Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes / Li CHEN in Development and Psychopathology, 27-1 (February 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-1 (February 2015) . - p.137-150 Titre : Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes Type de document : texte imprimé Auteurs : Li CHEN, Auteur ; Hong PAN, Auteur ; Ta Anh TUAN, Auteur ; Ai Ling TEH, Auteur ; Julia L. MACISAAC, Auteur ; Sarah M. MAH, Auteur ; Lisa M. MCEWEN, Auteur ; Yue LI, Auteur ; Helen CHEN, Auteur ; Birit F.P. BROEKMAN, Auteur ; Jan Paul BUSCHDORF, Auteur ; Yap Seng CHONG, Auteur ; Kenneth KWEK, Auteur ; Seang Mei SAW, Auteur ; Peter D. GLUCKMAN, Auteur ; Marielle V. FORTIER, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Michael S. KOBOR, Auteur ; Anqi QIU, Auteur ; Michael J. MEANEY, Auteur ; Joanna D. HOLBROOK, Auteur Article en page(s) : p.137-150 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early life environments interact with genotype to determine stable phenotypic outcomes. Here we examined the influence of a variant in the brain-derived neurotropic factor (BDNF) gene (Val66Met), which underlies synaptic plasticity throughout the central nervous system, on the degree to which antenatal maternal anxiety associated with neonatal DNA methylation. We also examined the association between neonatal DNA methylation and brain substructure volume, as a function of BDNF genotype. Infant, but not maternal, BDNF genotype dramatically influences the association of antenatal anxiety on the epigenome at birth as well as that between the epigenome and neonatal brain structure. There was a greater impact of antenatal maternal anxiety on the DNA methylation of infants with the methionine (Met)/Met compared to both Met/valine (Val) and Val/Val genotypes. There were significantly more cytosine–phosphate–guanine sites where methylation levels covaried with right amygdala volume among Met/Met compared with both Met/Val and Val/Val carriers. In contrast, more cytosine–phosphate–guanine sites covaried with left hippocampus volume in Val/Val infants compared with infants of the Met/Val or Met/Met genotype. Thus, antenatal Maternal Anxiety × BDNF Val66Met Polymorphism interactions at the level of the epigenome are reflected differently in the structure of the amygdala and the hippocampus. These findings suggest that BDNF genotype regulates the sensitivity of the methylome to early environment and that differential susceptibility to specific environmental conditions may be both tissue and function specific. En ligne : http://dx.doi.org/10.1017/S0954579414001357 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes [texte imprimé] / Li CHEN, Auteur ; Hong PAN, Auteur ; Ta Anh TUAN, Auteur ; Ai Ling TEH, Auteur ; Julia L. MACISAAC, Auteur ; Sarah M. MAH, Auteur ; Lisa M. MCEWEN, Auteur ; Yue LI, Auteur ; Helen CHEN, Auteur ; Birit F.P. BROEKMAN, Auteur ; Jan Paul BUSCHDORF, Auteur ; Yap Seng CHONG, Auteur ; Kenneth KWEK, Auteur ; Seang Mei SAW, Auteur ; Peter D. GLUCKMAN, Auteur ; Marielle V. FORTIER, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Michael S. KOBOR, Auteur ; Anqi QIU, Auteur ; Michael J. MEANEY, Auteur ; Joanna D. HOLBROOK, Auteur . - p.137-150. Langues : Anglais (eng) in Development and Psychopathology > 27-1 (February 2015) . - p.137-150 Index. décimale : PER Périodiques Résumé : Early life environments interact with genotype to determine stable phenotypic outcomes. Here we examined the influence of a variant in the brain-derived neurotropic factor (BDNF) gene (Val66Met), which underlies synaptic plasticity throughout the central nervous system, on the degree to which antenatal maternal anxiety associated with neonatal DNA methylation. We also examined the association between neonatal DNA methylation and brain substructure volume, as a function of BDNF genotype. Infant, but not maternal, BDNF genotype dramatically influences the association of antenatal anxiety on the epigenome at birth as well as that between the epigenome and neonatal brain structure. There was a greater impact of antenatal maternal anxiety on the DNA methylation of infants with the methionine (Met)/Met compared to both Met/valine (Val) and Val/Val genotypes. There were significantly more cytosine–phosphate–guanine sites where methylation levels covaried with right amygdala volume among Met/Met compared with both Met/Val and Val/Val carriers. In contrast, more cytosine–phosphate–guanine sites covaried with left hippocampus volume in Val/Val infants compared with infants of the Met/Val or Met/Met genotype. Thus, antenatal Maternal Anxiety × BDNF Val66Met Polymorphism interactions at the level of the epigenome are reflected differently in the structure of the amygdala and the hippocampus. These findings suggest that BDNF genotype regulates the sensitivity of the methylome to early environment and that differential susceptibility to specific environmental conditions may be both tissue and function specific. En ligne : http://dx.doi.org/10.1017/S0954579414001357 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

Child, Maternal and Demographic Factors Influencing Caregiver-Reported Autistic Trait Symptomatology in Toddlers / D.A. GOH in Journal of Autism and Developmental Disorders, 48-4 (April 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-4 (April 2018) . - p.1325-1337 Titre : Child, Maternal and Demographic Factors Influencing Caregiver-Reported Autistic Trait Symptomatology in Toddlers Type de document : texte imprimé Auteurs : D.A. GOH, Auteur ; D. GAN, Auteur ; J. KUNG, Auteur ; Simon BARON-COHEN, Auteur ; Carrie ALLISON, Auteur ; Haijia CHEN, Auteur ; Seang Mei SAW, Auteur ; Yap Seng CHONG, Auteur ; V.S. RAJADURAI, Auteur ; K.H. TAN, Auteur ; P.C.L. SHEK, Auteur ; F. YAP, Auteur ; Birit F.P. BROEKMAN, Auteur ; Iliana MAGIATI, Auteur Article en page(s) : p.1325-1337 Langues : Anglais (eng) Mots-clés : Autistic traits  Child  Demographic  Informant  Measurement  Predictors. Index. décimale : PER Périodiques Résumé : Current research on children's autistic traits in the general population relies predominantly on caregiver-report, yet the extent to which individual, caregiver or demographic characteristics are associated with informants' ratings has not been sufficiently explored. In this study, caregivers of 396 Singaporean two-year-olds from a birth cohort study completed the Quantitative Checklist for Autism in Toddlers. Children's gender, cognitive functioning and birth order, maternal age, and ethnic group membership were not significant predictors of caregiver-reported autistic traits. Poorer child language development and higher maternal depressive symptoms significantly predicted more social-communicative autistic traits, while lower maternal education predicted more behavioural autistic traits. Children's language and informants' educational level and depressive symptomatology may need to be considered in caregiver-reports of autistic traits. En ligne : http://dx.doi.org/10.1007/s10803-018-3471-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352 [article] Child, Maternal and Demographic Factors Influencing Caregiver-Reported Autistic Trait Symptomatology in Toddlers [texte imprimé] / D.A. GOH, Auteur ; D. GAN, Auteur ; J. KUNG, Auteur ; Simon BARON-COHEN, Auteur ; Carrie ALLISON, Auteur ; Haijia CHEN, Auteur ; Seang Mei SAW, Auteur ; Yap Seng CHONG, Auteur ; V.S. RAJADURAI, Auteur ; K.H. TAN, Auteur ; P.C.L. SHEK, Auteur ; F. YAP, Auteur ; Birit F.P. BROEKMAN, Auteur ; Iliana MAGIATI, Auteur . - p.1325-1337. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-4 (April 2018) . - p.1325-1337 Mots-clés : Autistic traits  Child  Demographic  Informant  Measurement  Predictors. Index. décimale : PER Périodiques Résumé : Current research on children's autistic traits in the general population relies predominantly on caregiver-report, yet the extent to which individual, caregiver or demographic characteristics are associated with informants' ratings has not been sufficiently explored. In this study, caregivers of 396 Singaporean two-year-olds from a birth cohort study completed the Quantitative Checklist for Autism in Toddlers. Children's gender, cognitive functioning and birth order, maternal age, and ethnic group membership were not significant predictors of caregiver-reported autistic traits. Poorer child language development and higher maternal depressive symptoms significantly predicted more social-communicative autistic traits, while lower maternal education predicted more behavioural autistic traits. Children's language and informants' educational level and depressive symptomatology may need to be considered in caregiver-reports of autistic traits. En ligne : http://dx.doi.org/10.1007/s10803-018-3471-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352

Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways / Jessica P. UY in Journal of Child Psychology and Psychiatry, 64-3 (March 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.426-436 Titre : Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways Type de document : texte imprimé Auteurs : Jessica P. UY, Auteur ; Ai Peng TAN, Auteur ; Birit F.P. BROEKMAN, Auteur ; Peter D. GLUCKMAN, Auteur ; Yap Seng CHONG, Auteur ; Helen CHEN, Auteur ; Marielle V. FORTIER, Auteur ; Michael J. MEANEY, Auteur ; Bridget L. CALLAGHAN, Auteur Article en page(s) : p.426-436 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Experiences of early life adversity pose significant psychological and physical health risks to exposed individuals. Emerging evidence suggests that these health risks can be transmitted across generations; however, the mechanisms underlying the intergenerational impacts of maternal early-life trauma on child health remain unknown. Methods The current study used a prospective longitudinal design to determine the unique and joint contributions of maternal childhood trauma (neglect and abuse) and maternal prenatal and postnatal mental health (anxiety and depressive symptoms) (N = 541) to children's resting frontoamygdala functional connectivity at 6 years (N = 89) and emotional health at 7-8 years, as indexed by parent-reported internalizing problems and child self-reported anxiety and depressive symptoms (N = 268-418). Results Greater maternal childhood neglect was indirectly associated with greater internalizing problems serially through a pathway of worse maternal prenatal and postnatal mental health (greater maternal anxiety and depressive symptoms). Worse maternal postnatal mental health was also uniquely associated with more negative child frontoamygdala resting-state functional connectivity, over and above maternal childhood trauma (both neglect and abuse) and prenatal mental health. More negative frontoamygdala functional connectivity was, in turn, associated with poorer child emotional health outcomes. Conclusions Findings from the current study provide support for the existence of intergenerational influences of parental exposure to childhood trauma on childhood risk for psychopathology in the next generation and point to the importance of maternal factors proximal to the second generation (maternal prenatal and postnatal mental health) in determining the intergenerational impact of maternal early experiences. En ligne : https://doi.org/10.1111/jcpp.13721 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 [article] Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways [texte imprimé] / Jessica P. UY, Auteur ; Ai Peng TAN, Auteur ; Birit F.P. BROEKMAN, Auteur ; Peter D. GLUCKMAN, Auteur ; Yap Seng CHONG, Auteur ; Helen CHEN, Auteur ; Marielle V. FORTIER, Auteur ; Michael J. MEANEY, Auteur ; Bridget L. CALLAGHAN, Auteur . - p.426-436. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.426-436 Index. décimale : PER Périodiques Résumé : Background Experiences of early life adversity pose significant psychological and physical health risks to exposed individuals. Emerging evidence suggests that these health risks can be transmitted across generations; however, the mechanisms underlying the intergenerational impacts of maternal early-life trauma on child health remain unknown. Methods The current study used a prospective longitudinal design to determine the unique and joint contributions of maternal childhood trauma (neglect and abuse) and maternal prenatal and postnatal mental health (anxiety and depressive symptoms) (N = 541) to children's resting frontoamygdala functional connectivity at 6 years (N = 89) and emotional health at 7-8 years, as indexed by parent-reported internalizing problems and child self-reported anxiety and depressive symptoms (N = 268-418). Results Greater maternal childhood neglect was indirectly associated with greater internalizing problems serially through a pathway of worse maternal prenatal and postnatal mental health (greater maternal anxiety and depressive symptoms). Worse maternal postnatal mental health was also uniquely associated with more negative child frontoamygdala resting-state functional connectivity, over and above maternal childhood trauma (both neglect and abuse) and prenatal mental health. More negative frontoamygdala functional connectivity was, in turn, associated with poorer child emotional health outcomes. Conclusions Findings from the current study provide support for the existence of intergenerational influences of parental exposure to childhood trauma on childhood risk for psychopathology in the next generation and point to the importance of maternal factors proximal to the second generation (maternal prenatal and postnatal mental health) in determining the intergenerational impact of maternal early experiences. En ligne : https://doi.org/10.1111/jcpp.13721 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493

Nucleus accumbens volume mediates the association between prenatal adversity and attention problems in youth / Chase ANTONACCI in Development and Psychopathology, 38-1 (February 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-1 (February 2026) . - p.117-129 Titre : Nucleus accumbens volume mediates the association between prenatal adversity and attention problems in youth Type de document : texte imprimé Auteurs : Chase ANTONACCI, Auteur ; Jessica L. BUTHMANN, Auteur ; Lauren R. BORCHERS, Auteur ; Marielle V. FORTIER, Auteur ; Yap Seng CHONG, Auteur ; Peter GLUCKMAN, Auteur ; Johan ERIKSSON, Auteur ; Helen Y. CHEN, Auteur ; Evelyn LAW, Auteur ; Michael J. MEANEY, Auteur ; Ai Peng TAN, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.117-129 Langues : Anglais (eng) Mots-clés : adversity attention maternal mental health nucleus accumbens perinatal Index. décimale : PER Périodiques Résumé : Exposure to adversity during the perinatal period has been associated with cognitive difficulties in children. Given the role of the nucleus accumbens (NAcc) in attention and impulsivity, we examined whether NAcc volume at age six mediates the relations between pre- and postnatal adversity and subsequent attention problems in offspring. 306 pregnant women were recruited as part of the Growing Up in Singapore Towards Healthy Outcomes Study. Psychosocial stress was assessed during pregnancy and across the first 5 years postpartum. At six years of age, children underwent structural MRI and, at age seven years, mothers reported on their children’s attention problems. Separate factor analyses conducted on measures of pre- and postnatal adversity each yielded two latent factors: maternal mental health and socioeconomic status. Both pre- and postnatal maternal mental health predicted children’s attention difficulties. Further, NAcc volume mediated the relation between prenatal, but not postnatal, maternal mental health and children’s attention problems. These findings suggest that the NAcc is particularly vulnerable to prenatal maternal mental health challenges and contributes to offspring attention problems. Characterizing the temporal sensitivity of neurobiological structures to adversity will help to elucidate mechanisms linking environmental exposures and behavior, facilitating the development of neuroscience-informed interventions for childhood difficulties. En ligne : https://dx.doi.org/10.1017/S0954579425000240 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579 [article] Nucleus accumbens volume mediates the association between prenatal adversity and attention problems in youth [texte imprimé] / Chase ANTONACCI, Auteur ; Jessica L. BUTHMANN, Auteur ; Lauren R. BORCHERS, Auteur ; Marielle V. FORTIER, Auteur ; Yap Seng CHONG, Auteur ; Peter GLUCKMAN, Auteur ; Johan ERIKSSON, Auteur ; Helen Y. CHEN, Auteur ; Evelyn LAW, Auteur ; Michael J. MEANEY, Auteur ; Ai Peng TAN, Auteur ; Ian H. GOTLIB, Auteur . - p.117-129. Langues : Anglais (eng) in Development and Psychopathology > 38-1 (February 2026) . - p.117-129 Mots-clés : adversity attention maternal mental health nucleus accumbens perinatal Index. décimale : PER Périodiques Résumé : Exposure to adversity during the perinatal period has been associated with cognitive difficulties in children. Given the role of the nucleus accumbens (NAcc) in attention and impulsivity, we examined whether NAcc volume at age six mediates the relations between pre- and postnatal adversity and subsequent attention problems in offspring. 306 pregnant women were recruited as part of the Growing Up in Singapore Towards Healthy Outcomes Study. Psychosocial stress was assessed during pregnancy and across the first 5 years postpartum. At six years of age, children underwent structural MRI and, at age seven years, mothers reported on their children’s attention problems. Separate factor analyses conducted on measures of pre- and postnatal adversity each yielded two latent factors: maternal mental health and socioeconomic status. Both pre- and postnatal maternal mental health predicted children’s attention difficulties. Further, NAcc volume mediated the relation between prenatal, but not postnatal, maternal mental health and children’s attention problems. These findings suggest that the NAcc is particularly vulnerable to prenatal maternal mental health challenges and contributes to offspring attention problems. Characterizing the temporal sensitivity of neurobiological structures to adversity will help to elucidate mechanisms linking environmental exposures and behavior, facilitating the development of neuroscience-informed interventions for childhood difficulties. En ligne : https://dx.doi.org/10.1017/S0954579425000240 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579

Positive maternal mental health during pregnancy associated with specific forms of adaptive development in early childhood: Evidence from a longitudinal study / Desiree Y. PHUA in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1573-1587 Titre : Positive maternal mental health during pregnancy associated with specific forms of adaptive development in early childhood: Evidence from a longitudinal study Type de document : texte imprimé Auteurs : Desiree Y. PHUA, Auteur ; Michelle K.Z.L. KEE, Auteur ; Dawn X.P. KOH, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Mary DANIELS, Auteur ; Helen CHEN, Auteur ; Yap Seng CHONG, Auteur ; Birit F.P. BROEKMAN, Auteur ; Iliana MAGIATI, Auteur ; Neerja KARNANI, Auteur ; Michael PLUESS, Auteur ; Michael J. MEANEY, Auteur Article en page(s) : p.1573-1587 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The quality of prenatal maternal mental health, from psychological stress and depressive symptoms to anxiety and other nonpsychotic mental disorders, profoundly affects fetal neurodevelopment. Despite the evidence for the influence of positive mental well-being on health, there is, to our knowledge, no research examining the possible effects of positive antenatal mental health on the development of the offspring. Using exploratory bifactor analysis, this prospective study (n = 1,066) demonstrated the feasibility of using common psychiatric screening tools to examine the effect of positive maternal mental health. Antenatal mental health was assessed during 26th week of pregnancy. The effects on offspring were assessed when the child was 12, 18, and 24 months old. Results showed that positive antenatal mental health was uniquely associated with the offspring's cognitive, language and parentally rated competences. This study shows that the effects of positive maternal mental health are likely to be specific and distinct from the sheer absence of symptoms of depression or anxiety. En ligne : http://dx.doi.org/10.1017/S0954579417001249 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Positive maternal mental health during pregnancy associated with specific forms of adaptive development in early childhood: Evidence from a longitudinal study [texte imprimé] / Desiree Y. PHUA, Auteur ; Michelle K.Z.L. KEE, Auteur ; Dawn X.P. KOH, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Mary DANIELS, Auteur ; Helen CHEN, Auteur ; Yap Seng CHONG, Auteur ; Birit F.P. BROEKMAN, Auteur ; Iliana MAGIATI, Auteur ; Neerja KARNANI, Auteur ; Michael PLUESS, Auteur ; Michael J. MEANEY, Auteur . - p.1573-1587. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1573-1587 Index. décimale : PER Périodiques Résumé : The quality of prenatal maternal mental health, from psychological stress and depressive symptoms to anxiety and other nonpsychotic mental disorders, profoundly affects fetal neurodevelopment. Despite the evidence for the influence of positive mental well-being on health, there is, to our knowledge, no research examining the possible effects of positive antenatal mental health on the development of the offspring. Using exploratory bifactor analysis, this prospective study (n = 1,066) demonstrated the feasibility of using common psychiatric screening tools to examine the effect of positive maternal mental health. Antenatal mental health was assessed during 26th week of pregnancy. The effects on offspring were assessed when the child was 12, 18, and 24 months old. Results showed that positive antenatal mental health was uniquely associated with the offspring's cognitive, language and parentally rated competences. This study shows that the effects of positive maternal mental health are likely to be specific and distinct from the sheer absence of symptoms of depression or anxiety. En ligne : http://dx.doi.org/10.1017/S0954579417001249 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Positive maternal mental health during pregnancy associated with specific forms of adaptive development in early childhood: Evidence from a longitudinal study—CORRIGENDUM / Desiree Y. PHUA in Development and Psychopathology, 30-4 (October 2018)  

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Preschoolers' emotion reactivity and regulation: Links with maternal psychological distress and child behavior problems / Stella TSOTSI in Development and Psychopathology, 35-3 (August 2023)  

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The psychometric properties of the Quantitative-Checklist for Autism in Toddlers (Q-CHAT) as a measure of autistic traits in a community sample of Singaporean infants and toddlers / Iliana MAGIATI in Molecular Autism, (June 2015)  

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