Annual Research Review: The role of the environment in the developmental psychopathology of autism spectrum condition / William MANDY in Journal of Child Psychology and Psychiatry, 57-3 (March 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-3 (March 2016) . - p.271-292 Titre : Annual Research Review: The role of the environment in the developmental psychopathology of autism spectrum condition Type de document : texte imprimé Auteurs : William MANDY, Auteur ; Meng-Chuan LAI, Auteur Article en page(s) : p.271-292 Langues : Anglais (eng) Mots-clés : Autism spectrum condition  autism spectrum disorder  autism  Asperger's syndrome  genetics  environment  developmental psychopathology Index. décimale : PER Périodiques Résumé : Background Although autism spectrum condition (ASC) is strongly genetic in origin, accumulating evidence points to the critical roles of various environmental influences on its emergence and subsequent developmental course. Methods A developmental psychopathology framework was used to synthesise literature on environmental factors associated with the onset and course of ASC (based on a systematic search of the literature using PubMed, PsychInfo and Google Scholar databases). Particular emphasis was placed on gene–environment interplay, including gene–environment interaction (G × E) and gene–environment correlation (rGE). Results Before conception, advanced paternal and maternal ages may independently enhance offspring risk for ASC. Exogenous prenatal risks are evident (e.g. valproate and toxic chemicals) or possible (e.g. selective serotonin reuptake inhibitors), and processes endogenous to the materno-foeto-placental unit (e.g. maternal diabetes, enhanced steroidogenic activities and maternal immune activation) likely heighten offspring vulnerability to ASC. Folate intake is a prenatal protective factor, with a particular window of action around 4 weeks preconception and during the first trimester. These prenatal risks and protective mechanisms appear to involve G × E and potentially rGE. A variety of perinatal risks are related to offspring ASC risk, possibly reflecting rGE. Postnatal social factors (e.g. caregiver–infant interaction, severe early deprivation) during the first years of life may operate through rGE to influence the likelihood of manifesting a full ASC phenotype from a ‘prodromal’ phase (a proposal distinct to the discredited and harmful ‘refrigerator mother hypothesis’); and later postnatal risks, after the full manifestation of ASC, shape life span development through transactions mediated by rGE. There is no evidence that vaccination is a postnatal risk for ASC. Conclusions Future investigations should consider the specificity of risks for ASC versus other atypical neurodevelopmental trajectories, timing of risk and protective mechanisms, animal model systems to study mechanisms underlying gene–environment interplay, large-sample genome–envirome designs to address G × E and longitudinal studies to elucidate how rGE plays out over time. Clinical and public health implications are discussed. En ligne : http://dx.doi.org/10.1111/jcpp.12501 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 [article] Annual Research Review: The role of the environment in the developmental psychopathology of autism spectrum condition [texte imprimé] / William MANDY, Auteur ; Meng-Chuan LAI, Auteur . - p.271-292. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-3 (March 2016) . - p.271-292 Mots-clés : Autism spectrum condition  autism spectrum disorder  autism  Asperger's syndrome  genetics  environment  developmental psychopathology Index. décimale : PER Périodiques Résumé : Background Although autism spectrum condition (ASC) is strongly genetic in origin, accumulating evidence points to the critical roles of various environmental influences on its emergence and subsequent developmental course. Methods A developmental psychopathology framework was used to synthesise literature on environmental factors associated with the onset and course of ASC (based on a systematic search of the literature using PubMed, PsychInfo and Google Scholar databases). Particular emphasis was placed on gene–environment interplay, including gene–environment interaction (G × E) and gene–environment correlation (rGE). Results Before conception, advanced paternal and maternal ages may independently enhance offspring risk for ASC. Exogenous prenatal risks are evident (e.g. valproate and toxic chemicals) or possible (e.g. selective serotonin reuptake inhibitors), and processes endogenous to the materno-foeto-placental unit (e.g. maternal diabetes, enhanced steroidogenic activities and maternal immune activation) likely heighten offspring vulnerability to ASC. Folate intake is a prenatal protective factor, with a particular window of action around 4 weeks preconception and during the first trimester. These prenatal risks and protective mechanisms appear to involve G × E and potentially rGE. A variety of perinatal risks are related to offspring ASC risk, possibly reflecting rGE. Postnatal social factors (e.g. caregiver–infant interaction, severe early deprivation) during the first years of life may operate through rGE to influence the likelihood of manifesting a full ASC phenotype from a ‘prodromal’ phase (a proposal distinct to the discredited and harmful ‘refrigerator mother hypothesis’); and later postnatal risks, after the full manifestation of ASC, shape life span development through transactions mediated by rGE. There is no evidence that vaccination is a postnatal risk for ASC. Conclusions Future investigations should consider the specificity of risks for ASC versus other atypical neurodevelopmental trajectories, timing of risk and protective mechanisms, animal model systems to study mechanisms underlying gene–environment interplay, large-sample genome–envirome designs to address G × E and longitudinal studies to elucidate how rGE plays out over time. Clinical and public health implications are discussed. En ligne : http://dx.doi.org/10.1111/jcpp.12501 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282

Assessing Autism in Adults: An Evaluation of the Developmental, Dimensional and Diagnostic Interview-Adult Version (3Di-Adult) / William MANDY in Journal of Autism and Developmental Disorders, 48-2 (February 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-2 (February 2018) . - p.549-560 Titre : Assessing Autism in Adults: An Evaluation of the Developmental, Dimensional and Diagnostic Interview-Adult Version (3Di-Adult) Type de document : texte imprimé Auteurs : William MANDY, Auteur ; Kiri CLARKE, Auteur ; M. MCKENNER, Auteur ; Andre STRYDOM, Auteur ; Jason CRABTREE, Auteur ; Meng-Chuan LAI, Auteur ; Carrie ALLISON, Auteur ; Simon BARON-COHEN, Auteur ; David SKUSE, Auteur Article en page(s) : p.549-560 Langues : Anglais (eng) Mots-clés : Adults  Assessment and diagnosis  Autism spectrum conditions (ASC)  Autism spectrum disorder (ASD)  Diagnostic and statistical manual, fifth edition (DSM-5) Index. décimale : PER Périodiques Résumé : We developed a brief, informant-report interview for assessing autism spectrum conditions (ASC) in adults, called the Developmental, Dimensional and Diagnostic Interview-Adult Version (3Di-Adult); and completed a preliminary evaluation. Informant reports were collected for participants with ASC (n = 39), a non-clinical comparison group (n = 29) and a clinical comparison group (n = 20) who had non-autistic mental health conditions. Mean administration time was 38 min (50 min for ASC). Internal consistency (alphas >/= 0.93) and inter-rater agreement (ICCs >/= 0.99) were high. When discriminating ASC from non-ASC, the 3Di-Adult showed excellent sensitivity (95%) and specificity (92%). The 3Di-Adult shows promise as a psychometrically sound and time-efficient interview for collecting standardised informant reports for DSM-5 assessments of ASC in adults, in research and clinical practice. En ligne : https://doi.org/10.1007/s10803-017-3321-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=338 [article] Assessing Autism in Adults: An Evaluation of the Developmental, Dimensional and Diagnostic Interview-Adult Version (3Di-Adult) [texte imprimé] / William MANDY, Auteur ; Kiri CLARKE, Auteur ; M. MCKENNER, Auteur ; Andre STRYDOM, Auteur ; Jason CRABTREE, Auteur ; Meng-Chuan LAI, Auteur ; Carrie ALLISON, Auteur ; Simon BARON-COHEN, Auteur ; David SKUSE, Auteur . - p.549-560. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-2 (February 2018) . - p.549-560 Mots-clés : Adults  Assessment and diagnosis  Autism spectrum conditions (ASC)  Autism spectrum disorder (ASD)  Diagnostic and statistical manual, fifth edition (DSM-5) Index. décimale : PER Périodiques Résumé : We developed a brief, informant-report interview for assessing autism spectrum conditions (ASC) in adults, called the Developmental, Dimensional and Diagnostic Interview-Adult Version (3Di-Adult); and completed a preliminary evaluation. Informant reports were collected for participants with ASC (n = 39), a non-clinical comparison group (n = 29) and a clinical comparison group (n = 20) who had non-autistic mental health conditions. Mean administration time was 38 min (50 min for ASC). Internal consistency (alphas >/= 0.93) and inter-rater agreement (ICCs >/= 0.99) were high. When discriminating ASC from non-ASC, the 3Di-Adult showed excellent sensitivity (95%) and specificity (92%). The 3Di-Adult shows promise as a psychometrically sound and time-efficient interview for collecting standardised informant reports for DSM-5 assessments of ASC in adults, in research and clinical practice. En ligne : https://doi.org/10.1007/s10803-017-3321-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=338

Assessing gender differences in autism spectrum disorder using the Gendered Autism Behavioral Scale (GABS): An exploratory study / Elaine B. CLARKE in Research in Autism Spectrum Disorders, 88 (October 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 88 (October 2021) . - 101844 Titre : Assessing gender differences in autism spectrum disorder using the Gendered Autism Behavioral Scale (GABS): An exploratory study Type de document : texte imprimé Auteurs : Elaine B. CLARKE, Auteur ; Laura HULL, Auteur ; Rachel LOOMES, Auteur ; Carolyn MCCORMICK, Auteur ; Stephen J. SHEINKOPF, Auteur ; William MANDY, Auteur Article en page(s) : 101844 Langues : Anglais (eng) Mots-clés : Gender  Sex  Diagnosis  ADOS  Autism spectrum disorder Index. décimale : PER Périodiques Résumé : Introduction Gendered differences in autism spectrum disorder (hereafter, ‘autism’) symptomatology, may contribute to delayed diagnoses for autistic females. The aim of this study was to develop a coding system, the Gendered Autism Behavioral Scale (GABS), to identify and measure hypothesized components of non-traditional autism phenotypes. Methods Two independent cohorts of autistic individuals completed modules 3 and 4 of the Autism Diagnostic Observation Schedule (ADOS, 2nd edition). Video-recorded ADOS administrations were coded using the GABS, and separate coding teams analyzed each cohort. Cohort 1 from the United Kingdom consisted of 22 males and 22 females, aged 9–15 years. Cohort 2 from the United States consisted of 40 males and 20 females, aged 4–59 years. Results The coders achieved acceptable inter-rater reliability both within and across coding teams. In exploratory analyses, gender differences between codes were assessed within cohorts. Within Cohort 1, there were significant gender differences, of a moderate size, on several individual items as well as the Managing Emotions subscale and the Total GABS score. Within Cohort 2, significant gender differences were found for two individual items. Conclusions This study demonstrated the feasibility of the GABS across different sites. Validity tests resulted in partial replication of gender differences on the GABS. Preliminary evidence from the GABS suggests that valuable data on hypothesized non-traditional autism phenotypes could be extracted from widely employed assessments such as the ADOS. Future work could capitalize on the GABS’ utility for secondary data analysis to study gender differences in ASD in larger, adequately powered samples. En ligne : https://doi.org/10.1016/j.rasd.2021.101844 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Assessing gender differences in autism spectrum disorder using the Gendered Autism Behavioral Scale (GABS): An exploratory study [texte imprimé] / Elaine B. CLARKE, Auteur ; Laura HULL, Auteur ; Rachel LOOMES, Auteur ; Carolyn MCCORMICK, Auteur ; Stephen J. SHEINKOPF, Auteur ; William MANDY, Auteur . - 101844. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 88 (October 2021) . - 101844 Mots-clés : Gender  Sex  Diagnosis  ADOS  Autism spectrum disorder Index. décimale : PER Périodiques Résumé : Introduction Gendered differences in autism spectrum disorder (hereafter, ‘autism’) symptomatology, may contribute to delayed diagnoses for autistic females. The aim of this study was to develop a coding system, the Gendered Autism Behavioral Scale (GABS), to identify and measure hypothesized components of non-traditional autism phenotypes. Methods Two independent cohorts of autistic individuals completed modules 3 and 4 of the Autism Diagnostic Observation Schedule (ADOS, 2nd edition). Video-recorded ADOS administrations were coded using the GABS, and separate coding teams analyzed each cohort. Cohort 1 from the United Kingdom consisted of 22 males and 22 females, aged 9–15 years. Cohort 2 from the United States consisted of 40 males and 20 females, aged 4–59 years. Results The coders achieved acceptable inter-rater reliability both within and across coding teams. In exploratory analyses, gender differences between codes were assessed within cohorts. Within Cohort 1, there were significant gender differences, of a moderate size, on several individual items as well as the Managing Emotions subscale and the Total GABS score. Within Cohort 2, significant gender differences were found for two individual items. Conclusions This study demonstrated the feasibility of the GABS across different sites. Validity tests resulted in partial replication of gender differences on the GABS. Preliminary evidence from the GABS suggests that valuable data on hypothesized non-traditional autism phenotypes could be extracted from widely employed assessments such as the ADOS. Future work could capitalize on the GABS’ utility for secondary data analysis to study gender differences in ASD in larger, adequately powered samples. En ligne : https://doi.org/10.1016/j.rasd.2021.101844 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Augmentation de la prévalence de l’autisme : quelle est son origine et sa signification? / William MANDY in Bulletin Scientifique de l'arapi (Le), 40 (Hiver 2017)

Public ISBD [article]  inBulletin Scientifique de l'arapi (Le) > 40 (Hiver 2017) . - p.12-18 Titre : Augmentation de la prévalence de l’autisme : quelle est son origine et sa signification? Type de document : texte imprimé Auteurs : William MANDY, Auteur ; Meng-Chuan LAI, Auteur Année de publication : 2017 Article en page(s) : p.12-18 Langues : Français (fre) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=373 [article] Augmentation de la prévalence de l’autisme : quelle est son origine et sa signification? [texte imprimé] / William MANDY, Auteur ; Meng-Chuan LAI, Auteur . - 2017 . - p.12-18. Langues : Français (fre) in Bulletin Scientifique de l'arapi (Le) > 40 (Hiver 2017) . - p.12-18 Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=373

Behavioural and cognitive sex/gender differences in autism spectrum condition and typically developing males and females / Laura HULL in Autism, 21-6 (August 2017)  

Public ISBD [article]  inAutism > 21-6 (August 2017) . - p.706-727 Titre : Behavioural and cognitive sex/gender differences in autism spectrum condition and typically developing males and females Type de document : texte imprimé Auteurs : Laura HULL, Auteur ; William MANDY, Auteur ; Konstantinos V. PETRIDES, Auteur Article en page(s) : p.706-727 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Studies assessing sex/gender differences in autism spectrum conditions often fail to include typically developing control groups. It is, therefore, unclear whether observed sex/gender differences reflect those found in the general population or are particular to autism spectrum conditions. A systematic search identified articles comparing behavioural and cognitive characteristics in males and females with and without an autism spectrum condition diagnosis. A total of 13 studies were included in meta-analyses of sex/gender differences in core autism spectrum condition symptoms (social/communication impairments and restricted/repetitive behaviours and interests) and intelligence quotient. A total of 20 studies were included in a qualitative review of sex/gender differences in additional autism spectrum condition symptoms. For core traits and intelligence quotient, sex/gender differences were comparable in autism spectrum conditions and typical samples. Some additional autism spectrum condition symptoms displayed different patterns of sex/gender differences in autism spectrum conditions and typically developing groups, including measures of executive function, empathising and systemising traits, internalising and externalising problems and play behaviours. Individuals with autism spectrum conditions display typical sex/gender differences in core autism spectrum condition traits, suggesting that diagnostic criteria based on these symptoms should take into account typical sex/gender differences. However, awareness of associated autism spectrum condition symptoms should include the possibility of different male and female phenotypes, to ensure those who do not fit the ?typical? autism spectrum condition presentation are not missed. En ligne : http://dx.doi.org/10.1177/1362361316669087 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=311 [article] Behavioural and cognitive sex/gender differences in autism spectrum condition and typically developing males and females [texte imprimé] / Laura HULL, Auteur ; William MANDY, Auteur ; Konstantinos V. PETRIDES, Auteur . - p.706-727. Langues : Anglais (eng) in Autism > 21-6 (August 2017) . - p.706-727 Index. décimale : PER Périodiques Résumé : Studies assessing sex/gender differences in autism spectrum conditions often fail to include typically developing control groups. It is, therefore, unclear whether observed sex/gender differences reflect those found in the general population or are particular to autism spectrum conditions. A systematic search identified articles comparing behavioural and cognitive characteristics in males and females with and without an autism spectrum condition diagnosis. A total of 13 studies were included in meta-analyses of sex/gender differences in core autism spectrum condition symptoms (social/communication impairments and restricted/repetitive behaviours and interests) and intelligence quotient. A total of 20 studies were included in a qualitative review of sex/gender differences in additional autism spectrum condition symptoms. For core traits and intelligence quotient, sex/gender differences were comparable in autism spectrum conditions and typical samples. Some additional autism spectrum condition symptoms displayed different patterns of sex/gender differences in autism spectrum conditions and typically developing groups, including measures of executive function, empathising and systemising traits, internalising and externalising problems and play behaviours. Individuals with autism spectrum conditions display typical sex/gender differences in core autism spectrum condition traits, suggesting that diagnostic criteria based on these symptoms should take into account typical sex/gender differences. However, awareness of associated autism spectrum condition symptoms should include the possibility of different male and female phenotypes, to ensure those who do not fit the ?typical? autism spectrum condition presentation are not missed. En ligne : http://dx.doi.org/10.1177/1362361316669087 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=311

Benefits and harms of interventions to improve anxiety, depression, and other mental health outcomes for autistic people: A systematic review and network meta-analysis of randomised controlled trials / Audrey LINDEN in Autism, 27-1 (January 2023)  

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Camouflaging in an everyday social context: An interpersonal recall study / Julia COOK in Autism, 26-5 (July 2022)  

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Camouflaging in an everyday social context: An interpersonal recall study / Julia COOK in Autism, 25-5 (July 2021)  

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Camouflaging Intent, First Impressions, and Age of ASC Diagnosis in Autistic Men and Women / Hannah L. BELCHER in Journal of Autism and Developmental Disorders, 52-8 (August 2022)  

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Child and Adult Factors Related to Quality of Life in Adults with Autism / Philippa MOSS in Journal of Autism and Developmental Disorders, 47-6 (June 2017)  

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Clinical evaluation of autistic symptoms in women with anorexia nervosa / Heather WESTWOOD in Molecular Autism, 8 (2017)  

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Cognitive Predictors of Self-Reported Camouflaging in Autistic Adolescents / Laura HULL in Autism Research, 14-3 (March 2021)  

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Commentary: 'Camouflaging' in autistic people - reflection on Fombonne (2020) / Meng-Chuan LAI in Journal of Child Psychology and Psychiatry, 62-8 (August 2021)  

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A comparison of methods for measuring camouflaging in autism / William MANDY ; Laura HULL in Autism Research, 16-1 (January 2023)  

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A comparison of self-report and discrepancy measures of camouflaging: Exploring sex differences in diagnosed autistic versus high autistic trait young adults / Victoria MILNER in Autism Research, 16-3 (March 2023)  

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