Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism / C. LAIDI in Journal of Autism and Developmental Disorders, 49-4 (April 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1402-1409 Titre : Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism Type de document : Texte imprimé et/ou numérique Auteurs : C. LAIDI, Auteur ; J. BOISGONTIER, Auteur ; A. DE PIERREFEU, Auteur ; Edouard DUCHESNAY, Auteur ; S. HOTIER, Auteur ; M. A. D'ALBIS, Auteur ; R. DELORME, Auteur ; Federico BOLOGNANI, Auteur ; C. CZECH, Auteur ; C. BOUQUET, Auteur ; Anouck AMESTOY, Auteur ; J. PETIT, Auteur ; S. HOLIGA, Auteur ; J. DUKART, Auteur ; A. GAMAN, Auteur ; E. TOLEDANO, Auteur ; M. LY-LE MOAL, Auteur ; Isabelle SCHEID, Auteur ; M. LEBOYER, Auteur ; J. HOUENOU, Auteur Article en page(s) : p.1402-1409 Langues : Anglais (eng) Mots-clés : Adults  Anterior cingulate cortex  Autism  Mri Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder underdiagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high functioning adults with ASD and 195 controls. We ran our analyses on a discovery (n = 301) and a replication sample (n = 61). The right caudal anterior cingulate cortical thickness was significantly thinner in adults with ASD compared to controls in both the discovery and the replication sample. Our work underlines the relevance of studying the brain anatomy of an adult ASD population. En ligne : https://dx.doi.org/10.1007/s10803-018-3807-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 [article] Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism [Texte imprimé et/ou numérique] / C. LAIDI, Auteur ; J. BOISGONTIER, Auteur ; A. DE PIERREFEU, Auteur ; Edouard DUCHESNAY, Auteur ; S. HOTIER, Auteur ; M. A. D'ALBIS, Auteur ; R. DELORME, Auteur ; Federico BOLOGNANI, Auteur ; C. CZECH, Auteur ; C. BOUQUET, Auteur ; Anouck AMESTOY, Auteur ; J. PETIT, Auteur ; S. HOLIGA, Auteur ; J. DUKART, Auteur ; A. GAMAN, Auteur ; E. TOLEDANO, Auteur ; M. LY-LE MOAL, Auteur ; Isabelle SCHEID, Auteur ; M. LEBOYER, Auteur ; J. HOUENOU, Auteur . - p.1402-1409. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1402-1409 Mots-clés : Adults  Anterior cingulate cortex  Autism  Mri Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder underdiagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high functioning adults with ASD and 195 controls. We ran our analyses on a discovery (n = 301) and a replication sample (n = 61). The right caudal anterior cingulate cortical thickness was significantly thinner in adults with ASD compared to controls in both the discovery and the replication sample. Our work underlines the relevance of studying the brain anatomy of an adult ASD population. En ligne : https://dx.doi.org/10.1007/s10803-018-3807-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388

Gender differences in autism spectrum disorders: Divergence among specific core symptoms / Anita BEGGIATO in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.680-689 Titre : Gender differences in autism spectrum disorders: Divergence among specific core symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Anita BEGGIATO, Auteur ; Hugo PEYRE, Auteur ; Anna MARUANI, Auteur ; Isabelle SCHEID, Auteur ; Maria RASTAM, Auteur ; Frédérique AMSELLEM, Auteur ; Carina I. GILLBERG, Auteur ; Marion LEBOYER, Auteur ; Thomas BOURGERON, Auteur ; Christopher GILLBERG, Auteur ; Richard DELORME, Auteur Article en page(s) : p.680-689 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  sex  gender  autism diagnosis interview-revised Index. décimale : PER Périodiques Résumé : Community-based studies have consistently shown a sex ratio heavily skewed towards males in autism spectrum disorders (ASD). The factors underlying this predominance of males are largely unknown, but the way girls score on standardized categorical diagnostic tools might account for the underrecognition of ASD in girls. Despite the existence of different norms for boys and girls with ASD on several major screening tests, the algorithm of the Autism Diagnosis Interview-Revised (ADI-R) has not been reformulated. The aim of our study was to investigate which ADI-R items discriminate between males and females, and to evaluate their weighting in the final diagnosis of autism. We then conducted discriminant analysis (DA) on a sample of 594 probands including 129 females with ASD, recruited by the Paris Autism Research International Sibpair (PARIS) Study. A replication analysis was run on an independent sample of 1716 probands including 338 females with ASD, recruited through the Autism Genetics Resource Exchange (AGRE) program. Entering the raw scores for all ADI-R items as independent variables, the DA correctly classified 78.9% of males and 72.9% of females (P? En ligne : http://dx.doi.org/10.1002/aur.1715 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Gender differences in autism spectrum disorders: Divergence among specific core symptoms [Texte imprimé et/ou numérique] / Anita BEGGIATO, Auteur ; Hugo PEYRE, Auteur ; Anna MARUANI, Auteur ; Isabelle SCHEID, Auteur ; Maria RASTAM, Auteur ; Frédérique AMSELLEM, Auteur ; Carina I. GILLBERG, Auteur ; Marion LEBOYER, Auteur ; Thomas BOURGERON, Auteur ; Christopher GILLBERG, Auteur ; Richard DELORME, Auteur . - p.680-689. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.680-689 Mots-clés : autism spectrum disorders  sex  gender  autism diagnosis interview-revised Index. décimale : PER Périodiques Résumé : Community-based studies have consistently shown a sex ratio heavily skewed towards males in autism spectrum disorders (ASD). The factors underlying this predominance of males are largely unknown, but the way girls score on standardized categorical diagnostic tools might account for the underrecognition of ASD in girls. Despite the existence of different norms for boys and girls with ASD on several major screening tests, the algorithm of the Autism Diagnosis Interview-Revised (ADI-R) has not been reformulated. The aim of our study was to investigate which ADI-R items discriminate between males and females, and to evaluate their weighting in the final diagnosis of autism. We then conducted discriminant analysis (DA) on a sample of 594 probands including 129 females with ASD, recruited by the Paris Autism Research International Sibpair (PARIS) Study. A replication analysis was run on an independent sample of 1716 probands including 338 females with ASD, recruited through the Autism Genetics Resource Exchange (AGRE) program. Entering the raw scores for all ADI-R items as independent variables, the DA correctly classified 78.9% of males and 72.9% of females (P? En ligne : http://dx.doi.org/10.1002/aur.1715 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Persistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events? / M. BENNABI in Molecular Autism, 10 (2019)  

Public ISBD [article]  inMolecular Autism > 10 (2019) . - 22p. Titre : Persistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events? Type de document : Texte imprimé et/ou numérique Auteurs : M. BENNABI, Auteur ; N. TARANTINO, Auteur ; A. GAMAN, Auteur ; Isabelle SCHEID, Auteur ; R. KRISHNAMOORTHY, Auteur ; P. DEBRE, Auteur ; A. BOULEAU, Auteur ; M. CARALP, Auteur ; S. GUEGUEN, Auteur ; M. L. LE-MOAL, Auteur ; Manuel P. BOUVARD, Auteur ; Anouck AMESTOY, Auteur ; R. DELORME, Auteur ; M. LEBOYER, Auteur ; R. TAMOUZA, Auteur ; V. VIEILLARD, Auteur Article en page(s) : 22p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  High-functioning autism  Natural killer cells  Pathogens Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASD) are characterized by abnormal neurodevelopment, genetic, and environmental risk factors, as well as immune dysfunctions. Several lines of evidence suggest alterations in innate immune responses in children with ASD. To address this question in adults with high-functioning ASD (hf-ASD), we sought to investigate the role of natural killer (NK) cells in the persistence of ASD. Methods: NK cells from 35 adults with hf-ASD were compared to that of 35 healthy controls (HC), selected for the absence of any immune dysfunctions, at different time-points, and over a 2-year follow-up period for four patients. The phenotype and polyfunctional capacities of NK cells were explored according to infectious stigma and clinical parameters (IQ, social, and communication scores). Results: As compared to HC, NK cells from patients with hf-ASD showed a high level of cell activation (p < 0.0001), spontaneous degranulation (p < 0.0001), and interferon-gamma production (p = 0.0004), whereas they were exhausted after in vitro stimulations (p = 0.0006). These data yielded a specific HLA-DR(+)KIR2DL1(+)NKG2C(+) NK-cell signature. Significant overexpression of NKG2C in hf-ASD patients (p = 0.0005), indicative of viral infections, was inversely correlated with the NKp46 receptor level (r = - 0.67; p < 0.0001), regardless of the IgG status of tested pathogens. Multivariate linear regression analysis also revealed that expression of the late-activating HLA-DR marker was both associated with structural language (r = 0.48; p = 0.007) and social awareness (r = 0.60; p = 0.0007) scores in adult patients with hf-ASD, while KIR2DL1 expression correlated with IQ scores (p = 0.0083). Conclusions: This study demonstrates that adults with hf-ASD have specific NK-cell profile. Presence of NKG2C overexpression together with high-level activation of NK cells suggest an association with underlying pathogens, a hypothesis warranting further exploration in future studies. En ligne : http://dx.doi.org/10.1186/s13229-019-0269-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402 [article] Persistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events? [Texte imprimé et/ou numérique] / M. BENNABI, Auteur ; N. TARANTINO, Auteur ; A. GAMAN, Auteur ; Isabelle SCHEID, Auteur ; R. KRISHNAMOORTHY, Auteur ; P. DEBRE, Auteur ; A. BOULEAU, Auteur ; M. CARALP, Auteur ; S. GUEGUEN, Auteur ; M. L. LE-MOAL, Auteur ; Manuel P. BOUVARD, Auteur ; Anouck AMESTOY, Auteur ; R. DELORME, Auteur ; M. LEBOYER, Auteur ; R. TAMOUZA, Auteur ; V. VIEILLARD, Auteur . - 22p. Langues : Anglais (eng) in Molecular Autism > 10 (2019) . - 22p. Mots-clés : Autism spectrum disorders  High-functioning autism  Natural killer cells  Pathogens Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASD) are characterized by abnormal neurodevelopment, genetic, and environmental risk factors, as well as immune dysfunctions. Several lines of evidence suggest alterations in innate immune responses in children with ASD. To address this question in adults with high-functioning ASD (hf-ASD), we sought to investigate the role of natural killer (NK) cells in the persistence of ASD. Methods: NK cells from 35 adults with hf-ASD were compared to that of 35 healthy controls (HC), selected for the absence of any immune dysfunctions, at different time-points, and over a 2-year follow-up period for four patients. The phenotype and polyfunctional capacities of NK cells were explored according to infectious stigma and clinical parameters (IQ, social, and communication scores). Results: As compared to HC, NK cells from patients with hf-ASD showed a high level of cell activation (p < 0.0001), spontaneous degranulation (p < 0.0001), and interferon-gamma production (p = 0.0004), whereas they were exhausted after in vitro stimulations (p = 0.0006). These data yielded a specific HLA-DR(+)KIR2DL1(+)NKG2C(+) NK-cell signature. Significant overexpression of NKG2C in hf-ASD patients (p = 0.0005), indicative of viral infections, was inversely correlated with the NKp46 receptor level (r = - 0.67; p < 0.0001), regardless of the IgG status of tested pathogens. Multivariate linear regression analysis also revealed that expression of the late-activating HLA-DR marker was both associated with structural language (r = 0.48; p = 0.007) and social awareness (r = 0.60; p = 0.0007) scores in adult patients with hf-ASD, while KIR2DL1 expression correlated with IQ scores (p = 0.0083). Conclusions: This study demonstrates that adults with hf-ASD have specific NK-cell profile. Presence of NKG2C overexpression together with high-level activation of NK cells suggest an association with underlying pathogens, a hypothesis warranting further exploration in future studies. En ligne : http://dx.doi.org/10.1186/s13229-019-0269-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402

"Reading the Mind in the Eyes" in Autistic Adults is Modulated by Valence and Difficulty: An InFoR Study / Matias BALTAZAR in Autism Research, 14-2 (February 2021)  

Public ISBD [article]  inAutism Research > 14-2 (February 2021) . - p.380-388 Titre : "Reading the Mind in the Eyes" in Autistic Adults is Modulated by Valence and Difficulty: An InFoR Study Type de document : Texte imprimé et/ou numérique Auteurs : Matias BALTAZAR, Auteur ; Marie-Maude GEOFFRAY, Auteur ; Christopher H. CHATHAM, Auteur ; Manuel P. BOUVARD, Auteur ; Axelle MARTINEZ TERUEL, Auteur ; David MONNET, Auteur ; Isabelle SCHEID, Auteur ; Eleonora MURZI, Auteur ; Sandrine COUFFIN-CADIERGUES, Auteur ; Daniel UMBRICHT, Auteur ; Lorraine MURTAGH, Auteur ; Richard DELORME, Auteur ; Myriam LY LE-MOAL, Auteur ; Marion LEBOYER, Auteur ; Anouck AMESTOY, Auteur Article en page(s) : p.380-388 Langues : Anglais (eng) Mots-clés : Generalized Linear Mixed Model  Reading the Mind in the Eyes  autism spectrum disorders  difficulty  valence Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are heterogeneous and complex neurodevelopmental conditions that urgently need reliable and sensitive measures to inform diagnosis properly. The Reading the Mind in the Eyes Task (or Eyes Test from now on) is widely used for this purpose. A recent study showed that subcategories of items of the children version of the Eyes Test could be especially discriminative to distinguish ASD and control children. Here, we analyzed the performance on the Eyes Test of 30 high functioning (IQ?>?70) adults with ASD and 29 controls from the InFoR cohort multicentric study, using a Generalized Linear Mixed Model. We found that valence and difficulty modulate the performance on the Eyes Test, with easy and positive items being the most discriminative to distinguish ASD and controls. In particular, we suggest this result might be actionable to discriminate ASD patients from controls in subgroups where their overall scores show less difference with controls. We propose for future research the computation of two additional indexes when using the Eyes Test: the first focusing on the easy and positive items (applying a threshold of 70% of correct responses for these items, above which people are at very low risk of having ASD) and the second focusing on the performance gain from difficult to easy items (with a progression of less than 15% showing high risk of having ASD). Our findings open the possibility for a major change in how the Eyes Test is used to inform diagnosis in ASD. LAY SUMMARY: The Eyes Test is used worldwide to inform autism spectrum disorders (ASD) diagnosis. We show here that ASD and neurotypical adults show the most difference in performance on subgroups of items: ASD adults do not improve as expected when comparing easy and difficult items, and they do not show an improvement for items displaying a positive feeling. We advise clinicians to focus on these comparisons to increase the property of the test to distinguish people with ASD from neurotypical adults. En ligne : http://dx.doi.org/10.1002/aur.2390 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441 [article] "Reading the Mind in the Eyes" in Autistic Adults is Modulated by Valence and Difficulty: An InFoR Study [Texte imprimé et/ou numérique] / Matias BALTAZAR, Auteur ; Marie-Maude GEOFFRAY, Auteur ; Christopher H. CHATHAM, Auteur ; Manuel P. BOUVARD, Auteur ; Axelle MARTINEZ TERUEL, Auteur ; David MONNET, Auteur ; Isabelle SCHEID, Auteur ; Eleonora MURZI, Auteur ; Sandrine COUFFIN-CADIERGUES, Auteur ; Daniel UMBRICHT, Auteur ; Lorraine MURTAGH, Auteur ; Richard DELORME, Auteur ; Myriam LY LE-MOAL, Auteur ; Marion LEBOYER, Auteur ; Anouck AMESTOY, Auteur . - p.380-388. Langues : Anglais (eng) in Autism Research > 14-2 (February 2021) . - p.380-388 Mots-clés : Generalized Linear Mixed Model  Reading the Mind in the Eyes  autism spectrum disorders  difficulty  valence Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are heterogeneous and complex neurodevelopmental conditions that urgently need reliable and sensitive measures to inform diagnosis properly. The Reading the Mind in the Eyes Task (or Eyes Test from now on) is widely used for this purpose. A recent study showed that subcategories of items of the children version of the Eyes Test could be especially discriminative to distinguish ASD and control children. Here, we analyzed the performance on the Eyes Test of 30 high functioning (IQ?>?70) adults with ASD and 29 controls from the InFoR cohort multicentric study, using a Generalized Linear Mixed Model. We found that valence and difficulty modulate the performance on the Eyes Test, with easy and positive items being the most discriminative to distinguish ASD and controls. In particular, we suggest this result might be actionable to discriminate ASD patients from controls in subgroups where their overall scores show less difference with controls. We propose for future research the computation of two additional indexes when using the Eyes Test: the first focusing on the easy and positive items (applying a threshold of 70% of correct responses for these items, above which people are at very low risk of having ASD) and the second focusing on the performance gain from difficult to easy items (with a progression of less than 15% showing high risk of having ASD). Our findings open the possibility for a major change in how the Eyes Test is used to inform diagnosis in ASD. LAY SUMMARY: The Eyes Test is used worldwide to inform autism spectrum disorders (ASD) diagnosis. We show here that ASD and neurotypical adults show the most difference in performance on subgroups of items: ASD adults do not improve as expected when comparing easy and difficult items, and they do not show an improvement for items displaying a positive feeling. We advise clinicians to focus on these comparisons to increase the property of the test to distinguish people with ASD from neurotypical adults. En ligne : http://dx.doi.org/10.1002/aur.2390 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441

Spatial and temporal analysis of postural control in children with high functioning Autism Spectrum Disorder / Nathalie GOULÈME in Research in Autism Spectrum Disorders, 40 (August 2017)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 40 (August 2017) . - p.13-23 Titre : Spatial and temporal analysis of postural control in children with high functioning Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Nathalie GOULÈME, Auteur ; Isabelle SCHEID, Auteur ; Hugo PEYRE, Auteur ; Anna MARUANI, Auteur ; Julia CLARKE, Auteur ; Richard DELORME, Auteur ; Maria Pia BUCCI, Auteur Article en page(s) : p.13-23 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Children  Postural control  Wavelet transformation  Sensorial inputs Index. décimale : PER Périodiques Résumé : AbstractBackground Children with autism spectrum disorders (ASD) have poor postural stability. The objective of our study was to explore further postural capabilities in ASD children by measuring spatial as well as temporal displacement of the center of pressure using wavelet analysis. Method Thirty children with ASD (12.1 ± 2.9 years) and 30 sex-, age- and IQ-matched typically developing children participated in the study. We recorded postural control using Multitest, also called Balance Quest, Equilibre from Framiral® in three viewing conditions (eyes open, eyes closed and with perturbed vision) and in two postural conditions (stable and unstable). Results Our results show that children with ASD displayed a deficit in postural stability in comparison with typically developing children, especially when sensory inputs are not all available. Conclusion Such poor postural control in children with ASD could be due to both an impairment in using sensorial inputs appropriately and a deficit in the ability to compensate for sensorial changes. En ligne : https://doi.org/10.1016/j.rasd.2017.05.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317 [article] Spatial and temporal analysis of postural control in children with high functioning Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Nathalie GOULÈME, Auteur ; Isabelle SCHEID, Auteur ; Hugo PEYRE, Auteur ; Anna MARUANI, Auteur ; Julia CLARKE, Auteur ; Richard DELORME, Auteur ; Maria Pia BUCCI, Auteur . - p.13-23. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 40 (August 2017) . - p.13-23 Mots-clés : Autism spectrum disorder  Children  Postural control  Wavelet transformation  Sensorial inputs Index. décimale : PER Périodiques Résumé : AbstractBackground Children with autism spectrum disorders (ASD) have poor postural stability. The objective of our study was to explore further postural capabilities in ASD children by measuring spatial as well as temporal displacement of the center of pressure using wavelet analysis. Method Thirty children with ASD (12.1 ± 2.9 years) and 30 sex-, age- and IQ-matched typically developing children participated in the study. We recorded postural control using Multitest, also called Balance Quest, Equilibre from Framiral® in three viewing conditions (eyes open, eyes closed and with perturbed vision) and in two postural conditions (stable and unstable). Results Our results show that children with ASD displayed a deficit in postural stability in comparison with typically developing children, especially when sensory inputs are not all available. Conclusion Such poor postural control in children with ASD could be due to both an impairment in using sensorial inputs appropriately and a deficit in the ability to compensate for sensorial changes. En ligne : https://doi.org/10.1016/j.rasd.2017.05.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317

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