Adaptive skill trajectories in infants with fragile X syndrome contrasted to typical controls and infants at high risk for autism / Kelly E. CARAVELLA in Research in Autism Spectrum Disorders, 40 (August 2017)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 40 (August 2017) . - p.1-12 Titre : Adaptive skill trajectories in infants with fragile X syndrome contrasted to typical controls and infants at high risk for autism Type de document : Texte imprimé et/ou numérique Auteurs : Kelly E. CARAVELLA, Auteur ; Jane E. ROBERTS, Auteur Article en page(s) : p.1-12 Langues : Anglais (eng) Mots-clés : Adaptive behavior  Fragile X syndrome  Infancy  Autism infant siblings Index. décimale : PER Périodiques Résumé : AbstractBackground Adaptive behaviors are essential for optimal outcomes and independence in individuals with developmental disabilities. This study examined longitudinal trajectories of adaptive behavior in infants with fragile X syndrome (FXS), compared to typical development (TD) and infant siblings of children diagnosed with autism (ASIBs). Method Participants included 76 male infants (FXS = 25, ASIBs = 27, TD = 24) assessed up to 4 times between 6 and 24 months of age for a total of 215 assessments of adaptive behavior. A sample of 12 females with FXS was included for a comparative sex analysis. Results Results indicate that infant males with FXS displayed lower initial adaptive behavior across all domains that emerged by 9 months-of-age with slower growth rates than both comparison groups. A flat profile across the domains at 24 months was evident. Increased severity of autism symptoms was related to reduced adaptive skills at 24 months-of-age. Females with FXS displayed higher scores than males on the Socialization and Motor domains and equivalent scores on the Communication and Daily Living domains at 9 months-of-age with different rates of growth across domains. Conclusions This is the first study to provide evidence of etiological specificity in adaptive behavior profiles during infancy across two populations at high risk for ASD. These findings support targeted adaptive behavior interventions in young children with FXS beginning as early at 9 months of age to reduce identified deficits and the cascading impacts of these early impairments. En ligne : https://doi.org/10.1016/j.rasd.2017.05.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317 [article] Adaptive skill trajectories in infants with fragile X syndrome contrasted to typical controls and infants at high risk for autism [Texte imprimé et/ou numérique] / Kelly E. CARAVELLA, Auteur ; Jane E. ROBERTS, Auteur . - p.1-12. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 40 (August 2017) . - p.1-12 Mots-clés : Adaptive behavior  Fragile X syndrome  Infancy  Autism infant siblings Index. décimale : PER Périodiques Résumé : AbstractBackground Adaptive behaviors are essential for optimal outcomes and independence in individuals with developmental disabilities. This study examined longitudinal trajectories of adaptive behavior in infants with fragile X syndrome (FXS), compared to typical development (TD) and infant siblings of children diagnosed with autism (ASIBs). Method Participants included 76 male infants (FXS = 25, ASIBs = 27, TD = 24) assessed up to 4 times between 6 and 24 months of age for a total of 215 assessments of adaptive behavior. A sample of 12 females with FXS was included for a comparative sex analysis. Results Results indicate that infant males with FXS displayed lower initial adaptive behavior across all domains that emerged by 9 months-of-age with slower growth rates than both comparison groups. A flat profile across the domains at 24 months was evident. Increased severity of autism symptoms was related to reduced adaptive skills at 24 months-of-age. Females with FXS displayed higher scores than males on the Socialization and Motor domains and equivalent scores on the Communication and Daily Living domains at 9 months-of-age with different rates of growth across domains. Conclusions This is the first study to provide evidence of etiological specificity in adaptive behavior profiles during infancy across two populations at high risk for ASD. These findings support targeted adaptive behavior interventions in young children with FXS beginning as early at 9 months of age to reduce identified deficits and the cascading impacts of these early impairments. En ligne : https://doi.org/10.1016/j.rasd.2017.05.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317

Autism Spectrum Disorder Symptoms in Infants with Fragile X Syndrome: A Prospective Case Series / Abigail L. HOGAN in Journal of Autism and Developmental Disorders, 47-6 (June 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1628-1644 Titre : Autism Spectrum Disorder Symptoms in Infants with Fragile X Syndrome: A Prospective Case Series Type de document : Texte imprimé et/ou numérique Auteurs : Abigail L. HOGAN, Auteur ; Kelly E. CARAVELLA, Auteur ; Jordan EZELL, Auteur ; Lisa RAGUE, Auteur ; Kimberly HILLS, Auteur ; Jane E. ROBERTS, Auteur Article en page(s) : p.1628-1644 Langues : Anglais (eng) Mots-clés : Fragile X syndrome  Autism spectrum disorder  Infants  Case studies Index. décimale : PER Périodiques Résumé : No studies to date have prospectively examined early autism spectrum disorder (ASD) markers in infants with fragile X syndrome (FXS), who are at elevated risk for ASD. This paper describes the developmental profiles of eight infants with FXS from 9 to 24 months of age. Four meet diagnostic criteria for ASD at 24 months of age, and four do not. Trends in these case studies suggest that early social-communicative deficits differentiate infants with and without later ASD diagnoses in ways that are similar to later-born siblings of children with ASD. Repetitive behaviors and cognitive and adaptive impairments are present in all FXS infants throughout development, suggesting that these deficits reflect the general FXS phenotype and not ASD in FXS specifically. En ligne : http://dx.doi.org/10.1007/s10803-017-3081-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308 [article] Autism Spectrum Disorder Symptoms in Infants with Fragile X Syndrome: A Prospective Case Series [Texte imprimé et/ou numérique] / Abigail L. HOGAN, Auteur ; Kelly E. CARAVELLA, Auteur ; Jordan EZELL, Auteur ; Lisa RAGUE, Auteur ; Kimberly HILLS, Auteur ; Jane E. ROBERTS, Auteur . - p.1628-1644. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1628-1644 Mots-clés : Fragile X syndrome  Autism spectrum disorder  Infants  Case studies Index. décimale : PER Périodiques Résumé : No studies to date have prospectively examined early autism spectrum disorder (ASD) markers in infants with fragile X syndrome (FXS), who are at elevated risk for ASD. This paper describes the developmental profiles of eight infants with FXS from 9 to 24 months of age. Four meet diagnostic criteria for ASD at 24 months of age, and four do not. Trends in these case studies suggest that early social-communicative deficits differentiate infants with and without later ASD diagnoses in ways that are similar to later-born siblings of children with ASD. Repetitive behaviors and cognitive and adaptive impairments are present in all FXS infants throughout development, suggesting that these deficits reflect the general FXS phenotype and not ASD in FXS specifically. En ligne : http://dx.doi.org/10.1007/s10803-017-3081-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308

Brief Report: Autism Symptoms in Infants with Fragile X Syndrome / Jane E. ROBERTS in Journal of Autism and Developmental Disorders, 46-12 (December 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-12 (December 2016) . - p.3830-3837 Titre : Brief Report: Autism Symptoms in Infants with Fragile X Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Jane E. ROBERTS, Auteur ; Bridgette L. TONNSEN, Auteur ; Lindsay M. MCCARY, Auteur ; Kelly E. CARAVELLA, Auteur ; Svetlana V. SHINKAREVA, Auteur Article en page(s) : p.3830-3837 Langues : Anglais (eng) Mots-clés : Autism  Fragile X  Infants  Autism Observation Scale for Infants Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is the most common known genetic cause of autism spectrum disorder (ASD). Although 50–75?% of children with FXS meet ASD criteria, no studies have compared ASD symptoms in infants with FXS versus other high risk groups, such as siblings of children with ASD (ASIBs). Using the Autism Observation Scale for Infants, our findings indicate that 53?% of 12-month infants with FXS fall in the “at risk” category compared to 17 and 6?% for age-matched ASIBs and controls, respectively. Elevated atypical motor behaviors were associated with elevated risk for FXS. Cross-syndrome comparisons are essential to understanding the heterogeneity of ASD and identifying candidate markers that will facilitate differential diagnosis of ASD in genetic disorders such as FXS. En ligne : http://dx.doi.org/10.1007/s10803-016-2903-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Brief Report: Autism Symptoms in Infants with Fragile X Syndrome [Texte imprimé et/ou numérique] / Jane E. ROBERTS, Auteur ; Bridgette L. TONNSEN, Auteur ; Lindsay M. MCCARY, Auteur ; Kelly E. CARAVELLA, Auteur ; Svetlana V. SHINKAREVA, Auteur . - p.3830-3837. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-12 (December 2016) . - p.3830-3837 Mots-clés : Autism  Fragile X  Infants  Autism Observation Scale for Infants Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is the most common known genetic cause of autism spectrum disorder (ASD). Although 50–75?% of children with FXS meet ASD criteria, no studies have compared ASD symptoms in infants with FXS versus other high risk groups, such as siblings of children with ASD (ASIBs). Using the Autism Observation Scale for Infants, our findings indicate that 53?% of 12-month infants with FXS fall in the “at risk” category compared to 17 and 6?% for age-matched ASIBs and controls, respectively. Elevated atypical motor behaviors were associated with elevated risk for FXS. Cross-syndrome comparisons are essential to understanding the heterogeneity of ASD and identifying candidate markers that will facilitate differential diagnosis of ASD in genetic disorders such as FXS. En ligne : http://dx.doi.org/10.1007/s10803-016-2903-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

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