Can Autism Spectrum Disorders and Social Anxiety Disorders be Differentiated by the Social Responsiveness Scale in Children and Adolescents? / Hannah CHOLEMKERY in Journal of Autism and Developmental Disorders, 44-5 (May 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-5 (May 2014) . - p.1168-1182 Titre : Can Autism Spectrum Disorders and Social Anxiety Disorders be Differentiated by the Social Responsiveness Scale in Children and Adolescents? Type de document : texte imprimé Auteurs : Hannah CHOLEMKERY, Auteur ; Laura MOJICA, Auteur ; Sonja ROHRMANN, Auteur ; Angelika GENSTHALER, Auteur ; Christine M. FREITAG, Auteur Année de publication : 2014 Article en page(s) : p.1168-1182 Langues : Anglais (eng) Mots-clés : Psychometric assessment  Differential diagnosis  Child psychiatric disorder  Autism spectrum disorder  Social anxiety disorders Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) as well as social phobia (SP), and selective mutism (SM) are characterised by impaired social interaction. We assessed the validity of the Social Responsiveness Scale (SRS) to differentiate between ASD, and SP/SM. Raw scores were compared in 6–18 year old individuals with ASD (N = 60), SP (N = 38), SM (N = 43), and typically developed (N = 42). Sensitivity and specificity were examined. The three disorders showed overlapping SRS scores. Especially in boys with SM (ROC–AUC = .81), presence of ASD was overestimated by the SRS. A combination of three disorder specific questionnaires resulted in marginally improved diagnostic accuracy. For the clinically very relevant differential diagnosis of SP/SM, SRS results must be interpreted with caution. En ligne : http://dx.doi.org/10.1007/s10803-013-1979-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232 [article] Can Autism Spectrum Disorders and Social Anxiety Disorders be Differentiated by the Social Responsiveness Scale in Children and Adolescents? [texte imprimé] / Hannah CHOLEMKERY, Auteur ; Laura MOJICA, Auteur ; Sonja ROHRMANN, Auteur ; Angelika GENSTHALER, Auteur ; Christine M. FREITAG, Auteur . - 2014 . - p.1168-1182. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-5 (May 2014) . - p.1168-1182 Mots-clés : Psychometric assessment  Differential diagnosis  Child psychiatric disorder  Autism spectrum disorder  Social anxiety disorders Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) as well as social phobia (SP), and selective mutism (SM) are characterised by impaired social interaction. We assessed the validity of the Social Responsiveness Scale (SRS) to differentiate between ASD, and SP/SM. Raw scores were compared in 6–18 year old individuals with ASD (N = 60), SP (N = 38), SM (N = 43), and typically developed (N = 42). Sensitivity and specificity were examined. The three disorders showed overlapping SRS scores. Especially in boys with SM (ROC–AUC = .81), presence of ASD was overestimated by the SRS. A combination of three disorder specific questionnaires resulted in marginally improved diagnostic accuracy. For the clinically very relevant differential diagnosis of SP/SM, SRS results must be interpreted with caution. En ligne : http://dx.doi.org/10.1007/s10803-013-1979-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232

Classifying Autism Spectrum Disorders by ADI-R: Subtypes or Severity Gradient? / Hannah CHOLEMKERY in Journal of Autism and Developmental Disorders, 46-7 (July 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-7 (July 2016) . - p.2327-2339 Titre : Classifying Autism Spectrum Disorders by ADI-R: Subtypes or Severity Gradient? Type de document : texte imprimé Auteurs : Hannah CHOLEMKERY, Auteur ; Juliane MEDDA, Auteur ; Thomas LEMPP, Auteur ; Christine M. FREITAG, Auteur Article en page(s) : p.2327-2339 Langues : Anglais (eng) Mots-clés : Autism Diagnostic Interview-revised  Psychometric assessment  Diagnosis  Autism spectrum disorder  Cluster analysis  DSM-5 Index. décimale : PER Périodiques Résumé : To reduce phenotypic heterogeneity of Autism spectrum disorders (ASD) and add to the current diagnostic discussion this study aimed at identifying clinically meaningful ASD subgroups. Cluster analyses were used to describe empirically derived groups based on the Autism Diagnostic Interview-revised (ADI-R) in a large sample of n = 463 individuals with ASD aged 3–21. Three clusters were observed. Most severely affected individuals regarding all core symptoms were allocated to cluster 2. Cluster 3 comprised moderate symptom severity of social communication impairments (SCI) and less stereotyped repetitive behavior (RRB). Minor SCI and relatively more RRB characterized cluster 1. This study offers support for both, a symptom profile, and a gradient model of ASD within the spectrum due to the sample included. En ligne : http://dx.doi.org/10.1007/s10803-016-2760-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290 [article] Classifying Autism Spectrum Disorders by ADI-R: Subtypes or Severity Gradient? [texte imprimé] / Hannah CHOLEMKERY, Auteur ; Juliane MEDDA, Auteur ; Thomas LEMPP, Auteur ; Christine M. FREITAG, Auteur . - p.2327-2339. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-7 (July 2016) . - p.2327-2339 Mots-clés : Autism Diagnostic Interview-revised  Psychometric assessment  Diagnosis  Autism spectrum disorder  Cluster analysis  DSM-5 Index. décimale : PER Périodiques Résumé : To reduce phenotypic heterogeneity of Autism spectrum disorders (ASD) and add to the current diagnostic discussion this study aimed at identifying clinically meaningful ASD subgroups. Cluster analyses were used to describe empirically derived groups based on the Autism Diagnostic Interview-revised (ADI-R) in a large sample of n = 463 individuals with ASD aged 3–21. Three clusters were observed. Most severely affected individuals regarding all core symptoms were allocated to cluster 2. Cluster 3 comprised moderate symptom severity of social communication impairments (SCI) and less stereotyped repetitive behavior (RRB). Minor SCI and relatively more RRB characterized cluster 1. This study offers support for both, a symptom profile, and a gradient model of ASD within the spectrum due to the sample included. En ligne : http://dx.doi.org/10.1007/s10803-016-2760-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290

Facilitation of biological motion processing by group-based autism specific social skills training / Christina LUCKHARDT in Autism Research, 11-10 (October 2018)  

Public ISBD [article]  inAutism Research > 11-10 (October 2018) . - p.1376-1387 Titre : Facilitation of biological motion processing by group-based autism specific social skills training Type de document : texte imprimé Auteurs : Christina LUCKHARDT, Auteur ; A. KROGER, Auteur ; Leyla ELSUNI, Auteur ; Hannah CHOLEMKERY, Auteur ; Stephan BENDER, Auteur ; Christine M. FREITAG, Auteur Article en page(s) : p.1376-1387 Langues : Anglais (eng) Mots-clés : autism  biological motion  event-related potentials  facial emotion recognition  intervention  social skills training Index. décimale : PER Périodiques Résumé : Abnormalities in neurophysiological correlates of social perception are a well-known feature of autism spectrum disorder (ASD). However, little is known if and how ASD specific behavioral interventions may affect neural processing in ASD. The aim of the current study was to investigate for the first time, whether the group-based social skills training SOSTA-FRA would elicit changes in neurophysiological correlates of social perception in high-functioning ASD individuals aged 8-17 years. Event-related potentials (ERPs) of a facial emotion recognition (FER) and a biological motion perception task were examined. ERPs were compared between a randomized intervention and a treatment as usual group at three time points (baseline, post-intervention, and at 3 months follow-up). A reduction of P100 amplitude in the right hemisphere and a trend toward reduced N200 latency in the biological motion task were found after the training only in the intervention group, whereas behavioral performance remained stable. Change in N200 latencies and parent-rated social responsiveness showed small but statistically nonsignificant correlations. No changes were observed regarding FER. Results indicate that the intervention changed neural correlates of social perception in ASD. Especially neural correlates of biological motion perception, which is an important prerequisite for successful social interaction, were sensitive to change. ERPs of social perception tasks that are impaired in ASD can well be used to objectively measure neural processing improvement by behavioral intervention. Autism Res 2018, 11: 1376-1387. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: It is well known that people with autism spectrum disorder (ASD) process social information differently than other people and that these differences can also be seen in their brain activity. We also know that behavioral therapies, such as group-based social skills trainings can help people with ASD improve their behavior. But it is unclear how therapy changes social processing in the brain. The aim of our study was therefore to examine how neural processing of social stimuli changed after behavioral intervention. Comparing a group of children and adolescents that received the group-based social skills training SOSTA-FRA to a control group we found that the neural processing of human motion became faster and involved less brain resources after the intervention, while behavioral performance remained stable. No changes were seen for the processing of emotional facial expressions. We recommend that future studies should also analyze changes in brain function as well as behavioral changes as a secondary therapy outcome parameter. En ligne : http://dx.doi.org/10.1002/aur.2013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 [article] Facilitation of biological motion processing by group-based autism specific social skills training [texte imprimé] / Christina LUCKHARDT, Auteur ; A. KROGER, Auteur ; Leyla ELSUNI, Auteur ; Hannah CHOLEMKERY, Auteur ; Stephan BENDER, Auteur ; Christine M. FREITAG, Auteur . - p.1376-1387. Langues : Anglais (eng) in Autism Research > 11-10 (October 2018) . - p.1376-1387 Mots-clés : autism  biological motion  event-related potentials  facial emotion recognition  intervention  social skills training Index. décimale : PER Périodiques Résumé : Abnormalities in neurophysiological correlates of social perception are a well-known feature of autism spectrum disorder (ASD). However, little is known if and how ASD specific behavioral interventions may affect neural processing in ASD. The aim of the current study was to investigate for the first time, whether the group-based social skills training SOSTA-FRA would elicit changes in neurophysiological correlates of social perception in high-functioning ASD individuals aged 8-17 years. Event-related potentials (ERPs) of a facial emotion recognition (FER) and a biological motion perception task were examined. ERPs were compared between a randomized intervention and a treatment as usual group at three time points (baseline, post-intervention, and at 3 months follow-up). A reduction of P100 amplitude in the right hemisphere and a trend toward reduced N200 latency in the biological motion task were found after the training only in the intervention group, whereas behavioral performance remained stable. Change in N200 latencies and parent-rated social responsiveness showed small but statistically nonsignificant correlations. No changes were observed regarding FER. Results indicate that the intervention changed neural correlates of social perception in ASD. Especially neural correlates of biological motion perception, which is an important prerequisite for successful social interaction, were sensitive to change. ERPs of social perception tasks that are impaired in ASD can well be used to objectively measure neural processing improvement by behavioral intervention. Autism Res 2018, 11: 1376-1387. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: It is well known that people with autism spectrum disorder (ASD) process social information differently than other people and that these differences can also be seen in their brain activity. We also know that behavioral therapies, such as group-based social skills trainings can help people with ASD improve their behavior. But it is unclear how therapy changes social processing in the brain. The aim of our study was therefore to examine how neural processing of social stimuli changed after behavioral intervention. Comparing a group of children and adolescents that received the group-based social skills training SOSTA-FRA to a control group we found that the neural processing of human motion became faster and involved less brain resources after the intervention, while behavioral performance remained stable. No changes were seen for the processing of emotional facial expressions. We recommend that future studies should also analyze changes in brain function as well as behavioral changes as a secondary therapy outcome parameter. En ligne : http://dx.doi.org/10.1002/aur.2013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

Group-based cognitive behavioural psychotherapy for children and adolescents with ASD: the randomized, multicentre, controlled SOSTA – net trial / Christine M. FREITAG in Journal of Child Psychology and Psychiatry, 57-5 (May 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-5 (May 2016) . - p.596-605 Titre : Group-based cognitive behavioural psychotherapy for children and adolescents with ASD: the randomized, multicentre, controlled SOSTA – net trial Type de document : texte imprimé Auteurs : Christine M. FREITAG, Auteur ; Katrin JENSEN, Auteur ; Leyla ELSUNI, Auteur ; Michael SACHSE, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Martin SCHULTE-RUTHER, Auteur ; Susann HÄNIG, Auteur ; Alexander VON GONTARD, Auteur ; Luise POUSTKA, Auteur ; Tanja SCHAD-HANSJOSTEN, Auteur ; Christina WENZL, Auteur ; Judith SINZIG, Auteur ; Regina TAURINES, Auteur ; Julia GEIßLER, Auteur ; Meinhard KIESER, Auteur ; Hannah CHOLEMKERY, Auteur Article en page(s) : p.596-605 Langues : Anglais (eng) Mots-clés : Group therapy  social skills  autism spectrum disorders  randomized-controlled trial Index. décimale : PER Périodiques Résumé : Background Group-based psychotherapy in Autism Spectrum Disorder (ASD) has predominantly been studied in the United States by small studies in school-aged children without long-term follow-up. We report results of a large, confirmatory, multicentre randomized-controlled phase-III trial in children and adolescents studying the ASD specific, manualized group-based cognitive behavioural SOSTA-FRA approach. Methods High-functioning ASD individuals aged 8–19 years old were randomized to 12 sessions SOSTA-FRA or treatment as usual. Primary outcomes were change in total raw score of the parent-rated Social Responsiveness Scale (pSRS) between baseline (T2) and end of intervention (T4), and between T2 and 3 months after end of intervention (T5). Trial registration: ISRCTN94863788. Results Between 20/5/2010 and 14/2/2013, n = 320 ASD patients were screened, n = 228 patients were randomized, and N = 209 analysed. Mean pSRS difference between groups at T4 was −6.5 (95% CI −11.6 to – 1.4; p = .013), and at T5 −6.4 (−11.5 to −1.3, p = .015). Pre-treatment SRS and IQ were positively associated with stronger improvement at T4 and T5. Conclusions Short-term ASD-specific add-on group-based psychotherapy has shown postintervention efficacy with regard to parent-rated social responsiveness predominantly in male high-functioning children and adolescents with ASD. Future studies should implement blinded standardized observational measures of peer-related social interaction. En ligne : http://dx.doi.org/10.1111/jcpp.12509 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 [article] Group-based cognitive behavioural psychotherapy for children and adolescents with ASD: the randomized, multicentre, controlled SOSTA – net trial [texte imprimé] / Christine M. FREITAG, Auteur ; Katrin JENSEN, Auteur ; Leyla ELSUNI, Auteur ; Michael SACHSE, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Martin SCHULTE-RUTHER, Auteur ; Susann HÄNIG, Auteur ; Alexander VON GONTARD, Auteur ; Luise POUSTKA, Auteur ; Tanja SCHAD-HANSJOSTEN, Auteur ; Christina WENZL, Auteur ; Judith SINZIG, Auteur ; Regina TAURINES, Auteur ; Julia GEIßLER, Auteur ; Meinhard KIESER, Auteur ; Hannah CHOLEMKERY, Auteur . - p.596-605. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-5 (May 2016) . - p.596-605 Mots-clés : Group therapy  social skills  autism spectrum disorders  randomized-controlled trial Index. décimale : PER Périodiques Résumé : Background Group-based psychotherapy in Autism Spectrum Disorder (ASD) has predominantly been studied in the United States by small studies in school-aged children without long-term follow-up. We report results of a large, confirmatory, multicentre randomized-controlled phase-III trial in children and adolescents studying the ASD specific, manualized group-based cognitive behavioural SOSTA-FRA approach. Methods High-functioning ASD individuals aged 8–19 years old were randomized to 12 sessions SOSTA-FRA or treatment as usual. Primary outcomes were change in total raw score of the parent-rated Social Responsiveness Scale (pSRS) between baseline (T2) and end of intervention (T4), and between T2 and 3 months after end of intervention (T5). Trial registration: ISRCTN94863788. Results Between 20/5/2010 and 14/2/2013, n = 320 ASD patients were screened, n = 228 patients were randomized, and N = 209 analysed. Mean pSRS difference between groups at T4 was −6.5 (95% CI −11.6 to – 1.4; p = .013), and at T5 −6.4 (−11.5 to −1.3, p = .015). Pre-treatment SRS and IQ were positively associated with stronger improvement at T4 and T5. Conclusions Short-term ASD-specific add-on group-based psychotherapy has shown postintervention efficacy with regard to parent-rated social responsiveness predominantly in male high-functioning children and adolescents with ASD. Future studies should implement blinded standardized observational measures of peer-related social interaction. En ligne : http://dx.doi.org/10.1111/jcpp.12509 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288

Neural Correlates of Explicit Versus Implicit Facial Emotion Processing in ASD / Christina LUCKHARDT in Journal of Autism and Developmental Disorders, 47-7 (July 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-7 (July 2017) . - p.1944-1955 Titre : Neural Correlates of Explicit Versus Implicit Facial Emotion Processing in ASD Type de document : texte imprimé Auteurs : Christina LUCKHARDT, Auteur ; Anne KRÖGER, Auteur ; Hannah CHOLEMKERY, Auteur ; Stephan BENDER, Auteur ; Christine M. FREITAG, Auteur Article en page(s) : p.1944-1955 Langues : Anglais (eng) Mots-clés : ERP  Facial emotion recognition  Intentional processing  Autism  ASD Index. décimale : PER Périodiques Résumé : The underlying neural mechanisms of implicit and explicit facial emotion recognition (FER) were studied in children and adolescents with autism spectrum disorder (ASD) compared to matched typically developing controls (TDC). EEG was obtained from N = 21 ASD and N = 16 TDC. Task performance, visual (P100, N170) and cognitive (late positive potential) event-related-potentials, as well as coherence were compared across groups. TDC showed a task-dependent increase and a stronger lateralization of P100 amplitude during the explicit task and task-dependent modulation of intra-hemispheric coherence in the beta band. In contrast, the ASD group showed no task dependent modulation. Results indicate disruptions in early visual processing and top-down attentional processes as contributing factors to FER deficits in ASD. En ligne : https://doi.org/10.1007/s10803-017-3141-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=313 [article] Neural Correlates of Explicit Versus Implicit Facial Emotion Processing in ASD [texte imprimé] / Christina LUCKHARDT, Auteur ; Anne KRÖGER, Auteur ; Hannah CHOLEMKERY, Auteur ; Stephan BENDER, Auteur ; Christine M. FREITAG, Auteur . - p.1944-1955. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-7 (July 2017) . - p.1944-1955 Mots-clés : ERP  Facial emotion recognition  Intentional processing  Autism  ASD Index. décimale : PER Périodiques Résumé : The underlying neural mechanisms of implicit and explicit facial emotion recognition (FER) were studied in children and adolescents with autism spectrum disorder (ASD) compared to matched typically developing controls (TDC). EEG was obtained from N = 21 ASD and N = 16 TDC. Task performance, visual (P100, N170) and cognitive (late positive potential) event-related-potentials, as well as coherence were compared across groups. TDC showed a task-dependent increase and a stronger lateralization of P100 amplitude during the explicit task and task-dependent modulation of intra-hemispheric coherence in the beta band. In contrast, the ASD group showed no task dependent modulation. Results indicate disruptions in early visual processing and top-down attentional processes as contributing factors to FER deficits in ASD. En ligne : https://doi.org/10.1007/s10803-017-3141-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=313

Pupil dilation during visuospatial orienting differentiates between autism spectrum disorder and attention-deficit/hyperactivity disorder / Sara BOXHOORN in Journal of Child Psychology and Psychiatry, 61-5 (May 2020)  

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Repetitive Behavior in Children and Adolescents: Psychometric Properties of the German Version of the Repetitive Behavior Scale-Revised / Isabella S. KÄSTEL in Journal of Autism and Developmental Disorders, 51-4 (April 2021)  

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Sensitivity and Specificity of the ADOS-2 Algorithm in a Large German Sample / Juliane E. MEDDA in Journal of Autism and Developmental Disorders, 49-2 (February 2019)  

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The Revised Children's Communication Checklist-2 (CCC-R): Factor Structure and Psychometric Evaluation / Sophia A.C. WELLNITZ in Autism Research, 14-4 (April 2021)  

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