Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45 / D. MASON in Autism Research, 14-8 (August 2021)  

Public ISBD [article]  inAutism Research > 14-8 (August 2021) . - p.1684-1694 Titre : Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45 Type de document : Texte imprimé et/ou numérique Auteurs : D. MASON, Auteur ; A. RONALD, Auteur ; A. AMBLER, Auteur ; Avshalom CASPI, Auteur ; R. HOUTS, Auteur ; R. POULTON, Auteur ; S. RAMRAKHA, Auteur ; J. WERTZ, Auteur ; T. E. MOFFITT, Auteur ; Francesca HAPPE, Auteur Article en page(s) : p.1684-1694 Langues : Anglais (eng) Mots-clés : Adult  Aging  Autism Spectrum Disorder  Autistic Disorder  Humans  Middle Aged  Surveys and Questionnaires  aging  autistic traits  intelligence  physical health  socioeconomic status Index. décimale : PER Périodiques Résumé : Growing evidence indicates that the defining characteristics of autism spectrum disorder (ASD) are distributed throughout the general population; hence, understanding the correlates of aging in people with high autistic traits could shed light on ASD and aging. 915 members of the Dunedin longitudinal birth cohort completed a measure of autistic traits at age 45. A composite measure of the "pace of aging" was derived by tracking the decline in 19 biomarkers across ages 26, 32, 38, and 45?years. Facial age was also assessed. Reports of perceived health were collected from participants themselves, informants, and interviewers. Higher self-reported autistic traits significantly correlated with a faster pace of aging, older facial age, and poorer self-, informant-, and interviewer-rated health. After control for sex, SES and IQ, autistic traits were significantly associated with each variable: pace of aging (? = 0.09), facial age (? = 0.08), self- (? = -0.15), informant (? = -0.12), and interviewer-rated (? = -0.17) health. Autistic traits measured at age 45 are associated with faster aging. Participants with high autistic traits appear to be more vulnerable to poor health outcomes, as previously reported for those clinically diagnosed with ASD. Therefore, autistic traits may have important health implications. Replicating these findings in samples of autistic people is needed to identify the mechanism of their effect on aging and physical health to improve outcomes for those with ASD diagnoses or high autistic traits. LAY SUMMARY: The role that autistic traits have in relation to health outcomes has not been investigated. We looked at how physical health and aging (measured with self-reported questions and decline in multiple biological measures) were related to autistic traits (measured with a questionnaire, at age 45). We found that higher autistic traits were associated with poorer reports of physical health, and a faster pace of aging. This suggests that both those with autism and those with higher autistic traits may be more likely to experience poorer health outcomes. En ligne : http://dx.doi.org/10.1002/aur.2534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45 [Texte imprimé et/ou numérique] / D. MASON, Auteur ; A. RONALD, Auteur ; A. AMBLER, Auteur ; Avshalom CASPI, Auteur ; R. HOUTS, Auteur ; R. POULTON, Auteur ; S. RAMRAKHA, Auteur ; J. WERTZ, Auteur ; T. E. MOFFITT, Auteur ; Francesca HAPPE, Auteur . - p.1684-1694. Langues : Anglais (eng) in Autism Research > 14-8 (August 2021) . - p.1684-1694 Mots-clés : Adult  Aging  Autism Spectrum Disorder  Autistic Disorder  Humans  Middle Aged  Surveys and Questionnaires  aging  autistic traits  intelligence  physical health  socioeconomic status Index. décimale : PER Périodiques Résumé : Growing evidence indicates that the defining characteristics of autism spectrum disorder (ASD) are distributed throughout the general population; hence, understanding the correlates of aging in people with high autistic traits could shed light on ASD and aging. 915 members of the Dunedin longitudinal birth cohort completed a measure of autistic traits at age 45. A composite measure of the "pace of aging" was derived by tracking the decline in 19 biomarkers across ages 26, 32, 38, and 45?years. Facial age was also assessed. Reports of perceived health were collected from participants themselves, informants, and interviewers. Higher self-reported autistic traits significantly correlated with a faster pace of aging, older facial age, and poorer self-, informant-, and interviewer-rated health. After control for sex, SES and IQ, autistic traits were significantly associated with each variable: pace of aging (? = 0.09), facial age (? = 0.08), self- (? = -0.15), informant (? = -0.12), and interviewer-rated (? = -0.17) health. Autistic traits measured at age 45 are associated with faster aging. Participants with high autistic traits appear to be more vulnerable to poor health outcomes, as previously reported for those clinically diagnosed with ASD. Therefore, autistic traits may have important health implications. Replicating these findings in samples of autistic people is needed to identify the mechanism of their effect on aging and physical health to improve outcomes for those with ASD diagnoses or high autistic traits. LAY SUMMARY: The role that autistic traits have in relation to health outcomes has not been investigated. We looked at how physical health and aging (measured with self-reported questions and decline in multiple biological measures) were related to autistic traits (measured with a questionnaire, at age 45). We found that higher autistic traits were associated with poorer reports of physical health, and a faster pace of aging. This suggests that both those with autism and those with higher autistic traits may be more likely to experience poorer health outcomes. En ligne : http://dx.doi.org/10.1002/aur.2534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Enhancing the Validity of a Quality of Life Measure for Autistic People / H. MCCONACHIE in Journal of Autism and Developmental Disorders, 48-5 (May 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-5 (May 2018) . - p.1596-1611 Titre : Enhancing the Validity of a Quality of Life Measure for Autistic People Type de document : Texte imprimé et/ou numérique Auteurs : H. MCCONACHIE, Auteur ; D. MASON, Auteur ; Jeremy R. PARR, Auteur ; D. GARLAND, Auteur ; C. Ellie WILSON, Auteur ; J. RODGERS, Auteur Article en page(s) : p.1596-1611 Langues : Anglais (eng) Mots-clés : Autism  Measurement properties  Public mental health  Quality of life Index. décimale : PER Périodiques Résumé : Accurate measurement of quality of life (QoL) is important for evaluation of autism services and trials of interventions. We undertook psychometric validation of the World Health Organisation measure-WHOQoL-BREF, examined construct validity of the WHO Disabilities module and developed nine additional autism-specific items (ASQoL) from extensive consultation with the autism community. The sample of 309 autistic people was recruited from the Adult Autism Spectrum Cohort-UK. The WHOQoL-BREF had good psychometric properties, including criterion, convergent, divergent and discriminant validity. The WHO Disabilities module showed adequate construct validity and reliability. The ASQoL items form a unitary factor of QoL, with one global item. Future studies can use the WHO measures alongside the ASQoL items to measure QoL of autistic people. En ligne : http://dx.doi.org/10.1007/s10803-017-3402-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=355 [article] Enhancing the Validity of a Quality of Life Measure for Autistic People [Texte imprimé et/ou numérique] / H. MCCONACHIE, Auteur ; D. MASON, Auteur ; Jeremy R. PARR, Auteur ; D. GARLAND, Auteur ; C. Ellie WILSON, Auteur ; J. RODGERS, Auteur . - p.1596-1611. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-5 (May 2018) . - p.1596-1611 Mots-clés : Autism  Measurement properties  Public mental health  Quality of life Index. décimale : PER Périodiques Résumé : Accurate measurement of quality of life (QoL) is important for evaluation of autism services and trials of interventions. We undertook psychometric validation of the World Health Organisation measure-WHOQoL-BREF, examined construct validity of the WHO Disabilities module and developed nine additional autism-specific items (ASQoL) from extensive consultation with the autism community. The sample of 309 autistic people was recruited from the Adult Autism Spectrum Cohort-UK. The WHOQoL-BREF had good psychometric properties, including criterion, convergent, divergent and discriminant validity. The WHO Disabilities module showed adequate construct validity and reliability. The ASQoL items form a unitary factor of QoL, with one global item. Future studies can use the WHO measures alongside the ASQoL items to measure QoL of autistic people. En ligne : http://dx.doi.org/10.1007/s10803-017-3402-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=355

A Meta-analysis of Outcome Studies of Autistic Adults: Quantifying Effect Size, Quality, and Meta-regression / D. MASON in Journal of Autism and Developmental Disorders, 51-9 (September 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3165-3179 Titre : A Meta-analysis of Outcome Studies of Autistic Adults: Quantifying Effect Size, Quality, and Meta-regression Type de document : Texte imprimé et/ou numérique Auteurs : D. MASON, Auteur ; Simone J CAPP, Auteur ; G. R. STEWART, Auteur ; M. J. KEMPTON, Auteur ; K. GLASER, Auteur ; P. HOWLIN, Auteur ; Francesca HAPPE, Auteur Article en page(s) : p.3165-3179 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder  Autistic Disorder  Humans  Outcome Assessment, Health Care  Autism spectrum disorder  Functioning  Meta-analysis  Outcome Index. décimale : PER Périodiques Résumé : Longitudinal studies have generally reported poor outcomes in adulthood for the majority of individuals (c.50-60%) with autism. Several factors putatively predict outcome (e.g. IQ), but findings remain mixed. This paper presents an updated meta-analysis of autism outcome studies and extends previous findings with additional analyses (including meta-regression). A total of 4088 records was screened and 18 studies, involving 1199 individuals, were included in the quantitative analysis. Estimated percentages indicated that 20.0% of participants were rated as having a good outcome, 26.6% a fair outcome, and 49.3% a poor outcome. Meta-regression indicated that lower IQ in adulthood was predictive of poor outcome; other meta-regression models did not survive correction for multiple comparisons. Overall, outcomes for autistic people are on average poor, and higher IQ appears to be protective against having a poor outcome. The limitations of current constructs of outcome are discussed. En ligne : http://dx.doi.org/10.1007/s10803-020-04763-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] A Meta-analysis of Outcome Studies of Autistic Adults: Quantifying Effect Size, Quality, and Meta-regression [Texte imprimé et/ou numérique] / D. MASON, Auteur ; Simone J CAPP, Auteur ; G. R. STEWART, Auteur ; M. J. KEMPTON, Auteur ; K. GLASER, Auteur ; P. HOWLIN, Auteur ; Francesca HAPPE, Auteur . - p.3165-3179. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3165-3179 Mots-clés : Adult  Autism Spectrum Disorder  Autistic Disorder  Humans  Outcome Assessment, Health Care  Autism spectrum disorder  Functioning  Meta-analysis  Outcome Index. décimale : PER Périodiques Résumé : Longitudinal studies have generally reported poor outcomes in adulthood for the majority of individuals (c.50-60%) with autism. Several factors putatively predict outcome (e.g. IQ), but findings remain mixed. This paper presents an updated meta-analysis of autism outcome studies and extends previous findings with additional analyses (including meta-regression). A total of 4088 records was screened and 18 studies, involving 1199 individuals, were included in the quantitative analysis. Estimated percentages indicated that 20.0% of participants were rated as having a good outcome, 26.6% a fair outcome, and 49.3% a poor outcome. Meta-regression indicated that lower IQ in adulthood was predictive of poor outcome; other meta-regression models did not survive correction for multiple comparisons. Overall, outcomes for autistic people are on average poor, and higher IQ appears to be protective against having a poor outcome. The limitations of current constructs of outcome are discussed. En ligne : http://dx.doi.org/10.1007/s10803-020-04763-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

Predictors of quality of life for autistic adults / D. MASON in Autism Research, 11-8 (August 2018)  

Public ISBD [article]  inAutism Research > 11-8 (August 2018) . - p.1138-1147 Titre : Predictors of quality of life for autistic adults Type de document : Texte imprimé et/ou numérique Auteurs : D. MASON, Auteur ; H. MCCONACHIE, Auteur ; D. GARLAND, Auteur ; A. PETROU, Auteur ; J. RODGERS, Auteur ; Jeremy R. PARR, Auteur Article en page(s) : p.1138-1147 Langues : Anglais (eng) Mots-clés : autism  gender  public mental health  quality of life Index. décimale : PER Périodiques Résumé : Research with adults on the autism spectrum is as yet limited in scope and quality. The present study describes quality of life (QoL) of a large sample of autistic adults in the UK and investigates characteristics that may be predictive of QoL. A total of 370 autistic adults from the Adult Autism Spectrum Cohort-UK (ASC-UK) completed the WHOQoL-BREF, and the Social Responsiveness Scale (SRS, autism symptom severity), along with the ASC-UK registration questionnaire giving information on mental health and their life situation. QoL for autistic adults was lower than for the general population for each WHOQoL domain. Younger participants reported higher QoL than older participants in psychological and environment domains. Males reported higher physical QoL than females, and females reported higher social QoL than males. Significant positive predictors of QoL were: being employed (physical QoL), receiving support (social and environment QoL), and being in a relationship (social QoL). Having a mental health condition and higher SRS total score were negative predictors of QoL across all four domains. Autistic adults require access to effective mental health interventions, and informal and formal support for their social difficulties, to improve their quality of life. Autism Res 2018, 11: 1138-1147. (c) 2018 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. LAY SUMMARY: There has been limited research into the lived experience of autistic adults. Using the World Health Organization quality of life measure, we found that autistic people (370) in the UK reported their quality of life to be lower than that of the general population. Better quality of life was associated with being in a relationship; those with a mental health condition had poorer quality of life. This research suggests some ways in which autistic people can be helped to improve their quality of life. En ligne : http://dx.doi.org/10.1002/aur.1965 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 [article] Predictors of quality of life for autistic adults [Texte imprimé et/ou numérique] / D. MASON, Auteur ; H. MCCONACHIE, Auteur ; D. GARLAND, Auteur ; A. PETROU, Auteur ; J. RODGERS, Auteur ; Jeremy R. PARR, Auteur . - p.1138-1147. Langues : Anglais (eng) in Autism Research > 11-8 (August 2018) . - p.1138-1147 Mots-clés : autism  gender  public mental health  quality of life Index. décimale : PER Périodiques Résumé : Research with adults on the autism spectrum is as yet limited in scope and quality. The present study describes quality of life (QoL) of a large sample of autistic adults in the UK and investigates characteristics that may be predictive of QoL. A total of 370 autistic adults from the Adult Autism Spectrum Cohort-UK (ASC-UK) completed the WHOQoL-BREF, and the Social Responsiveness Scale (SRS, autism symptom severity), along with the ASC-UK registration questionnaire giving information on mental health and their life situation. QoL for autistic adults was lower than for the general population for each WHOQoL domain. Younger participants reported higher QoL than older participants in psychological and environment domains. Males reported higher physical QoL than females, and females reported higher social QoL than males. Significant positive predictors of QoL were: being employed (physical QoL), receiving support (social and environment QoL), and being in a relationship (social QoL). Having a mental health condition and higher SRS total score were negative predictors of QoL across all four domains. Autistic adults require access to effective mental health interventions, and informal and formal support for their social difficulties, to improve their quality of life. Autism Res 2018, 11: 1138-1147. (c) 2018 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. LAY SUMMARY: There has been limited research into the lived experience of autistic adults. Using the World Health Organization quality of life measure, we found that autistic people (370) in the UK reported their quality of life to be lower than that of the general population. Better quality of life was associated with being in a relationship; those with a mental health condition had poorer quality of life. This research suggests some ways in which autistic people can be helped to improve their quality of life. En ligne : http://dx.doi.org/10.1002/aur.1965 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

Quality of life for older autistic people: The impact of mental health difficulties / D. MASON in Research in Autism Spectrum Disorders, 63 (July 2019)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 63 (July 2019) . - p.13-22 Titre : Quality of life for older autistic people: The impact of mental health difficulties Type de document : Texte imprimé et/ou numérique Auteurs : D. MASON, Auteur ; J. MACKINTOSH, Auteur ; H. MCCONACHIE, Auteur ; J. RODGERS, Auteur ; T. FINCH, Auteur ; Jeremy R. PARR, Auteur Article en page(s) : p.13-22 Langues : Anglais (eng) Mots-clés : Quality of life  Ageing  Mental health  Normative outcomes  Lifecourse goals Index. décimale : PER Périodiques Résumé : Background Having a mental health condition is related to significantly lower subjective Quality of Life (QoL) for people on the autism spectrum. Many autistic people do not participate in so-called ‘normative’ outcomes, i.e. the achievement of lifecourse goals judged to be important by adults in the general population (e.g. being employed). This study aimed to investigate whether there is an association between the presence of mental health conditions, subjective QoL and participation in normative outcomes in older autistic people. Methods 69 autistic people (n?=?48 males) aged 55 years and over were identified from two studies that are part of the UK Autism Spectrum Adulthood and Ageing research programme. Participants provided demographic data to establish normative outcome participation, and completed the World Health Organisation (WHO) QoL measure (WHOQoL-BREF) and the Hospital Anxiety and Depression Scale (HADS). Illustrative quotes focusing on normative outcomes were available from in-depth interviews (n?=?8). Results QoL scores across all domains were lower for individuals who met indicative clinical cut-offs for depression (F(8,126)?=?6.171, p? En ligne : https://doi.org/10.1016/j.rasd.2019.02.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=394 [article] Quality of life for older autistic people: The impact of mental health difficulties [Texte imprimé et/ou numérique] / D. MASON, Auteur ; J. MACKINTOSH, Auteur ; H. MCCONACHIE, Auteur ; J. RODGERS, Auteur ; T. FINCH, Auteur ; Jeremy R. PARR, Auteur . - p.13-22. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 63 (July 2019) . - p.13-22 Mots-clés : Quality of life  Ageing  Mental health  Normative outcomes  Lifecourse goals Index. décimale : PER Périodiques Résumé : Background Having a mental health condition is related to significantly lower subjective Quality of Life (QoL) for people on the autism spectrum. Many autistic people do not participate in so-called ‘normative’ outcomes, i.e. the achievement of lifecourse goals judged to be important by adults in the general population (e.g. being employed). This study aimed to investigate whether there is an association between the presence of mental health conditions, subjective QoL and participation in normative outcomes in older autistic people. Methods 69 autistic people (n?=?48 males) aged 55 years and over were identified from two studies that are part of the UK Autism Spectrum Adulthood and Ageing research programme. Participants provided demographic data to establish normative outcome participation, and completed the World Health Organisation (WHO) QoL measure (WHOQoL-BREF) and the Hospital Anxiety and Depression Scale (HADS). Illustrative quotes focusing on normative outcomes were available from in-depth interviews (n?=?8). Results QoL scores across all domains were lower for individuals who met indicative clinical cut-offs for depression (F(8,126)?=?6.171, p? En ligne : https://doi.org/10.1016/j.rasd.2019.02.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=394

A systematic review of quality of life of adults on the autism spectrum / M. AYRES in Autism, 22-7 (October 2018)  

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A Systematic Review of What Barriers and Facilitators Prevent and Enable Physical Healthcare Services Access for Autistic Adults / D. MASON in Journal of Autism and Developmental Disorders, 49-8 (August 2019)  

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The association between socioeconomic status and autism diagnosis in the United Kingdom for children aged 5-8 years of age: Findings from the Born in Bradford cohort / B. KELLY in Autism, 23-1 (January 2019)  

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