Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits / Dorothea L. FLORIS in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 35p. Titre : Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits Type de document : texte imprimé Auteurs : Dorothea L. FLORIS, Auteur ; Anita D. BARBER, Auteur ; Mary Beth NEBEL, Auteur ; Mary MARTINELLI, Auteur ; Meng-Chuan LAI, Auteur ; Deana CROCETTI, Auteur ; Simon BARON-COHEN, Auteur ; John SUCKLING, Auteur ; James J. PEKAR, Auteur ; Stewart H. MOSTOFSKY, Auteur Article en page(s) : 35p. Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/physiopathology  Brain/diagnostic imaging/physiopathology  Case-Control Studies  Child  Female  Functional Laterality/physiology  Humans  Image Processing, Computer-Assisted  Language  Magnetic Resonance Imaging  Male  Neuropsychological Tests  Autism  Hemispheric specialization  Intrinsic functional connectivity  Lateralization  Motor deficits Index. décimale : PER Périodiques Résumé : BACKGROUND: Atypical lateralization of language-related functions has been repeatedly found in individuals with autism spectrum conditions (ASC). Few studies have, however, investigated deviations from typically occurring asymmetry of other lateralized cognitive and behavioural domains. Motor deficits are among the earliest and most prominent symptoms in individuals with ASC and precede core social and communicative symptoms. METHODS: Here, we investigate whether motor circuit connectivity is (1) atypically lateralized in children with ASC and (2) whether this relates to core autistic symptoms and motor performance. Participants comprised 44 right-handed high-functioning children with autism (36 males, 8 females) and 80 typically developing control children (58 males, 22 females) matched on age, sex and performance IQ. We examined lateralization of functional motor circuit connectivity based on homotopic seeds derived from peak activations during a finger tapping paradigm. Motor performance was assessed using the Physical and Neurological Examination for Subtle Signs (PANESS). RESULTS: Children with ASC showed rightward lateralization in mean motor circuit connectivity compared to typically developing children, and this was associated with poorer performance on all three PANESS measures. CONCLUSIONS: Our findings reveal that atypical lateralization in ASC is not restricted to language functions but is also present in circuits subserving motor functions and may underlie motor deficits in children with ASC. Future studies should investigate whether this is an age-invariant finding extending to adolescents and adults and whether these asymmetries relate to atypical lateralization in the language domain. En ligne : http://dx.doi.org/10.1186/s13229-016-0096-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 [article] Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits [texte imprimé] / Dorothea L. FLORIS, Auteur ; Anita D. BARBER, Auteur ; Mary Beth NEBEL, Auteur ; Mary MARTINELLI, Auteur ; Meng-Chuan LAI, Auteur ; Deana CROCETTI, Auteur ; Simon BARON-COHEN, Auteur ; John SUCKLING, Auteur ; James J. PEKAR, Auteur ; Stewart H. MOSTOFSKY, Auteur . - 35p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 35p. Mots-clés : Autism Spectrum Disorder/physiopathology  Brain/diagnostic imaging/physiopathology  Case-Control Studies  Child  Female  Functional Laterality/physiology  Humans  Image Processing, Computer-Assisted  Language  Magnetic Resonance Imaging  Male  Neuropsychological Tests  Autism  Hemispheric specialization  Intrinsic functional connectivity  Lateralization  Motor deficits Index. décimale : PER Périodiques Résumé : BACKGROUND: Atypical lateralization of language-related functions has been repeatedly found in individuals with autism spectrum conditions (ASC). Few studies have, however, investigated deviations from typically occurring asymmetry of other lateralized cognitive and behavioural domains. Motor deficits are among the earliest and most prominent symptoms in individuals with ASC and precede core social and communicative symptoms. METHODS: Here, we investigate whether motor circuit connectivity is (1) atypically lateralized in children with ASC and (2) whether this relates to core autistic symptoms and motor performance. Participants comprised 44 right-handed high-functioning children with autism (36 males, 8 females) and 80 typically developing control children (58 males, 22 females) matched on age, sex and performance IQ. We examined lateralization of functional motor circuit connectivity based on homotopic seeds derived from peak activations during a finger tapping paradigm. Motor performance was assessed using the Physical and Neurological Examination for Subtle Signs (PANESS). RESULTS: Children with ASC showed rightward lateralization in mean motor circuit connectivity compared to typically developing children, and this was associated with poorer performance on all three PANESS measures. CONCLUSIONS: Our findings reveal that atypical lateralization in ASC is not restricted to language functions but is also present in circuits subserving motor functions and may underlie motor deficits in children with ASC. Future studies should investigate whether this is an age-invariant finding extending to adolescents and adults and whether these asymmetries relate to atypical lateralization in the language domain. En ligne : http://dx.doi.org/10.1186/s13229-016-0096-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328

Correction: Understanding the relationship between cerebellar structure and social abilities / Dorothea L. FLORIS ; Pierrick COUPÉ ; Edouard DUCHESNAY ; Angeline MIHAILOV ; Antoine GRIGIS ; Indrit BÈGUE ; Julie VICTOR ; Vincent FROUIN ; Marion LEBOYER ; Josselin HOUENOU ; Charles LAIDI in Molecular Autism, 14 (2023)  

Public ISBD [article]  inMolecular Autism > 14 (2023) . - 24 p. Titre : Correction: Understanding the relationship between cerebellar structure and social abilities Type de document : texte imprimé Auteurs : Dorothea L. FLORIS, Auteur ; Pierrick COUPÉ, Auteur ; Edouard DUCHESNAY, Auteur ; Angeline MIHAILOV, Auteur ; Antoine GRIGIS, Auteur ; Indrit BÈGUE, Auteur ; Julie VICTOR, Auteur ; Vincent FROUIN, Auteur ; Marion LEBOYER, Auteur ; Josselin HOUENOU, Auteur ; Charles LAIDI, Auteur Article en page(s) : 24 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1186/s13229-023-00553-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] Correction: Understanding the relationship between cerebellar structure and social abilities [texte imprimé] / Dorothea L. FLORIS, Auteur ; Pierrick COUPÉ, Auteur ; Edouard DUCHESNAY, Auteur ; Angeline MIHAILOV, Auteur ; Antoine GRIGIS, Auteur ; Indrit BÈGUE, Auteur ; Julie VICTOR, Auteur ; Vincent FROUIN, Auteur ; Marion LEBOYER, Auteur ; Josselin HOUENOU, Auteur ; Charles LAIDI, Auteur . - 24 p. Langues : Anglais (eng) in Molecular Autism > 14 (2023) . - 24 p. Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1186/s13229-023-00553-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

Gray matter covariations and core symptoms of autism: the EU-AIMS Longitudinal European Autism Project / Ting MEI in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) Titre : Gray matter covariations and core symptoms of autism: the EU-AIMS Longitudinal European Autism Project Type de document : texte imprimé Auteurs : Ting MEI, Auteur ; Alberto LLERA, Auteur ; Dorothea L. FLORIS, Auteur ; Natalie J. FORDE, Auteur ; Julian TILLMANN, Auteur ; Sarah DURSTON, Auteur ; Carolin MOESSNANG, Auteur ; Tobias BANASCHEWSKI, Auteur ; Rosemary J. HOLT, Auteur ; Simon BARON-COHEN, Auteur ; Annika RAUSCH, Auteur ; Eva LOTH, Auteur ; Flavio DELL'ACQUA, Auteur ; Tony CHARMAN, Auteur ; Declan G.M. MURPHY, Auteur ; Christine ECKER, Auteur ; Christian F. BECKMANN, Auteur ; Jan K. BUITELAAR, Auteur Langues : Anglais (eng) Mots-clés : Autism  Canonical correlation analysis  Independent component analysis  Magnetic resonance imaging  Voxel-based morphometry  Cilag BV, Eli Lilly, Shire, Lundbeck, Roche, and Servier. He is not an employee of  any of these companies, and not a stock shareholder of any of these companies. He  has no other financial or material support, including expert testimony, patents or  royalties. CFB is director and shareholder in SBGNeuro Ltd. TB served in an advisory  or consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH,  Shire, and Infectopharm. He received conference support or speaker’s fee by Lilly,  Medice, and Shire. He received royalties from Hogrefe, Kohlhammer, CIP Medien, and  Oxford University Press. TC has received consultancy from Roche and received book  royalties from Guildford Press and Sage. DGM has been a consultant to, and advisory  board member, for Roche and Servier. He is not an employee of any of these  companies, and not a stock shareholder of any of these companies. The present work  is unrelated to the above grants and relationships. The other authors report no  biomedical financial interests or potential conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Voxel-based morphometry (VBM) studies in autism spectrum disorder (autism) have yielded diverging results. This might partly be attributed to structural alterations being associating with the combined influence of several regions rather than with a single region. Further, these structural covariation differences may relate to continuous measures of autism rather than with categorical case-control contrasts. The current study aimed to identify structural covariation alterations in autism, and assessed canonical correlations between brain covariation patterns and core autism symptoms. METHODS: We studied 347 individuals with autism and 252 typically developing individuals, aged between 6 and 30 years, who have been deeply phenotyped in the Longitudinal European Autism Project. All participants' VBM maps were decomposed into spatially independent components using independent component analysis. A generalized linear model (GLM) was used to examine case-control differences. Next, canonical correlation analysis (CCA) was performed to separately explore the integrated effects between all the brain sources of gray matter variation and two sets of core autism symptoms. RESULTS: GLM analyses showed significant case-control differences for two independent components. The first component was primarily associated with decreased density of bilateral insula, inferior frontal gyrus, orbitofrontal cortex, and increased density of caudate nucleus in the autism group relative to typically developing individuals. The second component was related to decreased densities of the bilateral amygdala, hippocampus, and parahippocampal gyrus in the autism group relative to typically developing individuals. The CCA results showed significant correlations between components that involved variation of thalamus, putamen, precentral gyrus, frontal, parietal, and occipital lobes, and the cerebellum, and repetitive, rigid and stereotyped behaviors and abnormal sensory behaviors in autism individuals. LIMITATIONS: Only 55.9% of the participants with autism had complete questionnaire data on continuous parent-reported symptom measures. CONCLUSIONS: Covaried areas associated with autism diagnosis and/or symptoms are scattered across the whole brain and include the limbic system, basal ganglia, thalamus, cerebellum, precentral gyrus, and parts of the frontal, parietal, and occipital lobes. Some of these areas potentially subserve social-communicative behavior, whereas others may underpin sensory processing and integration, and motor behavior. En ligne : http://dx.doi.org/10.1186/s13229-020-00389-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438 [article] Gray matter covariations and core symptoms of autism: the EU-AIMS Longitudinal European Autism Project [texte imprimé] / Ting MEI, Auteur ; Alberto LLERA, Auteur ; Dorothea L. FLORIS, Auteur ; Natalie J. FORDE, Auteur ; Julian TILLMANN, Auteur ; Sarah DURSTON, Auteur ; Carolin MOESSNANG, Auteur ; Tobias BANASCHEWSKI, Auteur ; Rosemary J. HOLT, Auteur ; Simon BARON-COHEN, Auteur ; Annika RAUSCH, Auteur ; Eva LOTH, Auteur ; Flavio DELL'ACQUA, Auteur ; Tony CHARMAN, Auteur ; Declan G.M. MURPHY, Auteur ; Christine ECKER, Auteur ; Christian F. BECKMANN, Auteur ; Jan K. BUITELAAR, Auteur. Langues : Anglais (eng) in Molecular Autism > 11 (2020) Mots-clés : Autism  Canonical correlation analysis  Independent component analysis  Magnetic resonance imaging  Voxel-based morphometry  Cilag BV, Eli Lilly, Shire, Lundbeck, Roche, and Servier. He is not an employee of  any of these companies, and not a stock shareholder of any of these companies. He  has no other financial or material support, including expert testimony, patents or  royalties. CFB is director and shareholder in SBGNeuro Ltd. TB served in an advisory  or consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH,  Shire, and Infectopharm. He received conference support or speaker’s fee by Lilly,  Medice, and Shire. He received royalties from Hogrefe, Kohlhammer, CIP Medien, and  Oxford University Press. TC has received consultancy from Roche and received book  royalties from Guildford Press and Sage. DGM has been a consultant to, and advisory  board member, for Roche and Servier. He is not an employee of any of these  companies, and not a stock shareholder of any of these companies. The present work  is unrelated to the above grants and relationships. The other authors report no  biomedical financial interests or potential conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Voxel-based morphometry (VBM) studies in autism spectrum disorder (autism) have yielded diverging results. This might partly be attributed to structural alterations being associating with the combined influence of several regions rather than with a single region. Further, these structural covariation differences may relate to continuous measures of autism rather than with categorical case-control contrasts. The current study aimed to identify structural covariation alterations in autism, and assessed canonical correlations between brain covariation patterns and core autism symptoms. METHODS: We studied 347 individuals with autism and 252 typically developing individuals, aged between 6 and 30 years, who have been deeply phenotyped in the Longitudinal European Autism Project. All participants' VBM maps were decomposed into spatially independent components using independent component analysis. A generalized linear model (GLM) was used to examine case-control differences. Next, canonical correlation analysis (CCA) was performed to separately explore the integrated effects between all the brain sources of gray matter variation and two sets of core autism symptoms. RESULTS: GLM analyses showed significant case-control differences for two independent components. The first component was primarily associated with decreased density of bilateral insula, inferior frontal gyrus, orbitofrontal cortex, and increased density of caudate nucleus in the autism group relative to typically developing individuals. The second component was related to decreased densities of the bilateral amygdala, hippocampus, and parahippocampal gyrus in the autism group relative to typically developing individuals. The CCA results showed significant correlations between components that involved variation of thalamus, putamen, precentral gyrus, frontal, parietal, and occipital lobes, and the cerebellum, and repetitive, rigid and stereotyped behaviors and abnormal sensory behaviors in autism individuals. LIMITATIONS: Only 55.9% of the participants with autism had complete questionnaire data on continuous parent-reported symptom measures. CONCLUSIONS: Covaried areas associated with autism diagnosis and/or symptoms are scattered across the whole brain and include the limbic system, basal ganglia, thalamus, cerebellum, precentral gyrus, and parts of the frontal, parietal, and occipital lobes. Some of these areas potentially subserve social-communicative behavior, whereas others may underpin sensory processing and integration, and motor behavior. En ligne : http://dx.doi.org/10.1186/s13229-020-00389-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438

Gray matter covariations in autism: out-of-sample replication using the ENIGMA autism cohort / Ting MEI in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 3p. Titre : Gray matter covariations in autism: out-of-sample replication using the ENIGMA autism cohort Type de document : texte imprimé Auteurs : Ting MEI, Auteur ; Alberto LLERA, Auteur ; Natalie J. FORDE, Auteur ; Daan VAN ROOIJ, Auteur ; Dorothea L. FLORIS, Auteur ; Christian F. BECKMANN, Auteur ; Jan K. BUITELAAR, Auteur Article en page(s) : 3p. Langues : Anglais (eng) Mots-clés : Humans  Gray Matter/diagnostic imaging  Autistic Disorder/diagnostic imaging  Autism Spectrum Disorder/diagnostic imaging  Retrospective Studies  Magnetic Resonance Imaging/methods  Brain/diagnostic imaging  Autism  Gray matter volume covariation  Replication  advisory board member of, and a speaker for Janssen Cilag BV, Eli Lilly, Shire,  Lundbeck, Roche, and Servier. He is not an employee of any of these companies,  and not a stock shareholder of any of these companies. He has no other financial  or material support, including expert testimony, patents or royalties. The  present work is unrelated to the above grants and relationships. The other  authors report no biomedical financial interests or potential conflicts of  interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (henceforth autism) is a complex neurodevelopmental condition associated with differences in gray matter (GM) volume covariations, as reported in our previous study of the Longitudinal European Autism Project (LEAP) data. To make progress on the identification of potential neural markers and to validate the robustness of our previous findings, we aimed to replicate our results using data from the Enhancing Neuroimaging Genetics Through Meta-Analysis (ENIGMA) autism working group. METHODS: We studied 781 autistic and 927 non-autistic individuals (6-30 years, IQ?? 50), across 37 sites. Voxel-based morphometry was used to quantify GM volume as before. Subsequently, we used spatial maps of the two autism-related independent components (ICs) previously identified in the LEAP sample as templates for regression analyses to separately estimate the ENIGMA-participant loadings to each of these two ICs. Between-group differences in participants' loadings on each component were examined, and we additionally investigated the relation between participant loadings and autistic behaviors within the autism group. RESULTS: The two components of interest, previously identified in the LEAP dataset, showed significant between-group differences upon regressions into the ENIGMA cohort. The associated brain patterns were consistent with those found in the initial identification study. The first IC was primarily associated with increased volumes of bilateral insula, inferior frontal gyrus, orbitofrontal cortex, and caudate in the autism group relative to the control group (? = 0.129, p = 0.013). The second IC was related to increased volumes of the bilateral amygdala, hippocampus, and parahippocampal gyrus in the autism group relative to non-autistic individuals (? = 0.116, p = 0.024). However, when accounting for the site-by-group interaction effect, no significant main effect of the group can be identified (p > 0.590). We did not find significant univariate association between the brain measures and behavior in autism (p > 0.085). LIMITATIONS: The distributions of age, IQ, and sex between LEAP and ENIGMA are statistically different from each other. Owing to limited access to the behavioral data of the autism group, we were unable to further our understanding of the neural basis of behavioral dimensions of the sample. CONCLUSIONS: The current study is unable to fully replicate the autism-related brain patterns from LEAP in the ENIGMA cohort. The diverse group effects across ENIGMA sites demonstrate the challenges of generalizing the average findings of the GM covariation patterns to a large-scale cohort integrated retrospectively from multiple studies. Further analyses need to be conducted to gain additional insights into the generalizability of these two GM covariation patterns. En ligne : https://dx.doi.org/10.1186/s13229-024-00583-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537 [article] Gray matter covariations in autism: out-of-sample replication using the ENIGMA autism cohort [texte imprimé] / Ting MEI, Auteur ; Alberto LLERA, Auteur ; Natalie J. FORDE, Auteur ; Daan VAN ROOIJ, Auteur ; Dorothea L. FLORIS, Auteur ; Christian F. BECKMANN, Auteur ; Jan K. BUITELAAR, Auteur . - 3p. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 3p. Mots-clés : Humans  Gray Matter/diagnostic imaging  Autistic Disorder/diagnostic imaging  Autism Spectrum Disorder/diagnostic imaging  Retrospective Studies  Magnetic Resonance Imaging/methods  Brain/diagnostic imaging  Autism  Gray matter volume covariation  Replication  advisory board member of, and a speaker for Janssen Cilag BV, Eli Lilly, Shire,  Lundbeck, Roche, and Servier. He is not an employee of any of these companies,  and not a stock shareholder of any of these companies. He has no other financial  or material support, including expert testimony, patents or royalties. The  present work is unrelated to the above grants and relationships. The other  authors report no biomedical financial interests or potential conflicts of  interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (henceforth autism) is a complex neurodevelopmental condition associated with differences in gray matter (GM) volume covariations, as reported in our previous study of the Longitudinal European Autism Project (LEAP) data. To make progress on the identification of potential neural markers and to validate the robustness of our previous findings, we aimed to replicate our results using data from the Enhancing Neuroimaging Genetics Through Meta-Analysis (ENIGMA) autism working group. METHODS: We studied 781 autistic and 927 non-autistic individuals (6-30 years, IQ?? 50), across 37 sites. Voxel-based morphometry was used to quantify GM volume as before. Subsequently, we used spatial maps of the two autism-related independent components (ICs) previously identified in the LEAP sample as templates for regression analyses to separately estimate the ENIGMA-participant loadings to each of these two ICs. Between-group differences in participants' loadings on each component were examined, and we additionally investigated the relation between participant loadings and autistic behaviors within the autism group. RESULTS: The two components of interest, previously identified in the LEAP dataset, showed significant between-group differences upon regressions into the ENIGMA cohort. The associated brain patterns were consistent with those found in the initial identification study. The first IC was primarily associated with increased volumes of bilateral insula, inferior frontal gyrus, orbitofrontal cortex, and caudate in the autism group relative to the control group (? = 0.129, p = 0.013). The second IC was related to increased volumes of the bilateral amygdala, hippocampus, and parahippocampal gyrus in the autism group relative to non-autistic individuals (? = 0.116, p = 0.024). However, when accounting for the site-by-group interaction effect, no significant main effect of the group can be identified (p > 0.590). We did not find significant univariate association between the brain measures and behavior in autism (p > 0.085). LIMITATIONS: The distributions of age, IQ, and sex between LEAP and ENIGMA are statistically different from each other. Owing to limited access to the behavioral data of the autism group, we were unable to further our understanding of the neural basis of behavioral dimensions of the sample. CONCLUSIONS: The current study is unable to fully replicate the autism-related brain patterns from LEAP in the ENIGMA cohort. The diverse group effects across ENIGMA sites demonstrate the challenges of generalizing the average findings of the GM covariation patterns to a large-scale cohort integrated retrospectively from multiple studies. Further analyses need to be conducted to gain additional insights into the generalizability of these two GM covariation patterns. En ligne : https://dx.doi.org/10.1186/s13229-024-00583-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537

Linking functional and structural brain organisation with behaviour in autism: a multimodal EU-AIMS Longitudinal European Autism Project (LEAP) study / Alberto LLERA ; Ting MEI ; Koen HAAK ; Christina ISAKOGLOU ; Dorothea L. FLORIS ; Sarah DURSTON ; Carolin MOESSNANG ; Tobias BANASCHEWSKI ; Simon BARON-COHEN ; Eva LOTH ; Flavio DELL'ACQUA ; Tony CHARMAN ; Declan G.M. MURPHY ; Christine ECKER ; Jan K. BUITELAAR ; Christian F. BECKMANN in Molecular Autism, 14 (2023)  

Public ISBD [article]  inMolecular Autism > 14 (2023) . - 32 p. Titre : Linking functional and structural brain organisation with behaviour in autism: a multimodal EU-AIMS Longitudinal European Autism Project (LEAP) study Type de document : texte imprimé Auteurs : Alberto LLERA, Auteur ; Ting MEI, Auteur ; Koen HAAK, Auteur ; Christina ISAKOGLOU, Auteur ; Dorothea L. FLORIS, Auteur ; Sarah DURSTON, Auteur ; Carolin MOESSNANG, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Eva LOTH, Auteur ; Flavio DELL'ACQUA, Auteur ; Tony CHARMAN, Auteur ; Declan G.M. MURPHY, Auteur ; Christine ECKER, Auteur ; Jan K. BUITELAAR, Auteur ; Christian F. BECKMANN, Auteur Article en page(s) : 32 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Neuroimaging analyses of brain structure and function in autism have typically been conducted in isolation, missing the sensitivity gains of linking data across modalities. Here we focus on the integration of structural and functional organisational properties of brain regions. We aim to identify novel brain-organisation phenotypes of autism. We utilised multimodal MRI (T1-, diffusion-weighted and resting state functional), behavioural and clinical data from the EU AIMS Longitudinal European Autism Project (LEAP) from autistic (n=206) and non-autistic (n=196) participants. Of these, 97 had data from 2 timepoints resulting in a total scan number of 466. Grey matter density maps, probabilistic tractography connectivity matrices and connectopic maps were extracted from respective MRI modalities and were then integrated with Linked Independent Component Analysis. Linear mixed-effects models were used to evaluate the relationship between components and group while accounting for covariates and non-independence of participants with longitudinal data. Additional models were run to investigate associations with dimensional measures of behaviour. We identified one component that differed significantly between groups (coefficient=0.33, p(adj)=0.02). This was driven (99%) by variance of the right fusiform gyrus connectopic map 2. While there were multiple nominal (uncorrected p<0.05) associations with behavioural measures, none were significant following multiple comparison correction. Our analysis considered the relative contributions of both structural and functional brain phenotypes simultaneously, finding that functional phenotypes drive associations with autism. These findings expanded on previous unimodal studies by revealing the topographic organisation of functional connectivity patterns specific to autism and warrant further investigation. En ligne : http://dx.doi.org/10.1186/s13229-023-00564-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] Linking functional and structural brain organisation with behaviour in autism: a multimodal EU-AIMS Longitudinal European Autism Project (LEAP) study [texte imprimé] / Alberto LLERA, Auteur ; Ting MEI, Auteur ; Koen HAAK, Auteur ; Christina ISAKOGLOU, Auteur ; Dorothea L. FLORIS, Auteur ; Sarah DURSTON, Auteur ; Carolin MOESSNANG, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Eva LOTH, Auteur ; Flavio DELL'ACQUA, Auteur ; Tony CHARMAN, Auteur ; Declan G.M. MURPHY, Auteur ; Christine ECKER, Auteur ; Jan K. BUITELAAR, Auteur ; Christian F. BECKMANN, Auteur . - 32 p. Langues : Anglais (eng) in Molecular Autism > 14 (2023) . - 32 p. Index. décimale : PER Périodiques Résumé : Neuroimaging analyses of brain structure and function in autism have typically been conducted in isolation, missing the sensitivity gains of linking data across modalities. Here we focus on the integration of structural and functional organisational properties of brain regions. We aim to identify novel brain-organisation phenotypes of autism. We utilised multimodal MRI (T1-, diffusion-weighted and resting state functional), behavioural and clinical data from the EU AIMS Longitudinal European Autism Project (LEAP) from autistic (n=206) and non-autistic (n=196) participants. Of these, 97 had data from 2 timepoints resulting in a total scan number of 466. Grey matter density maps, probabilistic tractography connectivity matrices and connectopic maps were extracted from respective MRI modalities and were then integrated with Linked Independent Component Analysis. Linear mixed-effects models were used to evaluate the relationship between components and group while accounting for covariates and non-independence of participants with longitudinal data. Additional models were run to investigate associations with dimensional measures of behaviour. We identified one component that differed significantly between groups (coefficient=0.33, p(adj)=0.02). This was driven (99%) by variance of the right fusiform gyrus connectopic map 2. While there were multiple nominal (uncorrected p<0.05) associations with behavioural measures, none were significant following multiple comparison correction. Our analysis considered the relative contributions of both structural and functional brain phenotypes simultaneously, finding that functional phenotypes drive associations with autism. These findings expanded on previous unimodal studies by revealing the topographic organisation of functional connectivity patterns specific to autism and warrant further investigation. En ligne : http://dx.doi.org/10.1186/s13229-023-00564-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

Modulation of striatal functional connectivity differences in adults with and without autism spectrum disorder in a single-dose randomized trial of cannabidivarin / Charlotte M. PRETZSCH in Molecular Autism, 12 (2021)  

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Network-specific sex differentiation of intrinsic brain function in males with autism / Dorothea L. FLORIS in Molecular Autism, 9 (2018)  

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Patterns of connectome variability in autism across five functional activation tasks: findings from the LEAP project / Tristan LOODEN in Molecular Autism, 13 (2022)  

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Psychological Correlates of Handedness and Corpus Callosum Asymmetry in Autism: The left Hemisphere Dysfunction Theory Revisited / Dorothea L. FLORIS in Journal of Autism and Developmental Disorders, 43-8 (August 2013)  

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Reduced lateralization of multiple functional brain networks in autistic males / Madeline PETERSON in Journal of Neurodevelopmental Disorders, 16 (2024)  

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The neuroanatomical substrates of autism and ADHD and their link to putative genomic underpinnings / Caroline GURR ; Johanna LEYHAUSEN ; Hanna SEELEMEYER ; Anke BLETSCH ; Tim SCHAEFER ; Charlotte M. PRETZSCH ; Bethany OAKLEY ; Eva LOTH ; Dorothea L. FLORIS ; Jan K. BUITELAAR ; Christian F. BECKMANN ; Tobias BANASCHEWSKI ; Tony CHARMAN ; Emily J.H. JONES ; Julian TILLMANN ; Christopher H. CHATHAM ; Thomas BOURGERON ; EU-AIMS LEAP GROUP ; Declan G.M. MURPHY ; Christine ECKER in Molecular Autism, 14 (2023)  

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The oxytocin receptor gene predicts brain activity during an emotion recognition task in autism / Florina UZEFOVSKY in Molecular Autism, 10 (2019)  

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Towards robust and replicable sex differences in the intrinsic brain function of autism / Dorothea L. FLORIS in Molecular Autism, 12 (2021)  

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Understanding the relationship between cerebellar structure and social abilities / Dorothea L. FLORIS ; Pierrick COUPÉ ; Edouard DUCHESNAY ; Angeline MIHAILOV ; Antoine GRIGIS ; Indrit BÈGUE ; Julie VICTOR ; Vincent FROUIN ; Marion LEBOYER ; Josselin HOUENOU ; Charles LAIDI in Molecular Autism, 14 (2023)  

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