. Use of the deviation z- score method rectifies this problem, and accounts for significant additional variance in criterion validation measures, above and beyond the usual IQ scores. Additionally, individual and group-level cognitive strengths and weaknesses are recovered using deviation scores. CONCLUSION: Traditional methods for generating IQ scores in lower functioning individuals with ID are inaccurate and inadequate, leading to erroneously flat profiles. However assessment of cognitive abilities is substantially improved by measuring true deviation in performance from standardization sample norms. This work has important implications for standardized test development, clinical assessment, and research for which IQ is an important measure of interest in individuals with neurodevelopmental disorders and other forms of cognitive impairment. En ligne : http://dx.doi.org/10.1186/1866-1955-6-16 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346

Neurogenetic analysis of childhood disintegrative disorder / Abha R. GUPTA in Molecular Autism, 8 (2017)  

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Neuropsychological changes in FMR1 premutation carriers and onset of fragile X-associated tremor/ataxia syndrome / Jessica FAMULA in Journal of Neurodevelopmental Disorders, 14 (2022)  

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A randomized double-blind, placebo-controlled trial of ganaxolone in children and adolescents with fragile X syndrome / Andrew LIGSAY in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)  

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A solution to limitations of cognitive testing in children with intellectual disabilities: the case of fragile X syndrome / David HESSL in Journal of Neurodevelopmental Disorders, 1-1 (March 2009)  

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Specific EEG resting state biomarkers in FXS and ASD / Mélodie PROTEAU-LEMIEUX in Journal of Neurodevelopmental Disorders, 16 (2024)  

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The cognitive neuropsychological phenotype of carriers of the FMR1 premutation / Jim GRIGSBY in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)  

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The NIH Toolbox Cognitive Battery for intellectual disabilities: three preliminary studies and future directions / David HESSL in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)  

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