Adaptive behavior in autism: Minimal clinically important differences on the Vineland?II / Christopher H. CHATHAM in Autism Research, 11-2 (February 2018)  

Public ISBD [article]  inAutism Research > 11-2 (February 2018) . - p.270-283 Titre : Adaptive behavior in autism: Minimal clinically important differences on the Vineland?II Type de document : Texte imprimé et/ou numérique Auteurs : Christopher H. CHATHAM, Auteur ; K. I. TAYLOR, Auteur ; Tony CHARMAN, Auteur ; X. Liogier D'ARDHUY, Auteur ; E. EULE, Auteur ; A. FEDELE, Auteur ; A. Y. HARDAN, Auteur ; E. LOTH, Auteur ; L. MURTAGH, Auteur ; M. del Valle RUBIDO, Auteur ; Antonia SAN JOSE CACERES, Auteur ; J. SEVIGNY, Auteur ; L. SIKICH, Auteur ; L. SNYDER, Auteur ; J. E. TILLMANN, Auteur ; Pamela VENTOLA, Auteur ; Karen WALTON-BOWEN, Auteur ; P. P. WANG, Auteur ; T. WILLGOSS, Auteur ; Federico BOLOGNANI, Auteur Année de publication : 2018 Article en page(s) : p.270-283 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is associated with persistent impairments in adaptive abilities across multiple domains. These social, personal, and communicative impairments become increasingly pronounced with development, and are present regardless of IQ. The Vineland Adaptive Behavior Scales, Second Edition (Vineland?II) is the most commonly used instrument for quantifying these impairments, but minimal clinically important differences (MCIDs) on Vineland?II scores have not been rigorously established in ASD. We pooled data from several consortia/registries (EU?AIMS LEAP study, ABIDE?I, ABIDE?II, INFOR, Simons Simplex Collection and Autism Treatment Network [ATN]) and clinical investigations and trials (Stanford, Yale, Roche) resulting in a data set of over 9,000 individuals with ASD. Two approaches were used to estimate MCIDs: distribution?based methods and anchor?based methods. Distribution?based MCID [d?MCID] estimates included the standard error of the measurement, as well as one?fifth and one?half of the covariate?adjusted standard deviation (both cross?sectionally and longitudinally). Anchor?based MCID [a?MCID] estimates include the slope of linear regression of clinician ratings of severity on the Vineland?II score, the slope of linear regression of clinician ratings of longitudinal improvement category on Vineland?II change, the Vineland?II change score maximally differentiating clinical impressions of minimal versus no improvement, and equipercentile equating. Across strata, the Vineland?II Adaptive Behavior Composite standardized score MCID estimates range from 2.01 to 3.2 for distribution?based methods, and from 2.42 to 3.75 for sample?size?weighted anchor?based methods. Lower Vineland?II standardized score MCID estimates were observed for younger and more cognitively impaired populations. These MCID estimates enable users of Vineland?II to assess both the statistical and clinical significance of any observed change. Autism Res 2018, 11: 270–283. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary The Vineland Adaptive Behavior Scales (2nd edition; Vineland?II) is the most widely used scale for assessing day?to?day “adaptive” skills. Yet, it is unknown how much Vineland?II scores must change for those changes to be regarded as clinically significant. We pooled data from over 9,000 individuals with ASD to show that changes of 2–3.75 points on the Vineland?II Composite score represent the “minimal clinically?important difference.” These estimates will help evaluate the benefits of potential new treatments for ASD. En ligne : https://doi.org/10.1002/aur.1874 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334 [article] Adaptive behavior in autism: Minimal clinically important differences on the Vineland?II [Texte imprimé et/ou numérique] / Christopher H. CHATHAM, Auteur ; K. I. TAYLOR, Auteur ; Tony CHARMAN, Auteur ; X. Liogier D'ARDHUY, Auteur ; E. EULE, Auteur ; A. FEDELE, Auteur ; A. Y. HARDAN, Auteur ; E. LOTH, Auteur ; L. MURTAGH, Auteur ; M. del Valle RUBIDO, Auteur ; Antonia SAN JOSE CACERES, Auteur ; J. SEVIGNY, Auteur ; L. SIKICH, Auteur ; L. SNYDER, Auteur ; J. E. TILLMANN, Auteur ; Pamela VENTOLA, Auteur ; Karen WALTON-BOWEN, Auteur ; P. P. WANG, Auteur ; T. WILLGOSS, Auteur ; Federico BOLOGNANI, Auteur . - 2018 . - p.270-283. Langues : Anglais (eng) in Autism Research > 11-2 (February 2018) . - p.270-283 Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is associated with persistent impairments in adaptive abilities across multiple domains. These social, personal, and communicative impairments become increasingly pronounced with development, and are present regardless of IQ. The Vineland Adaptive Behavior Scales, Second Edition (Vineland?II) is the most commonly used instrument for quantifying these impairments, but minimal clinically important differences (MCIDs) on Vineland?II scores have not been rigorously established in ASD. We pooled data from several consortia/registries (EU?AIMS LEAP study, ABIDE?I, ABIDE?II, INFOR, Simons Simplex Collection and Autism Treatment Network [ATN]) and clinical investigations and trials (Stanford, Yale, Roche) resulting in a data set of over 9,000 individuals with ASD. Two approaches were used to estimate MCIDs: distribution?based methods and anchor?based methods. Distribution?based MCID [d?MCID] estimates included the standard error of the measurement, as well as one?fifth and one?half of the covariate?adjusted standard deviation (both cross?sectionally and longitudinally). Anchor?based MCID [a?MCID] estimates include the slope of linear regression of clinician ratings of severity on the Vineland?II score, the slope of linear regression of clinician ratings of longitudinal improvement category on Vineland?II change, the Vineland?II change score maximally differentiating clinical impressions of minimal versus no improvement, and equipercentile equating. Across strata, the Vineland?II Adaptive Behavior Composite standardized score MCID estimates range from 2.01 to 3.2 for distribution?based methods, and from 2.42 to 3.75 for sample?size?weighted anchor?based methods. Lower Vineland?II standardized score MCID estimates were observed for younger and more cognitively impaired populations. These MCID estimates enable users of Vineland?II to assess both the statistical and clinical significance of any observed change. Autism Res 2018, 11: 270–283. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary The Vineland Adaptive Behavior Scales (2nd edition; Vineland?II) is the most widely used scale for assessing day?to?day “adaptive” skills. Yet, it is unknown how much Vineland?II scores must change for those changes to be regarded as clinically significant. We pooled data from over 9,000 individuals with ASD to show that changes of 2–3.75 points on the Vineland?II Composite score represent the “minimal clinically?important difference.” These estimates will help evaluate the benefits of potential new treatments for ASD. En ligne : https://doi.org/10.1002/aur.1874 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334

Assessing Theory of Mind Nonverbally in Those With Intellectual Disability and ASD: The Penny Hiding Game / Antonia SAN JOSE CACERES in Autism Research, 7-5 (October 2014)  

Public ISBD [article]  inAutism Research > 7-5 (October 2014) . - p.608-616 Titre : Assessing Theory of Mind Nonverbally in Those With Intellectual Disability and ASD: The Penny Hiding Game Type de document : Texte imprimé et/ou numérique Auteurs : Antonia SAN JOSE CACERES, Auteur ; Noa KEREN, Auteur ; Rhonda BOOTH, Auteur ; Francesca HAPPE, Auteur Article en page(s) : p.608-616 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  intellectual disability  Penny Hiding Game  theory of mind  everyday functioning  adaptive functioning Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) and low intellectual/language abilities are often omitted from experimental studies because of the challenges of testing these individuals. It is vital to develop appropriate and accessible tasks so that this significant part of the spectrum is not neglected. The theory of mind (ToM) has been extensively assessed in ASD, predominantly in relatively high-functioning individuals with reasonable language skills. This study aims to assess the ToM abilities of a sample of 132 participants with intellectual disability (ID) with and without ASD, matched in verbal mental age (VMA) and chronological age, using a naturalistic and nonverbal deception task: the Penny Hiding Game (PHG). The relationship between performance on the PHG and everyday adaptation was also studied. The PHG proved accessible to most participants, suggesting its suitability for use with individuals with low cognitive skills, attentional problems, and limited language. The ASD?+?ID group showed significantly more PHG errors, and fewer tricks, than the ID group. PHG performance correlated with Vineland adaptation scores for both groups. VMA was a major predictor of passing the task in both groups, and participants with ASD?+?ID required, on average, 2 years higher VMA than those with ID only, to achieve the same level of PHG success. VMA moderated the association between PHG performance and real-life social skills for the ASD?+?ID more than the ID group, suggesting that severely impaired individuals with ASD may rely on verbal ability to overcome their social difficulties, whereas individuals with ID alone may use more intuitive social understanding both in the PHG and everyday situations. Autism Res 2014, 7: 608–616. © 2014 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1405 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 [article] Assessing Theory of Mind Nonverbally in Those With Intellectual Disability and ASD: The Penny Hiding Game [Texte imprimé et/ou numérique] / Antonia SAN JOSE CACERES, Auteur ; Noa KEREN, Auteur ; Rhonda BOOTH, Auteur ; Francesca HAPPE, Auteur . - p.608-616. Langues : Anglais (eng) in Autism Research > 7-5 (October 2014) . - p.608-616 Mots-clés : autism spectrum disorder  intellectual disability  Penny Hiding Game  theory of mind  everyday functioning  adaptive functioning Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) and low intellectual/language abilities are often omitted from experimental studies because of the challenges of testing these individuals. It is vital to develop appropriate and accessible tasks so that this significant part of the spectrum is not neglected. The theory of mind (ToM) has been extensively assessed in ASD, predominantly in relatively high-functioning individuals with reasonable language skills. This study aims to assess the ToM abilities of a sample of 132 participants with intellectual disability (ID) with and without ASD, matched in verbal mental age (VMA) and chronological age, using a naturalistic and nonverbal deception task: the Penny Hiding Game (PHG). The relationship between performance on the PHG and everyday adaptation was also studied. The PHG proved accessible to most participants, suggesting its suitability for use with individuals with low cognitive skills, attentional problems, and limited language. The ASD?+?ID group showed significantly more PHG errors, and fewer tricks, than the ID group. PHG performance correlated with Vineland adaptation scores for both groups. VMA was a major predictor of passing the task in both groups, and participants with ASD?+?ID required, on average, 2 years higher VMA than those with ID only, to achieve the same level of PHG success. VMA moderated the association between PHG performance and real-life social skills for the ASD?+?ID more than the ID group, suggesting that severely impaired individuals with ASD may rely on verbal ability to overcome their social difficulties, whereas individuals with ID alone may use more intuitive social understanding both in the PHG and everyday situations. Autism Res 2014, 7: 608–616. © 2014 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1405 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241

Feasibility study of the National Autistic Society EarlyBird parent support programme / M. PALMER in Autism, 24-1 (January 2020)  

Public ISBD [article]  inAutism > 24-1 (January 2020) . - p.147-159 Titre : Feasibility study of the National Autistic Society EarlyBird parent support programme Type de document : Texte imprimé et/ou numérique Auteurs : M. PALMER, Auteur ; Antonia SAN JOSE CACERES, Auteur ; J. TARVER, Auteur ; P. HOWLIN, Auteur ; V. SLONIMS, Auteur ; E. PELLICANO, Auteur ; Tony CHARMAN, Auteur Article en page(s) : p.147-159 Langues : Anglais (eng) Mots-clés : EarlyBird  autism  feasibility  intervention  psychoeducation Index. décimale : PER Périodiques Résumé : The EarlyBird programme is a group-based psychoeducation intervention for parents of young children with autism. Although it is widely used in the United Kingdom, the evidence base for the programme is very limited. Using a mixed method, non-randomised research design, we aimed to test (1) the acceptability of the research procedures (recruitment, retention, suitability of measures), (2) the parental acceptability of EarlyBird (attendance, views of the programme, perceived changes) and (3) the facilitator acceptability of EarlyBird (fidelity, views of the programme, perceived changes). Seventeen families with a 2- to 5-year-old autistic child and 10 EarlyBird facilitators took part. Pre- and post-intervention assessment included measures of the child's autism characteristics, cognitive ability, adaptive behaviour, emotional and behavioural problems and parent-reported autism knowledge, parenting competence, stress and wellbeing. Semi-structured interviews were completed at post-intervention with parents and facilitators. For those involved in the study, the research procedures were generally acceptable, retention rates were high and the research protocol was administered as planned. Generally, positive views of the intervention were expressed by parents and facilitators. Although the uncontrolled, within-participant design does not allow us to test for efficacy, change in several outcome measures from pre- to post-intervention was in the expected direction. Difficulties were encountered with recruitment (opt-in to the groups was ~56% and opt-in to the research was 63%), and strategies to enhance recruitment need to be built into any future trial. These findings should be used to inform protocols for pragmatic, controlled trials of EarlyBird and other group-based interventions for parents with young autistic children. En ligne : http://dx.doi.org/10.1177/1362361319851422 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414 [article] Feasibility study of the National Autistic Society EarlyBird parent support programme [Texte imprimé et/ou numérique] / M. PALMER, Auteur ; Antonia SAN JOSE CACERES, Auteur ; J. TARVER, Auteur ; P. HOWLIN, Auteur ; V. SLONIMS, Auteur ; E. PELLICANO, Auteur ; Tony CHARMAN, Auteur . - p.147-159. Langues : Anglais (eng) in Autism > 24-1 (January 2020) . - p.147-159 Mots-clés : EarlyBird  autism  feasibility  intervention  psychoeducation Index. décimale : PER Périodiques Résumé : The EarlyBird programme is a group-based psychoeducation intervention for parents of young children with autism. Although it is widely used in the United Kingdom, the evidence base for the programme is very limited. Using a mixed method, non-randomised research design, we aimed to test (1) the acceptability of the research procedures (recruitment, retention, suitability of measures), (2) the parental acceptability of EarlyBird (attendance, views of the programme, perceived changes) and (3) the facilitator acceptability of EarlyBird (fidelity, views of the programme, perceived changes). Seventeen families with a 2- to 5-year-old autistic child and 10 EarlyBird facilitators took part. Pre- and post-intervention assessment included measures of the child's autism characteristics, cognitive ability, adaptive behaviour, emotional and behavioural problems and parent-reported autism knowledge, parenting competence, stress and wellbeing. Semi-structured interviews were completed at post-intervention with parents and facilitators. For those involved in the study, the research procedures were generally acceptable, retention rates were high and the research protocol was administered as planned. Generally, positive views of the intervention were expressed by parents and facilitators. Although the uncontrolled, within-participant design does not allow us to test for efficacy, change in several outcome measures from pre- to post-intervention was in the expected direction. Difficulties were encountered with recruitment (opt-in to the groups was ~56% and opt-in to the research was 63%), and strategies to enhance recruitment need to be built into any future trial. These findings should be used to inform protocols for pragmatic, controlled trials of EarlyBird and other group-based interventions for parents with young autistic children. En ligne : http://dx.doi.org/10.1177/1362361319851422 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414

How do core autism traits and associated symptoms relate to quality of life? Findings from the Longitudinal European Autism Project / Bethany OAKLEY in Autism, 25-2 (February 2021)  

Public ISBD [article]  inAutism > 25-2 (February 2021) . - p.389-404 Titre : How do core autism traits and associated symptoms relate to quality of life? Findings from the Longitudinal European Autism Project Type de document : Texte imprimé et/ou numérique Auteurs : Bethany OAKLEY, Auteur ; Julian TILLMANN, Auteur ; Jumana AHMAD, Auteur ; Daisy CRAWLEY, Auteur ; Antonia SAN JOSE CACERES, Auteur ; Rosemary HOLT, Auteur ; Tony CHARMAN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Jan K. BUITELAAR, Auteur ; Emily SIMONOFF, Auteur ; Declan MURPHY, Auteur ; Eva LOTH, Auteur Article en page(s) : p.389-404 Langues : Anglais (eng) Mots-clés : anxiety  autism  depression  quality of life  well-being Index. décimale : PER Périodiques Résumé : Previous studies suggest that some autistic individuals report lower satisfaction, or well-being, with different aspects of everyday life than those without autism. It is unclear whether this might be partly explained by symptoms of anxiety and/or depression, which affect at least 20%-50% of autistic people. In this study, we measured individual differences in well-being in 573 six to thirty-year-olds with and without a diagnosis of autism. We investigated whether individual differences in well-being were explained by autism traits (e.g. social-communication difficulties) and/or anxiety and depression symptoms. We showed that, though well-being was lower for some autistic individuals, compared to those without autism, many autistic individuals reported good well-being. Where well-being was reduced, this was particularly explained by depression symptoms, across all ages. For children/adolescents, anxiety and social-communication difficulties were also related to some aspects of well-being. Our study suggests that support and services for improving mental health, especially depression symptoms, may also improve broader outcomes for autistic people. En ligne : http://dx.doi.org/10.1177/1362361320959959 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442 [article] How do core autism traits and associated symptoms relate to quality of life? Findings from the Longitudinal European Autism Project [Texte imprimé et/ou numérique] / Bethany OAKLEY, Auteur ; Julian TILLMANN, Auteur ; Jumana AHMAD, Auteur ; Daisy CRAWLEY, Auteur ; Antonia SAN JOSE CACERES, Auteur ; Rosemary HOLT, Auteur ; Tony CHARMAN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Jan K. BUITELAAR, Auteur ; Emily SIMONOFF, Auteur ; Declan MURPHY, Auteur ; Eva LOTH, Auteur . - p.389-404. Langues : Anglais (eng) in Autism > 25-2 (February 2021) . - p.389-404 Mots-clés : anxiety  autism  depression  quality of life  well-being Index. décimale : PER Périodiques Résumé : Previous studies suggest that some autistic individuals report lower satisfaction, or well-being, with different aspects of everyday life than those without autism. It is unclear whether this might be partly explained by symptoms of anxiety and/or depression, which affect at least 20%-50% of autistic people. In this study, we measured individual differences in well-being in 573 six to thirty-year-olds with and without a diagnosis of autism. We investigated whether individual differences in well-being were explained by autism traits (e.g. social-communication difficulties) and/or anxiety and depression symptoms. We showed that, though well-being was lower for some autistic individuals, compared to those without autism, many autistic individuals reported good well-being. Where well-being was reduced, this was particularly explained by depression symptoms, across all ages. For children/adolescents, anxiety and social-communication difficulties were also related to some aspects of well-being. Our study suggests that support and services for improving mental health, especially depression symptoms, may also improve broader outcomes for autistic people. En ligne : http://dx.doi.org/10.1177/1362361320959959 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442

Investigating the factors underlying adaptive functioning in autism in the EU-AIMS Longitudinal European Autism Project / J. TILLMANN in Autism Research, 12-4 (April 2019)  

Public ISBD [article]  inAutism Research > 12-4 (April 2019) . - p.645-657 Titre : Investigating the factors underlying adaptive functioning in autism in the EU-AIMS Longitudinal European Autism Project Type de document : Texte imprimé et/ou numérique Auteurs : J. TILLMANN, Auteur ; Antonia SAN JOSE CACERES, Auteur ; Christopher H. CHATHAM, Auteur ; D. CRAWLEY, Auteur ; R. HOLT, Auteur ; B. OAKLEY, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Sven BÖLTE, Auteur ; Jan K. BUITELAAR, Auteur ; S. DURSTON, Auteur ; L. HAM, Auteur ; E. LOTH, Auteur ; E. SIMONOFF, Auteur ; W. SPOOREN, Auteur ; D. G. MURPHY, Auteur ; Tony CHARMAN, Auteur Article en page(s) : p.645-657 Langues : Anglais (eng) Mots-clés : adaptive functioning  autism spectrum disorder  intellectual functioning  psychiatric symptoms  symptom severity Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) exhibit significant impairments in adaptive functioning that impact on their ability to meet the demands of everyday life. A recurrent finding is that there is a pronounced discrepancy between level of cognitive ability and adaptive functioning, and this is particularly prominent among higher-ability individuals. However, the key clinical and demographic associations of these discrepancies remain unclear. This study included a sample of 417 children, adolescents, and adults with ASD as part of the EU-AIMS LEAP cohort. We examined how age, sex, IQ, levels of ASD symptom and autistic trait severity and psychiatric symptomatology are associated with adaptive functioning as measured by the Vineland Adaptive Behavior Scales-Second Edition and IQ-adaptive functioning discrepancies. Older age, lower IQ and higher social-communication symptoms were associated with lower adaptive functioning. Results also demonstrate that older age, higher IQ and higher social-communication symptoms are associated with greater IQ-adaptive functioning discrepancy scores. By contrast, sensory ASD symptoms, repetitive and restricted behaviors, as well as symptoms of attention deficit/hyperactivity disorder (ADHD), anxiety and depression, were not associated with adaptive functioning or IQ-adaptive functioning discrepancy scores. These findings suggest that it is the core social communication problems that define ASD that contribute to adaptive function impairments that people with ASD experience. They show for the first time that sensory symptoms, repetitive behavior and associated psychiatric symptoms do not independently contribute to adaptive function impairments. Individuals with ASD require supportive interventions across the lifespan that take account of social-communicative ASD symptom severity. Autism Res 2019, 12: 645-657. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: This study investigated key clinical and demographic associations of adaptive functioning impairments in individuals with autism. We found that older age, lower IQ and more severe social-communicative symptoms, but not sensory or repetitive symptoms or co-occurring psychiatric symptoms, are associated with lower adaptive functioning and greater ability-adaptive function discrepancies. This suggests that interventions targeting adaptive skills acquisition should be flexible in their timing and intensity across developmental periods, levels of cognitive ability and take account of social-communicative ASD symptom severity. En ligne : https://dx.doi.org/10.1002/aur.2081 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 [article] Investigating the factors underlying adaptive functioning in autism in the EU-AIMS Longitudinal European Autism Project [Texte imprimé et/ou numérique] / J. TILLMANN, Auteur ; Antonia SAN JOSE CACERES, Auteur ; Christopher H. CHATHAM, Auteur ; D. CRAWLEY, Auteur ; R. HOLT, Auteur ; B. OAKLEY, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Sven BÖLTE, Auteur ; Jan K. BUITELAAR, Auteur ; S. DURSTON, Auteur ; L. HAM, Auteur ; E. LOTH, Auteur ; E. SIMONOFF, Auteur ; W. SPOOREN, Auteur ; D. G. MURPHY, Auteur ; Tony CHARMAN, Auteur . - p.645-657. Langues : Anglais (eng) in Autism Research > 12-4 (April 2019) . - p.645-657 Mots-clés : adaptive functioning  autism spectrum disorder  intellectual functioning  psychiatric symptoms  symptom severity Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) exhibit significant impairments in adaptive functioning that impact on their ability to meet the demands of everyday life. A recurrent finding is that there is a pronounced discrepancy between level of cognitive ability and adaptive functioning, and this is particularly prominent among higher-ability individuals. However, the key clinical and demographic associations of these discrepancies remain unclear. This study included a sample of 417 children, adolescents, and adults with ASD as part of the EU-AIMS LEAP cohort. We examined how age, sex, IQ, levels of ASD symptom and autistic trait severity and psychiatric symptomatology are associated with adaptive functioning as measured by the Vineland Adaptive Behavior Scales-Second Edition and IQ-adaptive functioning discrepancies. Older age, lower IQ and higher social-communication symptoms were associated with lower adaptive functioning. Results also demonstrate that older age, higher IQ and higher social-communication symptoms are associated with greater IQ-adaptive functioning discrepancy scores. By contrast, sensory ASD symptoms, repetitive and restricted behaviors, as well as symptoms of attention deficit/hyperactivity disorder (ADHD), anxiety and depression, were not associated with adaptive functioning or IQ-adaptive functioning discrepancy scores. These findings suggest that it is the core social communication problems that define ASD that contribute to adaptive function impairments that people with ASD experience. They show for the first time that sensory symptoms, repetitive behavior and associated psychiatric symptoms do not independently contribute to adaptive function impairments. Individuals with ASD require supportive interventions across the lifespan that take account of social-communicative ASD symptom severity. Autism Res 2019, 12: 645-657. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: This study investigated key clinical and demographic associations of adaptive functioning impairments in individuals with autism. We found that older age, lower IQ and more severe social-communicative symptoms, but not sensory or repetitive symptoms or co-occurring psychiatric symptoms, are associated with lower adaptive functioning and greater ability-adaptive function discrepancies. This suggests that interventions targeting adaptive skills acquisition should be flexible in their timing and intensity across developmental periods, levels of cognitive ability and take account of social-communicative ASD symptom severity. En ligne : https://dx.doi.org/10.1002/aur.2081 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389

Mapping the link between socio-economic factors, autistic traits and mental health across different settings / Teresa DEL BIANCO in Autism, 28-5 (May 2024)  

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Pharmacological and dietary-supplement treatments for autism spectrum disorder: a systematic review and network meta-analysis / Spyridon SIAFIS in Molecular Autism, 13 (2022)  

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Social brain activation during mentalizing in a large autism cohort: the Longitudinal European Autism Project / Carolin MOESSNANG in Molecular Autism, 11 (2020)  

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The EU-AIMS Longitudinal European Autism Project (LEAP): clinical characterisation / Tony CHARMAN in Molecular Autism, 8 (2017)  

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The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders / E. LOTH in Molecular Autism, 8 (2017)  

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