Long-Term Synaptic Depression / David E.J. LINDEN in Annual Review of Neuroscience, 18 (1995)

Public ISBD [article]  inAnnual Review of Neuroscience > 18 (1995) . - p.319-357 Titre : Long-Term Synaptic Depression Type de document : texte imprimé Auteurs : David E.J. LINDEN, Auteur ; John A. CONNOR, Auteur Année de publication : 1995 Article en page(s) : p.319-357 Langues : Anglais (eng) Mots-clés : Memory Synaptic-plasticity Cerebral-Cortex Hippocampus Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377 [article] Long-Term Synaptic Depression [texte imprimé] / David E.J. LINDEN, Auteur ; John A. CONNOR, Auteur . - 1995 . - p.319-357. Langues : Anglais (eng) in Annual Review of Neuroscience > 18 (1995) . - p.319-357 Mots-clés : Memory Synaptic-plasticity Cerebral-Cortex Hippocampus Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377

Neural excitation/inhibition imbalance and neurodevelopmental pathology in human copy number variant syndromes: a systematic review / Amy L. SYLVESTER in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : Neural excitation/inhibition imbalance and neurodevelopmental pathology in human copy number variant syndromes: a systematic review Type de document : texte imprimé Auteurs : Amy L. SYLVESTER, Auteur ; Eva HENSENNE, Auteur ; Dimo IVANOV, Auteur ; Benedikt A. POSER, Auteur ; David E.J. LINDEN, Auteur ; Thérèse VAN AMELSVOORT, Auteur ; Claudia VINGERHOETS, Auteur Langues : Anglais (eng) Mots-clés : Humans  DNA Copy Number Variations/genetics  Neurodevelopmental Disorders/genetics/physiopathology  Neural Inhibition/physiology  Copy number variation  Excitation  Glutamate  Inhibition  Neurodevelopmental disorders  γ-aminobutyric acid  for publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : Cumulative evidence suggests neurodevelopmental disorders are closely related. The risk of these disorders is increased by a series of copy number variant syndromes - phenotypically heterogeneous genetic disorders, present in a minority of the population. Recent models suggest that a disruption in the balance between excitatory and inhibitory neural activity may contribute to the aetiology of neurodevelopmental disorders, and may be additionally disturbed in copy number variant syndromes. In this systematic review, the databases PubMed, Embase, and Scopus were searched for studies of excitation/inhibition imbalance in relation to neurodevelopmental disorders in human copy number variant samples. A total of 53 studies were included, representing a variety of copy number variants and research methodologies. The resulting data suggests excitation/inhibition balance is indeed disrupted in different copy number variant populations, providing insight into a putative mechanism of both idiopathic and genetic neurodevelopmental disorders. However, the high level of heterogeneity in the data set, alongside emerging techniques for excitation/inhibition assessment, prompts further investigation of this field. En ligne : https://dx.doi.org/10.1186/s11689-025-09614-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Neural excitation/inhibition imbalance and neurodevelopmental pathology in human copy number variant syndromes: a systematic review [texte imprimé] / Amy L. SYLVESTER, Auteur ; Eva HENSENNE, Auteur ; Dimo IVANOV, Auteur ; Benedikt A. POSER, Auteur ; David E.J. LINDEN, Auteur ; Thérèse VAN AMELSVOORT, Auteur ; Claudia VINGERHOETS, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Humans  DNA Copy Number Variations/genetics  Neurodevelopmental Disorders/genetics/physiopathology  Neural Inhibition/physiology  Copy number variation  Excitation  Glutamate  Inhibition  Neurodevelopmental disorders  γ-aminobutyric acid  for publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : Cumulative evidence suggests neurodevelopmental disorders are closely related. The risk of these disorders is increased by a series of copy number variant syndromes - phenotypically heterogeneous genetic disorders, present in a minority of the population. Recent models suggest that a disruption in the balance between excitatory and inhibitory neural activity may contribute to the aetiology of neurodevelopmental disorders, and may be additionally disturbed in copy number variant syndromes. In this systematic review, the databases PubMed, Embase, and Scopus were searched for studies of excitation/inhibition imbalance in relation to neurodevelopmental disorders in human copy number variant samples. A total of 53 studies were included, representing a variety of copy number variants and research methodologies. The resulting data suggests excitation/inhibition balance is indeed disrupted in different copy number variant populations, providing insight into a putative mechanism of both idiopathic and genetic neurodevelopmental disorders. However, the high level of heterogeneity in the data set, alongside emerging techniques for excitation/inhibition assessment, prompts further investigation of this field. En ligne : https://dx.doi.org/10.1186/s11689-025-09614-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

Training the social brain: Clinical and neural effects of an 8-week real-time functional magnetic resonance imaging neurofeedback Phase IIa Clinical Trial in Autism / Bruno DIREITO in Autism, 25-6 (August 2021)  

Public ISBD [article]  inAutism > 25-6 (August 2021) . - p.1746-1760 Titre : Training the social brain: Clinical and neural effects of an 8-week real-time functional magnetic resonance imaging neurofeedback Phase IIa Clinical Trial in Autism Type de document : texte imprimé Auteurs : Bruno DIREITO, Auteur ; Susana MOUGA, Auteur ; Alexandre SAYAL, Auteur ; Marco SIMÕES, Auteur ; Hugo QUENTAL, Auteur ; Inês BERNARDINO, Auteur ; Rebecca PLAYLE, Auteur ; Rachel MCNAMARA, Auteur ; David E.J. LINDEN, Auteur ; Guiomar OLIVEIRA, Auteur ; Miguel CASTELO-BRANCO, Auteur Article en page(s) : p.1746-1760 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnostic imaging/therapy  Autistic Disorder/diagnostic imaging/therapy  Brain/diagnostic imaging  Humans  Magnetic Resonance Imaging  Neurofeedback  autism spectrum disorder  neurorehabilitation  posterior superior temporal sulcus  real-time functional magnetic resonance imaging  social cognition Index. décimale : PER Périodiques Résumé : Neurofeedback is an emerging therapeutic approach in neuropsychiatric disorders. Its potential application in autism spectrum disorder remains to be tested. Here, we demonstrate the feasibility of real-time functional magnetic resonance imaging volitional neurofeedback in targeting social brain regions in autism spectrum disorder. In this clinical trial, autism spectrum disorder patients were enrolled in a program with five training sessions of neurofeedback. Participants were able to control their own brain activity in this social brain region, with positive clinical and neural effects. Larger, controlled, and blinded clinical studies will be required to confirm the benefits. En ligne : http://dx.doi.org/10.1177/13623613211002052 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 [article] Training the social brain: Clinical and neural effects of an 8-week real-time functional magnetic resonance imaging neurofeedback Phase IIa Clinical Trial in Autism [texte imprimé] / Bruno DIREITO, Auteur ; Susana MOUGA, Auteur ; Alexandre SAYAL, Auteur ; Marco SIMÕES, Auteur ; Hugo QUENTAL, Auteur ; Inês BERNARDINO, Auteur ; Rebecca PLAYLE, Auteur ; Rachel MCNAMARA, Auteur ; David E.J. LINDEN, Auteur ; Guiomar OLIVEIRA, Auteur ; Miguel CASTELO-BRANCO, Auteur . - p.1746-1760. Langues : Anglais (eng) in Autism > 25-6 (August 2021) . - p.1746-1760 Mots-clés : Autism Spectrum Disorder/diagnostic imaging/therapy  Autistic Disorder/diagnostic imaging/therapy  Brain/diagnostic imaging  Humans  Magnetic Resonance Imaging  Neurofeedback  autism spectrum disorder  neurorehabilitation  posterior superior temporal sulcus  real-time functional magnetic resonance imaging  social cognition Index. décimale : PER Périodiques Résumé : Neurofeedback is an emerging therapeutic approach in neuropsychiatric disorders. Its potential application in autism spectrum disorder remains to be tested. Here, we demonstrate the feasibility of real-time functional magnetic resonance imaging volitional neurofeedback in targeting social brain regions in autism spectrum disorder. In this clinical trial, autism spectrum disorder patients were enrolled in a program with five training sessions of neurofeedback. Participants were able to control their own brain activity in this social brain region, with positive clinical and neural effects. Larger, controlled, and blinded clinical studies will be required to confirm the benefits. En ligne : http://dx.doi.org/10.1177/13623613211002052 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451

Training the social brain: Clinical and neural effects of an 8-week real-time functional magnetic resonance imaging neurofeedback Phase IIa Clinical Trial in Autism / Bruno DIREITO in Autism, 26-6 (August 2022)  

Public ISBD [article]  inAutism > 26-6 (August 2022) . - p.1746-1760 Titre : Training the social brain: Clinical and neural effects of an 8-week real-time functional magnetic resonance imaging neurofeedback Phase IIa Clinical Trial in Autism Type de document : texte imprimé Auteurs : Bruno DIREITO, Auteur ; Susana MOUGA, Auteur ; Alexandre SAYAL, Auteur ; Marco SIMÕES, Auteur ; Hugo QUENTAL, Auteur ; Inês BERNARDINO, Auteur ; Rebecca PLAYLE, Auteur ; Rachel MCNAMARA, Auteur ; David E.J. LINDEN, Auteur ; Guiomar OLIVEIRA, Auteur ; Miguel CASTELO-BRANCO, Auteur Article en page(s) : p.1746-1760 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnostic imaging/therapy  Autistic Disorder/diagnostic imaging/therapy  Brain/diagnostic imaging  Humans  Magnetic Resonance Imaging  Neurofeedback  autism spectrum disorder  neurofeedback  neurorehabilitation  posterior superior temporal sulcus  real-time functional magnetic resonance imaging  social cognition Index. décimale : PER Périodiques Résumé : Neurofeedback is an emerging therapeutic approach in neuropsychiatric disorders. Its potential application in autism spectrum disorder remains to be tested. Here, we demonstrate the feasibility of real-time functional magnetic resonance imaging volitional neurofeedback in targeting social brain regions in autism spectrum disorder. In this clinical trial, autism spectrum disorder patients were enrolled in a program with five training sessions of neurofeedback. Participants were able to control their own brain activity in this social brain region, with positive clinical and neural effects. Larger, controlled, and blinded clinical studies will be required to confirm the benefits. En ligne : http://dx.doi.org/10.1177/13623613211002052 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484 [article] Training the social brain: Clinical and neural effects of an 8-week real-time functional magnetic resonance imaging neurofeedback Phase IIa Clinical Trial in Autism [texte imprimé] / Bruno DIREITO, Auteur ; Susana MOUGA, Auteur ; Alexandre SAYAL, Auteur ; Marco SIMÕES, Auteur ; Hugo QUENTAL, Auteur ; Inês BERNARDINO, Auteur ; Rebecca PLAYLE, Auteur ; Rachel MCNAMARA, Auteur ; David E.J. LINDEN, Auteur ; Guiomar OLIVEIRA, Auteur ; Miguel CASTELO-BRANCO, Auteur . - p.1746-1760. Langues : Anglais (eng) in Autism > 26-6 (August 2022) . - p.1746-1760 Mots-clés : Autism Spectrum Disorder/diagnostic imaging/therapy  Autistic Disorder/diagnostic imaging/therapy  Brain/diagnostic imaging  Humans  Magnetic Resonance Imaging  Neurofeedback  autism spectrum disorder  neurofeedback  neurorehabilitation  posterior superior temporal sulcus  real-time functional magnetic resonance imaging  social cognition Index. décimale : PER Périodiques Résumé : Neurofeedback is an emerging therapeutic approach in neuropsychiatric disorders. Its potential application in autism spectrum disorder remains to be tested. Here, we demonstrate the feasibility of real-time functional magnetic resonance imaging volitional neurofeedback in targeting social brain regions in autism spectrum disorder. In this clinical trial, autism spectrum disorder patients were enrolled in a program with five training sessions of neurofeedback. Participants were able to control their own brain activity in this social brain region, with positive clinical and neural effects. Larger, controlled, and blinded clinical studies will be required to confirm the benefits. En ligne : http://dx.doi.org/10.1177/13623613211002052 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484

Using kinematic analyses to explore sensorimotor control impairments in children with 22q11.2 deletion syndrome / Adam C. CUNNINGHAM in Journal of Neurodevelopmental Disorders, 11-1 (December 2019)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 8 p. Titre : Using kinematic analyses to explore sensorimotor control impairments in children with 22q11.2 deletion syndrome Type de document : texte imprimé Auteurs : Adam C. CUNNINGHAM, Auteur ; Liam HILL, Auteur ; Mark MON-WILLIAMS, Auteur ; Kathryn J. PEALL, Auteur ; David E.J. LINDEN, Auteur ; Jeremy HALL, Auteur ; Michael J. OWEN, Auteur ; Marianne B.M. VAN DEN BREE, Auteur Article en page(s) : 8 p. Langues : Anglais (eng) Mots-clés : 22q11.2 deletion syndrome  Adhd  Asd  Anxiety  Coordination  Movement difficulties Index. décimale : PER Périodiques Résumé : BACKGROUND: The 22q11.2 deletion is associated with psychiatric and behavioural disorders, intellectual disability and multiple physical abnormalities. Recent research also indicates impaired coordination skills may be part of the clinical phenotype. This study aimed to characterise sensorimotor control abilities in children with 22q11.2 deletion syndrome (22q11.2DS) and investigate their relationships with co-occurring IQ impairments and psychopathology. METHODS: Fifty-four children with 22q11.2DS and 24 unaffected sibling controls, comparable in age and gender, underwent kinematic analysis of their hand movements, whilst performing a battery of three visuo-manual coordination tasks that measured their tracking, aiming and steering abilities. Additionally, standardised assessments of full-scale IQ (FSIQ), attention deficit hyperactivity disorder, indicative autism spectrum disorder (ASD) and anxiety disorder symptomatology were conducted. RESULTS: Children with 22q11.2DS showed deficits on seven of eight kinematic descriptors of movement quality across the three coordination tasks, compared to controls. Within 22q11.2DS cases, the extent of impairment on only three kinematic descriptors was significantly related to FSIQ after correction for multiple testing. Moreover, only error whilst visuo-manually tracking was nominally associated with ADHD symptom counts. CONCLUSIONS: Impairments in sensorimotor control are seen on a range of visuo-manual tasks in children with 22q11.2DS but the extent of these impairments are largely unrelated to the severity of other psychopathological and intellectual impairments commonly found in children with 22q11.2DS. En ligne : https://dx.doi.org/10.1186/s11689-019-9271-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] Using kinematic analyses to explore sensorimotor control impairments in children with 22q11.2 deletion syndrome [texte imprimé] / Adam C. CUNNINGHAM, Auteur ; Liam HILL, Auteur ; Mark MON-WILLIAMS, Auteur ; Kathryn J. PEALL, Auteur ; David E.J. LINDEN, Auteur ; Jeremy HALL, Auteur ; Michael J. OWEN, Auteur ; Marianne B.M. VAN DEN BREE, Auteur . - 8 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 8 p. Mots-clés : 22q11.2 deletion syndrome  Adhd  Asd  Anxiety  Coordination  Movement difficulties Index. décimale : PER Périodiques Résumé : BACKGROUND: The 22q11.2 deletion is associated with psychiatric and behavioural disorders, intellectual disability and multiple physical abnormalities. Recent research also indicates impaired coordination skills may be part of the clinical phenotype. This study aimed to characterise sensorimotor control abilities in children with 22q11.2 deletion syndrome (22q11.2DS) and investigate their relationships with co-occurring IQ impairments and psychopathology. METHODS: Fifty-four children with 22q11.2DS and 24 unaffected sibling controls, comparable in age and gender, underwent kinematic analysis of their hand movements, whilst performing a battery of three visuo-manual coordination tasks that measured their tracking, aiming and steering abilities. Additionally, standardised assessments of full-scale IQ (FSIQ), attention deficit hyperactivity disorder, indicative autism spectrum disorder (ASD) and anxiety disorder symptomatology were conducted. RESULTS: Children with 22q11.2DS showed deficits on seven of eight kinematic descriptors of movement quality across the three coordination tasks, compared to controls. Within 22q11.2DS cases, the extent of impairment on only three kinematic descriptors was significantly related to FSIQ after correction for multiple testing. Moreover, only error whilst visuo-manually tracking was nominally associated with ADHD symptom counts. CONCLUSIONS: Impairments in sensorimotor control are seen on a range of visuo-manual tasks in children with 22q11.2DS but the extent of these impairments are largely unrelated to the severity of other psychopathological and intellectual impairments commonly found in children with 22q11.2DS. En ligne : https://dx.doi.org/10.1186/s11689-019-9271-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

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