An Expanding Spectrum of Autism Models : From Fixed Developmental Defects to Reversible Functional Impairments / Martha R. HERBERT

Public ISBD contenu dans Autism / Andrew W. ZIMMERMAN Titre : An Expanding Spectrum of Autism Models : From Fixed Developmental Defects to Reversible Functional Impairments Type de document : Texte imprimé et/ou numérique Auteurs : Martha R. HERBERT, Auteur ; Matthew P. ANDERSON, Auteur Année de publication : 2008 Importance : p.429-463 Langues : Anglais (eng) Mots-clés : Modèles  Pathogenèse  Fonction  Plasticité  Epigenetique  Environnement Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=705 contenu dans Autism / Andrew W. ZIMMERMAN An Expanding Spectrum of Autism Models : From Fixed Developmental Defects to Reversible Functional Impairments [Texte imprimé et/ou numérique] / Martha R. HERBERT, Auteur ; Matthew P. ANDERSON, Auteur . - 2008 . - p.429-463. Langues : Anglais (eng) Mots-clés : Modèles  Pathogenèse  Fonction  Plasticité  Epigenetique  Environnement Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=705

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Auditory processing in noise is associated with complex patterns of disrupted functional connectivity in autism spectrum disorder / Fahimeh MAMASHLI in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.631-647 Titre : Auditory processing in noise is associated with complex patterns of disrupted functional connectivity in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Fahimeh MAMASHLI, Auteur ; Sheraz KHAN, Auteur ; Hari BHARADWAJ, Auteur ; Konstantinos MICHMIZOS, Auteur ; Santosh GANESAN, Auteur ; Keri-Lee A. GAREL, Auteur ; Javeria ALI HASHMI, Auteur ; Martha R. HERBERT, Auteur ; Matti HÄMÄLÄINEN, Auteur ; Tal KENET, Auteur Article en page(s) : p.631-647 Langues : Anglais (eng) Mots-clés : autism  MEG  auditory  noise  connectivity  feedback  top-down Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is associated with difficulty in processing speech in a noisy background, but the neural mechanisms that underlie this deficit have not been mapped. To address this question, we used magnetoencephalography to compare the cortical responses between ASD and typically developing (TD) individuals to a passive mismatch paradigm. We repeated the paradigm twice, once in a quiet background, and once in the presence of background noise. We focused on both the evoked mismatch field (MMF) response in temporal and frontal cortical locations, and functional connectivity with spectral specificity between those locations. In the quiet condition, we found common neural sources of the MMF response in both groups, in the right temporal gyrus and inferior frontal gyrus (IFG). In the noise condition, the MMF response in the right IFG was preserved in the TD group, but reduced relative to the quiet condition in ASD group. The MMF response in the right IFG also correlated with severity of ASD. Moreover, in noise, we found significantly reduced normalized coherence (deviant normalized by standard) in ASD relative to TD, in the beta band (14–25 Hz), between left temporal and left inferior frontal sub-regions. However, unnormalized coherence (coherence during deviant or standard) was significantly increased in ASD relative to TD, in multiple frequency bands. Our findings suggest increased recruitment of neural resources in ASD irrespective of the task difficulty, alongside a reduction in top-down modulations, usually mediated by the beta band, needed to mitigate the impact of noise on auditory processing. En ligne : http://dx.doi.org/10.1002/aur.1714 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Auditory processing in noise is associated with complex patterns of disrupted functional connectivity in autism spectrum disorder [Texte imprimé et/ou numérique] / Fahimeh MAMASHLI, Auteur ; Sheraz KHAN, Auteur ; Hari BHARADWAJ, Auteur ; Konstantinos MICHMIZOS, Auteur ; Santosh GANESAN, Auteur ; Keri-Lee A. GAREL, Auteur ; Javeria ALI HASHMI, Auteur ; Martha R. HERBERT, Auteur ; Matti HÄMÄLÄINEN, Auteur ; Tal KENET, Auteur . - p.631-647. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.631-647 Mots-clés : autism  MEG  auditory  noise  connectivity  feedback  top-down Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is associated with difficulty in processing speech in a noisy background, but the neural mechanisms that underlie this deficit have not been mapped. To address this question, we used magnetoencephalography to compare the cortical responses between ASD and typically developing (TD) individuals to a passive mismatch paradigm. We repeated the paradigm twice, once in a quiet background, and once in the presence of background noise. We focused on both the evoked mismatch field (MMF) response in temporal and frontal cortical locations, and functional connectivity with spectral specificity between those locations. In the quiet condition, we found common neural sources of the MMF response in both groups, in the right temporal gyrus and inferior frontal gyrus (IFG). In the noise condition, the MMF response in the right IFG was preserved in the TD group, but reduced relative to the quiet condition in ASD group. The MMF response in the right IFG also correlated with severity of ASD. Moreover, in noise, we found significantly reduced normalized coherence (deviant normalized by standard) in ASD relative to TD, in the beta band (14–25 Hz), between left temporal and left inferior frontal sub-regions. However, unnormalized coherence (coherence during deviant or standard) was significantly increased in ASD relative to TD, in multiple frequency bands. Our findings suggest increased recruitment of neural resources in ASD irrespective of the task difficulty, alongside a reduction in top-down modulations, usually mediated by the beta band, needed to mitigate the impact of noise on auditory processing. En ligne : http://dx.doi.org/10.1002/aur.1714 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Autism and Environmental Genomics: Synergistic Systems Approaches to Autism Complexity / Mark A. CORRALES

Public ISBD in Autism Spectrum Disorders / David G. AMARAL Titre : Autism and Environmental Genomics: Synergistic Systems Approaches to Autism Complexity Type de document : Texte imprimé et/ou numérique Auteurs : Mark A. CORRALES, Auteur ; Martha R. HERBERT, Auteur Année de publication : 2011 Importance : p.875-892 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139 in Autism Spectrum Disorders / David G. AMARAL Autism and Environmental Genomics: Synergistic Systems Approaches to Autism Complexity [Texte imprimé et/ou numérique] / Mark A. CORRALES, Auteur ; Martha R. HERBERT, Auteur . - 2011 . - p.875-892. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139

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Motor stereotypies and volumetric brain alterations in children with Autistic Disorder / Sylvie GOLDMAN in Research in Autism Spectrum Disorders, 7-1 (January 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-1 (January 2013) . - p.82-92 Titre : Motor stereotypies and volumetric brain alterations in children with Autistic Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Sylvie GOLDMAN, Auteur ; Liam M. O’BRIEN, Auteur ; Pauline A. FILIPEK, Auteur ; Isabelle RAPIN, Auteur ; Martha R. HERBERT, Auteur Année de publication : 2013 Article en page(s) : p.82-92 Langues : Anglais (eng) Mots-clés : Structural imaging  Volumetric brain analysis  Videotape scoringMotor stereotypies  Autistic Disorder Index. décimale : PER Périodiques Résumé : Motor stereotypies are defined as patterned, repetitive, purposeless movements. These stigmatizing motor behaviors represent one manifestation of the third core criterion for an Autistic Disorder (AD) diagnosis, and are becoming viewed as potential early markers of autism. Moreover, motor stereotypies might be a tangible expression of the underlying neurobiology of this neurodevelopmental disorder. In this study, we videoscored stereotypies recorded during semi-structured play sessions from school age children with AD. We examined the effect of severity and persistence over time of stereotypies on brain volumetric changes. Our findings confirmed that the brain volume of school age children with AD is, on average, larger than that of age-matched typically developing children. However, we have failed to detect any sign of volumetric differences in brain regions thought to be particularly linked to the pathophysiology of stereotypies. This negative finding may suggest that, at least with respect to motor stereotypies, functional rather than structural alterations might be the underpinning of these disruptive motor manifestations of autism. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.07.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 [article] Motor stereotypies and volumetric brain alterations in children with Autistic Disorder [Texte imprimé et/ou numérique] / Sylvie GOLDMAN, Auteur ; Liam M. O’BRIEN, Auteur ; Pauline A. FILIPEK, Auteur ; Isabelle RAPIN, Auteur ; Martha R. HERBERT, Auteur . - 2013 . - p.82-92. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 7-1 (January 2013) . - p.82-92 Mots-clés : Structural imaging  Volumetric brain analysis  Videotape scoringMotor stereotypies  Autistic Disorder Index. décimale : PER Périodiques Résumé : Motor stereotypies are defined as patterned, repetitive, purposeless movements. These stigmatizing motor behaviors represent one manifestation of the third core criterion for an Autistic Disorder (AD) diagnosis, and are becoming viewed as potential early markers of autism. Moreover, motor stereotypies might be a tangible expression of the underlying neurobiology of this neurodevelopmental disorder. In this study, we videoscored stereotypies recorded during semi-structured play sessions from school age children with AD. We examined the effect of severity and persistence over time of stereotypies on brain volumetric changes. Our findings confirmed that the brain volume of school age children with AD is, on average, larger than that of age-matched typically developing children. However, we have failed to detect any sign of volumetric differences in brain regions thought to be particularly linked to the pathophysiology of stereotypies. This negative finding may suggest that, at least with respect to motor stereotypies, functional rather than structural alterations might be the underpinning of these disruptive motor manifestations of autism. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.07.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179

Offering to Share: How to Put Heads Together in Autism Neuroimaging / Matthew K. BELMONTE in Journal of Autism and Developmental Disorders, 38-1 (January 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-1 (January 2008) . - p.2-13 Titre : Offering to Share: How to Put Heads Together in Autism Neuroimaging Type de document : Texte imprimé et/ou numérique Auteurs : Matthew K. BELMONTE, Auteur ; Anders M. DALE, Auteur ; Christos DAVATZIKOS, Auteur ; Guido GERIG, Auteur ; Martha R. HERBERT, Auteur ; Robert T. SCHULTZ, Auteur ; Janet E. LAINHART, Auteur ; Declan G. MURPHY, Auteur ; Thomas A. ZEFFIRO, Auteur ; Susan LEVI-PEARL, Auteur ; Clara LAJONCHERE, Auteur ; Diane C. CHUGANI, Auteur ; Rita M. CANTOR, Auteur ; Elizabeth H. AYLWARD, Auteur ; Allan L. REISS, Auteur ; Joseph PIVEN, Auteur ; Nancy J. MINSHEW, Auteur ; Eric COURCHESNE, Auteur ; David G. AMARAL, Auteur ; John C. MAZZIOTTA, Auteur ; Alan C. EVANS, Auteur ; Stephen R. DAGER, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Sophia A. COLAMARINO, Auteur Année de publication : 2008 Article en page(s) : p.2-13 Langues : Anglais (eng) Mots-clés : Imaging MRI PET Morphometry Segmentation Data-sharing Index. décimale : PER Périodiques Résumé : Data sharing in autism neuroimaging presents scientific, technical, and social obstacles. We outline the desiderata for a data-sharing scheme that combines imaging with other measures of phenotype and with genetics, defines requirements for comparability of derived data and recommendations for raw data, outlines a core protocol including multispectral structural and diffusion-tensor imaging and optional extensions, provides for the collection of prospective, confound-free normative data, and extends sharing and collaborative development not only to data but to the analytical tools and methods applied to these data. A theme in these requirements is the need to preserve creative approaches and risk-taking within individual laboratories at the same time as common standards are provided for these laboratories to build on. En ligne : http://dx.doi.org/10.1007/s10803-006-0352-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=315 [article] Offering to Share: How to Put Heads Together in Autism Neuroimaging [Texte imprimé et/ou numérique] / Matthew K. BELMONTE, Auteur ; Anders M. DALE, Auteur ; Christos DAVATZIKOS, Auteur ; Guido GERIG, Auteur ; Martha R. HERBERT, Auteur ; Robert T. SCHULTZ, Auteur ; Janet E. LAINHART, Auteur ; Declan G. MURPHY, Auteur ; Thomas A. ZEFFIRO, Auteur ; Susan LEVI-PEARL, Auteur ; Clara LAJONCHERE, Auteur ; Diane C. CHUGANI, Auteur ; Rita M. CANTOR, Auteur ; Elizabeth H. AYLWARD, Auteur ; Allan L. REISS, Auteur ; Joseph PIVEN, Auteur ; Nancy J. MINSHEW, Auteur ; Eric COURCHESNE, Auteur ; David G. AMARAL, Auteur ; John C. MAZZIOTTA, Auteur ; Alan C. EVANS, Auteur ; Stephen R. DAGER, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Sophia A. COLAMARINO, Auteur . - 2008 . - p.2-13. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-1 (January 2008) . - p.2-13 Mots-clés : Imaging MRI PET Morphometry Segmentation Data-sharing Index. décimale : PER Périodiques Résumé : Data sharing in autism neuroimaging presents scientific, technical, and social obstacles. We outline the desiderata for a data-sharing scheme that combines imaging with other measures of phenotype and with genetics, defines requirements for comparability of derived data and recommendations for raw data, outlines a core protocol including multispectral structural and diffusion-tensor imaging and optional extensions, provides for the collection of prospective, confound-free normative data, and extends sharing and collaborative development not only to data but to the analytical tools and methods applied to these data. A theme in these requirements is the need to preserve creative approaches and risk-taking within individual laboratories at the same time as common standards are provided for these laboratories to build on. En ligne : http://dx.doi.org/10.1007/s10803-006-0352-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=315

The Neuroanatomy of ASD / Martha R. HERBERT

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A Whole Body Systems Approach to ASD / Martha R. HERBERT

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