Improving emotional face perception in autism with diuretic bumetanide: A proof-of-concept behavioral and functional brain imaging pilot study / Nouchine HADJIKHANI in Autism, 19-2 (February 2015)  

Public ISBD [article]  inAutism > 19-2 (February 2015) . - p.149-157 Titre : Improving emotional face perception in autism with diuretic bumetanide: A proof-of-concept behavioral and functional brain imaging pilot study Type de document : Texte imprimé et/ou numérique Auteurs : Nouchine HADJIKHANI, Auteur ; Nicole R. ZÜRCHER, Auteur ; Ophelie ROGIER, Auteur ; Torsten RUEST, Auteur ; Loyse HIPPOLYTE, Auteur ; Yehezkel BEN-ARI, Auteur ; Eric LEMONNIER, Auteur Article en page(s) : p.149-157 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  bumetanide  emotion  face perception  fMRI  GABA  treatment Index. décimale : PER Périodiques Résumé : Clinical observations have shown that GABA-acting benzodiazepines exert paradoxical excitatory effects in autism, suggesting elevated intracellular chloride (Cl–)i and excitatory action of GABA. In a previous double-blind randomized study, we have shown that the diuretic NKCC1 chloride importer antagonist bumetanide, that decreases (Cl–)i and reinforces GABAergic inhibition, reduces the severity of autism symptoms. Here, we report results from an open-label trial pilot study in which we used functional magnetic resonance imaging and neuropsychological testing to determine the effects of 10 months bumetanide treatment in adolescents and young adults with autism. We show that bumetanide treatment improves emotion recognition and enhances the activation of brain regions involved in social and emotional perception during the perception of emotional faces. The improvement of emotion processing by bumetanide reinforces the usefulness of bumetanide as a promising treatment to improve social interactions in autism. En ligne : http://dx.doi.org/10.1177/1362361313514141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Improving emotional face perception in autism with diuretic bumetanide: A proof-of-concept behavioral and functional brain imaging pilot study [Texte imprimé et/ou numérique] / Nouchine HADJIKHANI, Auteur ; Nicole R. ZÜRCHER, Auteur ; Ophelie ROGIER, Auteur ; Torsten RUEST, Auteur ; Loyse HIPPOLYTE, Auteur ; Yehezkel BEN-ARI, Auteur ; Eric LEMONNIER, Auteur . - p.149-157. Langues : Anglais (eng) in Autism > 19-2 (February 2015) . - p.149-157 Mots-clés : Autism spectrum disorders  bumetanide  emotion  face perception  fMRI  GABA  treatment Index. décimale : PER Périodiques Résumé : Clinical observations have shown that GABA-acting benzodiazepines exert paradoxical excitatory effects in autism, suggesting elevated intracellular chloride (Cl–)i and excitatory action of GABA. In a previous double-blind randomized study, we have shown that the diuretic NKCC1 chloride importer antagonist bumetanide, that decreases (Cl–)i and reinforces GABAergic inhibition, reduces the severity of autism symptoms. Here, we report results from an open-label trial pilot study in which we used functional magnetic resonance imaging and neuropsychological testing to determine the effects of 10 months bumetanide treatment in adolescents and young adults with autism. We show that bumetanide treatment improves emotion recognition and enhances the activation of brain regions involved in social and emotional perception during the perception of emotional faces. The improvement of emotion processing by bumetanide reinforces the usefulness of bumetanide as a promising treatment to improve social interactions in autism. En ligne : http://dx.doi.org/10.1177/1362361313514141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

---

1 (1 - 1 / 1)