Neuromagnetic Oscillations Predict Evoked-Response Latency Delays and Core Language Deficits in Autism Spectrum Disorders / J. Christopher EDGAR in Journal of Autism and Developmental Disorders, 45-2 (February 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.395-405 Titre : Neuromagnetic Oscillations Predict Evoked-Response Latency Delays and Core Language Deficits in Autism Spectrum Disorders Type de document : texte imprimé Auteurs : J. Christopher EDGAR, Auteur ; Sarah Y. KHAN, Auteur ; Lisa BLASKEY, Auteur ; Vivian Y. CHOW, Auteur ; Michael REY, Auteur ; William GAETZ, Auteur ; Katelyn M. CANNON, Auteur ; Justin F. MONROE, Auteur ; Lauren CORNEW, Auteur ; Saba QASMIEH, Auteur ; Song LIU, Auteur ; John P. WELSH, Auteur ; Susan E. LEVY, Auteur ; Timothy P. L. ROBERTS, Auteur Article en page(s) : p.395-405 Langues : Anglais (eng) Mots-clés : Auditory  Autism spectrum disorders  M100  Gamma  Evoked  Inter-trial coherence  Phase-locking  Magnetoencephalography Index. décimale : PER Périodiques Résumé : Previous studies have observed evoked response latency as well as gamma band superior temporal gyrus (STG) auditory abnormalities in individuals with autism spectrum disorders (ASD). A limitation of these studies is that associations between these two abnormalities, as well as the full extent of oscillatory phenomena in ASD in terms of frequency and time, have not been examined. Subjects were presented pure tones at 200, 300, 500, and 1,000 Hz while magnetoencephalography assessed activity in STG auditory areas in a sample of 105 children with ASD and 36 typically developing controls (TD). Findings revealed a profile such that auditory STG processes in ASD were characterized by pre-stimulus abnormalities across multiple frequencies, then early high-frequency abnormalities followed by low-frequency abnormalities. Increased pre-stimulus activity was a ‘core’ abnormality, with pre-stimulus activity predicting post-stimulus neural abnormalities, group membership, and clinical symptoms (CELF-4 Core Language Index). Deficits in synaptic integration in the auditory cortex are associated with oscillatory abnormalities in ASD as well as patient symptoms. Increased pre-stimulus activity in ASD likely demonstrates a fundamental signal-to-noise deficit in individuals with ASD, with elevations in oscillatory activity suggesting an inability to maintain an appropriate ‘neural tone’ and an inability to rapidly return to a resting state prior to the next stimulus. En ligne : http://dx.doi.org/10.1007/s10803-013-1904-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Neuromagnetic Oscillations Predict Evoked-Response Latency Delays and Core Language Deficits in Autism Spectrum Disorders [texte imprimé] / J. Christopher EDGAR, Auteur ; Sarah Y. KHAN, Auteur ; Lisa BLASKEY, Auteur ; Vivian Y. CHOW, Auteur ; Michael REY, Auteur ; William GAETZ, Auteur ; Katelyn M. CANNON, Auteur ; Justin F. MONROE, Auteur ; Lauren CORNEW, Auteur ; Saba QASMIEH, Auteur ; Song LIU, Auteur ; John P. WELSH, Auteur ; Susan E. LEVY, Auteur ; Timothy P. L. ROBERTS, Auteur . - p.395-405. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.395-405 Mots-clés : Auditory  Autism spectrum disorders  M100  Gamma  Evoked  Inter-trial coherence  Phase-locking  Magnetoencephalography Index. décimale : PER Périodiques Résumé : Previous studies have observed evoked response latency as well as gamma band superior temporal gyrus (STG) auditory abnormalities in individuals with autism spectrum disorders (ASD). A limitation of these studies is that associations between these two abnormalities, as well as the full extent of oscillatory phenomena in ASD in terms of frequency and time, have not been examined. Subjects were presented pure tones at 200, 300, 500, and 1,000 Hz while magnetoencephalography assessed activity in STG auditory areas in a sample of 105 children with ASD and 36 typically developing controls (TD). Findings revealed a profile such that auditory STG processes in ASD were characterized by pre-stimulus abnormalities across multiple frequencies, then early high-frequency abnormalities followed by low-frequency abnormalities. Increased pre-stimulus activity was a ‘core’ abnormality, with pre-stimulus activity predicting post-stimulus neural abnormalities, group membership, and clinical symptoms (CELF-4 Core Language Index). Deficits in synaptic integration in the auditory cortex are associated with oscillatory abnormalities in ASD as well as patient symptoms. Increased pre-stimulus activity in ASD likely demonstrates a fundamental signal-to-noise deficit in individuals with ASD, with elevations in oscillatory activity suggesting an inability to maintain an appropriate ‘neural tone’ and an inability to rapidly return to a resting state prior to the next stimulus. En ligne : http://dx.doi.org/10.1007/s10803-013-1904-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

Resting-State Alpha in Autism Spectrum Disorder and Alpha Associations with Thalamic Volume / J. Christopher EDGAR in Journal of Autism and Developmental Disorders, 45-3 (March 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-3 (March 2015) . - p.795-804 Titre : Resting-State Alpha in Autism Spectrum Disorder and Alpha Associations with Thalamic Volume Type de document : texte imprimé Auteurs : J. Christopher EDGAR, Auteur ; Kory HEIKEN, Auteur ; Yu-Han CHEN, Auteur ; John D. HERRINGTON, Auteur ; Vivian Y. CHOW, Auteur ; Song LIU, Auteur ; Luke BLOY, Auteur ; Mingxiong HUANG, Auteur ; Juhi PANDEY, Auteur ; Katelyn M. CANNON, Auteur ; Saba QASMIEH, Auteur ; Susan E. LEVY, Auteur ; Robert T. SCHULTZ, Auteur ; Timothy P L. ROBERTS, Auteur Article en page(s) : p.795-804 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Alpha  Resting-state  Magnetoencephalography  Thalamus Index. décimale : PER Périodiques Résumé : Alpha circuits (8–12 Hz), necessary for basic and complex brain processes, are abnormal in autism spectrum disorder (ASD). The present study obtained estimates of resting-state (RS) alpha activity in children with ASD and examined associations between alpha activity, age, and clinical symptoms. Given that the thalamus modulates cortical RS alpha rhythms, associations between thalamic structure and alpha activity were examined. RS magnetoencephalography was obtained from 47 typically-developing children (TDC) and 41 children with ASD. RS alpha activity was measured using distributed source localization. Left and right thalamic volume measurements were also obtained. In both groups, the strongest alpha activity was observed in Calcarine Sulcus regions. In Calcarine regions, only TDC showed the expected association between age and alpha peak frequency. ASD had more alpha activity than TDC in regions bordering the Central Sulcus as well as parietal association cortices. In ASD, whereas greater left Central Sulcus relative alpha activity was associated with higher Social Responsiveness Scale (SRS) scores, greater Calcarine region relative alpha activity was associated with lower SRS scores. Although thalamic volume group differences were not observed, relationships between thalamic volume and Calcarine alpha power were unique to TDC. The present study also identified a failure to shift peak alpha frequency as a function of age in primary alpha-generating areas in children with ASD. Findings suggested that increased RS alpha activity in primary motor and somatosensory as well as parietal multimodal areas—with increased alpha thought to reflect greater inhibition—might impair the ability to identify or interpret social cues. Finally, to our knowledge, this is the first study to report associations between thalamic volume and alpha power, an association observed only in TDC. The lack of thalamic and alpha associations in ASD suggests thalamic contributions to RS alpha abnormalities in ASD. En ligne : http://dx.doi.org/10.1007/s10803-014-2236-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Resting-State Alpha in Autism Spectrum Disorder and Alpha Associations with Thalamic Volume [texte imprimé] / J. Christopher EDGAR, Auteur ; Kory HEIKEN, Auteur ; Yu-Han CHEN, Auteur ; John D. HERRINGTON, Auteur ; Vivian Y. CHOW, Auteur ; Song LIU, Auteur ; Luke BLOY, Auteur ; Mingxiong HUANG, Auteur ; Juhi PANDEY, Auteur ; Katelyn M. CANNON, Auteur ; Saba QASMIEH, Auteur ; Susan E. LEVY, Auteur ; Robert T. SCHULTZ, Auteur ; Timothy P L. ROBERTS, Auteur . - p.795-804. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-3 (March 2015) . - p.795-804 Mots-clés : Autism spectrum disorder  Alpha  Resting-state  Magnetoencephalography  Thalamus Index. décimale : PER Périodiques Résumé : Alpha circuits (8–12 Hz), necessary for basic and complex brain processes, are abnormal in autism spectrum disorder (ASD). The present study obtained estimates of resting-state (RS) alpha activity in children with ASD and examined associations between alpha activity, age, and clinical symptoms. Given that the thalamus modulates cortical RS alpha rhythms, associations between thalamic structure and alpha activity were examined. RS magnetoencephalography was obtained from 47 typically-developing children (TDC) and 41 children with ASD. RS alpha activity was measured using distributed source localization. Left and right thalamic volume measurements were also obtained. In both groups, the strongest alpha activity was observed in Calcarine Sulcus regions. In Calcarine regions, only TDC showed the expected association between age and alpha peak frequency. ASD had more alpha activity than TDC in regions bordering the Central Sulcus as well as parietal association cortices. In ASD, whereas greater left Central Sulcus relative alpha activity was associated with higher Social Responsiveness Scale (SRS) scores, greater Calcarine region relative alpha activity was associated with lower SRS scores. Although thalamic volume group differences were not observed, relationships between thalamic volume and Calcarine alpha power were unique to TDC. The present study also identified a failure to shift peak alpha frequency as a function of age in primary alpha-generating areas in children with ASD. Findings suggested that increased RS alpha activity in primary motor and somatosensory as well as parietal multimodal areas—with increased alpha thought to reflect greater inhibition—might impair the ability to identify or interpret social cues. Finally, to our knowledge, this is the first study to report associations between thalamic volume and alpha power, an association observed only in TDC. The lack of thalamic and alpha associations in ASD suggests thalamic contributions to RS alpha abnormalities in ASD. En ligne : http://dx.doi.org/10.1007/s10803-014-2236-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

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