Defining the social phenotype in Williams syndrome: A model for linking gene, the brain, and behavior / Anna JARVINEN-PASLEY in Development and Psychopathology, 20-1 (Winter 2008)  

Public ISBD [article]  inDevelopment and Psychopathology > 20-1 (Winter 2008) . - p.1-35 Titre : Defining the social phenotype in Williams syndrome: A model for linking gene, the brain, and behavior Type de document : texte imprimé Auteurs : Anna JARVINEN-PASLEY, Auteur ; Ursula BELLUGI, Auteur ; Allan L. REISS, Auteur ; Judy REILLY, Auteur ; Debra L. MILLS, Auteur ; Albert GALABURDA, Auteur ; Julie R. KORENBERG, Auteur Année de publication : 2008 Article en page(s) : p.1-35 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Research into phenotype–genotype correlations in neurodevelopmental disorders has greatly elucidated the contribution of genetic and neurobiological factors to variations in typical and atypical development. Etiologically relatively homogeneous disorders, such as Williams syndrome (WS), provide unique opportunities for elucidating gene–brain–behavior relationships. WS is a neurogenetic disorder caused by a hemizygous deletion of approximately 25 genes on chromosome 7q11.23. This results in a cascade of physical, cognitive–behavioral, affective, and neurobiological aberrations. WS is associated with a markedly uneven neurocognitive profile, and the mature state cognitive profile of WS is relatively well developed. Although anecdotally, individuals with WS have been frequently described as unusually friendly and sociable, personality remains a considerably less well studied area. This paper investigates genetic influences, cognitive–behavioral characteristics, aberrations in brain structure and function, and environmental and biological variables that influence the social outcomes of individuals with WS. We bring together a series of findings across multiple levels of scientific enquiry to examine the social phenotype in WS, reflecting the journey from gene to the brain to behavior. Understanding the complex multilevel scientific perspective in WS has implications for understanding typical social development by identifying important developmental events and markers, as well as helping to define the boundaries of psychopathology. En ligne : http://dx.doi.org/10.1017/s0954579408000011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331 [article] Defining the social phenotype in Williams syndrome: A model for linking gene, the brain, and behavior [texte imprimé] / Anna JARVINEN-PASLEY, Auteur ; Ursula BELLUGI, Auteur ; Allan L. REISS, Auteur ; Judy REILLY, Auteur ; Debra L. MILLS, Auteur ; Albert GALABURDA, Auteur ; Julie R. KORENBERG, Auteur . - 2008 . - p.1-35. Langues : Anglais (eng) in Development and Psychopathology > 20-1 (Winter 2008) . - p.1-35 Index. décimale : PER Périodiques Résumé : Research into phenotype–genotype correlations in neurodevelopmental disorders has greatly elucidated the contribution of genetic and neurobiological factors to variations in typical and atypical development. Etiologically relatively homogeneous disorders, such as Williams syndrome (WS), provide unique opportunities for elucidating gene–brain–behavior relationships. WS is a neurogenetic disorder caused by a hemizygous deletion of approximately 25 genes on chromosome 7q11.23. This results in a cascade of physical, cognitive–behavioral, affective, and neurobiological aberrations. WS is associated with a markedly uneven neurocognitive profile, and the mature state cognitive profile of WS is relatively well developed. Although anecdotally, individuals with WS have been frequently described as unusually friendly and sociable, personality remains a considerably less well studied area. This paper investigates genetic influences, cognitive–behavioral characteristics, aberrations in brain structure and function, and environmental and biological variables that influence the social outcomes of individuals with WS. We bring together a series of findings across multiple levels of scientific enquiry to examine the social phenotype in WS, reflecting the journey from gene to the brain to behavior. Understanding the complex multilevel scientific perspective in WS has implications for understanding typical social development by identifying important developmental events and markers, as well as helping to define the boundaries of psychopathology. En ligne : http://dx.doi.org/10.1017/s0954579408000011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331

Language and sociability: insights from Williams syndrome / Inna FISHMAN in Journal of Neurodevelopmental Disorders, 3-3 (September 2011)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 3-3 (September 2011) . - p.185-92 Titre : Language and sociability: insights from Williams syndrome Type de document : texte imprimé Auteurs : Inna FISHMAN, Auteur ; A. YAM, Auteur ; Ursula BELLUGI, Auteur ; Debra L. MILLS, Auteur Article en page(s) : p.185-92 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : One of the most compelling features of Williams syndrome (WS) is the widely reported excessive sociability, accompanied by a relative proficiency in expressive language, which stands in stark contrast with significant intellectual and nonverbal impairments. It has been proposed that the unique language skills observed in WS are implicated in the strong drive to interact and communicate with others, which has been widely documented in WS. Nevertheless, this proposition has yet to be empirically examined. The present study aimed at investigating the relationship between a brain index of language processing and judgments of approachability of faces, as a proxy for sociability, in individuals with WS as contrasted to typical controls. Results revealed a significant and substantial association between the two in the WS, but not in the control group, supporting the hitherto untested notion that language use in WS might be uniquely related to their excessive social drive. En ligne : http://dx.doi.org/10.1007/s11689-011-9086-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343 [article] Language and sociability: insights from Williams syndrome [texte imprimé] / Inna FISHMAN, Auteur ; A. YAM, Auteur ; Ursula BELLUGI, Auteur ; Debra L. MILLS, Auteur . - p.185-92. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 3-3 (September 2011) . - p.185-92 Index. décimale : PER Périodiques Résumé : One of the most compelling features of Williams syndrome (WS) is the widely reported excessive sociability, accompanied by a relative proficiency in expressive language, which stands in stark contrast with significant intellectual and nonverbal impairments. It has been proposed that the unique language skills observed in WS are implicated in the strong drive to interact and communicate with others, which has been widely documented in WS. Nevertheless, this proposition has yet to be empirically examined. The present study aimed at investigating the relationship between a brain index of language processing and judgments of approachability of faces, as a proxy for sociability, in individuals with WS as contrasted to typical controls. Results revealed a significant and substantial association between the two in the WS, but not in the control group, supporting the hitherto untested notion that language use in WS might be uniquely related to their excessive social drive. En ligne : http://dx.doi.org/10.1007/s11689-011-9086-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343

A preliminary study of orbitofrontal activation and hypersociability in Williams Syndrome / Masaru MIMURA in Journal of Neurodevelopmental Disorders, 2-2 (June 2010)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 2-2 (June 2010) . - p.93-98 Titre : A preliminary study of orbitofrontal activation and hypersociability in Williams Syndrome Type de document : texte imprimé Auteurs : Masaru MIMURA, Auteur ; Fumiko HOEFT, Auteur ; Motoichiro KATO, Auteur ; Nobuhisa KOBAYASHI, Auteur ; K. SHEAU, Auteur ; J. PIGGOT, Auteur ; Debra L. MILLS, Auteur ; Albert GALABURDA, Auteur ; Julie R. KORENBERG, Auteur ; Ursula BELLUGI, Auteur ; Allan L. REISS, Auteur Article en page(s) : p.93-98 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Individuals with Williams syndrome (WS) demonstrate an abnormally positive social bias. However, the neural substrates of this hypersociability, i.e., positive attribution bias and increased drive toward social interaction, have not fully been elucidated. METHODS: We performed an event-related functional magnetic resonance imaging study while individuals with WS and typically developing controls (TD) matched positive and negative emotional faces. WS compared to TD showed reduced right amygdala activation during presentation of negative faces, as in the previous literature. In addition, WS showed a unique pattern of right orbitofrontal cortex activation. While TD showed medial orbitofrontal cortex activation in response to positive, and lateral orbitofrontal cortex activation to negative, WS showed the opposite pattern. In light of the general notion of a medial/lateral gradient of reward/punishment processing in the orbitofrontal cortex, these findings provide an additional biological explanation for, or correlate of positive attribution bias and hypersociability in WS. En ligne : http://dx.doi.org/10.1007/s11689-009-9041-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342 [article] A preliminary study of orbitofrontal activation and hypersociability in Williams Syndrome [texte imprimé] / Masaru MIMURA, Auteur ; Fumiko HOEFT, Auteur ; Motoichiro KATO, Auteur ; Nobuhisa KOBAYASHI, Auteur ; K. SHEAU, Auteur ; J. PIGGOT, Auteur ; Debra L. MILLS, Auteur ; Albert GALABURDA, Auteur ; Julie R. KORENBERG, Auteur ; Ursula BELLUGI, Auteur ; Allan L. REISS, Auteur . - p.93-98. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 2-2 (June 2010) . - p.93-98 Index. décimale : PER Périodiques Résumé : Individuals with Williams syndrome (WS) demonstrate an abnormally positive social bias. However, the neural substrates of this hypersociability, i.e., positive attribution bias and increased drive toward social interaction, have not fully been elucidated. METHODS: We performed an event-related functional magnetic resonance imaging study while individuals with WS and typically developing controls (TD) matched positive and negative emotional faces. WS compared to TD showed reduced right amygdala activation during presentation of negative faces, as in the previous literature. In addition, WS showed a unique pattern of right orbitofrontal cortex activation. While TD showed medial orbitofrontal cortex activation in response to positive, and lateral orbitofrontal cortex activation to negative, WS showed the opposite pattern. In light of the general notion of a medial/lateral gradient of reward/punishment processing in the orbitofrontal cortex, these findings provide an additional biological explanation for, or correlate of positive attribution bias and hypersociability in WS. En ligne : http://dx.doi.org/10.1007/s11689-009-9041-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342

Training parent - child interactions / Laura SCHREIBMAN

Public ISBD contenu dans The Effects of Autism on the Family / Eric SCHOPLER Titre : Training parent - child interactions Type de document : texte imprimé Auteurs : Laura SCHREIBMAN, Auteur ; Robert L. KOEGEL, Auteur ; Debra L. MILLS, Auteur ; John C. BURKE, Auteur Année de publication : 1984 Importance : p.187-205 Langues : Anglais (eng) Index. décimale : VIE-G VIE-G - Vie Quotidienne - Parents - Aidants Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=954 contenu dans The Effects of Autism on the Family / Eric SCHOPLER Training parent - child interactions [texte imprimé] / Laura SCHREIBMAN, Auteur ; Robert L. KOEGEL, Auteur ; Debra L. MILLS, Auteur ; John C. BURKE, Auteur . - 1984 . - p.187-205. Langues : Anglais (eng) Index. décimale : VIE-G VIE-G - Vie Quotidienne - Parents - Aidants Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=954

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