Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes / Li CHEN in Development and Psychopathology, 27-1 (February 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-1 (February 2015) . - p.137-150 Titre : Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes Type de document : texte imprimé Auteurs : Li CHEN, Auteur ; Hong PAN, Auteur ; Ta Anh TUAN, Auteur ; Ai Ling TEH, Auteur ; Julia L. MACISAAC, Auteur ; Sarah M. MAH, Auteur ; Lisa M. MCEWEN, Auteur ; Yue LI, Auteur ; Helen CHEN, Auteur ; Birit F.P. BROEKMAN, Auteur ; Jan Paul BUSCHDORF, Auteur ; Yap Seng CHONG, Auteur ; Kenneth KWEK, Auteur ; Seang Mei SAW, Auteur ; Peter D. GLUCKMAN, Auteur ; Marielle V. FORTIER, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Michael S. KOBOR, Auteur ; Anqi QIU, Auteur ; Michael J. MEANEY, Auteur ; Joanna D. HOLBROOK, Auteur Article en page(s) : p.137-150 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early life environments interact with genotype to determine stable phenotypic outcomes. Here we examined the influence of a variant in the brain-derived neurotropic factor (BDNF) gene (Val66Met), which underlies synaptic plasticity throughout the central nervous system, on the degree to which antenatal maternal anxiety associated with neonatal DNA methylation. We also examined the association between neonatal DNA methylation and brain substructure volume, as a function of BDNF genotype. Infant, but not maternal, BDNF genotype dramatically influences the association of antenatal anxiety on the epigenome at birth as well as that between the epigenome and neonatal brain structure. There was a greater impact of antenatal maternal anxiety on the DNA methylation of infants with the methionine (Met)/Met compared to both Met/valine (Val) and Val/Val genotypes. There were significantly more cytosine–phosphate–guanine sites where methylation levels covaried with right amygdala volume among Met/Met compared with both Met/Val and Val/Val carriers. In contrast, more cytosine–phosphate–guanine sites covaried with left hippocampus volume in Val/Val infants compared with infants of the Met/Val or Met/Met genotype. Thus, antenatal Maternal Anxiety × BDNF Val66Met Polymorphism interactions at the level of the epigenome are reflected differently in the structure of the amygdala and the hippocampus. These findings suggest that BDNF genotype regulates the sensitivity of the methylome to early environment and that differential susceptibility to specific environmental conditions may be both tissue and function specific. En ligne : http://dx.doi.org/10.1017/S0954579414001357 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes [texte imprimé] / Li CHEN, Auteur ; Hong PAN, Auteur ; Ta Anh TUAN, Auteur ; Ai Ling TEH, Auteur ; Julia L. MACISAAC, Auteur ; Sarah M. MAH, Auteur ; Lisa M. MCEWEN, Auteur ; Yue LI, Auteur ; Helen CHEN, Auteur ; Birit F.P. BROEKMAN, Auteur ; Jan Paul BUSCHDORF, Auteur ; Yap Seng CHONG, Auteur ; Kenneth KWEK, Auteur ; Seang Mei SAW, Auteur ; Peter D. GLUCKMAN, Auteur ; Marielle V. FORTIER, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Michael S. KOBOR, Auteur ; Anqi QIU, Auteur ; Michael J. MEANEY, Auteur ; Joanna D. HOLBROOK, Auteur . - p.137-150. Langues : Anglais (eng) in Development and Psychopathology > 27-1 (February 2015) . - p.137-150 Index. décimale : PER Périodiques Résumé : Early life environments interact with genotype to determine stable phenotypic outcomes. Here we examined the influence of a variant in the brain-derived neurotropic factor (BDNF) gene (Val66Met), which underlies synaptic plasticity throughout the central nervous system, on the degree to which antenatal maternal anxiety associated with neonatal DNA methylation. We also examined the association between neonatal DNA methylation and brain substructure volume, as a function of BDNF genotype. Infant, but not maternal, BDNF genotype dramatically influences the association of antenatal anxiety on the epigenome at birth as well as that between the epigenome and neonatal brain structure. There was a greater impact of antenatal maternal anxiety on the DNA methylation of infants with the methionine (Met)/Met compared to both Met/valine (Val) and Val/Val genotypes. There were significantly more cytosine–phosphate–guanine sites where methylation levels covaried with right amygdala volume among Met/Met compared with both Met/Val and Val/Val carriers. In contrast, more cytosine–phosphate–guanine sites covaried with left hippocampus volume in Val/Val infants compared with infants of the Met/Val or Met/Met genotype. Thus, antenatal Maternal Anxiety × BDNF Val66Met Polymorphism interactions at the level of the epigenome are reflected differently in the structure of the amygdala and the hippocampus. These findings suggest that BDNF genotype regulates the sensitivity of the methylome to early environment and that differential susceptibility to specific environmental conditions may be both tissue and function specific. En ligne : http://dx.doi.org/10.1017/S0954579414001357 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

Child, Maternal and Demographic Factors Influencing Caregiver-Reported Autistic Trait Symptomatology in Toddlers / D.A. GOH in Journal of Autism and Developmental Disorders, 48-4 (April 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-4 (April 2018) . - p.1325-1337 Titre : Child, Maternal and Demographic Factors Influencing Caregiver-Reported Autistic Trait Symptomatology in Toddlers Type de document : texte imprimé Auteurs : D.A. GOH, Auteur ; D. GAN, Auteur ; J. KUNG, Auteur ; Simon BARON-COHEN, Auteur ; Carrie ALLISON, Auteur ; Haijia CHEN, Auteur ; Seang Mei SAW, Auteur ; Yap Seng CHONG, Auteur ; V.S. RAJADURAI, Auteur ; K.H. TAN, Auteur ; P.C.L. SHEK, Auteur ; F. YAP, Auteur ; Birit F.P. BROEKMAN, Auteur ; Iliana MAGIATI, Auteur Article en page(s) : p.1325-1337 Langues : Anglais (eng) Mots-clés : Autistic traits  Child  Demographic  Informant  Measurement  Predictors. Index. décimale : PER Périodiques Résumé : Current research on children's autistic traits in the general population relies predominantly on caregiver-report, yet the extent to which individual, caregiver or demographic characteristics are associated with informants' ratings has not been sufficiently explored. In this study, caregivers of 396 Singaporean two-year-olds from a birth cohort study completed the Quantitative Checklist for Autism in Toddlers. Children's gender, cognitive functioning and birth order, maternal age, and ethnic group membership were not significant predictors of caregiver-reported autistic traits. Poorer child language development and higher maternal depressive symptoms significantly predicted more social-communicative autistic traits, while lower maternal education predicted more behavioural autistic traits. Children's language and informants' educational level and depressive symptomatology may need to be considered in caregiver-reports of autistic traits. En ligne : http://dx.doi.org/10.1007/s10803-018-3471-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352 [article] Child, Maternal and Demographic Factors Influencing Caregiver-Reported Autistic Trait Symptomatology in Toddlers [texte imprimé] / D.A. GOH, Auteur ; D. GAN, Auteur ; J. KUNG, Auteur ; Simon BARON-COHEN, Auteur ; Carrie ALLISON, Auteur ; Haijia CHEN, Auteur ; Seang Mei SAW, Auteur ; Yap Seng CHONG, Auteur ; V.S. RAJADURAI, Auteur ; K.H. TAN, Auteur ; P.C.L. SHEK, Auteur ; F. YAP, Auteur ; Birit F.P. BROEKMAN, Auteur ; Iliana MAGIATI, Auteur . - p.1325-1337. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-4 (April 2018) . - p.1325-1337 Mots-clés : Autistic traits  Child  Demographic  Informant  Measurement  Predictors. Index. décimale : PER Périodiques Résumé : Current research on children's autistic traits in the general population relies predominantly on caregiver-report, yet the extent to which individual, caregiver or demographic characteristics are associated with informants' ratings has not been sufficiently explored. In this study, caregivers of 396 Singaporean two-year-olds from a birth cohort study completed the Quantitative Checklist for Autism in Toddlers. Children's gender, cognitive functioning and birth order, maternal age, and ethnic group membership were not significant predictors of caregiver-reported autistic traits. Poorer child language development and higher maternal depressive symptoms significantly predicted more social-communicative autistic traits, while lower maternal education predicted more behavioural autistic traits. Children's language and informants' educational level and depressive symptomatology may need to be considered in caregiver-reports of autistic traits. En ligne : http://dx.doi.org/10.1007/s10803-018-3471-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352

Early language ability and depressive symptoms in preadolescence: Sex-specific mediating effects of self-concept domains / Sharon TING in Development and Psychopathology, 38-3 (August 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-3 (August 2026) . - p.1468-1483 Titre : Early language ability and depressive symptoms in preadolescence: Sex-specific mediating effects of self-concept domains Type de document : texte imprimé Auteurs : Sharon TING, Auteur ; Germaine Y. Q. TNG, Auteur ; Pei HUANG, Auteur ; Jordan LEGASPI, Auteur ; Helen CHEN, Auteur ; Johan Gunnar ERIKSSON, Auteur ; Yap Seng CHONG, Auteur ; Henning TIEMEIER, Auteur ; Peipei SETOH, Auteur Article en page(s) : p.1468-1483 Langues : Anglais (eng) Mots-clés : depressive symptoms  language ability  longitudinal research  mediation  self-concept Index. décimale : PER Périodiques Résumé : Poorer language ability is a known risk factor for elevated depressive symptoms. However, the cognitive mechanisms underlying this association remain underexplored. Utilizing data from a comprehensive pre-birth cohort in Singapore (N = 473; 49.9% boys; 57.3% Chinese, 27.9% Malay, 14.8% Indian), the present study examined whether (i) self-concept domains mediate the association between early language ability and depressive symptoms during preadolescence, and (ii) these indirect pathways differ by child sex. Children’s early language ability was assessed at ages 2 and 4 using standardized assessments of vocabulary and phonological processing. Self-concept and depressive symptoms were measured at ages 8.5 and 10, respectively. Results indicated that the domain of behavioral adjustment mediated the relationship between early language ability and subsequent depressive symptoms for girls (β = −0.07, 95% CI [−0.15, −0.01]), whereas happiness and satisfaction served as a key mediator for boys (β = −0.12, 95% CI [−0.24, −0.03]). After accounting for these mediators, there was no direct association between early language ability and depressive symptoms. These findings highlight potential sex-specific mechanisms through which early language ability is prospectively associated with depressive symptoms. Future research is necessary to determine whether enhancing self-concept can mitigate depressive symptoms in children with early language difficulties. En ligne : https://dx.doi.org/10.1017/S0954579426101308 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590 [article] Early language ability and depressive symptoms in preadolescence: Sex-specific mediating effects of self-concept domains [texte imprimé] / Sharon TING, Auteur ; Germaine Y. Q. TNG, Auteur ; Pei HUANG, Auteur ; Jordan LEGASPI, Auteur ; Helen CHEN, Auteur ; Johan Gunnar ERIKSSON, Auteur ; Yap Seng CHONG, Auteur ; Henning TIEMEIER, Auteur ; Peipei SETOH, Auteur . - p.1468-1483. Langues : Anglais (eng) in Development and Psychopathology > 38-3 (August 2026) . - p.1468-1483 Mots-clés : depressive symptoms  language ability  longitudinal research  mediation  self-concept Index. décimale : PER Périodiques Résumé : Poorer language ability is a known risk factor for elevated depressive symptoms. However, the cognitive mechanisms underlying this association remain underexplored. Utilizing data from a comprehensive pre-birth cohort in Singapore (N = 473; 49.9% boys; 57.3% Chinese, 27.9% Malay, 14.8% Indian), the present study examined whether (i) self-concept domains mediate the association between early language ability and depressive symptoms during preadolescence, and (ii) these indirect pathways differ by child sex. Children’s early language ability was assessed at ages 2 and 4 using standardized assessments of vocabulary and phonological processing. Self-concept and depressive symptoms were measured at ages 8.5 and 10, respectively. Results indicated that the domain of behavioral adjustment mediated the relationship between early language ability and subsequent depressive symptoms for girls (β = −0.07, 95% CI [−0.15, −0.01]), whereas happiness and satisfaction served as a key mediator for boys (β = −0.12, 95% CI [−0.24, −0.03]). After accounting for these mediators, there was no direct association between early language ability and depressive symptoms. These findings highlight potential sex-specific mechanisms through which early language ability is prospectively associated with depressive symptoms. Future research is necessary to determine whether enhancing self-concept can mitigate depressive symptoms in children with early language difficulties. En ligne : https://dx.doi.org/10.1017/S0954579426101308 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590

Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways / Jessica P. UY in Journal of Child Psychology and Psychiatry, 64-3 (March 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.426-436 Titre : Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways Type de document : texte imprimé Auteurs : Jessica P. UY, Auteur ; Ai Peng TAN, Auteur ; Birit F.P. BROEKMAN, Auteur ; Peter D. GLUCKMAN, Auteur ; Yap Seng CHONG, Auteur ; Helen CHEN, Auteur ; Marielle V. FORTIER, Auteur ; Michael J. MEANEY, Auteur ; Bridget L. CALLAGHAN, Auteur Article en page(s) : p.426-436 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Experiences of early life adversity pose significant psychological and physical health risks to exposed individuals. Emerging evidence suggests that these health risks can be transmitted across generations; however, the mechanisms underlying the intergenerational impacts of maternal early-life trauma on child health remain unknown. Methods The current study used a prospective longitudinal design to determine the unique and joint contributions of maternal childhood trauma (neglect and abuse) and maternal prenatal and postnatal mental health (anxiety and depressive symptoms) (N = 541) to children's resting frontoamygdala functional connectivity at 6 years (N = 89) and emotional health at 7-8 years, as indexed by parent-reported internalizing problems and child self-reported anxiety and depressive symptoms (N = 268-418). Results Greater maternal childhood neglect was indirectly associated with greater internalizing problems serially through a pathway of worse maternal prenatal and postnatal mental health (greater maternal anxiety and depressive symptoms). Worse maternal postnatal mental health was also uniquely associated with more negative child frontoamygdala resting-state functional connectivity, over and above maternal childhood trauma (both neglect and abuse) and prenatal mental health. More negative frontoamygdala functional connectivity was, in turn, associated with poorer child emotional health outcomes. Conclusions Findings from the current study provide support for the existence of intergenerational influences of parental exposure to childhood trauma on childhood risk for psychopathology in the next generation and point to the importance of maternal factors proximal to the second generation (maternal prenatal and postnatal mental health) in determining the intergenerational impact of maternal early experiences. En ligne : https://doi.org/10.1111/jcpp.13721 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 [article] Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways [texte imprimé] / Jessica P. UY, Auteur ; Ai Peng TAN, Auteur ; Birit F.P. BROEKMAN, Auteur ; Peter D. GLUCKMAN, Auteur ; Yap Seng CHONG, Auteur ; Helen CHEN, Auteur ; Marielle V. FORTIER, Auteur ; Michael J. MEANEY, Auteur ; Bridget L. CALLAGHAN, Auteur . - p.426-436. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.426-436 Index. décimale : PER Périodiques Résumé : Background Experiences of early life adversity pose significant psychological and physical health risks to exposed individuals. Emerging evidence suggests that these health risks can be transmitted across generations; however, the mechanisms underlying the intergenerational impacts of maternal early-life trauma on child health remain unknown. Methods The current study used a prospective longitudinal design to determine the unique and joint contributions of maternal childhood trauma (neglect and abuse) and maternal prenatal and postnatal mental health (anxiety and depressive symptoms) (N = 541) to children's resting frontoamygdala functional connectivity at 6 years (N = 89) and emotional health at 7-8 years, as indexed by parent-reported internalizing problems and child self-reported anxiety and depressive symptoms (N = 268-418). Results Greater maternal childhood neglect was indirectly associated with greater internalizing problems serially through a pathway of worse maternal prenatal and postnatal mental health (greater maternal anxiety and depressive symptoms). Worse maternal postnatal mental health was also uniquely associated with more negative child frontoamygdala resting-state functional connectivity, over and above maternal childhood trauma (both neglect and abuse) and prenatal mental health. More negative frontoamygdala functional connectivity was, in turn, associated with poorer child emotional health outcomes. Conclusions Findings from the current study provide support for the existence of intergenerational influences of parental exposure to childhood trauma on childhood risk for psychopathology in the next generation and point to the importance of maternal factors proximal to the second generation (maternal prenatal and postnatal mental health) in determining the intergenerational impact of maternal early experiences. En ligne : https://doi.org/10.1111/jcpp.13721 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493

Maternal mood entropy and children’s hippocampal development: Enduring versus transient effects / Katherine E. JENNINGS in Development and Psychopathology, 38-3 (August 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-3 (August 2026) . - p.1454-1467 Titre : Maternal mood entropy and children’s hippocampal development: Enduring versus transient effects Type de document : texte imprimé Auteurs : Katherine E. JENNINGS, Auteur ; Daniela G. JUAREZ, Auteur ; Jessica P. UY, Auteur ; Jessica L. BUTHMANN, Auteur ; Yap Seng CHONG, Auteur ; Peter D. GLUCKMAN, Auteur ; Johan G. ERIKSSON, Auteur ; Marielle V. FORTIER, Auteur ; Helen CHEN, Auteur ; Michael J. MEANEY, Auteur ; Ai Peng TAN, Auteur ; Ian H. GOTLIB, Auteur ; Jonas G. MILLER, Auteur Article en page(s) : p.1454-1467 Langues : Anglais (eng) Mots-clés : biological embedding  enduring effects  hippocampus  maternal mood  revisionist effects Index. décimale : PER Périodiques Résumé : Recent research suggests that maternal mood entropy, a novel measure of mood dysfunction, is associated with child outcomes. However, the link between maternal mood entropy and children’s structural brain development, and how this association may change across childhood, remains unclear. In a longitudinal study with neuroimaging data collected at ages 4.5, 6, 7.5, and 10.5 years (n = 1,498; n = 674 with neuroimaging), we examined whether maternal mood entropy is associated with children’s hippocampal and amygdala volumes over time. Mothers reported on negative mood symptoms at several assessments between ages 3 months and 4.5 years. We calculated maternal mood levels as the sum of mood symptoms and computed maternal mood entropy by applying Shannon’s entropy to the distributions of mood questionnaire responses. Maternal mood measures were not associated with amygdala volumes; however, mood entropy was directly associated with smaller hippocampal volumes at age 4.5 years and indirectly associated with smaller hippocampal volumes at 10.5 years through rank-order stability over time. These effects were present beyond the effects of socioeconomic status and intracranial volume and were specific to mood entropy, not mood levels. Our findings indicate that patterns of maternal mood are embedded in early childhood brain structure, setting the stage for subsequent neurodevelopment. En ligne : https://dx.doi.org/10.1017/S0954579426101291 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590 [article] Maternal mood entropy and children’s hippocampal development: Enduring versus transient effects [texte imprimé] / Katherine E. JENNINGS, Auteur ; Daniela G. JUAREZ, Auteur ; Jessica P. UY, Auteur ; Jessica L. BUTHMANN, Auteur ; Yap Seng CHONG, Auteur ; Peter D. GLUCKMAN, Auteur ; Johan G. ERIKSSON, Auteur ; Marielle V. FORTIER, Auteur ; Helen CHEN, Auteur ; Michael J. MEANEY, Auteur ; Ai Peng TAN, Auteur ; Ian H. GOTLIB, Auteur ; Jonas G. MILLER, Auteur . - p.1454-1467. Langues : Anglais (eng) in Development and Psychopathology > 38-3 (August 2026) . - p.1454-1467 Mots-clés : biological embedding  enduring effects  hippocampus  maternal mood  revisionist effects Index. décimale : PER Périodiques Résumé : Recent research suggests that maternal mood entropy, a novel measure of mood dysfunction, is associated with child outcomes. However, the link between maternal mood entropy and children’s structural brain development, and how this association may change across childhood, remains unclear. In a longitudinal study with neuroimaging data collected at ages 4.5, 6, 7.5, and 10.5 years (n = 1,498; n = 674 with neuroimaging), we examined whether maternal mood entropy is associated with children’s hippocampal and amygdala volumes over time. Mothers reported on negative mood symptoms at several assessments between ages 3 months and 4.5 years. We calculated maternal mood levels as the sum of mood symptoms and computed maternal mood entropy by applying Shannon’s entropy to the distributions of mood questionnaire responses. Maternal mood measures were not associated with amygdala volumes; however, mood entropy was directly associated with smaller hippocampal volumes at age 4.5 years and indirectly associated with smaller hippocampal volumes at 10.5 years through rank-order stability over time. These effects were present beyond the effects of socioeconomic status and intracranial volume and were specific to mood entropy, not mood levels. Our findings indicate that patterns of maternal mood are embedded in early childhood brain structure, setting the stage for subsequent neurodevelopment. En ligne : https://dx.doi.org/10.1017/S0954579426101291 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590

Nucleus accumbens volume mediates the association between prenatal adversity and attention problems in youth / Chase ANTONACCI in Development and Psychopathology, 38-1 (February 2026)  

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Positive maternal mental health during pregnancy associated with specific forms of adaptive development in early childhood: Evidence from a longitudinal study / Desiree Y. PHUA in Development and Psychopathology, 29-5 (December 2017)  

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Positive maternal mental health during pregnancy associated with specific forms of adaptive development in early childhood: Evidence from a longitudinal study—CORRIGENDUM / Desiree Y. PHUA in Development and Psychopathology, 30-4 (October 2018)  

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Preschoolers' emotion reactivity and regulation: Links with maternal psychological distress and child behavior problems / Stella TSOTSI in Development and Psychopathology, 35-3 (August 2023)  

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The psychometric properties of the Quantitative-Checklist for Autism in Toddlers (Q-CHAT) as a measure of autistic traits in a community sample of Singaporean infants and toddlers / Iliana MAGIATI in Molecular Autism, (June 2015)  

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