Does intensive multimodal treatment for maternal ADHD improve the efficacy of parent training for children with ADHD? A randomized controlled multicenter trial / Thomas JANS in Journal of Child Psychology and Psychiatry, 56-12 (December 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-12 (December 2015) . - p.1298-1313 Titre : Does intensive multimodal treatment for maternal ADHD improve the efficacy of parent training for children with ADHD? A randomized controlled multicenter trial Type de document : Texte imprimé et/ou numérique Auteurs : Thomas JANS, Auteur ; Christian JACOB, Auteur ; Andreas WARNKE, Auteur ; Ulrike ZWANZGER, Auteur ; Silke GROß-LESCH, Auteur ; Swantje MATTHIES, Auteur ; Patricia BOREL, Auteur ; Klaus HENNIGHAUSEN, Auteur ; Barbara HAACK-DEES, Auteur ; Michael RÖSLER, Auteur ; Wolfgang RETZ, Auteur ; Alexander VON GONTARD, Auteur ; Susann HÄNIG, Auteur ; Esther SOBANSKI, Auteur ; Barbara ALM, Auteur ; Luise POUSTKA, Auteur ; Sarah HOHMANN, Auteur ; Michael COLLA, Auteur ; Laura GENTSCHOW, Auteur ; Charlotte JAITE, Auteur ; Viola KAPPEL, Auteur ; Katja BECKER, Auteur ; Martin HOLTMANN, Auteur ; Christine FREITAG, Auteur ; Erika GRAF, Auteur ; Gabriele IHORST, Auteur ; Alexandra PHILIPSEN, Auteur Article en page(s) : p.1298-1313 Langues : Anglais (eng) Mots-clés : Parental ADHD  parent training  dialectical behavioral therapy  stimulant medication Index. décimale : PER Périodiques Résumé : Background This is the first randomized controlled multicenter trial to evaluate the effect of two treatments of maternal attention-deficit hyperactivity disorder (ADHD) on response to parent–child training targeting children's external psychopathology. Methods Mother–child dyads (n = 144; ADHD according to DSM-IV; children: 73.5% males, mean age 9.4 years) from five specialized university outpatient units in Germany were centrally randomized to multimodal maternal ADHD treatment [group psychotherapy plus open methylphenidate medication; treatment group (TG): n = 77] or to clinical management [supportive counseling without psychotherapy or psychopharmacotherapy; control group (CG): n = 67]. After 12 weeks, the maternal ADHD treatment was supplemented by individual parent–child training for all dyads. The primary outcome was a change in the children's externalizing symptom scores (investigator blinded to the treatment assignment) from baseline to the end of the parent–child training 6 months later. Maintenance therapy continued for another 6 months. An intention-to-treat analysis was performed within a linear regression model, controlling for baseline and center after multiple imputations of missing values. Results Exactly, 206 dyads were assessed for eligibility, 144 were randomized, and 143 were analyzed (TG: n = 77; CG: n = 66). After 6 months, no significant between-group differences were found in change scores for children's externalizing symptoms (adjusted mean TG-mean CG=1.1, 95% confidence interval ?0.5–2.7; p = .1854), although maternal psychopathology improved more in the TG. Children's externalizing symptom scores improved from a mean of 14.8 at baseline to 11.4 (TG) and 10.3 (CG) after 6 months and to 10.8 (TG) and 10.1 (CG) after 1 year. No severe harms related to study treatments were found, but adverse events were more frequent in TG mothers than in CG mothers. Conclusions The response in children's externalizing psychopathology did not differ between maternal treatment groups. However, multimodal treatment was associated with more improvement in maternal ADHD. Child and maternal treatment gains were stable (CCT-ISRCTN73911400). En ligne : http://dx.doi.org/10.1111/jcpp.12443 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273 [article] Does intensive multimodal treatment for maternal ADHD improve the efficacy of parent training for children with ADHD? A randomized controlled multicenter trial [Texte imprimé et/ou numérique] / Thomas JANS, Auteur ; Christian JACOB, Auteur ; Andreas WARNKE, Auteur ; Ulrike ZWANZGER, Auteur ; Silke GROß-LESCH, Auteur ; Swantje MATTHIES, Auteur ; Patricia BOREL, Auteur ; Klaus HENNIGHAUSEN, Auteur ; Barbara HAACK-DEES, Auteur ; Michael RÖSLER, Auteur ; Wolfgang RETZ, Auteur ; Alexander VON GONTARD, Auteur ; Susann HÄNIG, Auteur ; Esther SOBANSKI, Auteur ; Barbara ALM, Auteur ; Luise POUSTKA, Auteur ; Sarah HOHMANN, Auteur ; Michael COLLA, Auteur ; Laura GENTSCHOW, Auteur ; Charlotte JAITE, Auteur ; Viola KAPPEL, Auteur ; Katja BECKER, Auteur ; Martin HOLTMANN, Auteur ; Christine FREITAG, Auteur ; Erika GRAF, Auteur ; Gabriele IHORST, Auteur ; Alexandra PHILIPSEN, Auteur . - p.1298-1313. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-12 (December 2015) . - p.1298-1313 Mots-clés : Parental ADHD  parent training  dialectical behavioral therapy  stimulant medication Index. décimale : PER Périodiques Résumé : Background This is the first randomized controlled multicenter trial to evaluate the effect of two treatments of maternal attention-deficit hyperactivity disorder (ADHD) on response to parent–child training targeting children's external psychopathology. Methods Mother–child dyads (n = 144; ADHD according to DSM-IV; children: 73.5% males, mean age 9.4 years) from five specialized university outpatient units in Germany were centrally randomized to multimodal maternal ADHD treatment [group psychotherapy plus open methylphenidate medication; treatment group (TG): n = 77] or to clinical management [supportive counseling without psychotherapy or psychopharmacotherapy; control group (CG): n = 67]. After 12 weeks, the maternal ADHD treatment was supplemented by individual parent–child training for all dyads. The primary outcome was a change in the children's externalizing symptom scores (investigator blinded to the treatment assignment) from baseline to the end of the parent–child training 6 months later. Maintenance therapy continued for another 6 months. An intention-to-treat analysis was performed within a linear regression model, controlling for baseline and center after multiple imputations of missing values. Results Exactly, 206 dyads were assessed for eligibility, 144 were randomized, and 143 were analyzed (TG: n = 77; CG: n = 66). After 6 months, no significant between-group differences were found in change scores for children's externalizing symptoms (adjusted mean TG-mean CG=1.1, 95% confidence interval ?0.5–2.7; p = .1854), although maternal psychopathology improved more in the TG. Children's externalizing symptom scores improved from a mean of 14.8 at baseline to 11.4 (TG) and 10.3 (CG) after 6 months and to 10.8 (TG) and 10.1 (CG) after 1 year. No severe harms related to study treatments were found, but adverse events were more frequent in TG mothers than in CG mothers. Conclusions The response in children's externalizing psychopathology did not differ between maternal treatment groups. However, multimodal treatment was associated with more improvement in maternal ADHD. Child and maternal treatment gains were stable (CCT-ISRCTN73911400). En ligne : http://dx.doi.org/10.1111/jcpp.12443 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273

Identifying structural brain markers of resilience to adversity in young people using voxel-based morphometry / Stephane DE BRITO ; Graeme FAIRCHILD ; Christine FREITAG ; Karen GONZALEZ-MADRUGA ; Catherine HAMILTON-GIACHRITSIS ; Gregor KOHLS ; Kerstin KONRAD ; Anne MARTINELLI ; Nora Maria RASCHLE ; Jack ROGERS ; Areti SMARAGDI ; Christina STADLER ; Marlene STAGINNUS ; Nicola TOSCHI in Development and Psychopathology, 35-5 (December 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-5 (December 2023) . - p.2302-2314 Titre : Identifying structural brain markers of resilience to adversity in young people using voxel-based morphometry Type de document : Texte imprimé et/ou numérique Auteurs : Stephane DE BRITO, Auteur ; Graeme FAIRCHILD, Auteur ; Christine FREITAG, Auteur ; Karen GONZALEZ-MADRUGA, Auteur ; Catherine HAMILTON-GIACHRITSIS, Auteur ; Gregor KOHLS, Auteur ; Kerstin KONRAD, Auteur ; Anne MARTINELLI, Auteur ; Nora Maria RASCHLE, Auteur ; Jack ROGERS, Auteur ; Areti SMARAGDI, Auteur ; Christina STADLER, Auteur ; Marlene STAGINNUS, Auteur ; Nicola TOSCHI, Auteur Article en page(s) : p.2302-2314 Mots-clés : Resilience  adversity  brain structure  voxel-based morphometry  youth Index. décimale : PER Périodiques Résumé : There is increasing evidence that resilience in youth may have a neurobiological basis. However, the existing literature lacks a consistent way of operationalizing resilience, often relying on arbitrary judgments or narrow definitions (e.g., not developing PTSD) to classify individuals as resilient. Therefore, this study used data-driven, continuous resilience scores based on adversity and psychopathology to investigate associations between resilience and brain structure in youth. Structural MRI data from 298 youth aged 9?18 years (Mage = 13.51; 51% female) who participated in the European multisite FemNAT-CD study were preprocessed using SPM12 and analyzed using voxel-based morphometry. Resilience scores were derived by regressing data on adversity exposure against current/lifetime psychopathology and quantifying each individual?s distance from the regression line. General linear models tested for associations between resilience and gray matter volume (GMV) and examined whether associations between resilience and GMV differed by sex. Resilience was positively correlated with GMV in the right inferior frontal and medial frontal gyri. Sex-by-resilience interactions were observed in the middle temporal and middle frontal gyri. These findings demonstrate that resilience in youth is associated with volume in brain regions implicated in executive functioning, emotion regulation, and attention. Our results also provide evidence for sex differences in the neurobiology of resilience. En ligne : https://dx.doi.org/10.1017/S0954579423000718 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519 [article] Identifying structural brain markers of resilience to adversity in young people using voxel-based morphometry [Texte imprimé et/ou numérique] / Stephane DE BRITO, Auteur ; Graeme FAIRCHILD, Auteur ; Christine FREITAG, Auteur ; Karen GONZALEZ-MADRUGA, Auteur ; Catherine HAMILTON-GIACHRITSIS, Auteur ; Gregor KOHLS, Auteur ; Kerstin KONRAD, Auteur ; Anne MARTINELLI, Auteur ; Nora Maria RASCHLE, Auteur ; Jack ROGERS, Auteur ; Areti SMARAGDI, Auteur ; Christina STADLER, Auteur ; Marlene STAGINNUS, Auteur ; Nicola TOSCHI, Auteur . - p.2302-2314. in Development and Psychopathology > 35-5 (December 2023) . - p.2302-2314 Mots-clés : Resilience  adversity  brain structure  voxel-based morphometry  youth Index. décimale : PER Périodiques Résumé : There is increasing evidence that resilience in youth may have a neurobiological basis. However, the existing literature lacks a consistent way of operationalizing resilience, often relying on arbitrary judgments or narrow definitions (e.g., not developing PTSD) to classify individuals as resilient. Therefore, this study used data-driven, continuous resilience scores based on adversity and psychopathology to investigate associations between resilience and brain structure in youth. Structural MRI data from 298 youth aged 9?18 years (Mage = 13.51; 51% female) who participated in the European multisite FemNAT-CD study were preprocessed using SPM12 and analyzed using voxel-based morphometry. Resilience scores were derived by regressing data on adversity exposure against current/lifetime psychopathology and quantifying each individual?s distance from the regression line. General linear models tested for associations between resilience and gray matter volume (GMV) and examined whether associations between resilience and GMV differed by sex. Resilience was positively correlated with GMV in the right inferior frontal and medial frontal gyri. Sex-by-resilience interactions were observed in the middle temporal and middle frontal gyri. These findings demonstrate that resilience in youth is associated with volume in brain regions implicated in executive functioning, emotion regulation, and attention. Our results also provide evidence for sex differences in the neurobiology of resilience. En ligne : https://dx.doi.org/10.1017/S0954579423000718 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519

Protein signatures of oxidative stress response in a patient specific cell line model for autism / Andreas G. CHIOCCHETTI in Molecular Autism, (February 2014)  

Public ISBD [article]  inMolecular Autism > (February 2014) Titre : Protein signatures of oxidative stress response in a patient specific cell line model for autism Type de document : Texte imprimé et/ou numérique Auteurs : Andreas G. CHIOCCHETTI, Auteur ; Denise HASLINGER, Auteur ; Maximilian BOESCH, Auteur ; Thomas KARL, Auteur ; Stefan WIEMANN, Auteur ; Christine FREITAG, Auteur ; Fritz POUSTKA, Auteur ; Burghardt SCHEIBE, Auteur ; Johann BAUER, Auteur ; Helmut HINTNER, Auteur ; Michael BREITENBACH, Auteur ; Josef KELLERMANN, Auteur ; Friedrich LOTTSPEICH, Auteur ; Sabine M. KLAUCK, Auteur ; Lore BREITENBACH-KOLLER, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Known genetic variants can account for 10% to 20% of all cases with autism spectrum disorders (ASD). Overlapping cellular pathomechanisms common to neurons of the central nervous system (CNS) and in tissues of peripheral organs, such as immune dysregulation, oxidative stress and dysfunctions in mitochondrial and protein synthesis metabolism, were suggested to support the wide spectrum of ASD on unifying disease phenotype. Here, we studied in patient-derived lymphoblastoid cell lines (LCLs) how an ASD-specific mutation in ribosomal protein RPL10 (RPL10[H213Q]) generates a distinct protein signature. We compared the RPL10[H213Q] expression pattern to expression patterns derived from unrelated ASD patients without RPL10[H213Q] mutation. In addition, a yeast rpl10 deficiency model served in a proof-of-principle study to test for alterations in protein patterns in response to oxidative stress. Protein extracts of LCLs from patients, relatives and controls, as well as diploid yeast cells hemizygous for rpl10, were subjected to two-dimensional gel electrophoresis and differentially regulated spots were identified by mass spectrometry. Subsequently, Gene Ontology database (GO)-term enrichment and network analysis was performed to map the identified proteins into cellular pathways. The protein signature generated by RPL10[H213Q] is a functionally related subset of the ASD-specific protein signature, sharing redox-sensitive elements in energy-, protein- and redox-metabolism. In yeast, rpl10 deficiency generates a specific protein signature, harboring components of pathways identified in both the RPL10[H213Q] subjects' and the ASD patients' set. Importantly, the rpl10 deficiency signature is a subset of the signature resulting from response of wild-type yeast to oxidative stress. Redox-sensitive protein signatures mapping into cellular pathways with pathophysiology in ASD have been identified in both LCLs carrying the ASD-specific mutation RPL10[H213Q] and LCLs from ASD patients without this mutation. At pathway levels, this redox-sensitive protein signature has also been identified in a yeast rpl10 deficiency and an oxidative stress model. These observations point to a common molecular pathomechanism in ASD, characterized in our study by dysregulation of redox balance. Importantly, this can be triggered by the known ASD-RPL10[H213Q] mutation or by yet unknown mutations of the ASD cohort that act upstream of RPL10 in differential expression of redox-sensitive proteins. En ligne : http://dx.doi.org/10.1186/2040-2392-5-10 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 [article] Protein signatures of oxidative stress response in a patient specific cell line model for autism [Texte imprimé et/ou numérique] / Andreas G. CHIOCCHETTI, Auteur ; Denise HASLINGER, Auteur ; Maximilian BOESCH, Auteur ; Thomas KARL, Auteur ; Stefan WIEMANN, Auteur ; Christine FREITAG, Auteur ; Fritz POUSTKA, Auteur ; Burghardt SCHEIBE, Auteur ; Johann BAUER, Auteur ; Helmut HINTNER, Auteur ; Michael BREITENBACH, Auteur ; Josef KELLERMANN, Auteur ; Friedrich LOTTSPEICH, Auteur ; Sabine M. KLAUCK, Auteur ; Lore BREITENBACH-KOLLER, Auteur. Langues : Anglais (eng) in Molecular Autism > (February 2014) Index. décimale : PER Périodiques Résumé : Known genetic variants can account for 10% to 20% of all cases with autism spectrum disorders (ASD). Overlapping cellular pathomechanisms common to neurons of the central nervous system (CNS) and in tissues of peripheral organs, such as immune dysregulation, oxidative stress and dysfunctions in mitochondrial and protein synthesis metabolism, were suggested to support the wide spectrum of ASD on unifying disease phenotype. Here, we studied in patient-derived lymphoblastoid cell lines (LCLs) how an ASD-specific mutation in ribosomal protein RPL10 (RPL10[H213Q]) generates a distinct protein signature. We compared the RPL10[H213Q] expression pattern to expression patterns derived from unrelated ASD patients without RPL10[H213Q] mutation. In addition, a yeast rpl10 deficiency model served in a proof-of-principle study to test for alterations in protein patterns in response to oxidative stress. Protein extracts of LCLs from patients, relatives and controls, as well as diploid yeast cells hemizygous for rpl10, were subjected to two-dimensional gel electrophoresis and differentially regulated spots were identified by mass spectrometry. Subsequently, Gene Ontology database (GO)-term enrichment and network analysis was performed to map the identified proteins into cellular pathways. The protein signature generated by RPL10[H213Q] is a functionally related subset of the ASD-specific protein signature, sharing redox-sensitive elements in energy-, protein- and redox-metabolism. In yeast, rpl10 deficiency generates a specific protein signature, harboring components of pathways identified in both the RPL10[H213Q] subjects' and the ASD patients' set. Importantly, the rpl10 deficiency signature is a subset of the signature resulting from response of wild-type yeast to oxidative stress. Redox-sensitive protein signatures mapping into cellular pathways with pathophysiology in ASD have been identified in both LCLs carrying the ASD-specific mutation RPL10[H213Q] and LCLs from ASD patients without this mutation. At pathway levels, this redox-sensitive protein signature has also been identified in a yeast rpl10 deficiency and an oxidative stress model. These observations point to a common molecular pathomechanism in ASD, characterized in our study by dysregulation of redox balance. Importantly, this can be triggered by the known ASD-RPL10[H213Q] mutation or by yet unknown mutations of the ASD cohort that act upstream of RPL10 in differential expression of redox-sensitive proteins. En ligne : http://dx.doi.org/10.1186/2040-2392-5-10 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227

Use of early intervention for young children with autism spectrum disorder across Europe / Erica SALOMONE in Autism, 20-2 (February 2016)  

Public ISBD [article]  inAutism > 20-2 (February 2016) . - p.233-249 Titre : Use of early intervention for young children with autism spectrum disorder across Europe Type de document : Texte imprimé et/ou numérique Auteurs : Erica SALOMONE, Auteur ; Št?pánka BERANOVÁ, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; Marlene BRICIET LAURITSEN, Auteur ; Magdalena BUDISTEANU, Auteur ; Jan K. BUITELAAR, Auteur ; Ricardo CANAL-BEDIA, Auteur ; Gabriella FELHOSI, Auteur ; Sue FLETCHER-WATSON, Auteur ; Christine FREITAG, Auteur ; Joaquin FUENTES, Auteur ; Louise GALLAGHER, Auteur ; Patricia GARCÍA PRIMO, Auteur ; Fotinica GLIGA, Auteur ; Marie GOMOT, Auteur ; Jonathan GREEN, Auteur ; Mikael HEIMANN, Auteur ; Sigrídur Lóa JONSDOTTIR, Auteur ; Anett KAALE, Auteur ; Rafal KAWA, Auteur ; Anneli KYLLIAINEN, Auteur ; Sanne LEMCKE, Auteur ; Silvana MARKOVSKA-SIMOSKA, Auteur ; Peter B MARSCHIK, Auteur ; Helen MCCONACHIE, Auteur ; Irma MOILANEN, Auteur ; Filippo MURATORI, Auteur ; Antonio NARZISI, Auteur ; Michele NOTERDAEME, Auteur ; Guiomar OLIVEIRA, Auteur ; Iris OOSTERLING, Auteur ; Mirjam PIJL, Auteur ; Nada POP-JORDANOVA, Auteur ; Luise POUSTKA, Auteur ; Herbert ROEYERS, Auteur ; Bernadette ROGE, Auteur ; Judith SINZIG, Auteur ; Astrid VICENTE, Auteur ; Petra WARREYN, Auteur ; Tony CHARMAN, Auteur Article en page(s) : p.233-249 Langues : Anglais (eng) Mots-clés : autism  Europe intervention  use of early intervention Index. décimale : PER Périodiques Résumé : Little is known about use of early interventions for autism spectrum disorder in Europe. Parents of children with autism spectrum disorder aged 7?years or younger (N?=?1680) were recruited through parent organisations in 18 European countries and completed an online survey about the interventions their child received. There was considerable variation in use of interventions, and in some countries more than 20% of children received no intervention at all. The most frequently reported interventions were speech and language therapy (64%) and behavioural, developmental and relationship-based interventions (55%). In some parts of Europe, use of behavioural, developmental and relationship-based interventions was associated with higher parental educational level and time passed since diagnosis, rather than with child characteristics. These findings highlight the need to monitor use of intervention for children with autism spectrum disorder in Europe in order to contrast inequalities. En ligne : http://dx.doi.org/10.1177/1362361315577218 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 [article] Use of early intervention for young children with autism spectrum disorder across Europe [Texte imprimé et/ou numérique] / Erica SALOMONE, Auteur ; Št?pánka BERANOVÁ, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; Marlene BRICIET LAURITSEN, Auteur ; Magdalena BUDISTEANU, Auteur ; Jan K. BUITELAAR, Auteur ; Ricardo CANAL-BEDIA, Auteur ; Gabriella FELHOSI, Auteur ; Sue FLETCHER-WATSON, Auteur ; Christine FREITAG, Auteur ; Joaquin FUENTES, Auteur ; Louise GALLAGHER, Auteur ; Patricia GARCÍA PRIMO, Auteur ; Fotinica GLIGA, Auteur ; Marie GOMOT, Auteur ; Jonathan GREEN, Auteur ; Mikael HEIMANN, Auteur ; Sigrídur Lóa JONSDOTTIR, Auteur ; Anett KAALE, Auteur ; Rafal KAWA, Auteur ; Anneli KYLLIAINEN, Auteur ; Sanne LEMCKE, Auteur ; Silvana MARKOVSKA-SIMOSKA, Auteur ; Peter B MARSCHIK, Auteur ; Helen MCCONACHIE, Auteur ; Irma MOILANEN, Auteur ; Filippo MURATORI, Auteur ; Antonio NARZISI, Auteur ; Michele NOTERDAEME, Auteur ; Guiomar OLIVEIRA, Auteur ; Iris OOSTERLING, Auteur ; Mirjam PIJL, Auteur ; Nada POP-JORDANOVA, Auteur ; Luise POUSTKA, Auteur ; Herbert ROEYERS, Auteur ; Bernadette ROGE, Auteur ; Judith SINZIG, Auteur ; Astrid VICENTE, Auteur ; Petra WARREYN, Auteur ; Tony CHARMAN, Auteur . - p.233-249. Langues : Anglais (eng) in Autism > 20-2 (February 2016) . - p.233-249 Mots-clés : autism  Europe intervention  use of early intervention Index. décimale : PER Périodiques Résumé : Little is known about use of early interventions for autism spectrum disorder in Europe. Parents of children with autism spectrum disorder aged 7?years or younger (N?=?1680) were recruited through parent organisations in 18 European countries and completed an online survey about the interventions their child received. There was considerable variation in use of interventions, and in some countries more than 20% of children received no intervention at all. The most frequently reported interventions were speech and language therapy (64%) and behavioural, developmental and relationship-based interventions (55%). In some parts of Europe, use of behavioural, developmental and relationship-based interventions was associated with higher parental educational level and time passed since diagnosis, rather than with child characteristics. These findings highlight the need to monitor use of intervention for children with autism spectrum disorder in Europe in order to contrast inequalities. En ligne : http://dx.doi.org/10.1177/1362361315577218 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278

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