Brief Report: Using the Social Communication Questionnaire to Identify Young People Residing in Secure Children's Homes with Symptom Complexes Compatible with Autistic Spectrum Disorder / P. J. KENNEDY in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.391-396 Titre : Brief Report: Using the Social Communication Questionnaire to Identify Young People Residing in Secure Children's Homes with Symptom Complexes Compatible with Autistic Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : P. J. KENNEDY, Auteur ; P. SINFIELD, Auteur ; L. TWEEDLIE, Auteur ; C. NIXON, Auteur ; A. MARTIN, Auteur ; K. EDWARDS, Auteur Article en page(s) : p.391-396 Langues : Anglais (eng) Mots-clés : Adolescent  Autistic spectrum disorders  Prevalence  Secure units  Social communication  Vulnerability Index. décimale : PER Périodiques Résumé : Autistic Spectrum Disorder (ASD) affects approximately 1% of the general population. The prevalence of ASD, or symptom complexes compatible with ASD, amongst young people residing within Secure Children's Homes (SCH's) remains ill understood. There are critical implications for the resourcing and understanding of the management of young people with social/communication difficulties. This paper describes a preliminary investigation of the prevalence of ASD within SCH's in the UK. The Social Communication Questionnaire (SCQ) was completed with support workers for 113 adolescents admitted to two SCH's in England as a screen for ASD. The SCQ identified 15 (13.3%) young people with symptoms compatible with an ASD presentation; differences in gender, legal status and a history of Child Sexual Exploitation (CSE) are discussed. En ligne : http://dx.doi.org/10.1007/s10803-018-3684-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377 [article] Brief Report: Using the Social Communication Questionnaire to Identify Young People Residing in Secure Children's Homes with Symptom Complexes Compatible with Autistic Spectrum Disorder [Texte imprimé et/ou numérique] / P. J. KENNEDY, Auteur ; P. SINFIELD, Auteur ; L. TWEEDLIE, Auteur ; C. NIXON, Auteur ; A. MARTIN, Auteur ; K. EDWARDS, Auteur . - p.391-396. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.391-396 Mots-clés : Adolescent  Autistic spectrum disorders  Prevalence  Secure units  Social communication  Vulnerability Index. décimale : PER Périodiques Résumé : Autistic Spectrum Disorder (ASD) affects approximately 1% of the general population. The prevalence of ASD, or symptom complexes compatible with ASD, amongst young people residing within Secure Children's Homes (SCH's) remains ill understood. There are critical implications for the resourcing and understanding of the management of young people with social/communication difficulties. This paper describes a preliminary investigation of the prevalence of ASD within SCH's in the UK. The Social Communication Questionnaire (SCQ) was completed with support workers for 113 adolescents admitted to two SCH's in England as a screen for ASD. The SCQ identified 15 (13.3%) young people with symptoms compatible with an ASD presentation; differences in gender, legal status and a history of Child Sexual Exploitation (CSE) are discussed. En ligne : http://dx.doi.org/10.1007/s10803-018-3684-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377

Dissociations in the neural substrates of language and social functioning in autism spectrum disorder / J. CRUTCHER in Autism Research, 11-8 (August 2018)  

Public ISBD [article]  inAutism Research > 11-8 (August 2018) . - p.1175-1186 Titre : Dissociations in the neural substrates of language and social functioning in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : J. CRUTCHER, Auteur ; A. MARTIN, Auteur ; Gregory L. WALLACE, Auteur Article en page(s) : p.1175-1186 Langues : Anglais (eng) Mots-clés : adulthood  autism  cortical thickness  language  social communication Index. décimale : PER Périodiques Résumé : Impairments in social communication (coupled with intact nonsocial language skills) are common in autism spectrum disorder (ASD). However, the neural correlates of these social communication deficits in adolescents and young adults with ASD are not fully understood. The communication checklist self-report (CC-SR) was administered to adolescents and young adults with ASD (n = 52) and typically developing (TD) controls (n = 64) to assess structural-language, pragmatic-language, and social-engagement. One high-resolution T1-weighted structural image was obtained from each participant. FreeSurfer was used to quantify cortical thickness. A main effect of diagnosis, with the ASD group performing worse than the TD group on all three CC-SR scales, and a diagnosis by scale interaction, driven by low social-engagement self-ratings in the ASD group, were found. There were also group differences in the relationship between scores on two of the three CC-SR scales and cortical thickness in multiple regions (pragmatic-language: left rostral frontal; social-engagement: left medial prefrontal). These interactions were driven by poorer self-ratings of language/social skills associated with decreased cortical thickness in the ASD group, while in the TD group worse self-ratings were associated with thicker cortex. Self-ratings of language/social-communication were lower in the ASD than the TD group. Moreover, language/social-communication self-ratings showed a different relationship with cortical thickness for the ASD and TD groups in the left inferior frontal region for pragmatic language ratings and the left medial prefrontal cortex for social engagement ratings. These findings suggest thinner cortex is associated with more impaired pragmatic language and social communication abilities in ASD. Autism Res 2018, 11: 1175-1186. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The present study examines the associations between brain structure and language/social communication ability in adolescents and young adults with autism spectrum disorder (ASD) as compared to neurotypical adolescents and young adults. We utilized thickness of the cerebral cortex as a measure of brain structure, and we found different correlations between language or social communication ability and cortical thickness in distinct regions for the ASD and TD groups. These findings suggest that for regions implicated in language/social communication ability, decreased cortical thickness is associated with more impaired pragmatic language and social communication abilities in ASD. En ligne : http://dx.doi.org/10.1002/aur.1969 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 [article] Dissociations in the neural substrates of language and social functioning in autism spectrum disorder [Texte imprimé et/ou numérique] / J. CRUTCHER, Auteur ; A. MARTIN, Auteur ; Gregory L. WALLACE, Auteur . - p.1175-1186. Langues : Anglais (eng) in Autism Research > 11-8 (August 2018) . - p.1175-1186 Mots-clés : adulthood  autism  cortical thickness  language  social communication Index. décimale : PER Périodiques Résumé : Impairments in social communication (coupled with intact nonsocial language skills) are common in autism spectrum disorder (ASD). However, the neural correlates of these social communication deficits in adolescents and young adults with ASD are not fully understood. The communication checklist self-report (CC-SR) was administered to adolescents and young adults with ASD (n = 52) and typically developing (TD) controls (n = 64) to assess structural-language, pragmatic-language, and social-engagement. One high-resolution T1-weighted structural image was obtained from each participant. FreeSurfer was used to quantify cortical thickness. A main effect of diagnosis, with the ASD group performing worse than the TD group on all three CC-SR scales, and a diagnosis by scale interaction, driven by low social-engagement self-ratings in the ASD group, were found. There were also group differences in the relationship between scores on two of the three CC-SR scales and cortical thickness in multiple regions (pragmatic-language: left rostral frontal; social-engagement: left medial prefrontal). These interactions were driven by poorer self-ratings of language/social skills associated with decreased cortical thickness in the ASD group, while in the TD group worse self-ratings were associated with thicker cortex. Self-ratings of language/social-communication were lower in the ASD than the TD group. Moreover, language/social-communication self-ratings showed a different relationship with cortical thickness for the ASD and TD groups in the left inferior frontal region for pragmatic language ratings and the left medial prefrontal cortex for social engagement ratings. These findings suggest thinner cortex is associated with more impaired pragmatic language and social communication abilities in ASD. Autism Res 2018, 11: 1175-1186. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The present study examines the associations between brain structure and language/social communication ability in adolescents and young adults with autism spectrum disorder (ASD) as compared to neurotypical adolescents and young adults. We utilized thickness of the cerebral cortex as a measure of brain structure, and we found different correlations between language or social communication ability and cortical thickness in distinct regions for the ASD and TD groups. These findings suggest that for regions implicated in language/social communication ability, decreased cortical thickness is associated with more impaired pragmatic language and social communication abilities in ASD. En ligne : http://dx.doi.org/10.1002/aur.1969 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

Gauging facial feature viewing preference as a stable individual trait in autism spectrum disorder / G. E. REIMANN in Autism Research, 14-8 (August 2021)  

Public ISBD [article]  inAutism Research > 14-8 (August 2021) . - p.1670-1683 Titre : Gauging facial feature viewing preference as a stable individual trait in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : G. E. REIMANN, Auteur ; C. WALSH, Auteur ; K. D. CSUMITTA, Auteur ; P. MCCLURE, Auteur ; F. PEREIRA, Auteur ; A. MARTIN, Auteur ; M. RAMOT, Auteur Article en page(s) : p.1670-1683 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder  Child  Face  Fixation, Ocular  Humans  Motion Pictures  Phenotype  Young Adult  machine learning  social behavior Index. décimale : PER Périodiques Résumé : Eye tracking provides insights into social processing deficits in autism spectrum disorder (ASD), especially in conjunction with dynamic, naturalistic free-viewing stimuli. However, the question remains whether gaze characteristics, such as preference for specific facial features, can be considered a stable individual trait, particularly in those with ASD. If so, how much data are needed for consistent estimations? To address these questions, we assessed the stability and robustness of gaze preference for facial features as incremental amounts of movie data were introduced for analysis. We trained an artificial neural network to create an object-based segmentation of naturalistic movie clips (14?s each, 7410 frames total). Thirty-three high-functioning individuals with ASD and 36 age- and IQ-equated typically developing individuals (age range: 12-30?years) viewed 22 Hollywood movie clips, each depicting a social interaction. As we evaluated combinations of one, three, five, eight, and 11 movie clips, gaze dwell times on core facial features became increasingly stable at within-subject, within-group, and between-group levels. Using a number of movie clips deemed sufficient by our analysis, we found that individuals with ASD displayed significantly less face-centered gaze (centralized on the nose; p? En ligne : http://dx.doi.org/10.1002/aur.2540 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Gauging facial feature viewing preference as a stable individual trait in autism spectrum disorder [Texte imprimé et/ou numérique] / G. E. REIMANN, Auteur ; C. WALSH, Auteur ; K. D. CSUMITTA, Auteur ; P. MCCLURE, Auteur ; F. PEREIRA, Auteur ; A. MARTIN, Auteur ; M. RAMOT, Auteur . - p.1670-1683. Langues : Anglais (eng) in Autism Research > 14-8 (August 2021) . - p.1670-1683 Mots-clés : Adolescent  Adult  Autism Spectrum Disorder  Child  Face  Fixation, Ocular  Humans  Motion Pictures  Phenotype  Young Adult  machine learning  social behavior Index. décimale : PER Périodiques Résumé : Eye tracking provides insights into social processing deficits in autism spectrum disorder (ASD), especially in conjunction with dynamic, naturalistic free-viewing stimuli. However, the question remains whether gaze characteristics, such as preference for specific facial features, can be considered a stable individual trait, particularly in those with ASD. If so, how much data are needed for consistent estimations? To address these questions, we assessed the stability and robustness of gaze preference for facial features as incremental amounts of movie data were introduced for analysis. We trained an artificial neural network to create an object-based segmentation of naturalistic movie clips (14?s each, 7410 frames total). Thirty-three high-functioning individuals with ASD and 36 age- and IQ-equated typically developing individuals (age range: 12-30?years) viewed 22 Hollywood movie clips, each depicting a social interaction. As we evaluated combinations of one, three, five, eight, and 11 movie clips, gaze dwell times on core facial features became increasingly stable at within-subject, within-group, and between-group levels. Using a number of movie clips deemed sufficient by our analysis, we found that individuals with ASD displayed significantly less face-centered gaze (centralized on the nose; p? En ligne : http://dx.doi.org/10.1002/aur.2540 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Insistence on sameness relates to increased covariance of gray matter structure in autism spectrum disorder / I. W. EISENBERG in Molecular Autism, (December 2015)  

Public ISBD [article]  inMolecular Autism > (December 2015) . - 54p. Titre : Insistence on sameness relates to increased covariance of gray matter structure in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : I. W. EISENBERG, Auteur ; Gregory L. WALLACE, Auteur ; L. KENWORTHY, Auteur ; S. J. GOTTS, Auteur ; A. MARTIN, Auteur Article en page(s) : 54p. Langues : Anglais (eng) Mots-clés : Autism  Insistence on sameness  Mri  Repetitive behavior  Structural covariance  Subcortex Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is characterized by atypical development of cortical and subcortical gray matter volume. Subcortical structural changes have been associated with restricted and repetitive behavior (RRB), a core component of ASD. Behavioral studies have identified insistence on sameness (IS) as a separable RRB dimension prominent in high-functioning ASD, though no simple brain-behavior relationship has emerged. Structural covariance, a measure of morphological coupling among brain regions using magnetic resonance imaging (MRI), has proven an informative measure of anatomical relationships in typical development and neurodevelopmental disorders. In this study, we use this measure to characterize the relationship between brain structure and IS. METHODS: We quantified the structural covariance of cortical and subcortical gray matter volume in 55 individuals with high-functioning ASD using 3T MRI. We then related these structural metrics to individual IS scores, as assessed by the Repetitive Behavior Scale-Revised (RBS-R). RESULTS: We found that increased coupling among subcortical regions and between subcortical and cortical regions related to greater IS symptom severity. Most pronounced, the striatum and amygdala participated in a plurality of identified relationships, indicating a central role for these structures in IS symptomatology. These structural associations were specific to IS and did not relate to any of the other RRB subcomponents measured by the RBS-R. CONCLUSIONS: This study indicates that behavioral dimensions in ASD can relate to the coordination of development across multiple brain regions, which might be otherwise obscured using typical brain-behavior correlations. It also expands the structures traditionally related to RRB in ASD and provides neuroanatomical evidence supportive of IS as a separate RRB dimension. TRIAL REGISTRATION: ClinicalTrials.gov NCT01031407. En ligne : http://dx.doi.org/10.1186/s13229-015-0047-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 [article] Insistence on sameness relates to increased covariance of gray matter structure in autism spectrum disorder [Texte imprimé et/ou numérique] / I. W. EISENBERG, Auteur ; Gregory L. WALLACE, Auteur ; L. KENWORTHY, Auteur ; S. J. GOTTS, Auteur ; A. MARTIN, Auteur . - 54p. Langues : Anglais (eng) in Molecular Autism > (December 2015) . - 54p. Mots-clés : Autism  Insistence on sameness  Mri  Repetitive behavior  Structural covariance  Subcortex Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is characterized by atypical development of cortical and subcortical gray matter volume. Subcortical structural changes have been associated with restricted and repetitive behavior (RRB), a core component of ASD. Behavioral studies have identified insistence on sameness (IS) as a separable RRB dimension prominent in high-functioning ASD, though no simple brain-behavior relationship has emerged. Structural covariance, a measure of morphological coupling among brain regions using magnetic resonance imaging (MRI), has proven an informative measure of anatomical relationships in typical development and neurodevelopmental disorders. In this study, we use this measure to characterize the relationship between brain structure and IS. METHODS: We quantified the structural covariance of cortical and subcortical gray matter volume in 55 individuals with high-functioning ASD using 3T MRI. We then related these structural metrics to individual IS scores, as assessed by the Repetitive Behavior Scale-Revised (RBS-R). RESULTS: We found that increased coupling among subcortical regions and between subcortical and cortical regions related to greater IS symptom severity. Most pronounced, the striatum and amygdala participated in a plurality of identified relationships, indicating a central role for these structures in IS symptomatology. These structural associations were specific to IS and did not relate to any of the other RRB subcomponents measured by the RBS-R. CONCLUSIONS: This study indicates that behavioral dimensions in ASD can relate to the coordination of development across multiple brain regions, which might be otherwise obscured using typical brain-behavior correlations. It also expands the structures traditionally related to RRB in ASD and provides neuroanatomical evidence supportive of IS as a separate RRB dimension. TRIAL REGISTRATION: ClinicalTrials.gov NCT01031407. En ligne : http://dx.doi.org/10.1186/s13229-015-0047-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328

Quality Control: A Congratulatory Critique / A. MARTIN in Journal of Autism and Developmental Disorders, 51-8 (August 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.3014-3015 Titre : Quality Control: A Congratulatory Critique Type de document : Texte imprimé et/ou numérique Auteurs : A. MARTIN, Auteur Article en page(s) : p.3014-3015 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Humans Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-020-04745-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] Quality Control: A Congratulatory Critique [Texte imprimé et/ou numérique] / A. MARTIN, Auteur . - p.3014-3015. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.3014-3015 Mots-clés : Autism Spectrum Disorder  Humans Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-020-04745-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

Reducing depression-related stigma and increasing treatment seeking among adolescents: randomized controlled trial of a brief video intervention / D. AMSALEM in Journal of Child Psychology and Psychiatry, 63-2 (February 2022)  

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Teasing apart the heterogeneity of autism: Same behavior, different brains in toddlers with fragile X syndrome and autism / Heather C. HAZLETT in Journal of Neurodevelopmental Disorders, 1-1 (March 2009)  

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What About the Girls? Sex-Based Differences in Autistic Traits and Adaptive Skills / Allison B. RATTO in Journal of Autism and Developmental Disorders, 48-5 (May 2018)  

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