Aberrant local striatal functional connectivity in attention-deficit/hyperactivity disorder / Daniel VON RHEIN in Journal of Child Psychology and Psychiatry, 57-6 (June 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-6 (June 2016) . - p.697-705 Titre : Aberrant local striatal functional connectivity in attention-deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Daniel VON RHEIN, Auteur ; Marianne OLDEHINKEL, Auteur ; Christian F. BECKMANN, Auteur ; Jaap OOSTERLAAN, Auteur ; Dirk J. HESLENFELD, Auteur ; Catharina A. HARTMAN, Auteur ; Pieter J. HOEKSTRA, Auteur ; Barbara FRANKE, Auteur ; Roshan COOLS, Auteur ; Jan K. BUITELAAR, Auteur ; Maarten MENNES, Auteur Article en page(s) : p.697-705 Langues : Anglais (eng) Mots-clés : Resting-state fMRI  functional connectivity  attention-deficit/hyperactivity disorder  cortico-striatal networks  striatum  putamen Index. décimale : PER Périodiques Résumé : Background Task-based and resting-state functional Magnetic Resonance Imaging (fMRI) studies report attention-deficit/hyperactivity disorder (ADHD)-related alterations in brain regions implicated in cortico-striatal networks. We assessed whether ADHD is associated with changes in the brain's global cortico-striatal functional architecture, or whether ADHD-related alterations are limited to local, intrastriatal functional connections. Methods We included a cohort of adolescents with ADHD (N = 181) and healthy controls (N = 140) and assessed functional connectivity of nucleus accumbens, caudate nucleus, anterior putamen, and posterior putamen. To assess global cortico-striatal functional architecture we computed whole-brain functional connectivity by including all regions of interest in one multivariate analysis. We assessed local striatal functional connectivity using partial correlations between the time series of the striatal regions. Results Diagnostic status did not influence global cortico-striatal functional architecture. However, compared to controls, participants with ADHD exhibited significantly increased local functional connectivity between anterior and posterior putamen (p = .0003; ADHD: z = .30, controls: z = .24). Results were not affected by medication use or comorbid oppositional defiant disorder and conduct disorder. Conclusions Our results do not support hypotheses that ADHD is associated with alterations in cortico-striatal networks, but suggest changes in local striatal functional connectivity. We interpret our findings as aberrant development of local functional connectivity of the putamen, potentially leading to decreased functional segregation between anterior and posterior putamen in ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.12529 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Aberrant local striatal functional connectivity in attention-deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Daniel VON RHEIN, Auteur ; Marianne OLDEHINKEL, Auteur ; Christian F. BECKMANN, Auteur ; Jaap OOSTERLAAN, Auteur ; Dirk J. HESLENFELD, Auteur ; Catharina A. HARTMAN, Auteur ; Pieter J. HOEKSTRA, Auteur ; Barbara FRANKE, Auteur ; Roshan COOLS, Auteur ; Jan K. BUITELAAR, Auteur ; Maarten MENNES, Auteur . - p.697-705. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-6 (June 2016) . - p.697-705 Mots-clés : Resting-state fMRI  functional connectivity  attention-deficit/hyperactivity disorder  cortico-striatal networks  striatum  putamen Index. décimale : PER Périodiques Résumé : Background Task-based and resting-state functional Magnetic Resonance Imaging (fMRI) studies report attention-deficit/hyperactivity disorder (ADHD)-related alterations in brain regions implicated in cortico-striatal networks. We assessed whether ADHD is associated with changes in the brain's global cortico-striatal functional architecture, or whether ADHD-related alterations are limited to local, intrastriatal functional connections. Methods We included a cohort of adolescents with ADHD (N = 181) and healthy controls (N = 140) and assessed functional connectivity of nucleus accumbens, caudate nucleus, anterior putamen, and posterior putamen. To assess global cortico-striatal functional architecture we computed whole-brain functional connectivity by including all regions of interest in one multivariate analysis. We assessed local striatal functional connectivity using partial correlations between the time series of the striatal regions. Results Diagnostic status did not influence global cortico-striatal functional architecture. However, compared to controls, participants with ADHD exhibited significantly increased local functional connectivity between anterior and posterior putamen (p = .0003; ADHD: z = .30, controls: z = .24). Results were not affected by medication use or comorbid oppositional defiant disorder and conduct disorder. Conclusions Our results do not support hypotheses that ADHD is associated with alterations in cortico-striatal networks, but suggest changes in local striatal functional connectivity. We interpret our findings as aberrant development of local functional connectivity of the putamen, potentially leading to decreased functional segregation between anterior and posterior putamen in ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.12529 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289

Commentary: Leveraging discovery science to advance child and adolescent psychiatric research – a commentary on Zhao and Castellanos 2016 / Maarten MENNES in Journal of Child Psychology and Psychiatry, 57-3 (March 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-3 (March 2016) . - p.440-442 Titre : Commentary: Leveraging discovery science to advance child and adolescent psychiatric research – a commentary on Zhao and Castellanos 2016 Type de document : Texte imprimé et/ou numérique Auteurs : Maarten MENNES, Auteur Article en page(s) : p.440-442 Langues : Anglais (eng) Mots-clés : Research design Index. décimale : PER Périodiques Résumé : ‘Big Data’ and ‘Population Imaging’ are becoming integral parts of inspiring research aimed at delineating the biological underpinnings of psychiatric disorders. The scientific strategies currently associated with big data and population imaging are typically embedded in so-called discovery science, thereby pointing to the hypothesis-generating rather than hypothesis-testing nature of discovery science. In this issue, Yihong Zhao and F. Xavier Castellanos provide a compelling overview of strategies for discovery science aimed at progressing our understanding of neuropsychiatric disorders. In particular, they focus on efforts in genetic and neuroimaging research, which, together with extended behavioural testing, form the main pillars of psychopathology research. En ligne : http://dx.doi.org/10.1111/jcpp.12538 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 [article] Commentary: Leveraging discovery science to advance child and adolescent psychiatric research – a commentary on Zhao and Castellanos 2016 [Texte imprimé et/ou numérique] / Maarten MENNES, Auteur . - p.440-442. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-3 (March 2016) . - p.440-442 Mots-clés : Research design Index. décimale : PER Périodiques Résumé : ‘Big Data’ and ‘Population Imaging’ are becoming integral parts of inspiring research aimed at delineating the biological underpinnings of psychiatric disorders. The scientific strategies currently associated with big data and population imaging are typically embedded in so-called discovery science, thereby pointing to the hypothesis-generating rather than hypothesis-testing nature of discovery science. In this issue, Yihong Zhao and F. Xavier Castellanos provide a compelling overview of strategies for discovery science aimed at progressing our understanding of neuropsychiatric disorders. In particular, they focus on efforts in genetic and neuroimaging research, which, together with extended behavioural testing, form the main pillars of psychopathology research. En ligne : http://dx.doi.org/10.1111/jcpp.12538 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282

Prenatal stress and the developing brain: Risks for neurodevelopmental disorders — ERRATUM / Bea R. H. VAN DEN BERGH in Development and Psychopathology, 31-1 (February 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-1 (February 2019) . - p.395-395 Titre : Prenatal stress and the developing brain: Risks for neurodevelopmental disorders — ERRATUM Type de document : Texte imprimé et/ou numérique Auteurs : Bea R. H. VAN DEN BERGH, Auteur ; Robert DAHNKE, Auteur ; Maarten MENNES, Auteur Article en page(s) : p.395-395 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579418001402 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383 [article] Prenatal stress and the developing brain: Risks for neurodevelopmental disorders — ERRATUM [Texte imprimé et/ou numérique] / Bea R. H. VAN DEN BERGH, Auteur ; Robert DAHNKE, Auteur ; Maarten MENNES, Auteur . - p.395-395. Langues : Anglais (eng) in Development and Psychopathology > 31-1 (February 2019) . - p.395-395 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579418001402 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383

White matter microstructure and developmental improvement of hyperactive/impulsive symptoms in attention-deficit/hyperactivity disorder / Winke FRANCX in Journal of Child Psychology and Psychiatry, 56-12 (December 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-12 (December 2015) . - p.1289-1297 Titre : White matter microstructure and developmental improvement of hyperactive/impulsive symptoms in attention-deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Winke FRANCX, Auteur ; Marcel P. ZWIERS, Auteur ; Maarten MENNES, Auteur ; Jaap OOSTERLAAN, Auteur ; Dirk J. HESLENFELD, Auteur ; Pieter J. HOEKSTRA, Auteur ; Catharina A. HARTMAN, Auteur ; Barbara FRANKE, Auteur ; Stephen V. FARAONE, Auteur ; Laurence O'DWYER, Auteur ; Jan K. BUITELAAR, Auteur Article en page(s) : p.1289-1297 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder  hyperactivity/impulsivity  white matter  diffusion tensor imaging  recovery  development Index. décimale : PER Périodiques Résumé : Background A developmental improvement of symptoms in attention-deficit/hyperactivity disorder (ADHD) is frequently reported, but the underlying neurobiological substrate has not been identified. The aim of this study was to determine whether white matter microstructure is related to developmental improvement of ADHD symptoms. Methods A cross-sectional magnetic resonance imaging (MRI) analysis was embedded in a prospective follow-up of an adolescent cohort of ADHD and control subjects (NeuroIMAGE). Mean age at baseline was 11.9 years, mean interval of follow-up was 5.9 years. About 75.3% of the original cohort was retained successfully. Data of 101 participants with ADHD combined type at baseline and 40 healthy controls were analysed. ADHD symptoms were measured with semistructured, investigator-based interviews and Conners' questionnaires, on the basis of DSM-IV criteria. Fractional anisotropy (FA) and mean diffusivity (MD) indices of white matter microstructure were measured using whole brain diffusion tensor imaging at follow-up only. In a dimensional analysis FA and MD were related to change in ADHD symptoms. To link this analysis to DSM-IV diagnoses, a post hoc categorical group analysis was conducted comparing participants with persistent (n = 59) versus remittent (n = 42) ADHD and controls. Results Over time, participants with ADHD showed improvement mainly in hyperactive/impulsive symptoms. This improvement was associated with lower FA and higher MD values in the left corticospinal tract at follow-up. Findings of the dimensional and the categorical analysis strongly converged. Changes in inattentive symptoms over time were minimal and not related to white matter microstructure. Conclusions The corticospinal tract is important in the control of voluntary movements, suggesting the importance of the motor system in the persistence of hyperactive/impulsive symptoms. En ligne : http://dx.doi.org/10.1111/jcpp.12379 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273 [article] White matter microstructure and developmental improvement of hyperactive/impulsive symptoms in attention-deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Winke FRANCX, Auteur ; Marcel P. ZWIERS, Auteur ; Maarten MENNES, Auteur ; Jaap OOSTERLAAN, Auteur ; Dirk J. HESLENFELD, Auteur ; Pieter J. HOEKSTRA, Auteur ; Catharina A. HARTMAN, Auteur ; Barbara FRANKE, Auteur ; Stephen V. FARAONE, Auteur ; Laurence O'DWYER, Auteur ; Jan K. BUITELAAR, Auteur . - p.1289-1297. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-12 (December 2015) . - p.1289-1297 Mots-clés : Attention-deficit/hyperactivity disorder  hyperactivity/impulsivity  white matter  diffusion tensor imaging  recovery  development Index. décimale : PER Périodiques Résumé : Background A developmental improvement of symptoms in attention-deficit/hyperactivity disorder (ADHD) is frequently reported, but the underlying neurobiological substrate has not been identified. The aim of this study was to determine whether white matter microstructure is related to developmental improvement of ADHD symptoms. Methods A cross-sectional magnetic resonance imaging (MRI) analysis was embedded in a prospective follow-up of an adolescent cohort of ADHD and control subjects (NeuroIMAGE). Mean age at baseline was 11.9 years, mean interval of follow-up was 5.9 years. About 75.3% of the original cohort was retained successfully. Data of 101 participants with ADHD combined type at baseline and 40 healthy controls were analysed. ADHD symptoms were measured with semistructured, investigator-based interviews and Conners' questionnaires, on the basis of DSM-IV criteria. Fractional anisotropy (FA) and mean diffusivity (MD) indices of white matter microstructure were measured using whole brain diffusion tensor imaging at follow-up only. In a dimensional analysis FA and MD were related to change in ADHD symptoms. To link this analysis to DSM-IV diagnoses, a post hoc categorical group analysis was conducted comparing participants with persistent (n = 59) versus remittent (n = 42) ADHD and controls. Results Over time, participants with ADHD showed improvement mainly in hyperactive/impulsive symptoms. This improvement was associated with lower FA and higher MD values in the left corticospinal tract at follow-up. Findings of the dimensional and the categorical analysis strongly converged. Changes in inattentive symptoms over time were minimal and not related to white matter microstructure. Conclusions The corticospinal tract is important in the control of voluntary movements, suggesting the importance of the motor system in the persistence of hyperactive/impulsive symptoms. En ligne : http://dx.doi.org/10.1111/jcpp.12379 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273

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