No relationship between early postnatal testosterone concentrations and autistic traits in 18 to 30-month-old children / Karson T.F. KUNG in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 15p. Titre : No relationship between early postnatal testosterone concentrations and autistic traits in 18 to 30-month-old children Type de document : texte imprimé Auteurs : Karson T.F. KUNG, Auteur ; Mihaela CONSTANTINESCU, Auteur ; Wendy V. BROWNE, Auteur ; Rebecca M. NOORDERHAVEN, Auteur ; Melissa HINES, Auteur Article en page(s) : 15p. Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder/metabolism/psychology  Birth Weight  Child Development  Child, Preschool  Female  Humans  Infant  Male  Maternal Age  Parents/education  Paternal Age  Risk Factors  Saliva/chemistry  Siblings  Surveys and Questionnaires  Symptom Assessment  Testosterone/analysis  Autism  Gender differences  Postnatal development  Sex differences  Testosterone Index. décimale : PER Périodiques Résumé : BACKGROUND: Some previous research has suggested that testosterone prenatally contributes to gender differences in autistic traits, but little is known about the role of testosterone during early postnatal development (mini-puberty). Two prior studies found no sex difference in testosterone postnatally in saliva samples and detected little to no relationship between testosterone postnatally and autistic traits in toddlers. These findings may reflect late measurements of testosterone at 3 to 4 months of age, after the peak of mini-puberty at 1 to 3 months of age. The present study examined the relationship between testosterone at 1 to 3 months of age and autistic traits at 18 to 30 months of age. FINDINGS: Testosterone was measured in saliva samples collected from children at 1 to 3 months of age. When the children (40 boys, 47 girls) reached 18 to 30 months of age, parents completed the Quantitative Checklist for Autism in Toddlers (Q-CHAT). Boys had higher concentrations of testosterone postnatally and higher Q-CHAT scores than girls. However, testosterone did not correlate with Q-CHAT scores in boys, girls, or the entire sample. CONCLUSIONS: The current results suggest that testosterone during the early postnatal period does not contribute to later autistic traits. Given our relatively small samples and therefore limited power, however, further research could usefully examine if testosterone in saliva samples collected during the peak of mini-puberty in larger groups predicts autistic traits or other traits that show gender differences. En ligne : http://dx.doi.org/10.1186/s13229-016-0078-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 [article] No relationship between early postnatal testosterone concentrations and autistic traits in 18 to 30-month-old children [texte imprimé] / Karson T.F. KUNG, Auteur ; Mihaela CONSTANTINESCU, Auteur ; Wendy V. BROWNE, Auteur ; Rebecca M. NOORDERHAVEN, Auteur ; Melissa HINES, Auteur . - 15p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 15p. Mots-clés : Adult  Autism Spectrum Disorder/metabolism/psychology  Birth Weight  Child Development  Child, Preschool  Female  Humans  Infant  Male  Maternal Age  Parents/education  Paternal Age  Risk Factors  Saliva/chemistry  Siblings  Surveys and Questionnaires  Symptom Assessment  Testosterone/analysis  Autism  Gender differences  Postnatal development  Sex differences  Testosterone Index. décimale : PER Périodiques Résumé : BACKGROUND: Some previous research has suggested that testosterone prenatally contributes to gender differences in autistic traits, but little is known about the role of testosterone during early postnatal development (mini-puberty). Two prior studies found no sex difference in testosterone postnatally in saliva samples and detected little to no relationship between testosterone postnatally and autistic traits in toddlers. These findings may reflect late measurements of testosterone at 3 to 4 months of age, after the peak of mini-puberty at 1 to 3 months of age. The present study examined the relationship between testosterone at 1 to 3 months of age and autistic traits at 18 to 30 months of age. FINDINGS: Testosterone was measured in saliva samples collected from children at 1 to 3 months of age. When the children (40 boys, 47 girls) reached 18 to 30 months of age, parents completed the Quantitative Checklist for Autism in Toddlers (Q-CHAT). Boys had higher concentrations of testosterone postnatally and higher Q-CHAT scores than girls. However, testosterone did not correlate with Q-CHAT scores in boys, girls, or the entire sample. CONCLUSIONS: The current results suggest that testosterone during the early postnatal period does not contribute to later autistic traits. Given our relatively small samples and therefore limited power, however, further research could usefully examine if testosterone in saliva samples collected during the peak of mini-puberty in larger groups predicts autistic traits or other traits that show gender differences. En ligne : http://dx.doi.org/10.1186/s13229-016-0078-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328

No relationship between prenatal androgen exposure and autistic traits: convergent evidence from studies of children with congenital adrenal hyperplasia and of amniotic testosterone concentrations in typically developing children / Karson T.F. KUNG in Journal of Child Psychology and Psychiatry, 57-12 (December 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-12 (December 2016) . - p.1455-1462 Titre : No relationship between prenatal androgen exposure and autistic traits: convergent evidence from studies of children with congenital adrenal hyperplasia and of amniotic testosterone concentrations in typically developing children Type de document : texte imprimé Auteurs : Karson T.F. KUNG, Auteur ; Debra SPENCER, Auteur ; Vickie PASTERSKI, Auteur ; Sharon NEUFELD, Auteur ; Vivette GLOVER, Auteur ; Thomas G. O'CONNOR, Auteur ; Peter C. HINDMARSH, Auteur ; Ieuan A. HUGHES, Auteur ; Carlo L. ACERINI, Auteur ; Melissa HINES, Auteur Article en page(s) : p.1455-1462 Langues : Anglais (eng) Mots-clés : Congenital adrenal hyperplasia  fetal testosterone  prenatal testosterone exposure  autism  autistic traits  extreme male brain Index. décimale : PER Périodiques Résumé : Background There is a marked male preponderance in autism spectrum conditions. The extreme male brain theory and the fetal androgen theory of autism suggest that elevated prenatal testosterone exposure is a key contributor to autistic traits. The current paper reports findings from two separate studies that test this hypothesis. Methods A parent-report questionnaire, the Childhood Autism Spectrum Test (CAST), was employed to measure autistic traits in both studies. The first study examined autistic traits in young children with congenital adrenal hyperplasia (CAH), a condition causing unusually high concentrations of testosterone prenatally in girls. Eighty one children with CAH (43 girls) and 72 unaffected relatives (41 girls), aged 4–11 years, were assessed. The second study examined autistic traits in relation to amniotic testosterone in 92 typically developing children (48 girls), aged 3–5 years. Results Findings from neither study supported the association between prenatal androgen (testosterone) exposure and autistic traits. Specifically, young girls with and without CAH did not differ significantly in CAST scores and amniotic testosterone concentrations were not significantly associated with CAST scores in boys, girls, or the whole sample. Conclusions These studies do not support a relationship between prenatal testosterone exposure and autistic traits. These findings augment prior research suggesting no consistent relationship between early androgen exposure and autistic traits. En ligne : http://dx.doi.org/10.1111/jcpp.12602 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] No relationship between prenatal androgen exposure and autistic traits: convergent evidence from studies of children with congenital adrenal hyperplasia and of amniotic testosterone concentrations in typically developing children [texte imprimé] / Karson T.F. KUNG, Auteur ; Debra SPENCER, Auteur ; Vickie PASTERSKI, Auteur ; Sharon NEUFELD, Auteur ; Vivette GLOVER, Auteur ; Thomas G. O'CONNOR, Auteur ; Peter C. HINDMARSH, Auteur ; Ieuan A. HUGHES, Auteur ; Carlo L. ACERINI, Auteur ; Melissa HINES, Auteur . - p.1455-1462. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-12 (December 2016) . - p.1455-1462 Mots-clés : Congenital adrenal hyperplasia  fetal testosterone  prenatal testosterone exposure  autism  autistic traits  extreme male brain Index. décimale : PER Périodiques Résumé : Background There is a marked male preponderance in autism spectrum conditions. The extreme male brain theory and the fetal androgen theory of autism suggest that elevated prenatal testosterone exposure is a key contributor to autistic traits. The current paper reports findings from two separate studies that test this hypothesis. Methods A parent-report questionnaire, the Childhood Autism Spectrum Test (CAST), was employed to measure autistic traits in both studies. The first study examined autistic traits in young children with congenital adrenal hyperplasia (CAH), a condition causing unusually high concentrations of testosterone prenatally in girls. Eighty one children with CAH (43 girls) and 72 unaffected relatives (41 girls), aged 4–11 years, were assessed. The second study examined autistic traits in relation to amniotic testosterone in 92 typically developing children (48 girls), aged 3–5 years. Results Findings from neither study supported the association between prenatal androgen (testosterone) exposure and autistic traits. Specifically, young girls with and without CAH did not differ significantly in CAST scores and amniotic testosterone concentrations were not significantly associated with CAST scores in boys, girls, or the whole sample. Conclusions These studies do not support a relationship between prenatal testosterone exposure and autistic traits. These findings augment prior research suggesting no consistent relationship between early androgen exposure and autistic traits. En ligne : http://dx.doi.org/10.1111/jcpp.12602 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

No relationship between prenatal or early postnatal androgen exposure and autistic traits: evidence using anogenital distance and penile length measurements at birth and 3 months of age / Karson T.F. KUNG in Journal of Child Psychology and Psychiatry, 62-7 (July 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.876-883 Titre : No relationship between prenatal or early postnatal androgen exposure and autistic traits: evidence using anogenital distance and penile length measurements at birth and 3 months of age Type de document : texte imprimé Auteurs : Karson T.F. KUNG, Auteur ; Ajay THANKAMONY, Auteur ; Ken K.L. ONG, Auteur ; Carlo L. ACERINI, Auteur ; David B. DUNGER, Auteur ; Ieuan A. HUGHES, Auteur ; Melissa HINES, Auteur Article en page(s) : p.876-883 Langues : Anglais (eng) Mots-clés : Androgens  Autistic Disorder  Child  Female  Humans  Infant, Newborn  Male  Pregnancy  Surveys and Questionnaires  Anogenital distance  autism  autistic traits  extreme male brain  gender  penile length Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism is more prevalent in males than in females. Hypotheses related to the extreme male brain theory of autism suggest that heightened androgen exposure during early development contributes to autistic traits. Whilst prior research focused mostly on the prenatal period, the current study tests the influences of androgen exposure during both the prenatal and the early postnatal periods on autistic traits during childhood. METHODS: Anthropometric measures that are putative biomarkers of early androgen exposure were employed. Anogenital distance (AGD) was measured at birth and 3 months of age in boys and girls. Penile length at birth and 3 months of age was also measured in boys. When the children were 9-13 years old, a parent-reported questionnaire (the 10-item children's version of the Autism Spectrum Quotient; AQ-10 Child) was used to assess autistic traits in 97 boys and 110 girls. RESULTS: There were no significant associations between any of the AGD or penile length measures and scores on the AQ-10 Child in boys, girls or the entire sample. CONCLUSIONS: The current study provides the first test of whether early measurements of AGD and/or penile length predict subsequent autistic traits. The current findings do not support a relationship between prenatal or early postnatal androgen exposure and autistic traits. The current study augments prior research showing no consistent relationship between early androgen exposure and autistic traits. En ligne : http://dx.doi.org/10.1111/jcpp.13335 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] No relationship between prenatal or early postnatal androgen exposure and autistic traits: evidence using anogenital distance and penile length measurements at birth and 3 months of age [texte imprimé] / Karson T.F. KUNG, Auteur ; Ajay THANKAMONY, Auteur ; Ken K.L. ONG, Auteur ; Carlo L. ACERINI, Auteur ; David B. DUNGER, Auteur ; Ieuan A. HUGHES, Auteur ; Melissa HINES, Auteur . - p.876-883. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.876-883 Mots-clés : Androgens  Autistic Disorder  Child  Female  Humans  Infant, Newborn  Male  Pregnancy  Surveys and Questionnaires  Anogenital distance  autism  autistic traits  extreme male brain  gender  penile length Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism is more prevalent in males than in females. Hypotheses related to the extreme male brain theory of autism suggest that heightened androgen exposure during early development contributes to autistic traits. Whilst prior research focused mostly on the prenatal period, the current study tests the influences of androgen exposure during both the prenatal and the early postnatal periods on autistic traits during childhood. METHODS: Anthropometric measures that are putative biomarkers of early androgen exposure were employed. Anogenital distance (AGD) was measured at birth and 3 months of age in boys and girls. Penile length at birth and 3 months of age was also measured in boys. When the children were 9-13 years old, a parent-reported questionnaire (the 10-item children's version of the Autism Spectrum Quotient; AQ-10 Child) was used to assess autistic traits in 97 boys and 110 girls. RESULTS: There were no significant associations between any of the AGD or penile length measures and scores on the AQ-10 Child in boys, girls or the entire sample. CONCLUSIONS: The current study provides the first test of whether early measurements of AGD and/or penile length predict subsequent autistic traits. The current findings do not support a relationship between prenatal or early postnatal androgen exposure and autistic traits. The current study augments prior research showing no consistent relationship between early androgen exposure and autistic traits. En ligne : http://dx.doi.org/10.1111/jcpp.13335 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

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