4 recherche sur le mot-clé 'Independent component analysis'

Dynamic functional adaptations during touch observation in autism: connectivity strength is linked to attitudes towards social touch and social responsiveness / Haemy LEE MASSON in Molecular Autism, 16 (2025)  

Public ISBD [article]  inMolecular Autism > 16 (2025) . - 11 Titre : Dynamic functional adaptations during touch observation in autism: connectivity strength is linked to attitudes towards social touch and social responsiveness Type de document : Texte imprimé et/ou numérique Auteurs : Haemy LEE MASSON, Auteur Article en page(s) : 11 Langues : Anglais (eng) Mots-clés : Humans  Male  Autistic Disorder/physiopathology/psychology/diagnostic imaging  Adult  Magnetic Resonance Imaging  Touch  Young Adult  Brain/diagnostic imaging/physiopathology  Social Behavior  Social Interaction  Brain Mapping  Autism  Embodied simulation  Functional connectivity  Generalized psychophysiological interaction  Independent component analysis  Social perception  Social responsiveness  Social touch  Vicarious touch  provided written informed consent, and the Medical Ethical Committee of KU Leuven  approved the original study (S53768 and S59577). Consent for publication: Not  applicable. Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autistic adults experience differences in social interactions involving physical contact. Brain imaging studies suggest that these differences may be related to atypical brain responses to social-affective cues, affecting both the experience of receiving touch and observing it in others. However, it remains unclear whether these atypical responses are limited to specific brain regions or represent broader alterations in brain connectivity. The current study investigated how the functional network architecture is modulated during touch observation associated with autism and explored the extent to which changes in this architecture are associated with individual differences in social touch preferences and social responsiveness. METHODS: By integrating generalized psychophysiological interaction (gPPI) analysis with independent component analysis (ICA), the current study analyzed existing fMRI datasets, in which 21 autistic and 21 non-autistic male adults viewed videos of social and nonsocial touch while undergoing MRI scans. RESULTS: A gPPI analysis of regions of interest revealed that autistic adults exhibited increased connectivity between sensory and social brain regions. The strength of some of these connections was positively associated with a higher preference for social touch and greater social responsiveness, suggesting neural compensatory mechanisms that may help autistic adults better understand the meaning of touch. At the level of large-scale brain networks extracted using ICA, atypical connectivity was predominantly observed between the sensorimotor network and other networks involved in social-emotional processing. Increased connectivity was observed in the sensorimotor network during nonsocial touch, suggesting that embodied simulation, the process by which individuals internally simulate touch experience of others in this context, may be more engaged when observing human-object interactions than during human-to-human touch. LIMITATIONS: This study focused on a specific subgroup of 21 autistic male adults with minimal support needs. Future research would benefit from including a more diverse autistic sample. CONCLUSIONS: This study reveals atypical context-dependent modulation of functional brain architecture associated with autism during touch observation. Neural compensatory mechanisms in autistic individuals who enjoy social touch and show higher social responsiveness may function as adaptive social responses. However, these compensations may be limited to specific brain regions, rather than occurring at the level of large-scale brain networks. En ligne : https://dx.doi.org/10.1186/s13229-025-00644-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555 [article] Dynamic functional adaptations during touch observation in autism: connectivity strength is linked to attitudes towards social touch and social responsiveness [Texte imprimé et/ou numérique] / Haemy LEE MASSON, Auteur . - 11. Langues : Anglais (eng) in Molecular Autism > 16 (2025) . - 11 Mots-clés : Humans  Male  Autistic Disorder/physiopathology/psychology/diagnostic imaging  Adult  Magnetic Resonance Imaging  Touch  Young Adult  Brain/diagnostic imaging/physiopathology  Social Behavior  Social Interaction  Brain Mapping  Autism  Embodied simulation  Functional connectivity  Generalized psychophysiological interaction  Independent component analysis  Social perception  Social responsiveness  Social touch  Vicarious touch  provided written informed consent, and the Medical Ethical Committee of KU Leuven  approved the original study (S53768 and S59577). Consent for publication: Not  applicable. Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autistic adults experience differences in social interactions involving physical contact. Brain imaging studies suggest that these differences may be related to atypical brain responses to social-affective cues, affecting both the experience of receiving touch and observing it in others. However, it remains unclear whether these atypical responses are limited to specific brain regions or represent broader alterations in brain connectivity. The current study investigated how the functional network architecture is modulated during touch observation associated with autism and explored the extent to which changes in this architecture are associated with individual differences in social touch preferences and social responsiveness. METHODS: By integrating generalized psychophysiological interaction (gPPI) analysis with independent component analysis (ICA), the current study analyzed existing fMRI datasets, in which 21 autistic and 21 non-autistic male adults viewed videos of social and nonsocial touch while undergoing MRI scans. RESULTS: A gPPI analysis of regions of interest revealed that autistic adults exhibited increased connectivity between sensory and social brain regions. The strength of some of these connections was positively associated with a higher preference for social touch and greater social responsiveness, suggesting neural compensatory mechanisms that may help autistic adults better understand the meaning of touch. At the level of large-scale brain networks extracted using ICA, atypical connectivity was predominantly observed between the sensorimotor network and other networks involved in social-emotional processing. Increased connectivity was observed in the sensorimotor network during nonsocial touch, suggesting that embodied simulation, the process by which individuals internally simulate touch experience of others in this context, may be more engaged when observing human-object interactions than during human-to-human touch. LIMITATIONS: This study focused on a specific subgroup of 21 autistic male adults with minimal support needs. Future research would benefit from including a more diverse autistic sample. CONCLUSIONS: This study reveals atypical context-dependent modulation of functional brain architecture associated with autism during touch observation. Neural compensatory mechanisms in autistic individuals who enjoy social touch and show higher social responsiveness may function as adaptive social responses. However, these compensations may be limited to specific brain regions, rather than occurring at the level of large-scale brain networks. En ligne : https://dx.doi.org/10.1186/s13229-025-00644-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555

Gray matter covariations and core symptoms of autism: the EU-AIMS Longitudinal European Autism Project / Ting MEI in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) Titre : Gray matter covariations and core symptoms of autism: the EU-AIMS Longitudinal European Autism Project Type de document : Texte imprimé et/ou numérique Auteurs : Ting MEI, Auteur ; Alberto LLERA, Auteur ; Dorothea L. FLORIS, Auteur ; Natalie J. FORDE, Auteur ; Julian TILLMANN, Auteur ; Sarah DURSTON, Auteur ; Carolin MOESSNANG, Auteur ; Tobias BANASCHEWSKI, Auteur ; Rosemary J. HOLT, Auteur ; Simon BARON-COHEN, Auteur ; Annika RAUSCH, Auteur ; Eva LOTH, Auteur ; Flavio DELL'ACQUA, Auteur ; Tony CHARMAN, Auteur ; Declan G. M. MURPHY, Auteur ; Christine ECKER, Auteur ; Christian F. BECKMANN, Auteur ; Jan K. BUITELAAR, Auteur Langues : Anglais (eng) Mots-clés : Autism  Canonical correlation analysis  Independent component analysis  Magnetic resonance imaging  Voxel-based morphometry  Cilag BV, Eli Lilly, Shire, Lundbeck, Roche, and Servier. He is not an employee of  any of these companies, and not a stock shareholder of any of these companies. He  has no other financial or material support, including expert testimony, patents or  royalties. CFB is director and shareholder in SBGNeuro Ltd. TB served in an advisory  or consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH,  Shire, and Infectopharm. He received conference support or speaker’s fee by Lilly,  Medice, and Shire. He received royalties from Hogrefe, Kohlhammer, CIP Medien, and  Oxford University Press. TC has received consultancy from Roche and received book  royalties from Guildford Press and Sage. DGM has been a consultant to, and advisory  board member, for Roche and Servier. He is not an employee of any of these  companies, and not a stock shareholder of any of these companies. The present work  is unrelated to the above grants and relationships. The other authors report no  biomedical financial interests or potential conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Voxel-based morphometry (VBM) studies in autism spectrum disorder (autism) have yielded diverging results. This might partly be attributed to structural alterations being associating with the combined influence of several regions rather than with a single region. Further, these structural covariation differences may relate to continuous measures of autism rather than with categorical case-control contrasts. The current study aimed to identify structural covariation alterations in autism, and assessed canonical correlations between brain covariation patterns and core autism symptoms. METHODS: We studied 347 individuals with autism and 252 typically developing individuals, aged between 6 and 30 years, who have been deeply phenotyped in the Longitudinal European Autism Project. All participants' VBM maps were decomposed into spatially independent components using independent component analysis. A generalized linear model (GLM) was used to examine case-control differences. Next, canonical correlation analysis (CCA) was performed to separately explore the integrated effects between all the brain sources of gray matter variation and two sets of core autism symptoms. RESULTS: GLM analyses showed significant case-control differences for two independent components. The first component was primarily associated with decreased density of bilateral insula, inferior frontal gyrus, orbitofrontal cortex, and increased density of caudate nucleus in the autism group relative to typically developing individuals. The second component was related to decreased densities of the bilateral amygdala, hippocampus, and parahippocampal gyrus in the autism group relative to typically developing individuals. The CCA results showed significant correlations between components that involved variation of thalamus, putamen, precentral gyrus, frontal, parietal, and occipital lobes, and the cerebellum, and repetitive, rigid and stereotyped behaviors and abnormal sensory behaviors in autism individuals. LIMITATIONS: Only 55.9% of the participants with autism had complete questionnaire data on continuous parent-reported symptom measures. CONCLUSIONS: Covaried areas associated with autism diagnosis and/or symptoms are scattered across the whole brain and include the limbic system, basal ganglia, thalamus, cerebellum, precentral gyrus, and parts of the frontal, parietal, and occipital lobes. Some of these areas potentially subserve social-communicative behavior, whereas others may underpin sensory processing and integration, and motor behavior. En ligne : http://dx.doi.org/10.1186/s13229-020-00389-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438 [article] Gray matter covariations and core symptoms of autism: the EU-AIMS Longitudinal European Autism Project [Texte imprimé et/ou numérique] / Ting MEI, Auteur ; Alberto LLERA, Auteur ; Dorothea L. FLORIS, Auteur ; Natalie J. FORDE, Auteur ; Julian TILLMANN, Auteur ; Sarah DURSTON, Auteur ; Carolin MOESSNANG, Auteur ; Tobias BANASCHEWSKI, Auteur ; Rosemary J. HOLT, Auteur ; Simon BARON-COHEN, Auteur ; Annika RAUSCH, Auteur ; Eva LOTH, Auteur ; Flavio DELL'ACQUA, Auteur ; Tony CHARMAN, Auteur ; Declan G. M. MURPHY, Auteur ; Christine ECKER, Auteur ; Christian F. BECKMANN, Auteur ; Jan K. BUITELAAR, Auteur. Langues : Anglais (eng) in Molecular Autism > 11 (2020) Mots-clés : Autism  Canonical correlation analysis  Independent component analysis  Magnetic resonance imaging  Voxel-based morphometry  Cilag BV, Eli Lilly, Shire, Lundbeck, Roche, and Servier. He is not an employee of  any of these companies, and not a stock shareholder of any of these companies. He  has no other financial or material support, including expert testimony, patents or  royalties. CFB is director and shareholder in SBGNeuro Ltd. TB served in an advisory  or consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH,  Shire, and Infectopharm. He received conference support or speaker’s fee by Lilly,  Medice, and Shire. He received royalties from Hogrefe, Kohlhammer, CIP Medien, and  Oxford University Press. TC has received consultancy from Roche and received book  royalties from Guildford Press and Sage. DGM has been a consultant to, and advisory  board member, for Roche and Servier. He is not an employee of any of these  companies, and not a stock shareholder of any of these companies. The present work  is unrelated to the above grants and relationships. The other authors report no  biomedical financial interests or potential conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Voxel-based morphometry (VBM) studies in autism spectrum disorder (autism) have yielded diverging results. This might partly be attributed to structural alterations being associating with the combined influence of several regions rather than with a single region. Further, these structural covariation differences may relate to continuous measures of autism rather than with categorical case-control contrasts. The current study aimed to identify structural covariation alterations in autism, and assessed canonical correlations between brain covariation patterns and core autism symptoms. METHODS: We studied 347 individuals with autism and 252 typically developing individuals, aged between 6 and 30 years, who have been deeply phenotyped in the Longitudinal European Autism Project. All participants' VBM maps were decomposed into spatially independent components using independent component analysis. A generalized linear model (GLM) was used to examine case-control differences. Next, canonical correlation analysis (CCA) was performed to separately explore the integrated effects between all the brain sources of gray matter variation and two sets of core autism symptoms. RESULTS: GLM analyses showed significant case-control differences for two independent components. The first component was primarily associated with decreased density of bilateral insula, inferior frontal gyrus, orbitofrontal cortex, and increased density of caudate nucleus in the autism group relative to typically developing individuals. The second component was related to decreased densities of the bilateral amygdala, hippocampus, and parahippocampal gyrus in the autism group relative to typically developing individuals. The CCA results showed significant correlations between components that involved variation of thalamus, putamen, precentral gyrus, frontal, parietal, and occipital lobes, and the cerebellum, and repetitive, rigid and stereotyped behaviors and abnormal sensory behaviors in autism individuals. LIMITATIONS: Only 55.9% of the participants with autism had complete questionnaire data on continuous parent-reported symptom measures. CONCLUSIONS: Covaried areas associated with autism diagnosis and/or symptoms are scattered across the whole brain and include the limbic system, basal ganglia, thalamus, cerebellum, precentral gyrus, and parts of the frontal, parietal, and occipital lobes. Some of these areas potentially subserve social-communicative behavior, whereas others may underpin sensory processing and integration, and motor behavior. En ligne : http://dx.doi.org/10.1186/s13229-020-00389-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438

Latent constructs underlying sensory subtypes in children with autism: A preliminary study / Brittany N. HAND in Autism Research, 10-8 (August 2017)  

Public ISBD [article]  inAutism Research > 10-8 (August 2017) . - p.1364-1371 Titre : Latent constructs underlying sensory subtypes in children with autism: A preliminary study Type de document : Texte imprimé et/ou numérique Auteurs : Brittany N. HAND, Auteur ; Simon DENNIS, Auteur ; Alison E. LANE, Auteur Article en page(s) : p.1364-1371 Langues : Anglais (eng) Mots-clés : autism  sensory subtypes  independent component analysis  sensory features  sensory processing Index. décimale : PER Périodiques Résumé : Recent reports identify sensory subtypes in ASD based on shared patterns of responses to daily sensory stimuli [Ausderau et al., 2014; Lane, Molloy, & Bishop, 2014]. Lane et al. propose that two broad sensory dimensions, sensory reactivity and multisensory integration, best explain the differences between subtypes, however this has yet to be tested. The present study tests this hypothesis by examining the latent constructs underlying Lane's sensory subtypes. Participants for this study were caregivers of children with autism spectrum disorder (ASD) aged 2–12 years. Caregiver responses on the Short Sensory Profile (SSP), used to establish Lane's sensory subtypes, were extracted from two existing datasets (total n?=?287). Independent component analyses were conducted to test the fit and interpretability of a two-construct structure underlying the SSP, and therefore, the sensory subtypes. The first construct was largely comprised of the taste/smell sensitivity domain, which describes hyper-reactivity to taste and smell stimuli. The second construct had a significant contribution from the low energy/weak domain, which describes behaviors that may be indicative of difficulties with multisensory integration. Findings provide initial support for our hypothesis that sensory reactivity and multisensory integration underlie Lane's sensory subtypes in ASD. En ligne : http://dx.doi.org/10.1002/aur.1787 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310 [article] Latent constructs underlying sensory subtypes in children with autism: A preliminary study [Texte imprimé et/ou numérique] / Brittany N. HAND, Auteur ; Simon DENNIS, Auteur ; Alison E. LANE, Auteur . - p.1364-1371. Langues : Anglais (eng) in Autism Research > 10-8 (August 2017) . - p.1364-1371 Mots-clés : autism  sensory subtypes  independent component analysis  sensory features  sensory processing Index. décimale : PER Périodiques Résumé : Recent reports identify sensory subtypes in ASD based on shared patterns of responses to daily sensory stimuli [Ausderau et al., 2014; Lane, Molloy, & Bishop, 2014]. Lane et al. propose that two broad sensory dimensions, sensory reactivity and multisensory integration, best explain the differences between subtypes, however this has yet to be tested. The present study tests this hypothesis by examining the latent constructs underlying Lane's sensory subtypes. Participants for this study were caregivers of children with autism spectrum disorder (ASD) aged 2–12 years. Caregiver responses on the Short Sensory Profile (SSP), used to establish Lane's sensory subtypes, were extracted from two existing datasets (total n?=?287). Independent component analyses were conducted to test the fit and interpretability of a two-construct structure underlying the SSP, and therefore, the sensory subtypes. The first construct was largely comprised of the taste/smell sensitivity domain, which describes hyper-reactivity to taste and smell stimuli. The second construct had a significant contribution from the low energy/weak domain, which describes behaviors that may be indicative of difficulties with multisensory integration. Findings provide initial support for our hypothesis that sensory reactivity and multisensory integration underlie Lane's sensory subtypes in ASD. En ligne : http://dx.doi.org/10.1002/aur.1787 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310

Sex Differences in Functional Connectivity Between Resting State Brain Networks in Autism Spectrum Disorder / Vânia TAVARES in Journal of Autism and Developmental Disorders, 52-7 (July 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3088-3101 Titre : Sex Differences in Functional Connectivity Between Resting State Brain Networks in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Vânia TAVARES, Auteur ; Luís Afonso FERNANDES, Auteur ; Marília ANTUNES, Auteur ; Hugo FERREIRA, Auteur ; Diana PRATA, Auteur Article en page(s) : p.3088-3101 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnostic imaging  Brain/diagnostic imaging  Brain Mapping/methods  Female  Humans  Magnetic Resonance Imaging/methods  Male  Neural Pathways  Sex Characteristics  Autism spectrum disorder  Functional connectivity  Functional magnetic resonance imaging  Independent component analysis  Resting-state networks Index. décimale : PER Périodiques Résumé : Functional brain connectivity (FBC) has previously been examined in autism spectrum disorder (ASD) between-resting-state networks (RSNs) using a highly sensitive and reproducible hypothesis-free approach. However, results have been inconsistent and sex differences have only recently been taken into consideration using this approach. We estimated main effects of diagnosis and sex and a diagnosis by sex interaction on between-RSNs FBC in 83 ASD (40 females/43 males) and 85 typically developing controls (TC; 43 females/42 males). We found increased connectivity between the default mode (DM) and (a) the executive control networks in ASD (vs. TC); (b) the cerebellum networks in males (vs. females); and (c) female-specific altered connectivity involving visual, language and basal ganglia (BG) networks in ASD-in suggestive compatibility with ASD cognitive and neuroscientific theories. En ligne : http://dx.doi.org/10.1007/s10803-021-05191-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Sex Differences in Functional Connectivity Between Resting State Brain Networks in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Vânia TAVARES, Auteur ; Luís Afonso FERNANDES, Auteur ; Marília ANTUNES, Auteur ; Hugo FERREIRA, Auteur ; Diana PRATA, Auteur . - p.3088-3101. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3088-3101 Mots-clés : Autism Spectrum Disorder/diagnostic imaging  Brain/diagnostic imaging  Brain Mapping/methods  Female  Humans  Magnetic Resonance Imaging/methods  Male  Neural Pathways  Sex Characteristics  Autism spectrum disorder  Functional connectivity  Functional magnetic resonance imaging  Independent component analysis  Resting-state networks Index. décimale : PER Périodiques Résumé : Functional brain connectivity (FBC) has previously been examined in autism spectrum disorder (ASD) between-resting-state networks (RSNs) using a highly sensitive and reproducible hypothesis-free approach. However, results have been inconsistent and sex differences have only recently been taken into consideration using this approach. We estimated main effects of diagnosis and sex and a diagnosis by sex interaction on between-RSNs FBC in 83 ASD (40 females/43 males) and 85 typically developing controls (TC; 43 females/42 males). We found increased connectivity between the default mode (DM) and (a) the executive control networks in ASD (vs. TC); (b) the cerebellum networks in males (vs. females); and (c) female-specific altered connectivity involving visual, language and basal ganglia (BG) networks in ASD-in suggestive compatibility with ASD cognitive and neuroscientific theories. En ligne : http://dx.doi.org/10.1007/s10803-021-05191-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477