Clarifying the Associations Between Language and Social Development in Autism: A Study of Non-native Phoneme Recognition / John N. CONSTANTINO in Journal of Autism and Developmental Disorders, 37-7 (August 2007)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 37-7 (August 2007) . - p.1256-1263 Titre : Clarifying the Associations Between Language and Social Development in Autism: A Study of Non-native Phoneme Recognition Type de document : Texte imprimé et/ou numérique Auteurs : John N. CONSTANTINO, Auteur ; Anna ABBACCHI, Auteur ; Dan YANG, Auteur ; Teddi L. GRAY, Auteur ; Maggie M. GROSS, Auteur ; Sarah C. SMITH, Auteur ; Catherine E. KOHN, Auteur ; Patricia K. KUHL, Auteur Année de publication : 2007 Article en page(s) : p.1256-1263 Langues : Anglais (eng) Mots-clés : Autism Language Social-Responsiveness-Scale Auditory-discrimination Speech-perception Information-processing Phonemic-awareness Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) are characterized by correlated deficiencies in social and language development. This study explored a fundamental aspect of auditory information processing (AIP) that is dependent on social experience and critical to early language development: the ability to compartmentalize close-sounding speech sounds into singular phonemes. We examined this ability by assessing whether close-sounding non-native language phonemes were more likely to be perceived as disparate sounds by school-aged children with high-functioning ASD (n = 27), than by unaffected control subjects (n = 35). No significant group differences were observed. Although earlier in autistic development there may exist qualitative deficits in this specific aspect of AIP, they are not an enduring characteristic of verbal school-aged children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-006-0269-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156 [article] Clarifying the Associations Between Language and Social Development in Autism: A Study of Non-native Phoneme Recognition [Texte imprimé et/ou numérique] / John N. CONSTANTINO, Auteur ; Anna ABBACCHI, Auteur ; Dan YANG, Auteur ; Teddi L. GRAY, Auteur ; Maggie M. GROSS, Auteur ; Sarah C. SMITH, Auteur ; Catherine E. KOHN, Auteur ; Patricia K. KUHL, Auteur . - 2007 . - p.1256-1263. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 37-7 (August 2007) . - p.1256-1263 Mots-clés : Autism Language Social-Responsiveness-Scale Auditory-discrimination Speech-perception Information-processing Phonemic-awareness Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) are characterized by correlated deficiencies in social and language development. This study explored a fundamental aspect of auditory information processing (AIP) that is dependent on social experience and critical to early language development: the ability to compartmentalize close-sounding speech sounds into singular phonemes. We examined this ability by assessing whether close-sounding non-native language phonemes were more likely to be perceived as disparate sounds by school-aged children with high-functioning ASD (n = 27), than by unaffected control subjects (n = 35). No significant group differences were observed. Although earlier in autistic development there may exist qualitative deficits in this specific aspect of AIP, they are not an enduring characteristic of verbal school-aged children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-006-0269-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156

Developmental course of autistic social impairment in males / John N. CONSTANTINO in Development and Psychopathology, 21-1 (January 2009)  

Public ISBD [article]  inDevelopment and Psychopathology > 21-1 (January 2009) . - p.127-138 Titre : Developmental course of autistic social impairment in males Type de document : Texte imprimé et/ou numérique Auteurs : John N. CONSTANTINO, Auteur ; Richard D. TODD, Auteur ; Lily CHIANG, Auteur ; Leah GIVENS, Auteur ; Hannah REED, Auteur ; Maggie M. GROSS, Auteur ; Teddi L. GRAY, Auteur ; Patricia LAVESSER, Auteur ; Anna ABBACCHI, Auteur ; Yi ZHANG, Auteur Année de publication : 2009 Article en page(s) : p.127-138 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Recent research has suggested that autistic social impairment (ASI) is continuously distributed in nature and that subtle autistic-like social impairments aggregate in the family members of children with pervasive developmental disorders (PDDs). This study examined the longitudinal course of quantitatively characterized ASI in 3- to 18-year-old boys with and without PDD. We obtained assessments of 95 epidemiologically ascertained male–male twin pairs and a clinical sample of 95 affected children using the Social Responsiveness Scale (SRS), at two time points, spaced 1–5 years apart. Longitudinal course was examined as a function of age, familial loading for PDD, and autistic severity at baseline. Interindividual variation in SRS scores was highly preserved over time, with test–retest correlation of 0.90 for the entire sample. SRS scores exhibited modest general improvement over the study period; individual trajectories varied as a function of severity at baseline and were highly familial. Quantitative measurements of ASI reflect heritable traitlike characteristics. Such measurements can serve as reliable indices of phenotypic severity for genetic and neurobiologic studies, and have potential utility for ascertaining incremental response to intervention. En ligne : http://dx.doi.org/10.1017/s095457940900008x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=680 [article] Developmental course of autistic social impairment in males [Texte imprimé et/ou numérique] / John N. CONSTANTINO, Auteur ; Richard D. TODD, Auteur ; Lily CHIANG, Auteur ; Leah GIVENS, Auteur ; Hannah REED, Auteur ; Maggie M. GROSS, Auteur ; Teddi L. GRAY, Auteur ; Patricia LAVESSER, Auteur ; Anna ABBACCHI, Auteur ; Yi ZHANG, Auteur . - 2009 . - p.127-138. Langues : Anglais (eng) in Development and Psychopathology > 21-1 (January 2009) . - p.127-138 Index. décimale : PER Périodiques Résumé : Recent research has suggested that autistic social impairment (ASI) is continuously distributed in nature and that subtle autistic-like social impairments aggregate in the family members of children with pervasive developmental disorders (PDDs). This study examined the longitudinal course of quantitatively characterized ASI in 3- to 18-year-old boys with and without PDD. We obtained assessments of 95 epidemiologically ascertained male–male twin pairs and a clinical sample of 95 affected children using the Social Responsiveness Scale (SRS), at two time points, spaced 1–5 years apart. Longitudinal course was examined as a function of age, familial loading for PDD, and autistic severity at baseline. Interindividual variation in SRS scores was highly preserved over time, with test–retest correlation of 0.90 for the entire sample. SRS scores exhibited modest general improvement over the study period; individual trajectories varied as a function of severity at baseline and were highly familial. Quantitative measurements of ASI reflect heritable traitlike characteristics. Such measurements can serve as reliable indices of phenotypic severity for genetic and neurobiologic studies, and have potential utility for ascertaining incremental response to intervention. En ligne : http://dx.doi.org/10.1017/s095457940900008x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=680

Lack of evidence for increased genetic loading for autism among families of affected females: A replication from family history data in two large samples / Robin P. GOIN-KOCHEL in Autism, 11-3 (May 2007)  

Public ISBD [article]  inAutism > 11-3 (May 2007) . - p.279-286 Titre : Lack of evidence for increased genetic loading for autism among families of affected females: A replication from family history data in two large samples Type de document : Texte imprimé et/ou numérique Auteurs : Robin P. GOIN-KOCHEL, Auteur ; John N. CONSTANTINO, Auteur ; Anna ABBACCHI, Auteur ; AUTISM GENETIC RESOURCE EXCHANGE CONSORTIUM, Auteur Année de publication : 2007 Article en page(s) : p.279-286 Langues : Anglais (eng) Mots-clés : Asperger's-disorder Autism Family-history Genetics Index. décimale : PER Périodiques Résumé : Both the broad and narrow phenotypes of autism have been consistently observed in family members of affected individuals. Additionally, autism spectrum disorders (ASDs) present four times more often in males than in females, for reasons that are currently unknown. In this study, we examined whether there were differences in familial loading of ASD among families of male versus female probands. Analyses were conducted with existing data from two distinct samples. The first sample contained 417 individuals with autism and Asperger's disorder and included information on the ASD diagnoses of their first- and second-degree relatives. The second sample consisted of 405 sibships participating in the Autism Genetic Resource Exchange, of which one or more siblings had an ASD diagnosis. Results from both samples did not suggest significant differences in the prevalence of ASD among relatives of affected males versus females. En ligne : http://dx.doi.org/10.1177/1362361307076857 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=112 [article] Lack of evidence for increased genetic loading for autism among families of affected females: A replication from family history data in two large samples [Texte imprimé et/ou numérique] / Robin P. GOIN-KOCHEL, Auteur ; John N. CONSTANTINO, Auteur ; Anna ABBACCHI, Auteur ; AUTISM GENETIC RESOURCE EXCHANGE CONSORTIUM, Auteur . - 2007 . - p.279-286. Langues : Anglais (eng) in Autism > 11-3 (May 2007) . - p.279-286 Mots-clés : Asperger's-disorder Autism Family-history Genetics Index. décimale : PER Périodiques Résumé : Both the broad and narrow phenotypes of autism have been consistently observed in family members of affected individuals. Additionally, autism spectrum disorders (ASDs) present four times more often in males than in females, for reasons that are currently unknown. In this study, we examined whether there were differences in familial loading of ASD among families of male versus female probands. Analyses were conducted with existing data from two distinct samples. The first sample contained 417 individuals with autism and Asperger's disorder and included information on the ASD diagnoses of their first- and second-degree relatives. The second sample consisted of 405 sibships participating in the Autism Genetic Resource Exchange, of which one or more siblings had an ASD diagnosis. Results from both samples did not suggest significant differences in the prevalence of ASD among relatives of affected males versus females. En ligne : http://dx.doi.org/10.1177/1362361307076857 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=112

Multi-informant Ratings of Psychiatric Symptom Severity in Children with Autism Spectrum Disorders: The Importance of Environmental Context / Stephen M. KANNE in Journal of Autism and Developmental Disorders, 39-6 (June 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-6 (June 2009) . - p.856-864 Titre : Multi-informant Ratings of Psychiatric Symptom Severity in Children with Autism Spectrum Disorders: The Importance of Environmental Context Type de document : Texte imprimé et/ou numérique Auteurs : Stephen M. KANNE, Auteur ; John N. CONSTANTINO, Auteur ; Anna ABBACCHI, Auteur Année de publication : 2009 Article en page(s) : p.856-864 Langues : Anglais (eng) Mots-clés : Autism Pervasive-developmental-disorder Prevalence CBCL Parent Teacher Index. décimale : PER Périodiques Résumé : The present study examines co-occurring psychiatric syndromes in a well-characterized sample of youths with autism spectrum disorders (ASD; n = 177) and their siblings (n = 148), reported independently by parents and teachers. In ASD, parents reported substantial comorbidity with affective (26%), anxiety (25%), attentional (25%), conduct (16%), oppositional (15%), and somatic problems (6%). Teachers reported a much lower prevalence. Autistic severity scores for children with ASD exhibited moderate correlations with general psychopathology within- but not across-informants, whereas, sibling correlations were significant both within- and across-informants. Results support the role of environmental context in psychiatric symptom expression in children affected by autism and suggest that informant discrepancies may more provide critical cues for these children via specific environmental modifications. En ligne : http://dx.doi.org/10.1007/s10803-009-0694-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=758 [article] Multi-informant Ratings of Psychiatric Symptom Severity in Children with Autism Spectrum Disorders: The Importance of Environmental Context [Texte imprimé et/ou numérique] / Stephen M. KANNE, Auteur ; John N. CONSTANTINO, Auteur ; Anna ABBACCHI, Auteur . - 2009 . - p.856-864. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-6 (June 2009) . - p.856-864 Mots-clés : Autism Pervasive-developmental-disorder Prevalence CBCL Parent Teacher Index. décimale : PER Périodiques Résumé : The present study examines co-occurring psychiatric syndromes in a well-characterized sample of youths with autism spectrum disorders (ASD; n = 177) and their siblings (n = 148), reported independently by parents and teachers. In ASD, parents reported substantial comorbidity with affective (26%), anxiety (25%), attentional (25%), conduct (16%), oppositional (15%), and somatic problems (6%). Teachers reported a much lower prevalence. Autistic severity scores for children with ASD exhibited moderate correlations with general psychopathology within- but not across-informants, whereas, sibling correlations were significant both within- and across-informants. Results support the role of environmental context in psychiatric symptom expression in children affected by autism and suggest that informant discrepancies may more provide critical cues for these children via specific environmental modifications. En ligne : http://dx.doi.org/10.1007/s10803-009-0694-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=758

Quantitative autistic trait measurements index background genetic risk for ASD in Hispanic families / J. PAGE in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 39p. Titre : Quantitative autistic trait measurements index background genetic risk for ASD in Hispanic families Type de document : Texte imprimé et/ou numérique Auteurs : J. PAGE, Auteur ; John N. CONSTANTINO, Auteur ; K. ZAMBRANA, Auteur ; E. MARTIN, Auteur ; I. TUNC, Auteur ; Y. ZHANG, Auteur ; Anna ABBACCHI, Auteur ; D. MESSINGER, Auteur Article en page(s) : 39p. Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/genetics  Child  Child, Preschool  Female  Genetic Predisposition to Disease  Hispanic Americans/genetics  Humans  Male  Parents  Phenotype  Siblings  Ancestry  Assortative mating  Hispanic  Measurement  Social Responsiveness Scale Index. décimale : PER Périodiques Résumé : BACKGROUND: Recent studies have indicated that quantitative autistic traits (QATs) of parents reflect inherited liabilities that may index background genetic risk for clinical autism spectrum disorder (ASD) in their offspring. Moreover, preferential mating for QATs has been observed as a potential factor in concentrating autistic liabilities in some families across generations. Heretofore, intergenerational studies of QATs have focused almost exclusively on Caucasian populations-the present study explored these phenomena in a well-characterized Hispanic population. METHODS: The present study examined QAT scores in siblings and parents of 83 Hispanic probands meeting research diagnostic criteria for ASD, and 64 non-ASD controls, using the Social Responsiveness Scale-2 (SRS-2). Ancestry of the probands was characterized by genotype, using information from 541,929 single nucleotide polymorphic markers. RESULTS: In families of Hispanic children with an ASD diagnosis, the pattern of quantitative trait correlations observed between ASD-affected children and their first-degree relatives (ICCs on the order of 0.20), between unaffected first-degree relatives in ASD-affected families (sibling/mother ICC = 0.36; sibling/father ICC = 0.53), and between spouses (mother/father ICC = 0.48) were in keeping with the influence of transmitted background genetic risk and strong preferential mating for variation in quantitative autistic trait burden. Results from analysis of ancestry-informative genetic markers among probands in this sample were consistent with that from other Hispanic populations. CONCLUSIONS: Quantitative autistic traits represent measurable indices of inherited liability to ASD in Hispanic families. The accumulation of autistic traits occurs within generations, between spouses, and across generations, among Hispanic families affected by ASD. The occurrence of preferential mating for QATs-the magnitude of which may vary across cultures-constitutes a mechanism by which background genetic liability for ASD can accumulate in a given family in successive generations. En ligne : http://dx.doi.org/10.1186/s13229-016-0100-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 [article] Quantitative autistic trait measurements index background genetic risk for ASD in Hispanic families [Texte imprimé et/ou numérique] / J. PAGE, Auteur ; John N. CONSTANTINO, Auteur ; K. ZAMBRANA, Auteur ; E. MARTIN, Auteur ; I. TUNC, Auteur ; Y. ZHANG, Auteur ; Anna ABBACCHI, Auteur ; D. MESSINGER, Auteur . - 39p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 39p. Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/genetics  Child  Child, Preschool  Female  Genetic Predisposition to Disease  Hispanic Americans/genetics  Humans  Male  Parents  Phenotype  Siblings  Ancestry  Assortative mating  Hispanic  Measurement  Social Responsiveness Scale Index. décimale : PER Périodiques Résumé : BACKGROUND: Recent studies have indicated that quantitative autistic traits (QATs) of parents reflect inherited liabilities that may index background genetic risk for clinical autism spectrum disorder (ASD) in their offspring. Moreover, preferential mating for QATs has been observed as a potential factor in concentrating autistic liabilities in some families across generations. Heretofore, intergenerational studies of QATs have focused almost exclusively on Caucasian populations-the present study explored these phenomena in a well-characterized Hispanic population. METHODS: The present study examined QAT scores in siblings and parents of 83 Hispanic probands meeting research diagnostic criteria for ASD, and 64 non-ASD controls, using the Social Responsiveness Scale-2 (SRS-2). Ancestry of the probands was characterized by genotype, using information from 541,929 single nucleotide polymorphic markers. RESULTS: In families of Hispanic children with an ASD diagnosis, the pattern of quantitative trait correlations observed between ASD-affected children and their first-degree relatives (ICCs on the order of 0.20), between unaffected first-degree relatives in ASD-affected families (sibling/mother ICC = 0.36; sibling/father ICC = 0.53), and between spouses (mother/father ICC = 0.48) were in keeping with the influence of transmitted background genetic risk and strong preferential mating for variation in quantitative autistic trait burden. Results from analysis of ancestry-informative genetic markers among probands in this sample were consistent with that from other Hispanic populations. CONCLUSIONS: Quantitative autistic traits represent measurable indices of inherited liability to ASD in Hispanic families. The accumulation of autistic traits occurs within generations, between spouses, and across generations, among Hispanic families affected by ASD. The occurrence of preferential mating for QATs-the magnitude of which may vary across cultures-constitutes a mechanism by which background genetic liability for ASD can accumulate in a given family in successive generations. En ligne : http://dx.doi.org/10.1186/s13229-016-0100-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329

Sensory Responsiveness as a Predictor of Social Severity in Children with High Functioning Autism Spectrum Disorders / Claudia HILTON in Journal of Autism and Developmental Disorders, 40-8 (August 2010)  

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