Evidence for interplay between genes and parenting on infant temperament in the first year of life: monoamine oxidase A polymorphism moderates effects of maternal sensitivity on infant anger proneness / Andrew PICKLES in Journal of Child Psychology and Psychiatry, 54-12 (December 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-12 (December 2013) . - p.1308-1317 Titre : Evidence for interplay between genes and parenting on infant temperament in the first year of life: monoamine oxidase A polymorphism moderates effects of maternal sensitivity on infant anger proneness Type de document : Texte imprimé et/ou numérique Auteurs : Andrew PICKLES, Auteur ; Jonathan HILL, Auteur ; Gerome BREEN, Auteur ; John QUINN, Auteur ; Kate ABBOTT, Auteur ; Helen JONES, Auteur ; Helen SHARP, Auteur Article en page(s) : p.1308-1317 Langues : Anglais (eng) Mots-clés : Monoamine oxidase A  promoter polymorphism  maternal sensitivity  infant temperament  anger proneness gene by environment interaction Index. décimale : PER Périodiques Résumé : Background The low expression polymorphism of the MAOA gene in interaction with adverse environments (G × E) is associated with antisocial behaviour disorders. These have their origins in early life, but it is not known whether MAOA G × E occurs in infants. We therefore examined whether MAOA G × E predicts infant anger proneness, a temperamental dimension associated with later antisocial behaviour disorders. In contrast to previous studies, we examined MAOA G × E prospectively using an observational measure of a key aspect of the infant environment, maternal sensitivity, at a specified developmental time point. Methods In a stratified epidemiological cohort recruited during pregnancy, we ascertained MAOA status (low vs. high expression alleles) from the saliva of 193 infants, and examined specific predictions to maternal report of infant temperament at 14 months from maternal sensitivity assessed at 29 weeks of age. Results Analyses, weighted to provide general population estimates, indicated a robust interaction between MAOA status and maternal sensitivity in the prediction of infant anger proneness (p = .003) which became stronger once possible confounders for maternal sensitivity were included in the model (p = .0001). The interaction terms were similar in males (p = .010) and females (p = .016), but the effects were different as a consequence of an additional sex of infant by maternal sensitivity interaction. Conclusions This prospective study provides the first evidence of moderation by the MAOA gene of effects of parenting on infant anger proneness, an important early risk for the development of disruptive and aggressive behaviour disorders. En ligne : http://dx.doi.org/10.1111/jcpp.12081 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219 [article] Evidence for interplay between genes and parenting on infant temperament in the first year of life: monoamine oxidase A polymorphism moderates effects of maternal sensitivity on infant anger proneness [Texte imprimé et/ou numérique] / Andrew PICKLES, Auteur ; Jonathan HILL, Auteur ; Gerome BREEN, Auteur ; John QUINN, Auteur ; Kate ABBOTT, Auteur ; Helen JONES, Auteur ; Helen SHARP, Auteur . - p.1308-1317. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-12 (December 2013) . - p.1308-1317 Mots-clés : Monoamine oxidase A  promoter polymorphism  maternal sensitivity  infant temperament  anger proneness gene by environment interaction Index. décimale : PER Périodiques Résumé : Background The low expression polymorphism of the MAOA gene in interaction with adverse environments (G × E) is associated with antisocial behaviour disorders. These have their origins in early life, but it is not known whether MAOA G × E occurs in infants. We therefore examined whether MAOA G × E predicts infant anger proneness, a temperamental dimension associated with later antisocial behaviour disorders. In contrast to previous studies, we examined MAOA G × E prospectively using an observational measure of a key aspect of the infant environment, maternal sensitivity, at a specified developmental time point. Methods In a stratified epidemiological cohort recruited during pregnancy, we ascertained MAOA status (low vs. high expression alleles) from the saliva of 193 infants, and examined specific predictions to maternal report of infant temperament at 14 months from maternal sensitivity assessed at 29 weeks of age. Results Analyses, weighted to provide general population estimates, indicated a robust interaction between MAOA status and maternal sensitivity in the prediction of infant anger proneness (p = .003) which became stronger once possible confounders for maternal sensitivity were included in the model (p = .0001). The interaction terms were similar in males (p = .010) and females (p = .016), but the effects were different as a consequence of an additional sex of infant by maternal sensitivity interaction. Conclusions This prospective study provides the first evidence of moderation by the MAOA gene of effects of parenting on infant anger proneness, an important early risk for the development of disruptive and aggressive behaviour disorders. En ligne : http://dx.doi.org/10.1111/jcpp.12081 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219

Evidence for sex differences in fetal programming of physiological stress reactivity in infancy / Florin TIBU in Development and Psychopathology, 26-4 (Part 1) (November 2014)  

Public ISBD [article]  inDevelopment and Psychopathology > 26-4 (Part 1) (November 2014) . - p.879-888 Titre : Evidence for sex differences in fetal programming of physiological stress reactivity in infancy Type de document : Texte imprimé et/ou numérique Auteurs : Florin TIBU, Auteur ; Jonathan HILL, Auteur ; Helen SHARP, Auteur ; Kate MARSHALL, Auteur ; Vivette GLOVER, Auteur ; Andrew PICKLES, Auteur Année de publication : 2014 Article en page(s) : p.879-888 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Associations between low birth weight and prenatal anxiety and later psychopathology may arise from programming effects likely to be adaptive under some, but not other, environmental exposures and modified by sex differences. If physiological reactivity, which also confers vulnerability or resilience in an environment-dependent manner, is associated with birth weight and prenatal anxiety, it will be a candidate to mediate the links with psychopathology. From a general population sample of 1,233 first-time mothers recruited at 20 weeks gestation, a sample of 316 stratified by adversity was assessed at 32 weeks and when their infants were aged 29 weeks (N = 271). Prenatal anxiety was assessed by self-report, birth weight from medical records, and vagal reactivity from respiratory sinus arrhythmia during four nonstressful and one stressful (still-face) procedure. Lower birth weight for gestational age predicted higher vagal reactivity only in girls (interaction term, p = .016), and prenatal maternal anxiety predicted lower vagal reactivity only in boys (interaction term, p = .014). These findings are consistent with sex differences in fetal programming, whereby prenatal risks are associated with increased stress reactivity in females but decreased reactivity in males, with distinctive advantages and penalties for each sex. En ligne : http://dx.doi.org/10.1017/S0954579414000194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=242 [article] Evidence for sex differences in fetal programming of physiological stress reactivity in infancy [Texte imprimé et/ou numérique] / Florin TIBU, Auteur ; Jonathan HILL, Auteur ; Helen SHARP, Auteur ; Kate MARSHALL, Auteur ; Vivette GLOVER, Auteur ; Andrew PICKLES, Auteur . - 2014 . - p.879-888. Langues : Anglais (eng) in Development and Psychopathology > 26-4 (Part 1) (November 2014) . - p.879-888 Index. décimale : PER Périodiques Résumé : Associations between low birth weight and prenatal anxiety and later psychopathology may arise from programming effects likely to be adaptive under some, but not other, environmental exposures and modified by sex differences. If physiological reactivity, which also confers vulnerability or resilience in an environment-dependent manner, is associated with birth weight and prenatal anxiety, it will be a candidate to mediate the links with psychopathology. From a general population sample of 1,233 first-time mothers recruited at 20 weeks gestation, a sample of 316 stratified by adversity was assessed at 32 weeks and when their infants were aged 29 weeks (N = 271). Prenatal anxiety was assessed by self-report, birth weight from medical records, and vagal reactivity from respiratory sinus arrhythmia during four nonstressful and one stressful (still-face) procedure. Lower birth weight for gestational age predicted higher vagal reactivity only in girls (interaction term, p = .016), and prenatal maternal anxiety predicted lower vagal reactivity only in boys (interaction term, p = .014). These findings are consistent with sex differences in fetal programming, whereby prenatal risks are associated with increased stress reactivity in females but decreased reactivity in males, with distinctive advantages and penalties for each sex. En ligne : http://dx.doi.org/10.1017/S0954579414000194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=242

Sex differences in foetal origins of child emotional symptoms: a test of evolutionary hypotheses in a large, general population cohort / Elizabeth C. BRAITHWAITE in Journal of Child Psychology and Psychiatry, 61-11 (November 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-11 (November 2020) . - p.1194-1202 Titre : Sex differences in foetal origins of child emotional symptoms: a test of evolutionary hypotheses in a large, general population cohort Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth C. BRAITHWAITE, Auteur ; Andrew PICKLES, Auteur ; Nicola WRIGHT, Auteur ; Helen SHARP, Auteur ; Jonathan HILL, Auteur Article en page(s) : p.1194-1202 Langues : Anglais (eng) Mots-clés : Sex differences  emotional disorder  maternal depression  postnatal  prenatal Index. décimale : PER Périodiques Résumé : BACKGROUND: Based on previous findings from the Wirral Child Health and Development Study (WCHADS), and on evolutionary hypotheses, we preregistered analyses of data from a large epidemiological sample (https://osf.io/fn5g9/register/564d31db8c5e4a7c9694b2be), to test for sex-dependent moderation by prenatal maternal depressive symptoms of the association between postnatal maternal depressive symptoms and child emotional problems. METHODS: A total of 8,354 mothers and children were followed from pregnancy to 3.5 years in the Avon Longitudinal Study of Parents and Children (ALSPAC). Self-report measures of prenatal and postnatal maternal depressive symptoms, and maternal report of child emotional symptoms were administered. RESULTS: There was a three-way interaction between maternal prenatal and postnatal depression, and child sex (Coeff .042 95% CI 0.015 to 0.068, p = .002). This arose from moderation by prenatal depression, in opposite directions in boys and in girls. In boys, the association between postnatal depression and child emotional symptoms was weaker following lower prenatal depressive symptoms (interaction term coeff = .030, p = .001), and in girls, to a lesser extent, the association was stronger following lower prenatal depressive symptoms (interaction term coeff = -.012, p = .221). CONCLUSIONS: We replicated the finding from the WCHADS that prenatal depression modifies the association between postnatal depression and children's emotional problems in a sex-dependent fashion. In ALSPAC, the sex difference was explained mainly by a protective effect of low prenatal depression in boys, while in WCHADS, it arose from greater vulnerability of girls to postnatal depression following low prenatal depression. In the light of these findings, in evaluating and implementing early interventions, there is need to consider that risks associated with postnatal depression may vary depending on maternal mood during pregnancy and may differ between boys and girls. En ligne : http://dx.doi.org/10.1111/jcpp.13229 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 [article] Sex differences in foetal origins of child emotional symptoms: a test of evolutionary hypotheses in a large, general population cohort [Texte imprimé et/ou numérique] / Elizabeth C. BRAITHWAITE, Auteur ; Andrew PICKLES, Auteur ; Nicola WRIGHT, Auteur ; Helen SHARP, Auteur ; Jonathan HILL, Auteur . - p.1194-1202. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-11 (November 2020) . - p.1194-1202 Mots-clés : Sex differences  emotional disorder  maternal depression  postnatal  prenatal Index. décimale : PER Périodiques Résumé : BACKGROUND: Based on previous findings from the Wirral Child Health and Development Study (WCHADS), and on evolutionary hypotheses, we preregistered analyses of data from a large epidemiological sample (https://osf.io/fn5g9/register/564d31db8c5e4a7c9694b2be), to test for sex-dependent moderation by prenatal maternal depressive symptoms of the association between postnatal maternal depressive symptoms and child emotional problems. METHODS: A total of 8,354 mothers and children were followed from pregnancy to 3.5 years in the Avon Longitudinal Study of Parents and Children (ALSPAC). Self-report measures of prenatal and postnatal maternal depressive symptoms, and maternal report of child emotional symptoms were administered. RESULTS: There was a three-way interaction between maternal prenatal and postnatal depression, and child sex (Coeff .042 95% CI 0.015 to 0.068, p = .002). This arose from moderation by prenatal depression, in opposite directions in boys and in girls. In boys, the association between postnatal depression and child emotional symptoms was weaker following lower prenatal depressive symptoms (interaction term coeff = .030, p = .001), and in girls, to a lesser extent, the association was stronger following lower prenatal depressive symptoms (interaction term coeff = -.012, p = .221). CONCLUSIONS: We replicated the finding from the WCHADS that prenatal depression modifies the association between postnatal depression and children's emotional problems in a sex-dependent fashion. In ALSPAC, the sex difference was explained mainly by a protective effect of low prenatal depression in boys, while in WCHADS, it arose from greater vulnerability of girls to postnatal depression following low prenatal depression. In the light of these findings, in evaluating and implementing early interventions, there is need to consider that risks associated with postnatal depression may vary depending on maternal mood during pregnancy and may differ between boys and girls. En ligne : http://dx.doi.org/10.1111/jcpp.13229 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434

Sex differences in the associations between vagal reactivity and oppositional defiant disorder symptoms / Pablo VIDAL-RIBAS in Journal of Child Psychology and Psychiatry, 58-9 (September 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-9 (September 2017) . - p.988-997 Titre : Sex differences in the associations between vagal reactivity and oppositional defiant disorder symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Pablo VIDAL-RIBAS, Auteur ; Andrew PICKLES, Auteur ; Florin TIBU, Auteur ; Helen SHARP, Auteur ; Jonathan HILL, Auteur Article en page(s) : p.988-997 Langues : Anglais (eng) Mots-clés : Vagal reactivity  oppositional defiant disorder  irritability  headstrong  sex differences Index. décimale : PER Périodiques Résumé : Background Vagal reactivity to stress in children has been associated with future psychiatric outcomes. However, results have been mixed possibly because these effects are in opposite direction in boys and girls. These sex differences are relevant in the context of development of psychopathology, whereby the rates of psychiatric disorders differ by sex. In this study, we aimed to examine the association between vagal reactivity, assessed as a reduction in respiratory sinus arrhythmia (RSA) in response to a challenge, and the development of future oppositional defiant disorder (ODD) symptoms in boys and girls. In addition, we examine the specific associations with ODD symptom dimensions, named irritability and headstrong. We hypothesized that increased vagal reactivity was associated with increased ODD symptoms in girls and a reduction in ODD symptoms in boys. Methods Participants were members of the Wirral Child Health and Development Study, a prospective epidemiological longitudinal study of 1,233 first-time mothers recruited at 20 weeks’ gestation. RSA during four nonstressful and one stressful (still-face) procedures was assessed when children were aged 29 weeks in a sample stratified by adversity (n = 270). Maternal reports of ODD symptoms were collected when children were 2.5 years old (n = 253), 3.5 years old (n = 826), and 5 years old (n = 770). Structural equation modeling (SEM) was employed to test our hypotheses. Results There was a significant sex difference in the prediction of ODD symptoms due to the opposite directionality in which increasing vagal reactivity was associated with an increase in ODD symptoms in girls and a reduction of ODD symptoms in boys. This Sex by Vagal reactivity interaction was common for both ODD dimensions, with no sex by dimension-specific associations. Conclusions Physiological reactivity to a stressful situation predicts differently ODD symptoms in boys and girls very early in life, with no difference across irritability and headstrong components. Findings are discussed in the context of the several mechanisms involved on the later development of distinct psychiatric disorders in boys and girls. En ligne : http://dx.doi.org/10.1111/jcpp.12750 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317 [article] Sex differences in the associations between vagal reactivity and oppositional defiant disorder symptoms [Texte imprimé et/ou numérique] / Pablo VIDAL-RIBAS, Auteur ; Andrew PICKLES, Auteur ; Florin TIBU, Auteur ; Helen SHARP, Auteur ; Jonathan HILL, Auteur . - p.988-997. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-9 (September 2017) . - p.988-997 Mots-clés : Vagal reactivity  oppositional defiant disorder  irritability  headstrong  sex differences Index. décimale : PER Périodiques Résumé : Background Vagal reactivity to stress in children has been associated with future psychiatric outcomes. However, results have been mixed possibly because these effects are in opposite direction in boys and girls. These sex differences are relevant in the context of development of psychopathology, whereby the rates of psychiatric disorders differ by sex. In this study, we aimed to examine the association between vagal reactivity, assessed as a reduction in respiratory sinus arrhythmia (RSA) in response to a challenge, and the development of future oppositional defiant disorder (ODD) symptoms in boys and girls. In addition, we examine the specific associations with ODD symptom dimensions, named irritability and headstrong. We hypothesized that increased vagal reactivity was associated with increased ODD symptoms in girls and a reduction in ODD symptoms in boys. Methods Participants were members of the Wirral Child Health and Development Study, a prospective epidemiological longitudinal study of 1,233 first-time mothers recruited at 20 weeks’ gestation. RSA during four nonstressful and one stressful (still-face) procedures was assessed when children were aged 29 weeks in a sample stratified by adversity (n = 270). Maternal reports of ODD symptoms were collected when children were 2.5 years old (n = 253), 3.5 years old (n = 826), and 5 years old (n = 770). Structural equation modeling (SEM) was employed to test our hypotheses. Results There was a significant sex difference in the prediction of ODD symptoms due to the opposite directionality in which increasing vagal reactivity was associated with an increase in ODD symptoms in girls and a reduction of ODD symptoms in boys. This Sex by Vagal reactivity interaction was common for both ODD dimensions, with no sex by dimension-specific associations. Conclusions Physiological reactivity to a stressful situation predicts differently ODD symptoms in boys and girls very early in life, with no difference across irritability and headstrong components. Findings are discussed in the context of the several mechanisms involved on the later development of distinct psychiatric disorders in boys and girls. En ligne : http://dx.doi.org/10.1111/jcpp.12750 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317

The effect of cleft lip and palate, and the timing of lip repair on mother–infant interactions and infant development / Lynne MURRAY in Journal of Child Psychology and Psychiatry, 49-2 (February 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-2 (February 2008) . - p.115–123 Titre : The effect of cleft lip and palate, and the timing of lip repair on mother–infant interactions and infant development Type de document : Texte imprimé et/ou numérique Auteurs : Lynne MURRAY, Auteur ; Tim GOODACRE, Auteur ; Tony MOSS, Auteur ; Peter WOODALL, Auteur ; Marianne KREUTZ, Auteur ; Beejal MISTRY, Auteur ; Janne KARPF, Auteur ; Jonathan HILL, Auteur ; Françoise HENTGES, Auteur ; CLEFT LIP AND PALATE STUDY TEAM, Auteur Année de publication : 2008 Article en page(s) : p.115–123 Langues : Anglais (eng) Mots-clés : Cleft-lip-and-palate mother–infant-interactions cognitive-development attachment behaviour-problems infancy intelligence sensitive-period Index. décimale : PER Périodiques Résumé : Children with cleft lip and palate are at risk for psychological problems. Difficulties in mother–child interactions may be relevant, and could be affected by the timing of lip repair. Method: We assessed cognitive development, behaviour problems, and attachment in 94 infants with cleft lip (with and without cleft palate) and 96 non-affected control infants at 18 months; mother–infant interactions were assessed at two, six and 12 months. Index infants received either ‘early’, neonatal, lip repair, or ‘late’ repair (3–4 months). Results: Index infants did not differ from controls on measures of behaviour problems or attachment, regardless of timing of lip repair; however, infants having late lip repair performed worse on the Bayley Scales of Mental Development; the cognitive development of early repair infants was not impaired. Difficulties in early mother–infant interactions mediated the effects of late lip repair on infant cognitive outcome. Conclusions: Early interaction difficulties between mothers and infants having late repair of cleft lip are associated with poor cognitive functioning at 18 months. Interventions to facilitate mother–infant interactions prior to surgical lip repair should be explored. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01833.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=320 [article] The effect of cleft lip and palate, and the timing of lip repair on mother–infant interactions and infant development [Texte imprimé et/ou numérique] / Lynne MURRAY, Auteur ; Tim GOODACRE, Auteur ; Tony MOSS, Auteur ; Peter WOODALL, Auteur ; Marianne KREUTZ, Auteur ; Beejal MISTRY, Auteur ; Janne KARPF, Auteur ; Jonathan HILL, Auteur ; Françoise HENTGES, Auteur ; CLEFT LIP AND PALATE STUDY TEAM, Auteur . - 2008 . - p.115–123. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-2 (February 2008) . - p.115–123 Mots-clés : Cleft-lip-and-palate mother–infant-interactions cognitive-development attachment behaviour-problems infancy intelligence sensitive-period Index. décimale : PER Périodiques Résumé : Children with cleft lip and palate are at risk for psychological problems. Difficulties in mother–child interactions may be relevant, and could be affected by the timing of lip repair. Method: We assessed cognitive development, behaviour problems, and attachment in 94 infants with cleft lip (with and without cleft palate) and 96 non-affected control infants at 18 months; mother–infant interactions were assessed at two, six and 12 months. Index infants received either ‘early’, neonatal, lip repair, or ‘late’ repair (3–4 months). Results: Index infants did not differ from controls on measures of behaviour problems or attachment, regardless of timing of lip repair; however, infants having late lip repair performed worse on the Bayley Scales of Mental Development; the cognitive development of early repair infants was not impaired. Difficulties in early mother–infant interactions mediated the effects of late lip repair on infant cognitive outcome. Conclusions: Early interaction difficulties between mothers and infants having late repair of cleft lip are associated with poor cognitive functioning at 18 months. Interventions to facilitate mother–infant interactions prior to surgical lip repair should be explored. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01833.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=320

The effect of cleft lip on cognitive development in school-aged children: a paradigm for examining sensitive period effects / Françoise HENTGES in Journal of Child Psychology and Psychiatry, 52-6 (June 2011)  

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The effect of cleft lip on socio-emotional functioning in school-aged children / Lynne MURRAY in Journal of Child Psychology and Psychiatry, 51-1 (January 2010)  

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The social domains organization of mentalizing processes in adolescents: a contribution to the conceptualization of personality function and dysfunction in young people / Jonathan HILL in Journal of Child Psychology and Psychiatry, 64-10 (October 2023)  

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Warmth and reciprocity with mothers, and young children's resilience to exposure to community violence in Colombia: findings from the La Sabana Parent-Child Study / Diana OBANDO in Journal of Child Psychology and Psychiatry, 64-1 (January 2023)  

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Why does early childhood deprivation increase the risk for depression and anxiety in adulthood? A developmental cascade model / Dennis GOLM in Journal of Child Psychology and Psychiatry, 61-9 (September 2020)  

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