Cord and Early Childhood Plasma Adiponectin Levels and Autism Risk: A Prospective Birth Cohort Study / R. RAGHAVAN in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.173-184 Titre : Cord and Early Childhood Plasma Adiponectin Levels and Autism Risk: A Prospective Birth Cohort Study Type de document : Texte imprimé et/ou numérique Auteurs : R. RAGHAVAN, Auteur ; M. D. FALLIN, Auteur ; X. HONG, Auteur ; G. WANG, Auteur ; Y. JI, Auteur ; E. A. STUART, Auteur ; D. PAIGE, Auteur ; X. WANG, Auteur Article en page(s) : p.173-184 Langues : Anglais (eng) Mots-clés : Adiponectin  Autism  Cytokines  Preterm birth Index. décimale : PER Périodiques Résumé : Emerging research suggests that adiponectin, a cytokine produced by adipose tissue, may be implicated in ASD. In this prospective birth cohort study (n = 847), we assessed the association between cord, early childhood plasma adiponectin and the risk of developing ASD. ASD was defined based on ICD codes of physician diagnosis. Cord adiponectin levels were inversely associated with ASD risk (aOR 0.50; 95% CI 0.33, 0.77), independent of preterm birth, early childhood adiponectin and other known ASD risk factors. Early childhood adiponectin, assessed prior to ASD diagnosis, was associated with lower risk of ASD, which attenuated after adjusting for cord adiponectin, indicating the relative importance of cord adiponectin in ASD risk. Further research is warranted to confirm our findings and elucidate biological mechanisms. En ligne : http://dx.doi.org/10.1007/s10803-018-3688-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376 [article] Cord and Early Childhood Plasma Adiponectin Levels and Autism Risk: A Prospective Birth Cohort Study [Texte imprimé et/ou numérique] / R. RAGHAVAN, Auteur ; M. D. FALLIN, Auteur ; X. HONG, Auteur ; G. WANG, Auteur ; Y. JI, Auteur ; E. A. STUART, Auteur ; D. PAIGE, Auteur ; X. WANG, Auteur . - p.173-184. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.173-184 Mots-clés : Adiponectin  Autism  Cytokines  Preterm birth Index. décimale : PER Périodiques Résumé : Emerging research suggests that adiponectin, a cytokine produced by adipose tissue, may be implicated in ASD. In this prospective birth cohort study (n = 847), we assessed the association between cord, early childhood plasma adiponectin and the risk of developing ASD. ASD was defined based on ICD codes of physician diagnosis. Cord adiponectin levels were inversely associated with ASD risk (aOR 0.50; 95% CI 0.33, 0.77), independent of preterm birth, early childhood adiponectin and other known ASD risk factors. Early childhood adiponectin, assessed prior to ASD diagnosis, was associated with lower risk of ASD, which attenuated after adjusting for cord adiponectin, indicating the relative importance of cord adiponectin in ASD risk. Further research is warranted to confirm our findings and elucidate biological mechanisms. En ligne : http://dx.doi.org/10.1007/s10803-018-3688-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376

Fetal and Infancy Growth Pattern, Cord and Early Childhood Plasma Leptin, and Development of Autism Spectrum Disorder in the Boston Birth Cohort / R. RAGHAVAN in Autism Research, 11-10 (October 2018)  

Public ISBD [article]  inAutism Research > 11-10 (October 2018) . - p.1416-1431 Titre : Fetal and Infancy Growth Pattern, Cord and Early Childhood Plasma Leptin, and Development of Autism Spectrum Disorder in the Boston Birth Cohort Type de document : Texte imprimé et/ou numérique Auteurs : R. RAGHAVAN, Auteur ; Barry S. ZUCKERMAN, Auteur ; X. HONG, Auteur ; G. WANG, Auteur ; Y. JI, Auteur ; D. PAIGE, Auteur ; J. DIBARI, Auteur ; C. ZHANG, Auteur ; M. D. FALLIN, Auteur ; X. WANG, Auteur Article en page(s) : p.1416-1431 Langues : Anglais (eng) Mots-clés : autism  birth weight for gestational age  leptin  rapid weight gain in infancy Index. décimale : PER Périodiques Résumé : Leptin is a proinflammatory cytokine that plays an important role in energy homeostasis. Emerging evidence suggests that leptin levels are altered in children with autism spectrum disorder (ASD); however, this has not been studied prospectively. Rapid growth during infancy and early childhood has been implicated in ASD, but the evidence is inconsistent. As leptin is involved in growth and is a potential risk factor for ASD, we explored the associations between (a) cord, early childhood leptin and ASD; and (b) birth weight for gestational age, early childhood weight gain, and ASD. We also assessed the mediating role of leptin in the relationship between weight gain during infancy and ASD. This study was conducted in a sample of 822 subjects from the Boston Birth Cohort. ASD was defined from diagnostic codes in electronic medical records. Extremely rapid weight gain during infancy was associated with a greater ASD risk and this persisted after adjusting for potential confounders (aOR: 3.11; 95% CI: 1.37, 7.07). Similarly, children that had higher plasma leptin levels, prior to ASD diagnosis, had an increased ASD risk in both unadjusted and adjusted models (aOR: 7.87; 95% CI: 2.06, 30.04). Further, early childhood leptin indirectly mediated the relationship between rapid weight gain and ASD. No associations were found between birth weight for gestational age, cord leptin and risk of ASD. Our findings provide a basis to further explore whether the combination of early life growth pattern and a biomarker such as leptin can predict ASD earlier. Autism Res 2018, 11: 1416-1431. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Is early life growth and a biomarker leptin related to ASD risk? To answer this question, we followed 822 children from birth and found that those who gained weight very quickly in infancy, had higher leptin levels in early childhood, had a greater chance of later ASD diagnosis. More research is needed to see if infant's weight gain pattern along with a biomarker (such as leptin) can be used to identify children with ASD sooner. En ligne : http://dx.doi.org/10.1002/aur.2011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 [article] Fetal and Infancy Growth Pattern, Cord and Early Childhood Plasma Leptin, and Development of Autism Spectrum Disorder in the Boston Birth Cohort [Texte imprimé et/ou numérique] / R. RAGHAVAN, Auteur ; Barry S. ZUCKERMAN, Auteur ; X. HONG, Auteur ; G. WANG, Auteur ; Y. JI, Auteur ; D. PAIGE, Auteur ; J. DIBARI, Auteur ; C. ZHANG, Auteur ; M. D. FALLIN, Auteur ; X. WANG, Auteur . - p.1416-1431. Langues : Anglais (eng) in Autism Research > 11-10 (October 2018) . - p.1416-1431 Mots-clés : autism  birth weight for gestational age  leptin  rapid weight gain in infancy Index. décimale : PER Périodiques Résumé : Leptin is a proinflammatory cytokine that plays an important role in energy homeostasis. Emerging evidence suggests that leptin levels are altered in children with autism spectrum disorder (ASD); however, this has not been studied prospectively. Rapid growth during infancy and early childhood has been implicated in ASD, but the evidence is inconsistent. As leptin is involved in growth and is a potential risk factor for ASD, we explored the associations between (a) cord, early childhood leptin and ASD; and (b) birth weight for gestational age, early childhood weight gain, and ASD. We also assessed the mediating role of leptin in the relationship between weight gain during infancy and ASD. This study was conducted in a sample of 822 subjects from the Boston Birth Cohort. ASD was defined from diagnostic codes in electronic medical records. Extremely rapid weight gain during infancy was associated with a greater ASD risk and this persisted after adjusting for potential confounders (aOR: 3.11; 95% CI: 1.37, 7.07). Similarly, children that had higher plasma leptin levels, prior to ASD diagnosis, had an increased ASD risk in both unadjusted and adjusted models (aOR: 7.87; 95% CI: 2.06, 30.04). Further, early childhood leptin indirectly mediated the relationship between rapid weight gain and ASD. No associations were found between birth weight for gestational age, cord leptin and risk of ASD. Our findings provide a basis to further explore whether the combination of early life growth pattern and a biomarker such as leptin can predict ASD earlier. Autism Res 2018, 11: 1416-1431. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Is early life growth and a biomarker leptin related to ASD risk? To answer this question, we followed 822 children from birth and found that those who gained weight very quickly in infancy, had higher leptin levels in early childhood, had a greater chance of later ASD diagnosis. More research is needed to see if infant's weight gain pattern along with a biomarker (such as leptin) can be used to identify children with ASD sooner. En ligne : http://dx.doi.org/10.1002/aur.2011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

Maternal prenatal selenium levels and child risk of neurodevelopmental disorders: A prospective birth cohort study / A. S. E. LEE in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2533-2543 Titre : Maternal prenatal selenium levels and child risk of neurodevelopmental disorders: A prospective birth cohort study Type de document : Texte imprimé et/ou numérique Auteurs : A. S. E. LEE, Auteur ; Y. JI, Auteur ; R. RAGHAVAN, Auteur ; G. WANG, Auteur ; X. HONG, Auteur ; C. PEARSON, Auteur ; G. MIROLLI, Auteur ; E. BIND, Auteur ; A. STEFFENS, Auteur ; J. MUKHERJEE, Auteur ; D. HALTMEIER, Auteur ; Z. T. FAN, Auteur ; X. WANG, Auteur Article en page(s) : p.2533-2543 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity  Autism Spectrum Disorder/epidemiology  Birth Cohort  Cohort Studies  Female  Humans  Neurodevelopmental Disorders/epidemiology  Pregnancy  Prenatal Exposure Delayed Effects  Prospective Studies  Selenium  attention deficit-hyperactivity disorder  children  environmental risk factors  epigenetics  gene-environment interaction  pediatrics  pre- and perinatal risk factors Index. décimale : PER Périodiques Résumé : Selenium (Se) is an essential trace element involved in various biological processes, including neurodevelopment. Available literature indicates that both Se deficiency and excess may be detrimental to health. It is also known that Se can cross the placenta from maternal to fetal circulation. To date, the role of maternal Se status in child long-term neurodevelopment is largely unexplored. This study investigated the temporal and dose-response associations between maternal Se status and child risk of neurodevelopmental disorders including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). It consisted of 1550 mother-infant dyads from the Boston Birth Cohort. Maternal red blood cell (RBC) Se levels were measured in samples collected within 72?h of delivery (biomarker of third trimester Se status). Pediatric neurodevelopmental diagnoses were obtained from electronic medical records. Data analyses showed that maternal RBC Se levels were positively associated with child risk of developing ASD, with an adjusted odds ratio of 1.49 for ASD (95% CI: 1.09, 2.02) per IQR increase in Se. There was also a positive association between maternal Se and ADHD (OR: 1.29; 95% CI: 1.04, 1.56, per IQR increase in Se). These associations remained robust even after adjusting for pertinent covariables; and there was no significant interaction between Se and these covariables. Our findings suggest that prenatal exposure to high maternal Se levels may adversely affect child neurodevelopment. Our findings warrant further investigation; if confirmed, optimizing maternal prenatal Se levels may be necessary to maximize its health benefits while preventing undue risk. LAY SUMMARY: Selenium (Se) is an essential nutrient for the health of the pregnant mother and her baby. While Se can readily cross the placenta from maternal to fetal circulation, little is known about maternal Se status on her child's neurodevelopmental outcomes. We studied over 1500 mother-child dyads from birth to school age of the child. We found that babies born from mothers with high blood Se levels may be at increased risk of developing autism spectrum disorder or attention deficit hyperactivity disorder. Given this is the first study of the kind, more study is needed to confirm our findings. En ligne : http://dx.doi.org/10.1002/aur.2617 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Maternal prenatal selenium levels and child risk of neurodevelopmental disorders: A prospective birth cohort study [Texte imprimé et/ou numérique] / A. S. E. LEE, Auteur ; Y. JI, Auteur ; R. RAGHAVAN, Auteur ; G. WANG, Auteur ; X. HONG, Auteur ; C. PEARSON, Auteur ; G. MIROLLI, Auteur ; E. BIND, Auteur ; A. STEFFENS, Auteur ; J. MUKHERJEE, Auteur ; D. HALTMEIER, Auteur ; Z. T. FAN, Auteur ; X. WANG, Auteur . - p.2533-2543. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2533-2543 Mots-clés : Attention Deficit Disorder with Hyperactivity  Autism Spectrum Disorder/epidemiology  Birth Cohort  Cohort Studies  Female  Humans  Neurodevelopmental Disorders/epidemiology  Pregnancy  Prenatal Exposure Delayed Effects  Prospective Studies  Selenium  attention deficit-hyperactivity disorder  children  environmental risk factors  epigenetics  gene-environment interaction  pediatrics  pre- and perinatal risk factors Index. décimale : PER Périodiques Résumé : Selenium (Se) is an essential trace element involved in various biological processes, including neurodevelopment. Available literature indicates that both Se deficiency and excess may be detrimental to health. It is also known that Se can cross the placenta from maternal to fetal circulation. To date, the role of maternal Se status in child long-term neurodevelopment is largely unexplored. This study investigated the temporal and dose-response associations between maternal Se status and child risk of neurodevelopmental disorders including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). It consisted of 1550 mother-infant dyads from the Boston Birth Cohort. Maternal red blood cell (RBC) Se levels were measured in samples collected within 72?h of delivery (biomarker of third trimester Se status). Pediatric neurodevelopmental diagnoses were obtained from electronic medical records. Data analyses showed that maternal RBC Se levels were positively associated with child risk of developing ASD, with an adjusted odds ratio of 1.49 for ASD (95% CI: 1.09, 2.02) per IQR increase in Se. There was also a positive association between maternal Se and ADHD (OR: 1.29; 95% CI: 1.04, 1.56, per IQR increase in Se). These associations remained robust even after adjusting for pertinent covariables; and there was no significant interaction between Se and these covariables. Our findings suggest that prenatal exposure to high maternal Se levels may adversely affect child neurodevelopment. Our findings warrant further investigation; if confirmed, optimizing maternal prenatal Se levels may be necessary to maximize its health benefits while preventing undue risk. LAY SUMMARY: Selenium (Se) is an essential nutrient for the health of the pregnant mother and her baby. While Se can readily cross the placenta from maternal to fetal circulation, little is known about maternal Se status on her child's neurodevelopmental outcomes. We studied over 1500 mother-child dyads from birth to school age of the child. We found that babies born from mothers with high blood Se levels may be at increased risk of developing autism spectrum disorder or attention deficit hyperactivity disorder. Given this is the first study of the kind, more study is needed to confirm our findings. En ligne : http://dx.doi.org/10.1002/aur.2617 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

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