Assessing a hyperarousal hypothesis of insomnia in adults with autism spectrum disorder / E. K. BAKER in Autism Research, 12-6 (June 2019)  

Public ISBD [article]  inAutism Research > 12-6 (June 2019) . - p.897-910 Titre : Assessing a hyperarousal hypothesis of insomnia in adults with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : E. K. BAKER, Auteur ; A. L. RICHDALE, Auteur ; Agnes HAZI, Auteur ; Luke A. PRENDERGAST, Auteur Année de publication : 2019 Article en page(s) : p.897-910 Langues : Anglais (eng) Mots-clés : anxiety  autism  cortisol  hyperarousal  insomnia  sleep Index. décimale : PER Périodiques Résumé : This study aimed to investigate the relationship between sleep, psychopathology (anxiety, depression and presleep arousal) symptoms, and cortisol in adults with autism spectrum disorder (ASD). The sample composed of 29 adults with ASD (51.7% males) and 29 control adults (51.7% males) aged 21-44 years. Thirteen adults with ASD were medicated for a comorbid diagnosis of anxiety and/or depression (ASD-Med), while the remaining 16 adults with ASD were not medicated for such diagnoses (ASD-Only). Participants completed a questionnaire battery, 14-day sleep/wake diary and 14-day actigraphy assessment. On one day during the data collection period, participants collected five saliva samples, hourly, prior to sleep and two morning samples; immediately upon waking and 30 min thereafter for the analysis of cortisol. Cortisol 1 hr prior to habitual sleep onset time was associated with poorer sleep efficiency in both ASD groups and increased wake after sleep onset duration (ASD-Only). Higher subjective somatic arousal was also associated with increased sleep onset latency, regardless of group, and poorer sleep efficiency in the ASD-Only group. ASD-Only participants had significantly greater reductions in evening cortisol concentrations compared to both ASD-Med and control participants. No significant group differences were found for the cortisol awakening response. Findings suggest a hyperarousal hypothesis of insomnia in adults with ASD. Moreover, the low cortisol levels observed in ASD-Only adults suggest dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. Longitudinal studies exploring the interplay between insomnia, anxiety and HPA axis regulation across the lifespan in those with ASD are warranted. Autism Res 2019, 12: 897-910. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Both objective (cortisol) and subjective (somatic) physiological arousal were associated with poor sleep quality in adults on the autism spectrum. Adults with autism spectrum disorder (ASD) who were not medicated for a comorbid diagnosis of anxiety and/or depression also had dampened cortisol secretion, suggesting a dysregulation of the hypothalamic pituitary axis. Longitudinal studies investigating the relationship between sleep, psychopathology symptoms and physiological arousal in autistic individuals are warranted. Autism Res 2019. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : https://dx.doi.org/10.1002/aur.2094 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400 [article] Assessing a hyperarousal hypothesis of insomnia in adults with autism spectrum disorder [Texte imprimé et/ou numérique] / E. K. BAKER, Auteur ; A. L. RICHDALE, Auteur ; Agnes HAZI, Auteur ; Luke A. PRENDERGAST, Auteur . - 2019 . - p.897-910. Langues : Anglais (eng) in Autism Research > 12-6 (June 2019) . - p.897-910 Mots-clés : anxiety  autism  cortisol  hyperarousal  insomnia  sleep Index. décimale : PER Périodiques Résumé : This study aimed to investigate the relationship between sleep, psychopathology (anxiety, depression and presleep arousal) symptoms, and cortisol in adults with autism spectrum disorder (ASD). The sample composed of 29 adults with ASD (51.7% males) and 29 control adults (51.7% males) aged 21-44 years. Thirteen adults with ASD were medicated for a comorbid diagnosis of anxiety and/or depression (ASD-Med), while the remaining 16 adults with ASD were not medicated for such diagnoses (ASD-Only). Participants completed a questionnaire battery, 14-day sleep/wake diary and 14-day actigraphy assessment. On one day during the data collection period, participants collected five saliva samples, hourly, prior to sleep and two morning samples; immediately upon waking and 30 min thereafter for the analysis of cortisol. Cortisol 1 hr prior to habitual sleep onset time was associated with poorer sleep efficiency in both ASD groups and increased wake after sleep onset duration (ASD-Only). Higher subjective somatic arousal was also associated with increased sleep onset latency, regardless of group, and poorer sleep efficiency in the ASD-Only group. ASD-Only participants had significantly greater reductions in evening cortisol concentrations compared to both ASD-Med and control participants. No significant group differences were found for the cortisol awakening response. Findings suggest a hyperarousal hypothesis of insomnia in adults with ASD. Moreover, the low cortisol levels observed in ASD-Only adults suggest dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. Longitudinal studies exploring the interplay between insomnia, anxiety and HPA axis regulation across the lifespan in those with ASD are warranted. Autism Res 2019, 12: 897-910. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Both objective (cortisol) and subjective (somatic) physiological arousal were associated with poor sleep quality in adults on the autism spectrum. Adults with autism spectrum disorder (ASD) who were not medicated for a comorbid diagnosis of anxiety and/or depression also had dampened cortisol secretion, suggesting a dysregulation of the hypothalamic pituitary axis. Longitudinal studies investigating the relationship between sleep, psychopathology symptoms and physiological arousal in autistic individuals are warranted. Autism Res 2019. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : https://dx.doi.org/10.1002/aur.2094 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400

Assessing the Dim Light Melatonin Onset in Adults with Autism Spectrum Disorder and No Comorbid Intellectual Disability / Emma K. BAKER in Journal of Autism and Developmental Disorders, 47-7 (July 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-7 (July 2017) . - p.2120-2137 Titre : Assessing the Dim Light Melatonin Onset in Adults with Autism Spectrum Disorder and No Comorbid Intellectual Disability Type de document : Texte imprimé et/ou numérique Auteurs : Emma K. BAKER, Auteur ; Amanda L. RICHDALE, Auteur ; Agnes HAZI, Auteur ; Luke A. PRENDERGAST, Auteur Article en page(s) : p.2120-2137 Langues : Anglais (eng) Mots-clés : Autism  Melatonin Sleep  DLMO  Circadian-Rhythm  Actigraphy Index. décimale : PER Périodiques Résumé : This study assessed melatonin levels and the dim light melatonin onset (DLMO) in adults with Autism Spectrum Disorder (ASD) and also investigated the relationships between melatonin and objectively measured sleep parameters. Sixteen adults with ASD (ASD-Only), 12 adults with ASD medicated for comorbid diagnoses of anxiety and/or depression (ASD-Med) and 32 controls participated in the study. Although, the timing of the DLMO did not differ between the two groups, advances and delays of the melatonin rhythm were observed in individual profiles. Overall mean melatonin levels were lower in the ASD-Med group compared to the two other groups. Lastly, greater increases in melatonin in the hour prior to sleep were associated with greater sleep efficiency in the ASD groups. En ligne : https://doi.org/10.1007/s10803-017-3122-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=314 [article] Assessing the Dim Light Melatonin Onset in Adults with Autism Spectrum Disorder and No Comorbid Intellectual Disability [Texte imprimé et/ou numérique] / Emma K. BAKER, Auteur ; Amanda L. RICHDALE, Auteur ; Agnes HAZI, Auteur ; Luke A. PRENDERGAST, Auteur . - p.2120-2137. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-7 (July 2017) . - p.2120-2137 Mots-clés : Autism  Melatonin Sleep  DLMO  Circadian-Rhythm  Actigraphy Index. décimale : PER Périodiques Résumé : This study assessed melatonin levels and the dim light melatonin onset (DLMO) in adults with Autism Spectrum Disorder (ASD) and also investigated the relationships between melatonin and objectively measured sleep parameters. Sixteen adults with ASD (ASD-Only), 12 adults with ASD medicated for comorbid diagnoses of anxiety and/or depression (ASD-Med) and 32 controls participated in the study. Although, the timing of the DLMO did not differ between the two groups, advances and delays of the melatonin rhythm were observed in individual profiles. Overall mean melatonin levels were lower in the ASD-Med group compared to the two other groups. Lastly, greater increases in melatonin in the hour prior to sleep were associated with greater sleep efficiency in the ASD groups. En ligne : https://doi.org/10.1007/s10803-017-3122-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=314

Follow-up of the Cool Little Kids translational trial into middle childhood / Jordana K. BAYER in Journal of Child Psychology and Psychiatry, 63-1 (January 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-1 (January 2022) . - p.88-98 Titre : Follow-up of the Cool Little Kids translational trial into middle childhood Type de document : Texte imprimé et/ou numérique Auteurs : Jordana K. BAYER, Auteur ; A. BROWN, Auteur ; Luke A. PRENDERGAST, Auteur ; L. BRETHERTON, Auteur ; H. HISCOCK, Auteur ; C. MIHALOPOULOS, Auteur ; M. NELSON-LOWE, Auteur ; T. GILBERTSON, Auteur ; K. NOONE, Auteur ; N. BISCHOF, Auteur ; C. BEECHEY, Auteur ; F. MULIADI, Auteur ; R. M. RAPEE, Auteur Article en page(s) : p.88-98 Langues : Anglais (eng) Mots-clés : Anxiety  Anxiety Disorders/diagnosis  Child  Child Behavior  Child, Preschool  Follow-Up Studies  Humans  Parenting  Internalising problems  anxiety disorders  prevention  randomised controlled trial  translation Index. décimale : PER Périodiques Résumé : BACKGROUND: Public health advocates have highlighted internalising problems as a leading cause of global burden of disease. Internalising problems (anxiety/depression) affect up to 20% of school-age children and can impact peer relations, school engagement and later employment and mortality. This translational trial aimed to determine whether a selective/indicated parenting group programme to prevent internalising distress in shy/inhibited preschool children had sustained effects in middle childhood. Translational design aspects were a brief parent-report screening tool for child inhibition offered universally across the population via preschools in the year before school, followed by an invitation to parents of all inhibited children to attend the parenting programme at venues in their local community. METHODS: Design of the study was a randomised controlled trial. The setting was 307 preschool services across eight socioeconomically diverse government areas in Melbourne, Australia. Participants were 545 parents of inhibited four-year-old children of which 456 (84%) were retained during middle childhood (age of seven to 10?years). Early intervention was the Cool Little Kids parenting group programme, and control was 'usual care' access to available support services in the community. Primary outcomes were child anxiety and depression symptoms (parent and child report) and DSM-IV anxiety disorders (assessor masked). Secondary outcomes were parenting practices and parent mental health. RESULTS: There was no significant difference in anxiety disorders between the intervention and control group during the three annual follow-ups of the cohort in middle childhood (2015 43% vs. 41%, 2016 40% vs. 36%, 2017 27% vs. 30%, respectively; p's?>?.05). There were also no significant differences in child anxiety or depression symptoms (by child or parent report), parenting practices or parent mental health, between the intervention and control group during middle childhood. However, a priori interaction tests suggested that for children with anxious parents, early intervention attenuated risk for middle childhood internalising problems. CONCLUSIONS: An issue for population translation is low levels of parent engagement in preventive interventions. Initial effects of the Cool Little Kids parenting group programme in reducing shy/inhibited preschool children's internalising distress at school entry dissipated over time, perhaps due to low engagement. Future translational research on early prevention of internalising problems could benefit from screening preschool children in the population at higher risk (combining temperamental inhibition and parent distress) and incorporating motivational techniques to facilitate family engagement. Trial registration ISRCTN30996662 http://www.isrctn.com/ISRCTN30996662. En ligne : http://dx.doi.org/10.1111/jcpp.13464 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Follow-up of the Cool Little Kids translational trial into middle childhood [Texte imprimé et/ou numérique] / Jordana K. BAYER, Auteur ; A. BROWN, Auteur ; Luke A. PRENDERGAST, Auteur ; L. BRETHERTON, Auteur ; H. HISCOCK, Auteur ; C. MIHALOPOULOS, Auteur ; M. NELSON-LOWE, Auteur ; T. GILBERTSON, Auteur ; K. NOONE, Auteur ; N. BISCHOF, Auteur ; C. BEECHEY, Auteur ; F. MULIADI, Auteur ; R. M. RAPEE, Auteur . - p.88-98. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-1 (January 2022) . - p.88-98 Mots-clés : Anxiety  Anxiety Disorders/diagnosis  Child  Child Behavior  Child, Preschool  Follow-Up Studies  Humans  Parenting  Internalising problems  anxiety disorders  prevention  randomised controlled trial  translation Index. décimale : PER Périodiques Résumé : BACKGROUND: Public health advocates have highlighted internalising problems as a leading cause of global burden of disease. Internalising problems (anxiety/depression) affect up to 20% of school-age children and can impact peer relations, school engagement and later employment and mortality. This translational trial aimed to determine whether a selective/indicated parenting group programme to prevent internalising distress in shy/inhibited preschool children had sustained effects in middle childhood. Translational design aspects were a brief parent-report screening tool for child inhibition offered universally across the population via preschools in the year before school, followed by an invitation to parents of all inhibited children to attend the parenting programme at venues in their local community. METHODS: Design of the study was a randomised controlled trial. The setting was 307 preschool services across eight socioeconomically diverse government areas in Melbourne, Australia. Participants were 545 parents of inhibited four-year-old children of which 456 (84%) were retained during middle childhood (age of seven to 10?years). Early intervention was the Cool Little Kids parenting group programme, and control was 'usual care' access to available support services in the community. Primary outcomes were child anxiety and depression symptoms (parent and child report) and DSM-IV anxiety disorders (assessor masked). Secondary outcomes were parenting practices and parent mental health. RESULTS: There was no significant difference in anxiety disorders between the intervention and control group during the three annual follow-ups of the cohort in middle childhood (2015 43% vs. 41%, 2016 40% vs. 36%, 2017 27% vs. 30%, respectively; p's?>?.05). There were also no significant differences in child anxiety or depression symptoms (by child or parent report), parenting practices or parent mental health, between the intervention and control group during middle childhood. However, a priori interaction tests suggested that for children with anxious parents, early intervention attenuated risk for middle childhood internalising problems. CONCLUSIONS: An issue for population translation is low levels of parent engagement in preventive interventions. Initial effects of the Cool Little Kids parenting group programme in reducing shy/inhibited preschool children's internalising distress at school entry dissipated over time, perhaps due to low engagement. Future translational research on early prevention of internalising problems could benefit from screening preschool children in the population at higher risk (combining temperamental inhibition and parent distress) and incorporating motivational techniques to facilitate family engagement. Trial registration ISRCTN30996662 http://www.isrctn.com/ISRCTN30996662. En ligne : http://dx.doi.org/10.1111/jcpp.13464 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Severity of Autism is Related to Children's Language Processing / Edith L. BAVIN in Autism Research, 7-6 (December 2014)  

Public ISBD [article]  inAutism Research > 7-6 (December 2014) . - p.687-694 Titre : Severity of Autism is Related to Children's Language Processing Type de document : Texte imprimé et/ou numérique Auteurs : Edith L. BAVIN, Auteur ; Evan KIDD, Auteur ; Luke A. PRENDERGAST, Auteur ; Emma K. BAKER, Auteur ; Cheryl DISSANAYAKE, Auteur ; Margot PRIOR, Auteur Article en page(s) : p.687-694 Langues : Anglais (eng) Mots-clés : lexical processing  severity of ASD  eye tracking  children Index. décimale : PER Périodiques Résumé : Problems in language processing have been associated with autism spectrum disorder (ASD), with some research attributing the problems to overall language skills rather than a diagnosis of ASD. Lexical access was assessed in a looking-while-listening task in three groups of 5- to 7-year-old children; two had high-functioning ASD (HFA), an ASD severe (ASD-S) group (n?=?16) and an ASD moderate (ASD-M) group (n?=?21). The third group were typically developing (TD) (n?=?48). Participants heard sentences of the form “Where's the x?” and their eye movements to targets (e.g., train), phonological competitors (e.g., tree), and distractors were recorded. Proportions of looking time at target were analyzed within 200?ms intervals. Significant group differences were found between the ASD-S and TD groups only, at time intervals 1000–1200 and 1200–1400?ms postonset. The TD group was more likely to be fixated on target. These differences were maintained after adjusting for language, verbal and nonverbal IQ, and attention scores. An analysis using parent report of autistic-like behaviors showed higher scores to be associated with lower proportions of looking time at target, regardless of group. Further analysis showed fixation for the TD group to be significantly faster than for the ASD-S. In addition, incremental processing was found for all groups. The study findings suggest that severity of autistic behaviors will impact significantly on children's language processing in real life situations when exposed to syntactically complex material. They also show the value of using online methods for understanding how young children with ASD process language. En ligne : http://dx.doi.org/10.1002/aur.1410 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Severity of Autism is Related to Children's Language Processing [Texte imprimé et/ou numérique] / Edith L. BAVIN, Auteur ; Evan KIDD, Auteur ; Luke A. PRENDERGAST, Auteur ; Emma K. BAKER, Auteur ; Cheryl DISSANAYAKE, Auteur ; Margot PRIOR, Auteur . - p.687-694. Langues : Anglais (eng) in Autism Research > 7-6 (December 2014) . - p.687-694 Mots-clés : lexical processing  severity of ASD  eye tracking  children Index. décimale : PER Périodiques Résumé : Problems in language processing have been associated with autism spectrum disorder (ASD), with some research attributing the problems to overall language skills rather than a diagnosis of ASD. Lexical access was assessed in a looking-while-listening task in three groups of 5- to 7-year-old children; two had high-functioning ASD (HFA), an ASD severe (ASD-S) group (n?=?16) and an ASD moderate (ASD-M) group (n?=?21). The third group were typically developing (TD) (n?=?48). Participants heard sentences of the form “Where's the x?” and their eye movements to targets (e.g., train), phonological competitors (e.g., tree), and distractors were recorded. Proportions of looking time at target were analyzed within 200?ms intervals. Significant group differences were found between the ASD-S and TD groups only, at time intervals 1000–1200 and 1200–1400?ms postonset. The TD group was more likely to be fixated on target. These differences were maintained after adjusting for language, verbal and nonverbal IQ, and attention scores. An analysis using parent report of autistic-like behaviors showed higher scores to be associated with lower proportions of looking time at target, regardless of group. Further analysis showed fixation for the TD group to be significantly faster than for the ASD-S. In addition, incremental processing was found for all groups. The study findings suggest that severity of autistic behaviors will impact significantly on children's language processing in real life situations when exposed to syntactically complex material. They also show the value of using online methods for understanding how young children with ASD process language. En ligne : http://dx.doi.org/10.1002/aur.1410 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

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