Adaptive skill trajectories in infants with fragile X syndrome contrasted to typical controls and infants at high risk for autism / Kelly E. CARAVELLA in Research in Autism Spectrum Disorders, 40 (August 2017)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 40 (August 2017) . - p.1-12 Titre : Adaptive skill trajectories in infants with fragile X syndrome contrasted to typical controls and infants at high risk for autism Type de document : texte imprimé Auteurs : Kelly E. CARAVELLA, Auteur ; Jane E. ROBERTS, Auteur Article en page(s) : p.1-12 Langues : Anglais (eng) Mots-clés : Adaptive behavior  Fragile X syndrome  Infancy  Autism infant siblings Index. décimale : PER Périodiques Résumé : AbstractBackground Adaptive behaviors are essential for optimal outcomes and independence in individuals with developmental disabilities. This study examined longitudinal trajectories of adaptive behavior in infants with fragile X syndrome (FXS), compared to typical development (TD) and infant siblings of children diagnosed with autism (ASIBs). Method Participants included 76 male infants (FXS = 25, ASIBs = 27, TD = 24) assessed up to 4 times between 6 and 24 months of age for a total of 215 assessments of adaptive behavior. A sample of 12 females with FXS was included for a comparative sex analysis. Results Results indicate that infant males with FXS displayed lower initial adaptive behavior across all domains that emerged by 9 months-of-age with slower growth rates than both comparison groups. A flat profile across the domains at 24 months was evident. Increased severity of autism symptoms was related to reduced adaptive skills at 24 months-of-age. Females with FXS displayed higher scores than males on the Socialization and Motor domains and equivalent scores on the Communication and Daily Living domains at 9 months-of-age with different rates of growth across domains. Conclusions This is the first study to provide evidence of etiological specificity in adaptive behavior profiles during infancy across two populations at high risk for ASD. These findings support targeted adaptive behavior interventions in young children with FXS beginning as early at 9 months of age to reduce identified deficits and the cascading impacts of these early impairments. En ligne : https://doi.org/10.1016/j.rasd.2017.05.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317 [article] Adaptive skill trajectories in infants with fragile X syndrome contrasted to typical controls and infants at high risk for autism [texte imprimé] / Kelly E. CARAVELLA, Auteur ; Jane E. ROBERTS, Auteur . - p.1-12. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 40 (August 2017) . - p.1-12 Mots-clés : Adaptive behavior  Fragile X syndrome  Infancy  Autism infant siblings Index. décimale : PER Périodiques Résumé : AbstractBackground Adaptive behaviors are essential for optimal outcomes and independence in individuals with developmental disabilities. This study examined longitudinal trajectories of adaptive behavior in infants with fragile X syndrome (FXS), compared to typical development (TD) and infant siblings of children diagnosed with autism (ASIBs). Method Participants included 76 male infants (FXS = 25, ASIBs = 27, TD = 24) assessed up to 4 times between 6 and 24 months of age for a total of 215 assessments of adaptive behavior. A sample of 12 females with FXS was included for a comparative sex analysis. Results Results indicate that infant males with FXS displayed lower initial adaptive behavior across all domains that emerged by 9 months-of-age with slower growth rates than both comparison groups. A flat profile across the domains at 24 months was evident. Increased severity of autism symptoms was related to reduced adaptive skills at 24 months-of-age. Females with FXS displayed higher scores than males on the Socialization and Motor domains and equivalent scores on the Communication and Daily Living domains at 9 months-of-age with different rates of growth across domains. Conclusions This is the first study to provide evidence of etiological specificity in adaptive behavior profiles during infancy across two populations at high risk for ASD. These findings support targeted adaptive behavior interventions in young children with FXS beginning as early at 9 months of age to reduce identified deficits and the cascading impacts of these early impairments. En ligne : https://doi.org/10.1016/j.rasd.2017.05.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317

Autism Spectrum Disorder Symptoms in Infants with Fragile X Syndrome: A Prospective Case Series / Abigail L. HOGAN in Journal of Autism and Developmental Disorders, 47-6 (June 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1628-1644 Titre : Autism Spectrum Disorder Symptoms in Infants with Fragile X Syndrome: A Prospective Case Series Type de document : texte imprimé Auteurs : Abigail L. HOGAN, Auteur ; Kelly E. CARAVELLA, Auteur ; Jordan EZELL, Auteur ; Lisa RAGUE, Auteur ; Kimberly HILLS, Auteur ; Jane E. ROBERTS, Auteur Article en page(s) : p.1628-1644 Langues : Anglais (eng) Mots-clés : Fragile X syndrome  Autism spectrum disorder  Infants  Case studies Index. décimale : PER Périodiques Résumé : No studies to date have prospectively examined early autism spectrum disorder (ASD) markers in infants with fragile X syndrome (FXS), who are at elevated risk for ASD. This paper describes the developmental profiles of eight infants with FXS from 9 to 24 months of age. Four meet diagnostic criteria for ASD at 24 months of age, and four do not. Trends in these case studies suggest that early social-communicative deficits differentiate infants with and without later ASD diagnoses in ways that are similar to later-born siblings of children with ASD. Repetitive behaviors and cognitive and adaptive impairments are present in all FXS infants throughout development, suggesting that these deficits reflect the general FXS phenotype and not ASD in FXS specifically. En ligne : http://dx.doi.org/10.1007/s10803-017-3081-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308 [article] Autism Spectrum Disorder Symptoms in Infants with Fragile X Syndrome: A Prospective Case Series [texte imprimé] / Abigail L. HOGAN, Auteur ; Kelly E. CARAVELLA, Auteur ; Jordan EZELL, Auteur ; Lisa RAGUE, Auteur ; Kimberly HILLS, Auteur ; Jane E. ROBERTS, Auteur . - p.1628-1644. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1628-1644 Mots-clés : Fragile X syndrome  Autism spectrum disorder  Infants  Case studies Index. décimale : PER Périodiques Résumé : No studies to date have prospectively examined early autism spectrum disorder (ASD) markers in infants with fragile X syndrome (FXS), who are at elevated risk for ASD. This paper describes the developmental profiles of eight infants with FXS from 9 to 24 months of age. Four meet diagnostic criteria for ASD at 24 months of age, and four do not. Trends in these case studies suggest that early social-communicative deficits differentiate infants with and without later ASD diagnoses in ways that are similar to later-born siblings of children with ASD. Repetitive behaviors and cognitive and adaptive impairments are present in all FXS infants throughout development, suggesting that these deficits reflect the general FXS phenotype and not ASD in FXS specifically. En ligne : http://dx.doi.org/10.1007/s10803-017-3081-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308

Brief Report: Autism Symptoms in Infants with Fragile X Syndrome / Jane E. ROBERTS in Journal of Autism and Developmental Disorders, 46-12 (December 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-12 (December 2016) . - p.3830-3837 Titre : Brief Report: Autism Symptoms in Infants with Fragile X Syndrome Type de document : texte imprimé Auteurs : Jane E. ROBERTS, Auteur ; Bridgette L. TONNSEN, Auteur ; Lindsay M. MCCARY, Auteur ; Kelly E. CARAVELLA, Auteur ; Svetlana V. SHINKAREVA, Auteur Article en page(s) : p.3830-3837 Langues : Anglais (eng) Mots-clés : Autism  Fragile X  Infants  Autism Observation Scale for Infants Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is the most common known genetic cause of autism spectrum disorder (ASD). Although 50–75 % of children with FXS meet ASD criteria, no studies have compared ASD symptoms in infants with FXS versus other high risk groups, such as siblings of children with ASD (ASIBs). Using the Autism Observation Scale for Infants, our findings indicate that 53 % of 12-month infants with FXS fall in the “at risk” category compared to 17 and 6 % for age-matched ASIBs and controls, respectively. Elevated atypical motor behaviors were associated with elevated risk for FXS. Cross-syndrome comparisons are essential to understanding the heterogeneity of ASD and identifying candidate markers that will facilitate differential diagnosis of ASD in genetic disorders such as FXS. En ligne : http://dx.doi.org/10.1007/s10803-016-2903-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Brief Report: Autism Symptoms in Infants with Fragile X Syndrome [texte imprimé] / Jane E. ROBERTS, Auteur ; Bridgette L. TONNSEN, Auteur ; Lindsay M. MCCARY, Auteur ; Kelly E. CARAVELLA, Auteur ; Svetlana V. SHINKAREVA, Auteur . - p.3830-3837. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-12 (December 2016) . - p.3830-3837 Mots-clés : Autism  Fragile X  Infants  Autism Observation Scale for Infants Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is the most common known genetic cause of autism spectrum disorder (ASD). Although 50–75 % of children with FXS meet ASD criteria, no studies have compared ASD symptoms in infants with FXS versus other high risk groups, such as siblings of children with ASD (ASIBs). Using the Autism Observation Scale for Infants, our findings indicate that 53 % of 12-month infants with FXS fall in the “at risk” category compared to 17 and 6 % for age-matched ASIBs and controls, respectively. Elevated atypical motor behaviors were associated with elevated risk for FXS. Cross-syndrome comparisons are essential to understanding the heterogeneity of ASD and identifying candidate markers that will facilitate differential diagnosis of ASD in genetic disorders such as FXS. En ligne : http://dx.doi.org/10.1007/s10803-016-2903-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

Differential cognitive and behavioral development from 6 to 24 months in autism and fragile X syndrome / Lindsay J. MULLIN in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : Differential cognitive and behavioral development from 6 to 24 months in autism and fragile X syndrome Type de document : texte imprimé Auteurs : Lindsay J. MULLIN, Auteur ; Joshua RUTSOHN, Auteur ; Julia L. GROSS, Auteur ; Kelly E. CARAVELLA, Auteur ; Rebecca L. GRZADZINSKI, Auteur ; Leigh Anne WEISENFELD, Auteur ; Lisa FLAKE, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; Annette M. ESTES, Auteur ; Juhi PANDEY, Auteur ; Robert T. SCHULTZ, Auteur ; Tanya ST JOHN, Auteur ; Jason J. WOLFF, Auteur ; Mark D. SHEN, Auteur ; Joseph PIVEN, Auteur ; Heather C. HAZLETT, Auteur ; Jessica B. GIRAULT, Auteur Langues : Anglais (eng) Mots-clés : Infant  Humans  Fragile X Syndrome/complications/psychology  Autism Spectrum Disorder/complications/psychology  Autistic Disorder  Language  Cognition  Autism  Behavioral  Cognitive  Development  Fragile X syndrome  Infancy Index. décimale : PER Périodiques Résumé : BACKGROUND: Specifying early developmental differences among neurodevelopmental disorders with distinct etiologies is critical to improving early identification and tailored intervention during the first years of life. Recent studies have uncovered important differences between infants with fragile X syndrome (FXS) and infants with familial history of autism spectrum disorder who go on to develop autism themselves (FH-ASD), including differences in brain development and behavior. Thus far, there have been no studies longitudinally investigating differential developmental skill profiles in FXS and FH-ASD infants. METHODS: The current study contrasted longitudinal trajectories of verbal (expressive and receptive language) and nonverbal (gross and fine motor, visual reception) skills in FXS and FH-ASD infants, compared to FH infants who did not develop ASD (FH-nonASD) and typically developing controls. RESULTS: Infants with FXS showed delays on a nonverbal composite compared to FH-ASD (as well as FH-nonASD and control) infants as early as 6 months of age. By 12 months an ordinal pattern of scores was established between groups on all domains tested, such that controls > FH-nonASD > FH-ASD > FXS. This pattern persisted through 24 months. Cognitive level differentially influenced developmental trajectories for FXS and FH-ASD. CONCLUSIONS: Our results demonstrate detectable group differences by 6 months between FXS and FH-ASD as well as differential trajectories on each domain throughout infancy. This work further highlights an earlier onset of global cognitive delays in FXS and, conversely, a protracted period of more slowly emerging delays in FH-ASD. Divergent neural and cognitive development in infancy between FXS and FH-ASD contributes to our understanding of important distinctions in the development and behavioral phenotype of these two groups. En ligne : https://dx.doi.org/10.1186/s11689-024-09519-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Differential cognitive and behavioral development from 6 to 24 months in autism and fragile X syndrome [texte imprimé] / Lindsay J. MULLIN, Auteur ; Joshua RUTSOHN, Auteur ; Julia L. GROSS, Auteur ; Kelly E. CARAVELLA, Auteur ; Rebecca L. GRZADZINSKI, Auteur ; Leigh Anne WEISENFELD, Auteur ; Lisa FLAKE, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; Annette M. ESTES, Auteur ; Juhi PANDEY, Auteur ; Robert T. SCHULTZ, Auteur ; Tanya ST JOHN, Auteur ; Jason J. WOLFF, Auteur ; Mark D. SHEN, Auteur ; Joseph PIVEN, Auteur ; Heather C. HAZLETT, Auteur ; Jessica B. GIRAULT, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Infant  Humans  Fragile X Syndrome/complications/psychology  Autism Spectrum Disorder/complications/psychology  Autistic Disorder  Language  Cognition  Autism  Behavioral  Cognitive  Development  Fragile X syndrome  Infancy Index. décimale : PER Périodiques Résumé : BACKGROUND: Specifying early developmental differences among neurodevelopmental disorders with distinct etiologies is critical to improving early identification and tailored intervention during the first years of life. Recent studies have uncovered important differences between infants with fragile X syndrome (FXS) and infants with familial history of autism spectrum disorder who go on to develop autism themselves (FH-ASD), including differences in brain development and behavior. Thus far, there have been no studies longitudinally investigating differential developmental skill profiles in FXS and FH-ASD infants. METHODS: The current study contrasted longitudinal trajectories of verbal (expressive and receptive language) and nonverbal (gross and fine motor, visual reception) skills in FXS and FH-ASD infants, compared to FH infants who did not develop ASD (FH-nonASD) and typically developing controls. RESULTS: Infants with FXS showed delays on a nonverbal composite compared to FH-ASD (as well as FH-nonASD and control) infants as early as 6 months of age. By 12 months an ordinal pattern of scores was established between groups on all domains tested, such that controls > FH-nonASD > FH-ASD > FXS. This pattern persisted through 24 months. Cognitive level differentially influenced developmental trajectories for FXS and FH-ASD. CONCLUSIONS: Our results demonstrate detectable group differences by 6 months between FXS and FH-ASD as well as differential trajectories on each domain throughout infancy. This work further highlights an earlier onset of global cognitive delays in FXS and, conversely, a protracted period of more slowly emerging delays in FH-ASD. Divergent neural and cognitive development in infancy between FXS and FH-ASD contributes to our understanding of important distinctions in the development and behavioral phenotype of these two groups. En ligne : https://dx.doi.org/10.1186/s11689-024-09519-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

Navigating family messaging: Qualitative experiences of Black caregivers of children with autism / Dalia MARQUEZ in Autism, 29-12 (December 2025)  

Public ISBD [article]  inAutism > 29-12 (December 2025) . - p.3047-3057 Titre : Navigating family messaging: Qualitative experiences of Black caregivers of children with autism Type de document : texte imprimé Auteurs : Dalia MARQUEZ, Auteur ; Kattia MATA, Auteur ; Felicia WILLIAMS BROWN, Auteur ; Mary E. GREWE, Auteur ; Joseph PIVEN, Auteur ; Kelly E. CARAVELLA, Auteur Article en page(s) : p.3047-3057 Langues : Anglais (eng) Mots-clés : autism  Black families  caregivers  family messaging Index. décimale : PER Périodiques Résumé : Black caregivers of children with autism express that there are gaps in both knowledge and acceptance of disabilities within their communities. This lack of information and resources provided to Black communities can lead to tensions within families regarding autism diagnoses and how to support individuals with autism in their families. As part of a larger qualitative study, 23 Black caregivers of children with autism shared their experiences with the messages received from family members about their child’s autism diagnosis. Two overarching themes emerged regarding family messaging: Lack of Understanding and Denial of Autism and Supportive Acceptance and Inclusion. Six subthemes were identified that highlight the nuance within the messaging content. These findings can inform strategies to develop culturally tailored interventions to support Black caregivers in navigating the range of messages received from family members when their child receives a diagnosis of autism. Further research should build on these findings to investigate how directly this family messaging links to broader messaging in Black culture regarding autism, as well as how both family and cultural messaging may interact with factors such as awareness or use of autism resources, attitudes toward research, and long-term social and behavioral outcomes for Black children with autism.Lay abstract Black caregivers of children with autism say there are gaps in knowledge and acceptance of disabilities in their communities. This lack of information and resources can cause tensions in families about autism diagnoses and how to support their children. This study talked to 23 Black caregivers to learn about their experiences with the messages they received about their child’s autism diagnosis from family members. We found two main themes: Lack of Understanding and Denial of Autism, and Supportive Acceptance and Inclusion. Within these themes, parents shared different experiences, like family members denying autism exists, not wanting to learn about it, or being very supportive and inclusive. Black caregivers also talked about the emotional toll the negative messages take on them. This work is important because it can help create culturally tailored support for Black caregivers of children with autism, so that they can engage with family members in more supportive ways. Future research should look at how these messages affect the use of autism resources, attitudes toward research, and long-term outcomes for Black children with autism. En ligne : https://dx.doi.org/10.1177/13623613251361604 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572 [article] Navigating family messaging: Qualitative experiences of Black caregivers of children with autism [texte imprimé] / Dalia MARQUEZ, Auteur ; Kattia MATA, Auteur ; Felicia WILLIAMS BROWN, Auteur ; Mary E. GREWE, Auteur ; Joseph PIVEN, Auteur ; Kelly E. CARAVELLA, Auteur . - p.3047-3057. Langues : Anglais (eng) in Autism > 29-12 (December 2025) . - p.3047-3057 Mots-clés : autism  Black families  caregivers  family messaging Index. décimale : PER Périodiques Résumé : Black caregivers of children with autism express that there are gaps in both knowledge and acceptance of disabilities within their communities. This lack of information and resources provided to Black communities can lead to tensions within families regarding autism diagnoses and how to support individuals with autism in their families. As part of a larger qualitative study, 23 Black caregivers of children with autism shared their experiences with the messages received from family members about their child’s autism diagnosis. Two overarching themes emerged regarding family messaging: Lack of Understanding and Denial of Autism and Supportive Acceptance and Inclusion. Six subthemes were identified that highlight the nuance within the messaging content. These findings can inform strategies to develop culturally tailored interventions to support Black caregivers in navigating the range of messages received from family members when their child receives a diagnosis of autism. Further research should build on these findings to investigate how directly this family messaging links to broader messaging in Black culture regarding autism, as well as how both family and cultural messaging may interact with factors such as awareness or use of autism resources, attitudes toward research, and long-term social and behavioral outcomes for Black children with autism.Lay abstract Black caregivers of children with autism say there are gaps in knowledge and acceptance of disabilities in their communities. This lack of information and resources can cause tensions in families about autism diagnoses and how to support their children. This study talked to 23 Black caregivers to learn about their experiences with the messages they received about their child’s autism diagnosis from family members. We found two main themes: Lack of Understanding and Denial of Autism, and Supportive Acceptance and Inclusion. Within these themes, parents shared different experiences, like family members denying autism exists, not wanting to learn about it, or being very supportive and inclusive. Black caregivers also talked about the emotional toll the negative messages take on them. This work is important because it can help create culturally tailored support for Black caregivers of children with autism, so that they can engage with family members in more supportive ways. Future research should look at how these messages affect the use of autism resources, attitudes toward research, and long-term outcomes for Black children with autism. En ligne : https://dx.doi.org/10.1177/13623613251361604 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572

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