Dépouillements

Cultural differences in social communication and interaction: A gap in autism research / M. E. GOLSON in Autism Research, 15-2 (February 2022)  

Public ISBD [article]  inAutism Research > 15-2 (February 2022) . - p.208-214 Titre : Cultural differences in social communication and interaction: A gap in autism research Type de document : Texte imprimé et/ou numérique Auteurs : M. E. GOLSON, Auteur ; E. FICKLIN, Auteur ; C. R. HAVERKAMP, Auteur ; M. B. MCCLAIN, Auteur ; B. HARRIS, Auteur Article en page(s) : p.208-214 Langues : Anglais (eng) Mots-clés : culture  race and ethnicity  social communication Index. décimale : PER Périodiques Résumé : Social communication and interaction deficits are a diagnostic criteria of autism and integral to practitioner and researcher conceptualization. Culture is an influential factor in expectations for, and demonstration of, social communication and interaction skills, but there is limited research published in autism journals on this topic. This paucity of autism research examining cultural factors related to social communication and interaction may contribute to known identification disparities for racial and ethnic populations minoritized by systemic factors and research bias. We call for increased commitment from researchers to recruit racially and ethnically minoritized participants, prioritize investigating cultural expectations and perceptions of social communication and interaction, and evaluate measures related to social communication for cultural and linguistic responsivity. LAY SUMMARY: A diagnosis of autism requires the presence of deficits in social communication and interaction. Examples of these behaviors and skills include holding a back-and-forth conversation, the use of nonverbal communicative behaviors (e.g., gestures), and developing and maintaining social relationships. Culture influences the expectations for, and presentation of, these behaviors. However, research on this topic is lacking. Conducting more research related to culture and social communication could help reduce the disparities in autism identification across racially and ethnically minoritized populations. En ligne : http://dx.doi.org/10.1002/aur.2657 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Cultural differences in social communication and interaction: A gap in autism research [Texte imprimé et/ou numérique] / M. E. GOLSON, Auteur ; E. FICKLIN, Auteur ; C. R. HAVERKAMP, Auteur ; M. B. MCCLAIN, Auteur ; B. HARRIS, Auteur . - p.208-214. Langues : Anglais (eng) in Autism Research > 15-2 (February 2022) . - p.208-214 Mots-clés : culture  race and ethnicity  social communication Index. décimale : PER Périodiques Résumé : Social communication and interaction deficits are a diagnostic criteria of autism and integral to practitioner and researcher conceptualization. Culture is an influential factor in expectations for, and demonstration of, social communication and interaction skills, but there is limited research published in autism journals on this topic. This paucity of autism research examining cultural factors related to social communication and interaction may contribute to known identification disparities for racial and ethnic populations minoritized by systemic factors and research bias. We call for increased commitment from researchers to recruit racially and ethnically minoritized participants, prioritize investigating cultural expectations and perceptions of social communication and interaction, and evaluate measures related to social communication for cultural and linguistic responsivity. LAY SUMMARY: A diagnosis of autism requires the presence of deficits in social communication and interaction. Examples of these behaviors and skills include holding a back-and-forth conversation, the use of nonverbal communicative behaviors (e.g., gestures), and developing and maintaining social relationships. Culture influences the expectations for, and presentation of, these behaviors. However, research on this topic is lacking. Conducting more research related to culture and social communication could help reduce the disparities in autism identification across racially and ethnically minoritized populations. En ligne : http://dx.doi.org/10.1002/aur.2657 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

The ALA5/ALA6/ALA7 repeat polymorphisms of the glutathione peroxidase-1 (GPx1) gene and autism spectrum disorder / F. CARDUCCI in Autism Research, 15-2 (February 2022)  

Public ISBD [article]  inAutism Research > 15-2 (February 2022) . - p.215-221 Titre : The ALA5/ALA6/ALA7 repeat polymorphisms of the glutathione peroxidase-1 (GPx1) gene and autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : F. CARDUCCI, Auteur ; C. ARDICCIONI, Auteur ; R. FIORINI, Auteur ; A. VIGNINI, Auteur ; A. DI PAOLO, Auteur ; S. ALIA, Auteur ; M. BARUCCA, Auteur ; M. A. BISCOTTI, Auteur Article en page(s) : p.215-221 Langues : Anglais (eng) Mots-clés : Asd  GPx1 genetic screening  GPx1 in vitro protein production  GPx1 polymorphisms  GPx1 protein activity  autism spectrum disorder  glutathione peroxidase 1 Index. décimale : PER Périodiques Résumé : Autism is a severe neurodevelopmental disorder leading to deficits in social interaction, communication, and several activities. An increasing number of evidence suggests a role of oxidative stress in the etiology of autism spectrum disorder (ASD). Indeed, impaired antioxidant mechanisms may lead to the inadequate removal of H(2) O(2) with a consequent increase in highly active hydroxyl radicals and other reactive oxygen species causing cellular damages. The GPx1 is one of the most important enzymes counteracting oxidative stress. In this work, we investigated a possible correlation between the GCG repeat polymorphism present in the first exon of GPx1 gene encoding a tract of five to seven alanine residues (ALA5, ALA6, and ALA7) and ASD. Our findings highlighted a high frequency of ALA5 allele in ASD subjects. Moreover, proteins corresponding to the three GPx1 variants were produced in vitro, and the evaluation of their activity showed a lower values for GPx1 having ALA5 polymorphism. The comparison of the secondary and tertiary structure predictions revealed an alpha-helix in correspondence of alanine stretch only in the case of GPx1-ALA7 variant. Finally, to better investigate protein structure, steady-state fluorescence measurements of GPx1 intrinsic tryptophan were carried out and the three tested proteins exhibited a different stability under denaturing conditions. This work demonstrates the importance in adopting a multidisciplinary strategy to comprehend the role of GPx1 in ASD. LAY SUMMARY: Results here obtained suggest a possible role of ALA5 GPx1 variant in ASD. However, given the multifactorial nature of autism, this evidence might be a piece of a more complex puzzle being the GPx1 enzyme part of a complex pathway in which several proteins are involved. En ligne : http://dx.doi.org/10.1002/aur.2655 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] The ALA5/ALA6/ALA7 repeat polymorphisms of the glutathione peroxidase-1 (GPx1) gene and autism spectrum disorder [Texte imprimé et/ou numérique] / F. CARDUCCI, Auteur ; C. ARDICCIONI, Auteur ; R. FIORINI, Auteur ; A. VIGNINI, Auteur ; A. DI PAOLO, Auteur ; S. ALIA, Auteur ; M. BARUCCA, Auteur ; M. A. BISCOTTI, Auteur . - p.215-221. Langues : Anglais (eng) in Autism Research > 15-2 (February 2022) . - p.215-221 Mots-clés : Asd  GPx1 genetic screening  GPx1 in vitro protein production  GPx1 polymorphisms  GPx1 protein activity  autism spectrum disorder  glutathione peroxidase 1 Index. décimale : PER Périodiques Résumé : Autism is a severe neurodevelopmental disorder leading to deficits in social interaction, communication, and several activities. An increasing number of evidence suggests a role of oxidative stress in the etiology of autism spectrum disorder (ASD). Indeed, impaired antioxidant mechanisms may lead to the inadequate removal of H(2) O(2) with a consequent increase in highly active hydroxyl radicals and other reactive oxygen species causing cellular damages. The GPx1 is one of the most important enzymes counteracting oxidative stress. In this work, we investigated a possible correlation between the GCG repeat polymorphism present in the first exon of GPx1 gene encoding a tract of five to seven alanine residues (ALA5, ALA6, and ALA7) and ASD. Our findings highlighted a high frequency of ALA5 allele in ASD subjects. Moreover, proteins corresponding to the three GPx1 variants were produced in vitro, and the evaluation of their activity showed a lower values for GPx1 having ALA5 polymorphism. The comparison of the secondary and tertiary structure predictions revealed an alpha-helix in correspondence of alanine stretch only in the case of GPx1-ALA7 variant. Finally, to better investigate protein structure, steady-state fluorescence measurements of GPx1 intrinsic tryptophan were carried out and the three tested proteins exhibited a different stability under denaturing conditions. This work demonstrates the importance in adopting a multidisciplinary strategy to comprehend the role of GPx1 in ASD. LAY SUMMARY: Results here obtained suggest a possible role of ALA5 GPx1 variant in ASD. However, given the multifactorial nature of autism, this evidence might be a piece of a more complex puzzle being the GPx1 enzyme part of a complex pathway in which several proteins are involved. En ligne : http://dx.doi.org/10.1002/aur.2655 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

The autistic brain can process local but not global emotion regularities in facial and musical sequences / J. XU in Autism Research, 15-2 (February 2022)  

Public ISBD [article]  inAutism Research > 15-2 (February 2022) . - p.222-240 Titre : The autistic brain can process local but not global emotion regularities in facial and musical sequences Type de document : Texte imprimé et/ou numérique Auteurs : J. XU, Auteur ; L. ZHOU, Auteur ; F. LIU, Auteur ; C. XUE, Auteur ; J. JIANG, Auteur ; C. JIANG, Auteur Article en page(s) : p.222-240 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  facial emotion  global deficit  musical emotion  regularity Index. décimale : PER Périodiques Résumé : Whether autism spectrum disorder (ASD) is associated with a global processing deficit remains controversial. Global integration requires extraction of regularity across various timescales, yet little is known about how individuals with ASD process regularity at local (short timescale) versus global (long timescale) levels. To this end, we used event-related potentials to investigate whether individuals with ASD would show different neural responses to local (within trial) versus global (across trials) emotion regularities extracted from sequential facial expressions; and if so, whether this visual abnormality would generalize to the music (auditory) domain. Twenty individuals with ASD and 21 age- and IQ-matched individuals with typical development participated in this study. At an early processing stage, ASD participants exhibited preserved neural responses to violations of local emotion regularity for both faces and music. At a later stage, however, there was an absence of neural responses in ASD to violations of global emotion regularity for both faces and music. These findings suggest that the autistic brain responses to emotion regularity are modulated by the timescale of sequential stimuli, and provide insight into the neural mechanisms underlying emotional processing in ASD. En ligne : http://dx.doi.org/10.1002/aur.2635 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] The autistic brain can process local but not global emotion regularities in facial and musical sequences [Texte imprimé et/ou numérique] / J. XU, Auteur ; L. ZHOU, Auteur ; F. LIU, Auteur ; C. XUE, Auteur ; J. JIANG, Auteur ; C. JIANG, Auteur . - p.222-240. Langues : Anglais (eng) in Autism Research > 15-2 (February 2022) . - p.222-240 Mots-clés : autism spectrum disorder  facial emotion  global deficit  musical emotion  regularity Index. décimale : PER Périodiques Résumé : Whether autism spectrum disorder (ASD) is associated with a global processing deficit remains controversial. Global integration requires extraction of regularity across various timescales, yet little is known about how individuals with ASD process regularity at local (short timescale) versus global (long timescale) levels. To this end, we used event-related potentials to investigate whether individuals with ASD would show different neural responses to local (within trial) versus global (across trials) emotion regularities extracted from sequential facial expressions; and if so, whether this visual abnormality would generalize to the music (auditory) domain. Twenty individuals with ASD and 21 age- and IQ-matched individuals with typical development participated in this study. At an early processing stage, ASD participants exhibited preserved neural responses to violations of local emotion regularity for both faces and music. At a later stage, however, there was an absence of neural responses in ASD to violations of global emotion regularity for both faces and music. These findings suggest that the autistic brain responses to emotion regularity are modulated by the timescale of sequential stimuli, and provide insight into the neural mechanisms underlying emotional processing in ASD. En ligne : http://dx.doi.org/10.1002/aur.2635 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Impaired attentional bias toward one's own face in autism spectrum disorder: ERP evidence / H. B. CYGAN in Autism Research, 15-2 (February 2022)  

Public ISBD [article]  inAutism Research > 15-2 (February 2022) . - p.241-253 Titre : Impaired attentional bias toward one's own face in autism spectrum disorder: ERP evidence Type de document : Texte imprimé et/ou numérique Auteurs : H. B. CYGAN, Auteur ; M. M. NOWICKA, Auteur ; A. NOWICKA, Auteur Article en page(s) : p.241-253 Langues : Anglais (eng) Mots-clés : Erp  attention  autism  self-face Index. décimale : PER Périodiques Résumé : Converging lines of evidence seem to indicate reduced self-referential processing in individuals with autism spectrum disorder (ASD). However, processing of one's own face has rarely been investigated in the context of ASD. Thus, the aim of the present study was to elucidate the role of attentional biases in the processing of self- and other faces in ASD. To achieve this goal we presented participants with images of their own face, the face of a close-other, and famous and unknown faces in a Stroop-like paradigm. Participants (22 with ASD, 22 typically developing [TD]) were instructed to indicate the color of presented faces while EEG was recorded. Our event-related potential results clearly showed that self-face was associated with larger P3 amplitudes than all other faces in the TD group, thus indicating a strong attentional bias toward one's own face. In the ASD group, P3 to the self-face and the close-other's face did not differ, suggesting similar attentional biases in both cases. In line with these P3 findings, nonparametric cluster-based permutation tests showed an analogous pattern of results: significant clusters for the self-face compared with all other faces in the TD group, and no significant cluster in the ASD group. Overall, our findings revealed impaired attentional bias to one's own face and diminished self versus other differentiation in individuals with ASD. The similar neural underpinnings of the self-face and other faces supports previous findings indicating reduced self-prioritization among individuals with ASD. En ligne : http://dx.doi.org/10.1002/aur.2647 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Impaired attentional bias toward one's own face in autism spectrum disorder: ERP evidence [Texte imprimé et/ou numérique] / H. B. CYGAN, Auteur ; M. M. NOWICKA, Auteur ; A. NOWICKA, Auteur . - p.241-253. Langues : Anglais (eng) in Autism Research > 15-2 (February 2022) . - p.241-253 Mots-clés : Erp  attention  autism  self-face Index. décimale : PER Périodiques Résumé : Converging lines of evidence seem to indicate reduced self-referential processing in individuals with autism spectrum disorder (ASD). However, processing of one's own face has rarely been investigated in the context of ASD. Thus, the aim of the present study was to elucidate the role of attentional biases in the processing of self- and other faces in ASD. To achieve this goal we presented participants with images of their own face, the face of a close-other, and famous and unknown faces in a Stroop-like paradigm. Participants (22 with ASD, 22 typically developing [TD]) were instructed to indicate the color of presented faces while EEG was recorded. Our event-related potential results clearly showed that self-face was associated with larger P3 amplitudes than all other faces in the TD group, thus indicating a strong attentional bias toward one's own face. In the ASD group, P3 to the self-face and the close-other's face did not differ, suggesting similar attentional biases in both cases. In line with these P3 findings, nonparametric cluster-based permutation tests showed an analogous pattern of results: significant clusters for the self-face compared with all other faces in the TD group, and no significant cluster in the ASD group. Overall, our findings revealed impaired attentional bias to one's own face and diminished self versus other differentiation in individuals with ASD. The similar neural underpinnings of the self-face and other faces supports previous findings indicating reduced self-prioritization among individuals with ASD. En ligne : http://dx.doi.org/10.1002/aur.2647 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Prompting visual attention to print versus pictures during shared book reading with digital storybooks for preschoolers with ASD compared to TD peers / R. WICKS in Autism Research, 15-2 (February 2022)  

Public ISBD [article]  inAutism Research > 15-2 (February 2022) . - p.254-269 Titre : Prompting visual attention to print versus pictures during shared book reading with digital storybooks for preschoolers with ASD compared to TD peers Type de document : Texte imprimé et/ou numérique Auteurs : R. WICKS, Auteur ; Marleen F. WESTERVELD, Auteur ; M. STAINER, Auteur ; J. PAYNTER, Auteur Article en page(s) : p.254-269 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  eye gaze  eye tracking  prompting  shared book reading Index. décimale : PER Périodiques Résumé : Prompting children to look at print and picture content during shared book reading (SBR) facilitates joint attention and early language and literacy learning opportunities for typically developing (TD) children. Whether preschoolers with autism spectrum disorder (ASD) respond similarly to bids for joint attention during SBR and how autism characteristics impact upon their responsiveness is currently unclear. This is important given these children are at risk of persistent language and literacy challenges. To address this, we examined the effects of prompts that were solely verbal versus verbal with pointing on visual attention to print and picture targets during SBR with digital storybooks for 34 children with ASD and 27 TD peers. Children with ASD looked as frequently at print targets, but less frequently at picture targets, when prompted compared to TD peers. Both prompt types showed similar effects in shifting children's visual attention to print and picture targets at group level. When groups were combined, autism characteristics influenced children's responsiveness to verbal versus verbal with pointing prompts to print targets, but not to picture targets; children looked more frequently at print targets as autism characteristics increased when verbal prompts were used, with a large effect shown (d = 0.91). Overall, findings suggest that prompting children with ASD to look at print and pictures during SBR with digital storybooks may be helpful in facilitating joint attention to storybook content. Implications for the development of effective early interventions aimed at providing emergent literacy support for children with ASD are discussed. LAY SUMMARY: We looked at how prompting impacted upon where children with autism look during shared book reading with digital storybooks compared to children without autism using eye-tracking. We found the target (pictures or print) was what mattered and number of autism characteristics impacted how responsive children were to different types of prompts. This helps us to understand how prompting may help children with autism to look at print or pictures during shared book reading which could support language or reading interventions. En ligne : http://dx.doi.org/10.1002/aur.2623 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Prompting visual attention to print versus pictures during shared book reading with digital storybooks for preschoolers with ASD compared to TD peers [Texte imprimé et/ou numérique] / R. WICKS, Auteur ; Marleen F. WESTERVELD, Auteur ; M. STAINER, Auteur ; J. PAYNTER, Auteur . - p.254-269. Langues : Anglais (eng) in Autism Research > 15-2 (February 2022) . - p.254-269 Mots-clés : autism spectrum disorder  eye gaze  eye tracking  prompting  shared book reading Index. décimale : PER Périodiques Résumé : Prompting children to look at print and picture content during shared book reading (SBR) facilitates joint attention and early language and literacy learning opportunities for typically developing (TD) children. Whether preschoolers with autism spectrum disorder (ASD) respond similarly to bids for joint attention during SBR and how autism characteristics impact upon their responsiveness is currently unclear. This is important given these children are at risk of persistent language and literacy challenges. To address this, we examined the effects of prompts that were solely verbal versus verbal with pointing on visual attention to print and picture targets during SBR with digital storybooks for 34 children with ASD and 27 TD peers. Children with ASD looked as frequently at print targets, but less frequently at picture targets, when prompted compared to TD peers. Both prompt types showed similar effects in shifting children's visual attention to print and picture targets at group level. When groups were combined, autism characteristics influenced children's responsiveness to verbal versus verbal with pointing prompts to print targets, but not to picture targets; children looked more frequently at print targets as autism characteristics increased when verbal prompts were used, with a large effect shown (d = 0.91). Overall, findings suggest that prompting children with ASD to look at print and pictures during SBR with digital storybooks may be helpful in facilitating joint attention to storybook content. Implications for the development of effective early interventions aimed at providing emergent literacy support for children with ASD are discussed. LAY SUMMARY: We looked at how prompting impacted upon where children with autism look during shared book reading with digital storybooks compared to children without autism using eye-tracking. We found the target (pictures or print) was what mattered and number of autism characteristics impacted how responsive children were to different types of prompts. This helps us to understand how prompting may help children with autism to look at print or pictures during shared book reading which could support language or reading interventions. En ligne : http://dx.doi.org/10.1002/aur.2623 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Bilingualism effects in pronoun comprehension: Evidence from children with autism / V. SKRIMPA in Autism Research, 15-2 (February 2022)  

Public ISBD [article]  inAutism Research > 15-2 (February 2022) . - p.270-283 Titre : Bilingualism effects in pronoun comprehension: Evidence from children with autism Type de document : Texte imprimé et/ou numérique Auteurs : V. SKRIMPA, Auteur ; V. SPANOU, Auteur ; C. BONGARTZ, Auteur ; E. PERISTERI, Auteur ; M. ANDREOU, Auteur ; D. PAPADOPOULOU, Auteur Article en page(s) : p.270-283 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  bilingualism  language deficits  pronoun resolution Index. décimale : PER Périodiques Résumé : The prevalence of autism worldwide has risen steadily in the last two decades, while bilingualism is also becoming increasingly prevalent in today's rapidly globalizing world. The current study aimed to investigate bilingualism effects in the pronoun resolution skills of children with autism in comparison to age-matched monolingual children with autism, as well as monolingual and bilingual children of typical development (? = 20 participants per group). Results showed that autistic children had general difficulty anchoring ambiguous pronouns to entities that were linguistically expressed in discourse, yet, the bilingual children with autism were more sensitive to the topicality of the entities in syntactic subject position and more prone to identify them as suitable referents of ambiguous null pronouns as compared to their monolingual peers. The findings suggest that bilingualism is not detrimental to autistic children's pronoun resolution skills. The current study aimed at determining how bilingualism influences ambiguous pronoun comprehension in children with autism as compared to bilingual and monolingual children of typical development. The findings show that bilingualism was not detrimental to the autistic children's pronoun resolution skills, further suggesting that having acquired more than one language does not exacerbate autistic children's deficits in the comprehension of pronouns. En ligne : http://dx.doi.org/10.1002/aur.2634 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Bilingualism effects in pronoun comprehension: Evidence from children with autism [Texte imprimé et/ou numérique] / V. SKRIMPA, Auteur ; V. SPANOU, Auteur ; C. BONGARTZ, Auteur ; E. PERISTERI, Auteur ; M. ANDREOU, Auteur ; D. PAPADOPOULOU, Auteur . - p.270-283. Langues : Anglais (eng) in Autism Research > 15-2 (February 2022) . - p.270-283 Mots-clés : autism spectrum disorder  bilingualism  language deficits  pronoun resolution Index. décimale : PER Périodiques Résumé : The prevalence of autism worldwide has risen steadily in the last two decades, while bilingualism is also becoming increasingly prevalent in today's rapidly globalizing world. The current study aimed to investigate bilingualism effects in the pronoun resolution skills of children with autism in comparison to age-matched monolingual children with autism, as well as monolingual and bilingual children of typical development (? = 20 participants per group). Results showed that autistic children had general difficulty anchoring ambiguous pronouns to entities that were linguistically expressed in discourse, yet, the bilingual children with autism were more sensitive to the topicality of the entities in syntactic subject position and more prone to identify them as suitable referents of ambiguous null pronouns as compared to their monolingual peers. The findings suggest that bilingualism is not detrimental to autistic children's pronoun resolution skills. The current study aimed at determining how bilingualism influences ambiguous pronoun comprehension in children with autism as compared to bilingual and monolingual children of typical development. The findings show that bilingualism was not detrimental to the autistic children's pronoun resolution skills, further suggesting that having acquired more than one language does not exacerbate autistic children's deficits in the comprehension of pronouns. En ligne : http://dx.doi.org/10.1002/aur.2634 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Using the Clinical Global Impression scale to assess social communication change in minimally verbal children with autism spectrum disorder / C. TOOLAN in Autism Research, 15-2 (February 2022)  

Public ISBD [article]  inAutism Research > 15-2 (February 2022) . - p.284-295 Titre : Using the Clinical Global Impression scale to assess social communication change in minimally verbal children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : C. TOOLAN, Auteur ; A. HOLBROOK, Auteur ; A. SCHLINK, Auteur ; S. SHIRE, Auteur ; N. BRADY, Auteur ; Connie KASARI, Auteur Article en page(s) : p.284-295 Langues : Anglais (eng) Mots-clés : Clinical Global Impression Scale  Communication Complexity Scale  Jasper  assessment  autism spectrum disorder  minimally verbal  social communication Index. décimale : PER Périodiques Résumé : Assessing improvements in social communication behaviors in minimally verbal children with autism spectrum disorder (ASD) is often challenging. The Clinical Global Impression Scale (CGI) is a 7-point scale that has been adapted so that clinicians can easily and quickly rate social communication behaviors. The current study evaluated the CGI-Improvement (CGI-I) subscale as a measure of social communication change in minimally verbal children with ASD. The sample included 54 minimally verbal school-age children with ASD enrolled in a social communication intervention trial. CGIs were rated by interventionists and the study coordinator at baseline and at Week 6 of intervention, and were compared to scores on the Communication Complexity Scale (CCS). Results indicated that CGI ratings corresponded with CCS scores at baseline and Week 6. Children who were rated as more severe on social communication at baseline demonstrated lower complexity of communication compared to those who were rated as less severe. Those who demonstrated fast response to intervention at Week 6 showed greater improvement in their joint attention than those who were slower responders. These results provide support for the utility and validity of the CGI-I as a measure of social communication change in minimally verbal children. This study tested the CGI, a clinician rating scale, with a group of children with ASD with limited language who received intervention to improve social interactions and communication. Children's CGI ratings were comparable to other assessments in measuring social communication. The CGI may be a useful tool for those interested in quickly and easily tracking changes in children's social communication over the course of treatment. LAY SUMMARY: This study tested the Clinical Global Impression (CGI), a clinician rating scale, with a group of children with ASD with limited language who received intervention to improve social interactions and communication. Children's CGI ratings were comparable to other assessments in measuring social communication. The CGI may be a useful tool for those interested in quickly and easily tracking changes in children's social communication over the course of treatment. En ligne : http://dx.doi.org/10.1002/aur.2638 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Using the Clinical Global Impression scale to assess social communication change in minimally verbal children with autism spectrum disorder [Texte imprimé et/ou numérique] / C. TOOLAN, Auteur ; A. HOLBROOK, Auteur ; A. SCHLINK, Auteur ; S. SHIRE, Auteur ; N. BRADY, Auteur ; Connie KASARI, Auteur . - p.284-295. Langues : Anglais (eng) in Autism Research > 15-2 (February 2022) . - p.284-295 Mots-clés : Clinical Global Impression Scale  Communication Complexity Scale  Jasper  assessment  autism spectrum disorder  minimally verbal  social communication Index. décimale : PER Périodiques Résumé : Assessing improvements in social communication behaviors in minimally verbal children with autism spectrum disorder (ASD) is often challenging. The Clinical Global Impression Scale (CGI) is a 7-point scale that has been adapted so that clinicians can easily and quickly rate social communication behaviors. The current study evaluated the CGI-Improvement (CGI-I) subscale as a measure of social communication change in minimally verbal children with ASD. The sample included 54 minimally verbal school-age children with ASD enrolled in a social communication intervention trial. CGIs were rated by interventionists and the study coordinator at baseline and at Week 6 of intervention, and were compared to scores on the Communication Complexity Scale (CCS). Results indicated that CGI ratings corresponded with CCS scores at baseline and Week 6. Children who were rated as more severe on social communication at baseline demonstrated lower complexity of communication compared to those who were rated as less severe. Those who demonstrated fast response to intervention at Week 6 showed greater improvement in their joint attention than those who were slower responders. These results provide support for the utility and validity of the CGI-I as a measure of social communication change in minimally verbal children. This study tested the CGI, a clinician rating scale, with a group of children with ASD with limited language who received intervention to improve social interactions and communication. Children's CGI ratings were comparable to other assessments in measuring social communication. The CGI may be a useful tool for those interested in quickly and easily tracking changes in children's social communication over the course of treatment. LAY SUMMARY: This study tested the Clinical Global Impression (CGI), a clinician rating scale, with a group of children with ASD with limited language who received intervention to improve social interactions and communication. Children's CGI ratings were comparable to other assessments in measuring social communication. The CGI may be a useful tool for those interested in quickly and easily tracking changes in children's social communication over the course of treatment. En ligne : http://dx.doi.org/10.1002/aur.2638 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

What are we optimizing for in autism screening? Examination of algorithmic changes in the M-CHAT / Synnve SCHJØLBERG in Autism Research, 15-2 (February 2022)  

Public ISBD [article]  inAutism Research > 15-2 (February 2022) . - p.296-304 Titre : What are we optimizing for in autism screening? Examination of algorithmic changes in the M-CHAT Type de document : Texte imprimé et/ou numérique Auteurs : Synnve SCHJØLBERG, Auteur ; F. SHIC, Auteur ; Fred R. VOLKMAR, Auteur ; Anders NORDAHL-HANSEN, Auteur ; N. STENBERG, Auteur ; T. TORSKE, Auteur ; K. LARSEN, Auteur ; K. RILEY, Auteur ; D. G. SUKHODOLSKY, Auteur ; J. F. LECKMAN, Auteur ; Katarzyna CHAWARSKA, Auteur ; Roald A. ØIEN, Auteur Article en page(s) : p.296-304 Langues : Anglais (eng) Mots-clés : children  early detection  psychometrics  (includes financial disclosures): None Index. décimale : PER Périodiques Résumé : The present study objectives were to examine the performance of the new M-CHAT-R algorithm to the original M-CHAT algorithm. The main purpose was to examine if the algorithmic changes increase identification of children later diagnosed with ASD, and to examine if there is a trade-off when changing algorithms. We included 54,463 screened cases from the Norwegian Mother and Child Cohort Study. Children were screened using the 23 items of the M-CHAT at 18?months. Further, the performance of the M-CHAT-R algorithm was compared to the M-CHAT algorithm on the 23-items. In total, 337 individuals were later diagnosed with ASD. Using M-CHAT-R algorithm decreased the number of correctly identified ASD children by 12 compared to M-CHAT, with no children with ASD screening negative on the M-CHAT criteria subsequently screening positive utilizing the M-CHAT-R algorithm. A nonparametric McNemar's test determined a statistically significant difference in identifying ASD utilizing the M-CHAT-R algorithm. The present study examined the application of 20-item MCHAT-R scoring criterion to the 23-item MCHAT. We found that this resulted in decreased sensitivity and increased specificity for identifying children with ASD, which is a trade-off that needs further investigation in terms of cost-effectiveness. However, further research is needed to optimize screening for ASD in the early developmental period to increase identification of false negatives. En ligne : http://dx.doi.org/10.1002/aur.2643 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] What are we optimizing for in autism screening? Examination of algorithmic changes in the M-CHAT [Texte imprimé et/ou numérique] / Synnve SCHJØLBERG, Auteur ; F. SHIC, Auteur ; Fred R. VOLKMAR, Auteur ; Anders NORDAHL-HANSEN, Auteur ; N. STENBERG, Auteur ; T. TORSKE, Auteur ; K. LARSEN, Auteur ; K. RILEY, Auteur ; D. G. SUKHODOLSKY, Auteur ; J. F. LECKMAN, Auteur ; Katarzyna CHAWARSKA, Auteur ; Roald A. ØIEN, Auteur . - p.296-304. Langues : Anglais (eng) in Autism Research > 15-2 (February 2022) . - p.296-304 Mots-clés : children  early detection  psychometrics  (includes financial disclosures): None Index. décimale : PER Périodiques Résumé : The present study objectives were to examine the performance of the new M-CHAT-R algorithm to the original M-CHAT algorithm. The main purpose was to examine if the algorithmic changes increase identification of children later diagnosed with ASD, and to examine if there is a trade-off when changing algorithms. We included 54,463 screened cases from the Norwegian Mother and Child Cohort Study. Children were screened using the 23 items of the M-CHAT at 18?months. Further, the performance of the M-CHAT-R algorithm was compared to the M-CHAT algorithm on the 23-items. In total, 337 individuals were later diagnosed with ASD. Using M-CHAT-R algorithm decreased the number of correctly identified ASD children by 12 compared to M-CHAT, with no children with ASD screening negative on the M-CHAT criteria subsequently screening positive utilizing the M-CHAT-R algorithm. A nonparametric McNemar's test determined a statistically significant difference in identifying ASD utilizing the M-CHAT-R algorithm. The present study examined the application of 20-item MCHAT-R scoring criterion to the 23-item MCHAT. We found that this resulted in decreased sensitivity and increased specificity for identifying children with ASD, which is a trade-off that needs further investigation in terms of cost-effectiveness. However, further research is needed to optimize screening for ASD in the early developmental period to increase identification of false negatives. En ligne : http://dx.doi.org/10.1002/aur.2643 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Excessive and less complex body movement in children with autism during face-to-face conversation: An objective approach to behavioral quantification / Z. ZHAO in Autism Research, 15-2 (February 2022)  

Public ISBD [article]  inAutism Research > 15-2 (February 2022) . - p.305-316 Titre : Excessive and less complex body movement in children with autism during face-to-face conversation: An objective approach to behavioral quantification Type de document : Texte imprimé et/ou numérique Auteurs : Z. ZHAO, Auteur ; H. TANG, Auteur ; C. ALVIAR, Auteur ; C. T. KELLO, Auteur ; X. ZHANG, Auteur ; X. HU, Auteur ; X. QU, Auteur ; J. LU, Auteur Article en page(s) : p.305-316 Langues : Anglais (eng) Mots-clés : autism  complexity matching  face-to-face  movement dynamics  social interaction  spectral analysis Index. décimale : PER Périodiques Résumé : The majority of existing studies investigating characteristics of overt social behavior in individuals with autism spectrum disorder (ASD) relied on informants' evaluation through questionnaires and behavioral coding techniques. As a novelty, this study aimed to quantify the complex movements produced during social interactions in order to test differences in ASD movement dynamics and their convergence, or lack thereof, during social interactions. Twenty children with ASD and twenty-three children with typical development (TD) were videotaped while engaged in a face-to-face conversation with an interviewer. An image differencing technique was utilized to extract the movement time series. Spectral analyses were conducted to quantify the average power of movement, and the fractal scaling of movement. The degree of complexity matching was calculated to capture the level of behavioral coordination between the interviewer and children. Results demonstrated that the average power was significantly higher (p? En ligne : http://dx.doi.org/10.1002/aur.2646 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Excessive and less complex body movement in children with autism during face-to-face conversation: An objective approach to behavioral quantification [Texte imprimé et/ou numérique] / Z. ZHAO, Auteur ; H. TANG, Auteur ; C. ALVIAR, Auteur ; C. T. KELLO, Auteur ; X. ZHANG, Auteur ; X. HU, Auteur ; X. QU, Auteur ; J. LU, Auteur . - p.305-316. Langues : Anglais (eng) in Autism Research > 15-2 (February 2022) . - p.305-316 Mots-clés : autism  complexity matching  face-to-face  movement dynamics  social interaction  spectral analysis Index. décimale : PER Périodiques Résumé : The majority of existing studies investigating characteristics of overt social behavior in individuals with autism spectrum disorder (ASD) relied on informants' evaluation through questionnaires and behavioral coding techniques. As a novelty, this study aimed to quantify the complex movements produced during social interactions in order to test differences in ASD movement dynamics and their convergence, or lack thereof, during social interactions. Twenty children with ASD and twenty-three children with typical development (TD) were videotaped while engaged in a face-to-face conversation with an interviewer. An image differencing technique was utilized to extract the movement time series. Spectral analyses were conducted to quantify the average power of movement, and the fractal scaling of movement. The degree of complexity matching was calculated to capture the level of behavioral coordination between the interviewer and children. Results demonstrated that the average power was significantly higher (p? En ligne : http://dx.doi.org/10.1002/aur.2646 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Development and psychometric evaluation of a Thai Diagnostic Autism Scale for the early diagnosis of Autism Spectrum Disorder / D. TANGVIRIYAPAIBOON in Autism Research, 15-2 (February 2022)  

Public ISBD [article]  inAutism Research > 15-2 (February 2022) . - p.317-327 Titre : Development and psychometric evaluation of a Thai Diagnostic Autism Scale for the early diagnosis of Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : D. TANGVIRIYAPAIBOON, Auteur ; S. SIRITHONGTHAWORN, Auteur ; H. APIKOMONKON, Auteur ; C. SUYAKONG, Auteur ; P. SRIKUMMOON, Auteur ; S. KAWILAPAT, Auteur ; P. TRAISATHIT, Auteur Article en page(s) : p.317-327 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Thai Diagnostic Autism Scale  diagnostic tool  early diagnosis Index. décimale : PER Périodiques Résumé : The Thai Diagnostic Autism Scale (TDAS) was developed for use as a diagnostic tool for the early diagnosis of Autism Spectrum Disorder (ASD) in Thai children aged 12-48?months old. TDAS consists of 23 items (13 and 17 items in the observational and interview sections, respectively) classified into seven domains (A1-A3 and B1-B4) according to the criteria in the Diagnostic and Statistical Manual of Mental Disorder, fifth edition (DSM-5). Children with a single score in the A1-A3 domains and at least two of the B1-B4 domains were classified with ASD. The item-objective congruence (IOC) index, confirmatory factor analysis, and Kappa coefficient were used to evaluate the content, constructs, and inter-rater validity levels between the evaluators and concurrent validity between TDAS and physicians' diagnoses, respectively. TDAS showed good overall content validity (IOC range 0.71-1.00), suitable construct validity (root-mean-squared errors of approximation of 0.076 and 0.067, comparative fit indexes of 0.902 and 0.858, and Tucker-Lewis indexes of 0.882 and 0.837 for the observation and interview sections, respectively), and excellent diagnostic agreement between TDAS and the evaluators (Kappa = 1.000) as well as between TDAS and the physicians' diagnoses (Kappa = 0.871). The sensitivity and specificity of TDAS were 100% and 82.4%, respectively. In conclusion, TDAS yielded a high level of content validity, concurrent validity, and inter-rater reliability for the early diagnosis of ASD in Thai children. A large-scale study using TDAS is needed to determine an appropriate cut-off point as well as its efficacy. LAY SUMMARY: The Thai Diagnostic Autism Scale was developed for use as a diagnostic tool for the early diagnosis of Autism Spectrum Disorder (ASD) among Thai children. It contains 23 items in seven domains for the screening via observations and interviews. The psychometric properties of this diagnostic tool provide its reliability and suitability for the early diagnosis of ASD. A large-scale study using it is needed to determine an appropriate cut-off point as well as its efficacy. En ligne : http://dx.doi.org/10.1002/aur.2631 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Development and psychometric evaluation of a Thai Diagnostic Autism Scale for the early diagnosis of Autism Spectrum Disorder [Texte imprimé et/ou numérique] / D. TANGVIRIYAPAIBOON, Auteur ; S. SIRITHONGTHAWORN, Auteur ; H. APIKOMONKON, Auteur ; C. SUYAKONG, Auteur ; P. SRIKUMMOON, Auteur ; S. KAWILAPAT, Auteur ; P. TRAISATHIT, Auteur . - p.317-327. Langues : Anglais (eng) in Autism Research > 15-2 (February 2022) . - p.317-327 Mots-clés : Autism Spectrum Disorder  Thai Diagnostic Autism Scale  diagnostic tool  early diagnosis Index. décimale : PER Périodiques Résumé : The Thai Diagnostic Autism Scale (TDAS) was developed for use as a diagnostic tool for the early diagnosis of Autism Spectrum Disorder (ASD) in Thai children aged 12-48?months old. TDAS consists of 23 items (13 and 17 items in the observational and interview sections, respectively) classified into seven domains (A1-A3 and B1-B4) according to the criteria in the Diagnostic and Statistical Manual of Mental Disorder, fifth edition (DSM-5). Children with a single score in the A1-A3 domains and at least two of the B1-B4 domains were classified with ASD. The item-objective congruence (IOC) index, confirmatory factor analysis, and Kappa coefficient were used to evaluate the content, constructs, and inter-rater validity levels between the evaluators and concurrent validity between TDAS and physicians' diagnoses, respectively. TDAS showed good overall content validity (IOC range 0.71-1.00), suitable construct validity (root-mean-squared errors of approximation of 0.076 and 0.067, comparative fit indexes of 0.902 and 0.858, and Tucker-Lewis indexes of 0.882 and 0.837 for the observation and interview sections, respectively), and excellent diagnostic agreement between TDAS and the evaluators (Kappa = 1.000) as well as between TDAS and the physicians' diagnoses (Kappa = 0.871). The sensitivity and specificity of TDAS were 100% and 82.4%, respectively. In conclusion, TDAS yielded a high level of content validity, concurrent validity, and inter-rater reliability for the early diagnosis of ASD in Thai children. A large-scale study using TDAS is needed to determine an appropriate cut-off point as well as its efficacy. LAY SUMMARY: The Thai Diagnostic Autism Scale was developed for use as a diagnostic tool for the early diagnosis of Autism Spectrum Disorder (ASD) among Thai children. It contains 23 items in seven domains for the screening via observations and interviews. The psychometric properties of this diagnostic tool provide its reliability and suitability for the early diagnosis of ASD. A large-scale study using it is needed to determine an appropriate cut-off point as well as its efficacy. En ligne : http://dx.doi.org/10.1002/aur.2631 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Autism spectrum disorder in a rural community in Bangladesh: A mid-childhood assessment / H. ALI in Autism Research, 15-2 (February 2022)  

Public ISBD [article]  inAutism Research > 15-2 (February 2022) . - p.328-339 Titre : Autism spectrum disorder in a rural community in Bangladesh: A mid-childhood assessment Type de document : Texte imprimé et/ou numérique Auteurs : H. ALI, Auteur ; H. RAHMAN, Auteur ; L. C. LEE, Auteur ; N. Z. KHAN, Auteur ; L. S. WU, Auteur ; S. MEHRA, Auteur ; M. MITRA, Auteur ; A. B. LABRIQUE, Auteur ; K. P. WEST, Auteur ; P. CHRISTIAN, Auteur Article en page(s) : p.328-339 Langues : Anglais (eng) Mots-clés : Bangladesh  children  diagnosis  prevalence  sex differences Index. décimale : PER Périodiques Résumé : Population-based studies employing standardized diagnostics are needed to determine the burden of autism spectrum disorder (ASD) in low-resource settings. A community-based study was conducted among 8-11?year old children in rural, northwestern Bangladesh to establish the prevalence of ASD. A standardized screening and diagnosis protocol was adapted and deployed comprising the social communication questionnaire (SCQ), and the autism diagnostic observation schedule 2, (ADOS-2), and the autism diagnostic interview, revised (ADI-R), respectively. A year-long research training was conducted for a clinical psychologist to be certified to administer ADOS-2 and ADI-R. Over 8000 children were visited at home and administered the SCQ leading to some, based on their score, being further evaluated using the ADOS-2 and ADI-R by the clinical psychologist. Based on ADOS-2 applying the diagnoses of autism or autism spectrum, the prevalence was 40 (95% CI: 27, 54) per 10,000. Autistic disorder using ADI-R was found at 12 (95% CI: 5, 20) per 10,000. Boys were at a higher risk than girls with the rates among boys being 46 (95% CI: 25, 67) using ADOS-2 and 19 (95% CI:6, 33) using ADI-R. Among girls the rates were 34 (95% CI:16, 52) and 5 (95% CI:0, 12) per 10,000, respectively. Challenges to undertaking ASD research in a rural South Asian context are discussed. There was a low-to-moderate prevalence of ASD in a rural, child population in Bangladesh. Future research is needed to estimate rates of ASD and its causes and socioeconomic consequences in rural and urban settings of South Asia. LAY SUMMARY: In a study of over 8000, 8-11?year old children in a rural area of Bangladesh, two to four out of 1000 had ASD. Boys more than girls had ASD. Conducting ASD assessment in this setting was difficult, but more such research is needed to understand what causes ASD and its consequences for the individual, families and the society in rural and urban areas of low-income countries. En ligne : http://dx.doi.org/10.1002/aur.2651 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Autism spectrum disorder in a rural community in Bangladesh: A mid-childhood assessment [Texte imprimé et/ou numérique] / H. ALI, Auteur ; H. RAHMAN, Auteur ; L. C. LEE, Auteur ; N. Z. KHAN, Auteur ; L. S. WU, Auteur ; S. MEHRA, Auteur ; M. MITRA, Auteur ; A. B. LABRIQUE, Auteur ; K. P. WEST, Auteur ; P. CHRISTIAN, Auteur . - p.328-339. Langues : Anglais (eng) in Autism Research > 15-2 (February 2022) . - p.328-339 Mots-clés : Bangladesh  children  diagnosis  prevalence  sex differences Index. décimale : PER Périodiques Résumé : Population-based studies employing standardized diagnostics are needed to determine the burden of autism spectrum disorder (ASD) in low-resource settings. A community-based study was conducted among 8-11?year old children in rural, northwestern Bangladesh to establish the prevalence of ASD. A standardized screening and diagnosis protocol was adapted and deployed comprising the social communication questionnaire (SCQ), and the autism diagnostic observation schedule 2, (ADOS-2), and the autism diagnostic interview, revised (ADI-R), respectively. A year-long research training was conducted for a clinical psychologist to be certified to administer ADOS-2 and ADI-R. Over 8000 children were visited at home and administered the SCQ leading to some, based on their score, being further evaluated using the ADOS-2 and ADI-R by the clinical psychologist. Based on ADOS-2 applying the diagnoses of autism or autism spectrum, the prevalence was 40 (95% CI: 27, 54) per 10,000. Autistic disorder using ADI-R was found at 12 (95% CI: 5, 20) per 10,000. Boys were at a higher risk than girls with the rates among boys being 46 (95% CI: 25, 67) using ADOS-2 and 19 (95% CI:6, 33) using ADI-R. Among girls the rates were 34 (95% CI:16, 52) and 5 (95% CI:0, 12) per 10,000, respectively. Challenges to undertaking ASD research in a rural South Asian context are discussed. There was a low-to-moderate prevalence of ASD in a rural, child population in Bangladesh. Future research is needed to estimate rates of ASD and its causes and socioeconomic consequences in rural and urban settings of South Asia. LAY SUMMARY: In a study of over 8000, 8-11?year old children in a rural area of Bangladesh, two to four out of 1000 had ASD. Boys more than girls had ASD. Conducting ASD assessment in this setting was difficult, but more such research is needed to understand what causes ASD and its consequences for the individual, families and the society in rural and urban areas of low-income countries. En ligne : http://dx.doi.org/10.1002/aur.2651 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Association between autism spectrum disorder and inflammatory bowel disease: A systematic review and meta-analysis / J. Y. KIM in Autism Research, 15-2 (February 2022)  

Public ISBD [article]  inAutism Research > 15-2 (February 2022) . - p.340-352 Titre : Association between autism spectrum disorder and inflammatory bowel disease: A systematic review and meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : J. Y. KIM, Auteur ; M. J. CHOI, Auteur ; S. HA, Auteur ; J. HWANG, Auteur ; A. KOYANAGI, Auteur ; E. DRAGIOTI, Auteur ; J. RADUA, Auteur ; L. SMITH, Auteur ; L. JACOB, Auteur ; G. S. DE PABLO, Auteur ; S. W. LEE, Auteur ; D. K. YON, Auteur ; T. THOMPSON, Auteur ; S. CORTESE, Auteur ; G. LOLLO, Auteur ; C. S. LIANG, Auteur ; C. S. CHU, Auteur ; P. FUSAR-POLI, Auteur ; Keun-Ah CHEON, Auteur ; J. I. SHIN, Auteur ; M. SOLMI, Auteur Article en page(s) : p.340-352 Langues : Anglais (eng) Mots-clés : Crohn's disease  autism spectrum disorder  inflammatory bowel disease  meta-analysis  ulcerative colitis Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) are frequently diagnosed with co-occurring medical conditions including inflammatory bowel disease (IBD). To investigate the association, we conducted a systematic review registered in PROSPERO (ID:CRD42021236263) with a random-effects meta-analysis. We searched PubMed, Embase, and PsycInfo (last search on January 25, 2021), and manually searched relevant publications. We included observational studies measuring the association between ASD and IBD. The primary outcome was the association (odds ratio, OR) between ASD and later development of IBD. Sensitivity analyses were conducted by quality, confounding adjustment, and study design. We performed meta-regression analyses and assessed heterogeneity, publication bias, and quality of studies with the Newcastle-Ottawa Scale. Overall, we included six studies consisting of eight datasets, including over 11 million participants. We found that ASD was significantly associated with subsequent incident IBD (any IBD, OR = 1.66, 95% confidence interval[CI] = 1.25-2.21, p  En ligne : http://dx.doi.org/10.1002/aur.2656 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Association between autism spectrum disorder and inflammatory bowel disease: A systematic review and meta-analysis [Texte imprimé et/ou numérique] / J. Y. KIM, Auteur ; M. J. CHOI, Auteur ; S. HA, Auteur ; J. HWANG, Auteur ; A. KOYANAGI, Auteur ; E. DRAGIOTI, Auteur ; J. RADUA, Auteur ; L. SMITH, Auteur ; L. JACOB, Auteur ; G. S. DE PABLO, Auteur ; S. W. LEE, Auteur ; D. K. YON, Auteur ; T. THOMPSON, Auteur ; S. CORTESE, Auteur ; G. LOLLO, Auteur ; C. S. LIANG, Auteur ; C. S. CHU, Auteur ; P. FUSAR-POLI, Auteur ; Keun-Ah CHEON, Auteur ; J. I. SHIN, Auteur ; M. SOLMI, Auteur . - p.340-352. Langues : Anglais (eng) in Autism Research > 15-2 (February 2022) . - p.340-352 Mots-clés : Crohn's disease  autism spectrum disorder  inflammatory bowel disease  meta-analysis  ulcerative colitis Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) are frequently diagnosed with co-occurring medical conditions including inflammatory bowel disease (IBD). To investigate the association, we conducted a systematic review registered in PROSPERO (ID:CRD42021236263) with a random-effects meta-analysis. We searched PubMed, Embase, and PsycInfo (last search on January 25, 2021), and manually searched relevant publications. We included observational studies measuring the association between ASD and IBD. The primary outcome was the association (odds ratio, OR) between ASD and later development of IBD. Sensitivity analyses were conducted by quality, confounding adjustment, and study design. We performed meta-regression analyses and assessed heterogeneity, publication bias, and quality of studies with the Newcastle-Ottawa Scale. Overall, we included six studies consisting of eight datasets, including over 11 million participants. We found that ASD was significantly associated with subsequent incident IBD (any IBD, OR = 1.66, 95% confidence interval[CI] = 1.25-2.21, p  En ligne : http://dx.doi.org/10.1002/aur.2656 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Parenting stress in caregiver-mediated interventions for toddlers with autism: An application of quantile regression mixed models / A. SCHLINK in Autism Research, 15-2 (February 2022)  

Public ISBD [article]  inAutism Research > 15-2 (February 2022) . - p.353-365 Titre : Parenting stress in caregiver-mediated interventions for toddlers with autism: An application of quantile regression mixed models Type de document : Texte imprimé et/ou numérique Auteurs : A. SCHLINK, Auteur ; J. WILLIAMS, Auteur ; M. PIZZANO, Auteur ; A. GULSRUD, Auteur ; Connie KASARI, Auteur Article en page(s) : p.353-365 Langues : Anglais (eng) Mots-clés : Jasper  autism spectrum disorder  caregiver-mediated interventions  linear quantile mixed models  parenting stress  toddlers Index. décimale : PER Périodiques Résumé : Traditional longitudinal modeling approaches require normally distributed data and do not account for sample heterogeneity. Parenting stress, in particular, can be difficult to model across time without transforming the data as it is usually high for caregivers of children with ASD. This study used novel linear quantile mixed models (LQMMs) to model non-normal parent stress scores across two caregiver-mediated interventions involving toddlers with ASD. The sample included 86 caregiver-child dyads who were randomized to either a parent-only psychoeducational intervention or hands-on parent training in a naturalistic developmental intervention. Child and parent-related domains of the Parenting Stress Index (PSI) were the primary outcomes in this study. The PSI was collected at entry, 10-week exit, 3-month follow-up, and 6-month follow-up periods. Separate LQMMs were used to model five specific quantiles ( ? = 0.1, 0.25, 0.5, 0.75, and 0.9) of the two PSI domains across the complete intervention timeline. These five quantiles effectively modeled the entire conditional distribution of parenting stress scores. The LQMMs indicated that child-related parenting stress decreased across all quantiles within both interventions, with no difference in the rate of parenting stress change between the intervention groups. For parent-related parenting stress, the effect of intervention depended on the group's stress level; some parents increased their perceived stress within the hands-on intervention at the 3-month follow-up. Overall, this study demonstrated that the use of LQMMs yielded additional information, beyond traditional longitudinal models, regarding the relationship between parenting stress within two caregiver-mediated intervention protocols. This study also discussed the methodological contributions and potential future applications of LQMMs. LAY SUMMARY: This study used a newer longitudinal modeling technique to examine how parenting stress changed across two caregiver-mediated interventions for toddlers with ASD. Results showed that certain parents in the JASPER condition might require additional support as they exit the study and enter into their first follow-up period. It was also determined that this new modeling technique could be a valuable tool to analyze highly variable data often present in ASD intervention studies. En ligne : http://dx.doi.org/10.1002/aur.2637 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Parenting stress in caregiver-mediated interventions for toddlers with autism: An application of quantile regression mixed models [Texte imprimé et/ou numérique] / A. SCHLINK, Auteur ; J. WILLIAMS, Auteur ; M. PIZZANO, Auteur ; A. GULSRUD, Auteur ; Connie KASARI, Auteur . - p.353-365. Langues : Anglais (eng) in Autism Research > 15-2 (February 2022) . - p.353-365 Mots-clés : Jasper  autism spectrum disorder  caregiver-mediated interventions  linear quantile mixed models  parenting stress  toddlers Index. décimale : PER Périodiques Résumé : Traditional longitudinal modeling approaches require normally distributed data and do not account for sample heterogeneity. Parenting stress, in particular, can be difficult to model across time without transforming the data as it is usually high for caregivers of children with ASD. This study used novel linear quantile mixed models (LQMMs) to model non-normal parent stress scores across two caregiver-mediated interventions involving toddlers with ASD. The sample included 86 caregiver-child dyads who were randomized to either a parent-only psychoeducational intervention or hands-on parent training in a naturalistic developmental intervention. Child and parent-related domains of the Parenting Stress Index (PSI) were the primary outcomes in this study. The PSI was collected at entry, 10-week exit, 3-month follow-up, and 6-month follow-up periods. Separate LQMMs were used to model five specific quantiles ( ? = 0.1, 0.25, 0.5, 0.75, and 0.9) of the two PSI domains across the complete intervention timeline. These five quantiles effectively modeled the entire conditional distribution of parenting stress scores. The LQMMs indicated that child-related parenting stress decreased across all quantiles within both interventions, with no difference in the rate of parenting stress change between the intervention groups. For parent-related parenting stress, the effect of intervention depended on the group's stress level; some parents increased their perceived stress within the hands-on intervention at the 3-month follow-up. Overall, this study demonstrated that the use of LQMMs yielded additional information, beyond traditional longitudinal models, regarding the relationship between parenting stress within two caregiver-mediated intervention protocols. This study also discussed the methodological contributions and potential future applications of LQMMs. LAY SUMMARY: This study used a newer longitudinal modeling technique to examine how parenting stress changed across two caregiver-mediated interventions for toddlers with ASD. Results showed that certain parents in the JASPER condition might require additional support as they exit the study and enter into their first follow-up period. It was also determined that this new modeling technique could be a valuable tool to analyze highly variable data often present in ASD intervention studies. En ligne : http://dx.doi.org/10.1002/aur.2637 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Caregiver responsiveness as a mechanism to improve social communication in toddlers: Secondary analysis of a randomized controlled trial / P. H. DAVIS in Autism Research, 15-2 (February 2022)  

Public ISBD [article]  inAutism Research > 15-2 (February 2022) . - p.366-378 Titre : Caregiver responsiveness as a mechanism to improve social communication in toddlers: Secondary analysis of a randomized controlled trial Type de document : Texte imprimé et/ou numérique Auteurs : P. H. DAVIS, Auteur ; H. ELSAYED, Auteur ; Elizabeth R. CRAIS, Auteur ; Linda R. WATSON, Auteur ; R. GRZADZINSKI, Auteur Article en page(s) : p.366-378 Langues : Anglais (eng) Mots-clés : Boscc  autism spectrum disorder  caregiver responsiveness  early intervention  social communication  treatment response measure  Dr. Grzadzinski has received compensation for trainings she has led on the ADOS and  BOSCC  she did not receive compensation for trainings associated with this  manuscript. Additionally, Dr. Watson and Dr. Crais have received compensation for  invited talks/workshops on the ART intervention and its strategies. Index. décimale : PER Périodiques Résumé : Early intensive behavioral interventions (EIBI) for children at elevated likelihood for a later diagnosis of autism spectrum disorder (EL-ASD), are often delivered through parent-mediated models. An area of current exploration is whether changes in caregiver behaviors are a mechanism through which to improve and track child behaviors in these interventions. Toddlers and their caregivers participated in an intervention trial (randomized controlled trial) and were randomized to either a parent-mediated intervention (adapted responsive teaching; ART) or a control condition (referral to early intervention and monitoring; REIM). Changes in toddler social communication (SC) behaviors and characteristics of caregiver responsiveness (CR) were quantified over 8?months. Analyses were conducted to assess whether changes in CR mediated the relation between group (ART vs. REIM) and changes in child SC. Results of the current study indicated that caregivers who participated in a parent-mediated intervention improved in three domains of CR (contingent verbal sensitivity, responsivity, affect). CR was also found to be a mechanism through which children's SC skills improved. This work provides evidence that qualities of CR serve as mechanisms through which to improve and monitor child behaviors over the course of EIBIs. These results may lead to novel intervention targets, methods for tracking change, and tailored treatment planning for toddlers with EL-ASD. The data used in this study comes from a clinical trial that was prospectively registered with the Registry of Efficacy and Effectiveness Studies (Registry ID: 316.1v1). LAY SUMMARY: Interventions for toddlers with high likelihood for a later diagnosis of autism often include the caregiver as an active participant in the intervention. In this study, we aimed to understand qualities of caregiver responsiveness (CR) that facilitate improvements in child behaviors during intervention. Results show that increasing verbal CR and affect are ways to improve child social skills over the course of intervention. En ligne : http://dx.doi.org/10.1002/aur.2640 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Caregiver responsiveness as a mechanism to improve social communication in toddlers: Secondary analysis of a randomized controlled trial [Texte imprimé et/ou numérique] / P. H. DAVIS, Auteur ; H. ELSAYED, Auteur ; Elizabeth R. CRAIS, Auteur ; Linda R. WATSON, Auteur ; R. GRZADZINSKI, Auteur . - p.366-378. Langues : Anglais (eng) in Autism Research > 15-2 (February 2022) . - p.366-378 Mots-clés : Boscc  autism spectrum disorder  caregiver responsiveness  early intervention  social communication  treatment response measure  Dr. Grzadzinski has received compensation for trainings she has led on the ADOS and  BOSCC  she did not receive compensation for trainings associated with this  manuscript. Additionally, Dr. Watson and Dr. Crais have received compensation for  invited talks/workshops on the ART intervention and its strategies. Index. décimale : PER Périodiques Résumé : Early intensive behavioral interventions (EIBI) for children at elevated likelihood for a later diagnosis of autism spectrum disorder (EL-ASD), are often delivered through parent-mediated models. An area of current exploration is whether changes in caregiver behaviors are a mechanism through which to improve and track child behaviors in these interventions. Toddlers and their caregivers participated in an intervention trial (randomized controlled trial) and were randomized to either a parent-mediated intervention (adapted responsive teaching; ART) or a control condition (referral to early intervention and monitoring; REIM). Changes in toddler social communication (SC) behaviors and characteristics of caregiver responsiveness (CR) were quantified over 8?months. Analyses were conducted to assess whether changes in CR mediated the relation between group (ART vs. REIM) and changes in child SC. Results of the current study indicated that caregivers who participated in a parent-mediated intervention improved in three domains of CR (contingent verbal sensitivity, responsivity, affect). CR was also found to be a mechanism through which children's SC skills improved. This work provides evidence that qualities of CR serve as mechanisms through which to improve and monitor child behaviors over the course of EIBIs. These results may lead to novel intervention targets, methods for tracking change, and tailored treatment planning for toddlers with EL-ASD. The data used in this study comes from a clinical trial that was prospectively registered with the Registry of Efficacy and Effectiveness Studies (Registry ID: 316.1v1). LAY SUMMARY: Interventions for toddlers with high likelihood for a later diagnosis of autism often include the caregiver as an active participant in the intervention. In this study, we aimed to understand qualities of caregiver responsiveness (CR) that facilitate improvements in child behaviors during intervention. Results show that increasing verbal CR and affect are ways to improve child social skills over the course of intervention. En ligne : http://dx.doi.org/10.1002/aur.2640 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450