Cytokine levels and associations with symptom severity in male and female children with autism spectrum disorder / A. MASI in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 63p. Titre : Cytokine levels and associations with symptom severity in male and female children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : A. MASI, Auteur ; E. J. BREEN, Auteur ; Gail A. ALVARES, Auteur ; N. GLOZIER, Auteur ; I. B. HICKIE, Auteur ; A. HUNT, Auteur ; J. HUI, Auteur ; J. BEILBY, Auteur ; D. RAVINE, Auteur ; J. WRAY, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; A. J. GUASTELLA, Auteur Article en page(s) : 63p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Behavior  Cytokine  Pediatric  Severity Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASDs) are complex, pervasive, and heterogeneous neurodevelopmental conditions with varying trajectories, significant male bias and largely unknown etiology. However, an understanding of the biological mechanisms driving pathophysiology is evolving. Immune system aberrations, as identified through cytokine profiles, are believed to have a role in ASD. Altered cytokine levels may facilitate identification of ASD subtypes as well as provide biological markers of response to effective treatments. Research exploring the relationship between cytokine profiles and ASD symptoms is, however, in its infancy. The objective of this study was to explore relationships between cytokine levels and the severity of ASD and other clinical traits. Methods: Multiplex assay techniques were used to measure levels of 27 cytokines in plasma samples from a cohort of 144 children diagnosed with ASD. Results: Overall, results showed a significant negative association between platelet-derived growth factor (PDGF)-BB, and the severity of ASD symptoms. Furthermore, a significant interaction with sex suggested a different immune profile for females compared to males. ASD symptom severity was negatively associated with levels of 4 cytokines, IL-1beta, IL-8, MIP-1beta, and VEGF, in females, but not in males. Conclusions: Results of the present study suggest that an altered cytokine response or profile is associated with the severity of ASD-related symptoms, with sex a potential modifier of this relationship. Further research in larger populations which recognizes the importance of sex comparisons and longitudinal assessments are now required to extend and further describe the role of the immune system in ASD. En ligne : http://dx.doi.org/10.1186/s13229-017-0176-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 [article] Cytokine levels and associations with symptom severity in male and female children with autism spectrum disorder [Texte imprimé et/ou numérique] / A. MASI, Auteur ; E. J. BREEN, Auteur ; Gail A. ALVARES, Auteur ; N. GLOZIER, Auteur ; I. B. HICKIE, Auteur ; A. HUNT, Auteur ; J. HUI, Auteur ; J. BEILBY, Auteur ; D. RAVINE, Auteur ; J. WRAY, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; A. J. GUASTELLA, Auteur . - 63p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 63p. Mots-clés : Autism spectrum disorder  Behavior  Cytokine  Pediatric  Severity Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASDs) are complex, pervasive, and heterogeneous neurodevelopmental conditions with varying trajectories, significant male bias and largely unknown etiology. However, an understanding of the biological mechanisms driving pathophysiology is evolving. Immune system aberrations, as identified through cytokine profiles, are believed to have a role in ASD. Altered cytokine levels may facilitate identification of ASD subtypes as well as provide biological markers of response to effective treatments. Research exploring the relationship between cytokine profiles and ASD symptoms is, however, in its infancy. The objective of this study was to explore relationships between cytokine levels and the severity of ASD and other clinical traits. Methods: Multiplex assay techniques were used to measure levels of 27 cytokines in plasma samples from a cohort of 144 children diagnosed with ASD. Results: Overall, results showed a significant negative association between platelet-derived growth factor (PDGF)-BB, and the severity of ASD symptoms. Furthermore, a significant interaction with sex suggested a different immune profile for females compared to males. ASD symptom severity was negatively associated with levels of 4 cytokines, IL-1beta, IL-8, MIP-1beta, and VEGF, in females, but not in males. Conclusions: Results of the present study suggest that an altered cytokine response or profile is associated with the severity of ASD-related symptoms, with sex a potential modifier of this relationship. Further research in larger populations which recognizes the importance of sex comparisons and longitudinal assessments are now required to extend and further describe the role of the immune system in ASD. En ligne : http://dx.doi.org/10.1186/s13229-017-0176-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330

Predictors of adaptive functioning in preschool aged children with autism spectrum disorder / M. A. HODGE in Autism Research, 14-7 (July 2021)  

Public ISBD [article]  inAutism Research > 14-7 (July 2021) . - p.1444-1455 Titre : Predictors of adaptive functioning in preschool aged children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : M. A. HODGE, Auteur ; Kelsie A. BOULTON, Auteur ; R. SUTHERLAND, Auteur ; D. BARNETT, Auteur ; B. BENNETT, Auteur ; Esther W. CHAN, Auteur ; J. CRAMSIE, Auteur ; S. DREVENSEK, Auteur ; V. EAPEN, Auteur ; K. GANESALINGAM, Auteur ; A. MASI, Auteur ; N. ONG, Auteur ; M. WILLIAMSZ, Auteur ; A. J. GUASTELLA, Auteur ; N. SILOVE, Auteur Article en page(s) : p.1444-1455 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications  Autistic Disorder  Child  Child, Preschool  Cognition  Humans  Motivation  Social Skills  adaptive functioning  autism spectrum disorder  children  cognitive function  preschool  socioeconomic status  symptom severity Index. décimale : PER Périodiques Résumé : Difficulties in adaptive functioning are common in autism spectrum disorder (ASD) and contribute to negative outcomes across the lifespan. Research indicates that cognitive ability is related to degree of adaptive functioning impairments, particularly in young children with ASD. However, the extent to which other factors, such as socioeconomic status (SES) and ASD symptom severity, predict impairments in adaptive functioning remains unclear. The goal of this study was to determine the extent to which SES, ASD symptom severity, and cognitive ability contribute to variability in domain-specific and global components of adaptive functioning in preschool-aged children with ASD. Participants were 99 preschool-aged children (2-6?years) with ASD who attended a tertiary diagnostic service. Results demonstrate that cognitive ability accounted for a significant proportion of variance in domain-specific and global components of adaptive functioning, with higher cognitive ability predicting better adaptive functioning. Results also demonstrate that SES accounted for some variability in domain-specific communication skills and global adaptive functioning when compared to basic demographic factors alone (age and gender). By contrast, ASD symptom severity did not predict variability in domain-specific or global components of adaptive functioning. These findings provide support for a relationship between cognitive ability and adaptive functioning in preschool-aged children with ASD and help to explain specific contributions of verbal and nonverbal ability to adaptive functioning; from this, we can better understand which children are likely to show the greatest degree of impairments across components of adaptive functioning early in development. LAY SUMMARY: People with autism often have difficulties with everyday communication, daily living, and social skills, which are also called adaptive functioning skills. This study investigated factors that might be related to these difficulties in preschoolers with autism. We found that better cognitive ability, but not autism symptoms, were associated with better adaptive functioning. This suggests that interventions for young children with autism should take into account cognitive ability to better understand which children are likely to have difficulties with adaptive functioning. En ligne : http://dx.doi.org/10.1002/aur.2501 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Predictors of adaptive functioning in preschool aged children with autism spectrum disorder [Texte imprimé et/ou numérique] / M. A. HODGE, Auteur ; Kelsie A. BOULTON, Auteur ; R. SUTHERLAND, Auteur ; D. BARNETT, Auteur ; B. BENNETT, Auteur ; Esther W. CHAN, Auteur ; J. CRAMSIE, Auteur ; S. DREVENSEK, Auteur ; V. EAPEN, Auteur ; K. GANESALINGAM, Auteur ; A. MASI, Auteur ; N. ONG, Auteur ; M. WILLIAMSZ, Auteur ; A. J. GUASTELLA, Auteur ; N. SILOVE, Auteur . - p.1444-1455. Langues : Anglais (eng) in Autism Research > 14-7 (July 2021) . - p.1444-1455 Mots-clés : Autism Spectrum Disorder/complications  Autistic Disorder  Child  Child, Preschool  Cognition  Humans  Motivation  Social Skills  adaptive functioning  autism spectrum disorder  children  cognitive function  preschool  socioeconomic status  symptom severity Index. décimale : PER Périodiques Résumé : Difficulties in adaptive functioning are common in autism spectrum disorder (ASD) and contribute to negative outcomes across the lifespan. Research indicates that cognitive ability is related to degree of adaptive functioning impairments, particularly in young children with ASD. However, the extent to which other factors, such as socioeconomic status (SES) and ASD symptom severity, predict impairments in adaptive functioning remains unclear. The goal of this study was to determine the extent to which SES, ASD symptom severity, and cognitive ability contribute to variability in domain-specific and global components of adaptive functioning in preschool-aged children with ASD. Participants were 99 preschool-aged children (2-6?years) with ASD who attended a tertiary diagnostic service. Results demonstrate that cognitive ability accounted for a significant proportion of variance in domain-specific and global components of adaptive functioning, with higher cognitive ability predicting better adaptive functioning. Results also demonstrate that SES accounted for some variability in domain-specific communication skills and global adaptive functioning when compared to basic demographic factors alone (age and gender). By contrast, ASD symptom severity did not predict variability in domain-specific or global components of adaptive functioning. These findings provide support for a relationship between cognitive ability and adaptive functioning in preschool-aged children with ASD and help to explain specific contributions of verbal and nonverbal ability to adaptive functioning; from this, we can better understand which children are likely to show the greatest degree of impairments across components of adaptive functioning early in development. LAY SUMMARY: People with autism often have difficulties with everyday communication, daily living, and social skills, which are also called adaptive functioning skills. This study investigated factors that might be related to these difficulties in preschoolers with autism. We found that better cognitive ability, but not autism symptoms, were associated with better adaptive functioning. This suggests that interventions for young children with autism should take into account cognitive ability to better understand which children are likely to have difficulties with adaptive functioning. En ligne : http://dx.doi.org/10.1002/aur.2501 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

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